Project Steve's 10th Anniversary

Posted 16 February 2013 by

Today is the 10th anniversary of NCSE's Project Steve:
"Project Steve" is a tongue-in-cheek parody of a long-standing creationist tradition of amassing lists of "scientists who doubt evolution" or "scientists who dissent from Darwinism."
Conceived in discussions amongst NCSE staffers and members of the old TalkDesign group (several of whom went on to be founding contributors to Panda's Thumb), the Steve-O-Meter currrently shows 1,239 scientists whose first name is Steve or a cognate, including the two eligible living Nobel winners (Chu and Weinberg), who have signed on to this statement:
Evolution is a vital, well-supported, unifying principle of the biological sciences, and the scientific evidence is overwhelmingly in favor of the idea that all living things share a common ancestry. Although there are legitimate debates about the patterns and processes of evolution, there is no serious scientific doubt that evolution occurred or that natural selection is a major mechanism in its occurrence. It is scientifically inappropriate and pedagogically irresponsible for creationist pseudoscience, including but not limited to "intelligent design," to be introduced into the science curricula of our nation's public schools.
Since "Steve" and cognates comprise roughly 1% of first names, that corresponds to over 120,000 scientists concurring with the statement. Compare that to the wishy-washy Scientific Dissent from Darwinism statement maintained by the Disco 'Tute:
We are skeptical of claims for the ability of random mutation and natural selection to account for the complexity of life. Careful examination of the evidence for Darwinian theory should be encouraged.

240 Comments

Gary_Hurd · 16 February 2013

That was a lot of fun. As I recall it was Matt Inslay (Sp?) who made the initial suggestion. Wasn't Stephen "Steve" Hawkings the first noble holder to sign? (And the first person not a biologist).

Rolf · 16 February 2013

Ill fate bestowed on me, to mention the 's'...
Yes, I am a nitpicker from way back, I am burdened with an eye for typos.

Richard B. Hoppe · 16 February 2013

Hawking signed, but doesn't have a Nobel.

Rolf, I don't see it.

Robert Byers · 16 February 2013

This comment has been moved to The Bathroom Wall.

Gary_Hurd · 16 February 2013

Right! I can't keep all these guys straight.

Dave Luckett · 16 February 2013

For a change, Byers is somewhat coherent. He's merely catastrophically wrong in fact.

He applies a particularly disgusting double standard to the ICR vs Project Steve. Both lists of signatories include scientists who are not evolutionary biologists, but Byers criticises only Project Steve for this, and ignores the fact that the ICR's list includes many who are not working scientists at all. He also ignores the fact that the signatories to the ICR's list are not actually endorsing creationism, whereas the signatories to Project Steve are specifically endorsing evolution.

With the complete insouciance of the severely deranged, he also simply ignores his own earlier vox populi arguments. Faced with the undeniable fact that the opposition to evolution among actual scientists is vanishingly negligible, he tells us that it doesn't matter. But Byers has spent years here pushing the idea that creationism must be true, because a lot of Americans believe it. He only introduces this counterargument now because it is convenient to him.

He wants evidence, he says. This is simply untrue. There is no evidence that would satisfy Byers. He shows no sign of understanding it or even admitting it into existence.

What does he want demonstrated? Common descent? The SINE insertion data is unequivocal evidence for it. Deep time? Sedimentary stratification alone was enough to convince the first real geologists; since then the evidence has gone from convincing to overwhelming to undeniable several times over. Speciation? Observed in the field multiple times: The London Underground mosquito; the apple maggot fly; several others. Morphological change over deep time? The fossil record provides a huge amount of evidence. There are studies from sediments in African lakes that plainly show detail changes appearing, spreading through a population and new species radiating.

Watch this space. If he's allowed to, Byers will simply ignore or deny it all.

https://www.google.com/accounts/o8/id?id=AItOawm-WhebH0itIDDTj06EQo2vtiF0BBqF10Q · 17 February 2013

It should be noted that the DI keeps C. Steven Murphree on their Dissent from Darwinism list although he left the dark side to become the 1184th Steve back in January 2012. David H. Bailey has a nice graph on his pages displaying the following facts
As of October 2012, the NCSE list had 1229 names, compared with 840 on the Discovery Institute list. If we count only those persons on these two lists who had a Ph.D. degree and/or professional position in a core field closely related to evolution (Anatomy, Anthropology, Bacteriology, Biochemistry, Biology, Biophysics, Botany, Ecology, Entomology, Epidemiology, Genetics, Geology, Geophysics, Molecular Biology, Microbiology, Neurophysiology, Paleontology, Physiology, Taxonomy, Virology or Zoology), who thus are particularly well-qualified to make such a declaration, then 683 (55.6%) of the names on the NCSE list were so qualified, compared with only 236 (28.1%) of the Discovery Institute list, according to a detailed check performed by the present author. If we then further limit the Discovery Institute core field list to those persons named Steve or one of the variants above, so that the size of this list can be directly compared with the NCSE core field list, then only two signers remain (in general agreement with the fact that persons named Steve or one of the above variants constitute roughly 1% of the U.S. population).
Since Bailey doesn't mention him it seems likely that he counted Murphree as one of the two Steves on the DI list.

Tenncrain · 17 February 2013

https://www.google.com/accounts/o8/id?id=AItOawm-WhebH0itIDDTj06EQo2vtiF0BBqF10Q said: It should be noted that the DI keeps C. Steven Murphree on their Dissent from Darwinism list although he left the dark side to become the 1184th Steve back in January 2012. David H. Bailey has a nice graph on his pages displaying the following facts
As of October 2012, the NCSE list had 1229 names, compared with 840 on the Discovery Institute list. If we count only those persons on these two lists who had a Ph.D. degree and/or professional position in a core field closely related to evolution (Anatomy, Anthropology, Bacteriology, Biochemistry, Biology, Biophysics, Botany, Ecology, Entomology, Epidemiology, Genetics, Geology, Geophysics, Molecular Biology, Microbiology, Neurophysiology, Paleontology, Physiology, Taxonomy, Virology or Zoology), who thus are particularly well-qualified to make such a declaration, then 683 (55.6%) of the names on the NCSE list were so qualified, compared with only 236 (28.1%) of the Discovery Institute list, according to a detailed check performed by the present author. If we then further limit the Discovery Institute core field list to those persons named Steve or one of the variants above, so that the size of this list can be directly compared with the NCSE core field list, then only two signers remain (in general agreement with the fact that persons named Steve or one of the above variants constitute roughly 1% of the U.S. population).
Since Bailey doesn't mention him it seems likely that he counted Murphree as one of the two Steves on the DI list.
The Discovery Institute list has two Steves, two Stevens and two Etiennes (no Stephanies, no Stefans, no Estebans, etc); so six members including "non-core" members. This compares to 1239 Steves/Stephanies/Stevens/etc on Project Steve as of Feb 7 2013.

Tenncrain · 17 February 2013

If Byers wants to respond, he will need to reply on the BW. Several have already replied there starting here:

http://pandasthumb.org/bw/index.html#comment-300106

Rolf · 17 February 2013

Richard B. Hoppe said: Hawking signed, but doesn't have a Nobel. Rolf, I don't see it.
Sorry, my bad. When a quick google would have saved me the embarassment. But there are a couple of points that ease my shame a little. While familiar with names like Hawking and Hawkins, I had never heard 'Hawkings' before. Add to that mention of a "nobel price". It so happens that in my language, nobel means - noble! So I didn't connet with Nobel, but more like a 'noble' price, just as we don't say 'Gold medal' inside a sentence. Taken all together, while I had misgivings and I really was a little puzzled by the whole thing, what heppened happened.

Gary_Hurd · 18 February 2013

Sorry Rolf. The life of a copy editor sucks.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 18 February 2013

there is no serious scientific doubt that evolution occurred
Depends entirely on how "evolution" is defined since virtually all creationists accept that living organisms can change/evolve within natural limits. The NCSE can't seem to do something as basic as that.
or that natural selection is a major mechanism in its occurrence.
Natural selection is not a "mechanism". It is just the inevitable outcome of differential reproduction. It explains why things stay the same rather than why they change. It fails to account for creativity in evolution.

Henry J · 18 February 2013

Variation + selection effects + feedback loops -> occasional creativity

DS · 18 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
there is no serious scientific doubt that evolution occurred
Depends entirely on how "evolution" is defined since virtually all creationists accept that living organisms can change/evolve within natural limits. The NCSE can't seem to do something as basic as that.
or that natural selection is a major mechanism in its occurrence.
Natural selection is not a "mechanism". It is just the inevitable outcome of differential reproduction. It explains why things stay the same rather than why they change. It fails to account for creativity in evolution.
There is no scientific doubt as to a single origin of life or descent with modification. Those who are too obstinate to admit it notwithstanding. Now where have we heard this nonsense about natural selection before? Get another string for your bango.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 18 February 2013

DS said: There is no scientific doubt as to a single origin of life or descent with modification. Those who are too obstinate to admit it notwithstanding.
So is W. Ford Doolittle not a scientific voice of doubt on the subject of universal common ancestry? http://shiva.msu.montana.edu/courses/mb437_537_2005_fall/docs/uprooting.pdf
Now where have we heard this nonsense about natural selection before? Get another string for your bango.
It isn't "nonsense" to deduce that natural selection works by reducing variation and preserving DNA sequences. You need to read up on Stephen Jay Gould: http://www.nybooks.com/articles/archives/1997/jun/12/darwinian-fundamentalism/?pagination=false In the most stunning evolutionary discoveries of our decade, developmental biologists have documented an astonishing “conservation".....most biologists feel that such stability acts primarily as a constraint upon the range and potentiality of adaptation.

harold · 18 February 2013

Depends entirely on how “evolution” is defined since virtually all creationists accept that living organisms can change/evolve within natural limits. The NCSE can’t seem to do something as basic as that.
Semantic word game/presumption of privilege. You're free to make up your own "true definition" of evolution", just don't expect anyone else to care. Your perfect right to privately use words as you wish does not give you a right to force others to use them as you demand.
Natural selection is not a “mechanism”. It is just the inevitable outcome of differential reproduction.
Semantic word game/non sequitur. Natural selection is indeed the inevitable result of differential reproduction. It is still a mechanism.
It explains why things stay the same rather than why they change.
Self-contradiction. This would make it a mechanism, even by your own claims. In fact, it sometimes does, in very adapted populations in stable environments, tend to reinforce stasis. Just not always.
It fails to account for creativity in evolution.
Gross misunderstanding of the basic subject under discussion. Natural selection applies to phenotypes that have already been "created" by genetics, developmental environment, etc. Also a semantic word game. Let's see, we've got three semantic word games, a non sequitur, a self-contradiction, and, of course, gross misunderstanding of the underlying subject matter, all in one short comment.

DS · 18 February 2013

I call POE. Unless this is yet another cretin trying to quote mine Gould. Now who would do such a thing? I wonder.

co · 18 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: all creationists accept that living organisms can change/evolve within natural limits
There's a good chance for you to explain exactly what a "natural limit" is. But you've tried and failed before, haven't you?

harold · 18 February 2013

So is W. Ford Doolittle not a scientific voice of doubt on the subject of universal common ancestry?
1) Gross misunderstaning of the subject matter - link leads to an article that does not question common ancestry, nor promote creationism. 2) Not only an appeal to authority, but a special type of appeal to authority that creationists love, which is even more flawed than typical appeal to authority. Hypocritical ppeal to authority of one individual, while ignoring the view of other experts with the same qualifications. Here it doesn't matter, since you've lied about the writer's intent to begin with.
It isn’t “nonsense” to deduce that natural selection works by reducing variation and preserving DNA sequences. You need to read up on Stephen Jay Gould:
Gross misunderstanding of the subject matter and misrepresentation of another person's views again. Son, dishonest, illogical, and arrogant is no way to go through life.

harold · 18 February 2013

DS said: I call POE. Unless this is yet another cretin trying to quote mine Gould. Now who would do such a thing? I wonder.
Either very good satire or very typical clueless dishonesty. I hope you are right.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 18 February 2013

co said: There's a good chance for you to explain exactly what a "natural limit" is.
I would strongly recommend reading this explanation of the limits to biological change by natural selection offered by two evolutionary biologists: Limits to natural selection: http://www.ufscar.br/~evolucao/popgen/ref12-5.pdf Enjoy.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 18 February 2013

harold said: 2) Not only an appeal to authority, but a special type of appeal to authority that creationists love, which is even more flawed than typical appeal to authority. Hypocritical ppeal to authority of one individual, while ignoring the view of other experts with the same qualifications. Here it doesn't matter, since you've lied about the writer's intent to begin with.
You are aware that the subject of this thread is precisely about an appeal to scientific authority by the NCSE? This "objection" you raise is a joke on your part, right?
Gross misunderstanding of the subject matter and misrepresentation of another person's views again.
It is just a fact that natural selection has conserved DNA sequences right across the phylogenetic board. Those in comparative genomics know this only too well.

co · 18 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
co said: There's a good chance for you to explain exactly what a "natural limit" is.
I would strongly recommend reading this explanation of the limits to biological change by natural selection offered by two evolutionary biologists: Limits to natural selection: http://www.ufscar.br/~evolucao/popgen/ref12-5.pdf Enjoy.
Yeah. Cute. Old concepts, applied to a population evolving to a steady state in the absence of changing environment. Want to try again, Joe?

harold · 18 February 2013

Yep, this is probably Joe. That tragic pattern of actually almost being able to understand, and then getting unhinged and derailed by obsession.
It is just a fact that natural selection has conserved DNA sequences right across the phylogenetic board. Those in comparative genomics know this only too well.
This statement, of course, is true. (It's just that natural selection doesn't only conserve, and that it conserves some things strongly, like the enzymes of basic metabolic pathways, while other aspects of the phenotype may be much less constrained.) Although "a masked panda" is getting the science wrong, he's getting a little closer than, say, the typical internet creationist, or, say, Casey Luskin, would be able to. But not quite close enough to be Todd Wood. Sure sounds like Joe.

Evan Witt · 18 February 2013

It's been a glorious ten years for Project Steve. I thought it was a very fitting and clever response when it first came out, and the same still holds true today.

DS · 18 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
harold said: 2) Not only an appeal to authority, but a special type of appeal to authority that creationists love, which is even more flawed than typical appeal to authority. Hypocritical ppeal to authority of one individual, while ignoring the view of other experts with the same qualifications. Here it doesn't matter, since you've lied about the writer's intent to begin with.
You are aware that the subject of this thread is precisely about an appeal to scientific authority by the NCSE? This "objection" you raise is a joke on your part, right?
Gross misunderstanding of the subject matter and misrepresentation of another person's views again.
It is just a fact that natural selection has conserved DNA sequences right across the phylogenetic board. Those in comparative genomics know this only too well.
That's right Joe. And not one of them ever said that that meant that all of the diversity of life could not be produced by this process. You're about to be dumped again. Bye bye.

Richard B. Hoppe · 18 February 2013

An anonymous commenter said
I would strongly recommend reading this explanation of the limits to biological change by natural selection offered by two evolutionary biologists: Limits to natural selection: http://www.ufscar.br/~evolucao/popgen/ref12-5.pdf Enjoy.
Of course there are limits to what evolution by random heritable variation and natural selection (along with a couple of other mechanisms) can do. That's what a good scientific theory does: it defines constraints on what will occur, what will be observed in lab or field. That's how one tests theories: by ascertaining whether those constraints are violated in nature or laboratory. What this anonymous commenter implies, but does not show, is that the constraints on variation and natural selection in the theory of evolution prohibit the naturalistic evolution of the array of diverse biological structures and processes we observe. That he/she has not done. Nor does the linked paper suggest that's the case. Nowhere does it suggest that the various forms of constraints it describes make evolutionary theory unable to account for the observed phenomena. Now contrast that with the so-called "theory" of intelligent design. It places no constraints whatsoever on the actions of the putative designer(s). As a consequence, it is untestable. By being able to explain absolutely anything, by placing no constraints on what the putative designer(s) can do, it explains nothing at all.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 18 February 2013

Richard B. Hoppe said: Nor does the linked paper suggest that's the case. Nowhere does it suggest that the various forms of constraints it describes make evolutionary theory unable to account for the observed phenomena.
The authors of the paper have this to say: "The most obvious limit to natural selection is that suitable variation may not be available." They cite some examples of where this is a real problem. It is an extremely pertinent point to note because natural selection can only work with what is available, and not with the variations that some evolutionary biologists speculate might be possible.
Now contrast that with the so-called "theory" of intelligent design. It places no constraints whatsoever on the actions of the putative designer(s). As a consequence, it is untestable. By being able to explain absolutely anything, by placing no constraints on what the putative designer(s) can do, it explains nothing at all.
The authors go on to say this: "Darwin's strongest evidence for the power of natural selection was by analogy with the dramatic success of artificial selection." Except that human experience with artificial selection has shown that there are indeed limits to the manner in which we can induce change in organisms, as any breeder is aware. And, moreover, artificial selection is a form of intelligent design. We can't get pigs to grow wings and fly even if we wanted to achieve this (ask Jerry Fodor).

co · 18 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
Richard B. Hoppe said: Nor does the linked paper suggest that's the case. Nowhere does it suggest that the various forms of constraints it describes make evolutionary theory unable to account for the observed phenomena.
The authors of the paper have this to say: "The most obvious limit to natural selection is that suitable variation may not be available." They cite some examples of where this is a real problem. It is an extremely pertinent point to note because natural selection can only work with what is available, and not with the variations that some evolutionary biologists speculate might be possible.
Now contrast that with the so-called "theory" of intelligent design. It places no constraints whatsoever on the actions of the putative designer(s). As a consequence, it is untestable. By being able to explain absolutely anything, by placing no constraints on what the putative designer(s) can do, it explains nothing at all.
The authors go on to say this: "Darwin's strongest evidence for the power of natural selection was by analogy with the dramatic success of artificial selection." Except that human experience with artificial selection has shown that there are indeed limits to the manner in which we can induce change in organisms, as any breeder is aware. And, moreover, artificial selection is a form of intelligent design. We can't get pigs to grow wings and fly even if we wanted to achieve this (ask Jerry Fodor).
Keep setting up strawmen and burning them down, Joe. You appear to be good at it. Stick with what you know.

Richard B. Hoppe · 18 February 2013

The anonymous commenter wrote:
Richard B. Hoppe said: Nor does the linked paper suggest that's the case. Nowhere does it suggest that the various forms of constraints it describes make evolutionary theory unable to account for the observed phenomena.
The authors of the paper have this to say: "The most obvious limit to natural selection is that suitable variation may not be available."
Well, of course. Variation is the raw material on which selection operates. But that statement doesn't imply that there was insufficient variation over billions of years to produce the biogical diversity we see.
They cite some examples of where this is a real problem. It is an extremely pertinent point to note because natural selection can only work with what is available, and not with the variations that some evolutionary biologists speculate might be possible.
What specific examples are you referring to here?
RBH: Now contrast that with the so-called "theory" of intelligent design. It places no constraints whatsoever on the actions of the putative designer(s). As a consequence, it is untestable. By being able to explain absolutely anything, by placing no constraints on what the putative designer(s) can do, it explains nothing at all.
Anonymous commenter: The authors go on to say this: "Darwin's strongest evidence for the power of natural selection was by analogy with the dramatic success of artificial selection." Except that human experience with artificial selection has shown that there are indeed limits to the manner in which we can induce change in organisms, as any breeder is aware. And, moreover, artificial selection is a form of intelligent design. We can't get pigs to grow wings and fly even if we wanted to achieve this (ask Jerry Fodor).
Once again, of course there are limits: not everything is possible to be evolved by natural selection operating on random variation, and we don't see pigs flying precisely because of constraints on what is possible. Evolution is descent with modification. But once again, the authors do not suggest that precludes accounting for the diversity of biological life that we observe. The authors wrote
In a broad sense, this is clearly why different lineages are constrained to particular ways of life: almost all of the multiple changes needed to allow a pig to fly would be deleterious. However, there is a sequence of ancestral phenotypes that connects pigs with bats and birds, and a combination of appropriate environments and appropriate genetic variability has taken organisms along this path.
Pigs don't fly, but their evolutionary cousins do. And we know why extant pigs won't evolve to fly. Intelligent design "theory" gives us no reason to suppose that some intelligent agent couldn't produce flying pigs. After all, an intelligent agent could skip over all those pesky intermediate forms. In addition, we're back to the "if it's an experimental outcome, it's intelligent design" foolishness. And I'll also note that "human experience" spans a tiny fraction of the time available for the diversification of life.

harold · 18 February 2013

Joe's deliberate misunderstanding for the day is to pretend to believe that scientists think that biological evolution has no limits.

Although Joe is unique in many ways, here he exhibits the creationist tendency to project their own flaws (which they must unconsciously recognize) onto scientists.

It is creationists who believe in sudden poofing into existence of modern species, fire-breathing dragons as historical facts, and so on. They are the ones who believe in a process that has no limits.

DS · 18 February 2013

What about the limits to intelligent design? Isn't is limited by the intelligence and capabilities of the designer? So, what we can conclude from the evidence is that, if there is indeed a designer, she is no more able to overcoming the limitations than natural selection. She appears to be constrained by historical contingency, just like natural selection. She appears to recycle old and inappropriate designs and to rely on exaptation, just like natural selection. In short, she is a completely unnecessary hypothesis. And we can tell all of this by simply looking at the limits of natural selection. Glad that's settled.

Just Bob · 18 February 2013

Mr. Masked,

I would like to ask you what kind of barrier exists that prevents one species from varying enough, over time, to give rise to a distinctly separate species. Is it:

A) some physical barrier, perhaps a code in the DNA, that allows only minor variation and "knows" to prevent variation beyond a predetermined(?) point; or

B) a supernatural (spiritual, divine, miraculous, magical, etc.) effect that observes all reproduction events and 1) prevents ones with too much variation, or 2) aborts all offspring with too much variation, or 3) repairs any DNA variation beyond the allowable limit, or 4) some combination of the above; or

C) some other barrier?

If the barrier is in fact physical, is it in principal detectable? Should we be able to discover the DNA barrier that is in every species which prevents an impermissible degree of variation?

Henry J · 18 February 2013

About item A), it would also have to somewhere keep a record of either where it started, so that the amount of change could be checked, or the point at which to block further change. In either case there would have to be some way of calculating the alleged limit point.

DS · 18 February 2013

Natural selection is like a sculpter. By itself it never adds anything new and yet it produces the most beautiful works of art, all from the stone that just happened to be there all along.

Henry J · 18 February 2013

Except that the stone used by a sculpture doesn't change internally (or grow new parts) during the process.

gnome de net · 18 February 2013

DS said: Natural selection is like a sculpter. By itself it never adds anything new and yet it produces the most beautiful works of art, all from the stone that just happened to be there all along.
Poetic, DS; poetic indeed!

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 18 February 2013

Richard B. Hoppe said: Well, of course. Variation is the raw material on which selection operates. But that statement doesn't imply that there was insufficient variation over billions of years to produce the biogical diversity we see.
Well, we may not know much about variation that occurred in the distant past, but we do know enough about random variation as it occurs today. We know that mutations in our own DNA are either harmful, and so cause disease, or else contribute to largely neutral and non-adaptive differences among us. What these random variations do not seem to provide is any raw material for significant evolutionary change by way of natural selection.
What specific examples are you referring to here?
(1) enzyme catalysis by the rate of diffusion of substrates to the active site, (2) mutation rate by the thermodynamics of base pairing, (3) reaction times by the speed of propagation of nerve impulses, and (4) the acuity of the eye by spherical aberration.
Once again, of course there are limits: not everything is possible to be evolved by natural selection operating on random variation, and we don't see pigs flying precisely because of constraints on what is possible. Evolution is descent with modification.
Yes. And the question that has been posed since Darwin's time is whether the accumulation of "slight modifications" can (at least in principle) generate the manifold "endless forms most beautiful and wonderful" evident in the living world. There is scant evidence for this.
But once again, the authors do not suggest that precludes accounting for the diversity of biological life that we observe.
I would be shocked if they did, considering that the authors are both eminent evolutionary biologists. What is noteworthy is that they are prepared to admit this limitation in a way in which the NCSE does not appear to be prepared to acknowledge.
Pigs don't fly, but their evolutionary cousins do. And we know why extant pigs won't evolve to fly. Intelligent design "theory" gives us no reason to suppose that some intelligent agent couldn't produce flying pigs. After all, an intelligent agent could skip over all those pesky intermediate forms.
There are mechanics involved that make some designs good and others less than optimal. A flying pig would, for simple physical reasons, be a flawed engineering design and would thus not be viable. You build things to last, not to fail (hence intelligent design).
In addition, we're back to the "if it's an experimental outcome, it's intelligent design" foolishness. And I'll also note that "human experience" spans a tiny fraction of the time available for the diversification of life.
Some of the best evidence for evolution comes through a directed process of design by artificial selection rather than by the blind working of natural selection: http://www.nature.com/nrm/journal/v10/n12/abs/nrm2805.html ftp://ftp.dbkgroup.org/pub/pdf_direvol/jackel_arb08.pdf

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 18 February 2013

DS said: Natural selection is like a sculpter. By itself it never adds anything new and yet it produces the most beautiful works of art, all from the stone that just happened to be there all along.
Except that this is not a fitting analogy when describing proteins (like collagen) encoded in genes that were not in any form present in the genome of the primordial organism.

Scott F · 18 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: Some of the best evidence for evolution comes through a directed process of design by artificial selection rather than by the blind working of natural selection:
Why do you characterize "artificial selection" as "directed", yet you characterize "natural selection" as "blind"? The adjectives appear to be arbitrary bias on your part. In "natural selection", the implicit selection criteria (or rather one of the many selection criteria) is "reproduces more offspring in the current environment". In what sense is this criteria "blind"? "Blind" to what? How is such selection not "directed" by reproductive success? Also, the adjective "Blind" would suggest that there is some Living Being with "Sight", and that this "Sight" is somehow inhibited from working. No one characterizes rocks or rain as "blind", for example. Why would you anthropomorphize a non-living process such as "Natural Selection" as "Blind"? In "artificial selection", the selection criteria is whatever the human has decided upon. Yet, such criteria are often "blind" to other features of the organism unrelated to the selection criteria. For example, I recall a study (in Russia, IIRC) where the humans were trying to breed domesticated foxes. They started with wild foxes, and selected each new generation for "friendliness" (or some social characteristic like "tamability"). However, it turned out that over many generations the "friendliest" animals turned out to have floppy ears. But "floppy ears" was not one of the chosen selection criteria. In fact, none of the original animals in the study had floppy ears, nor does any wild fox have floppy ears. Was the trait "floppy ears" a "directed" mutation? If so, how did the humans "direct" such a mutation, when no such mutation was in evidence at the start of the study, nor was it part of the selection criteria? See here and here. In general, how could humans possibly "direct" that certain mutations come into existence, and "direct" that other mutations not come into existence? Specifically, how did humans "direct" the creation of the original mutation for Belgian Blue cattle? Sure, human breeders can ensure that such cattle survive by artificial means (such as caesareans), but are you saying that humans "directed" the mutation to occur in the first place? In 1807?

Scott F · 18 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
DS said: Natural selection is like a sculpter. By itself it never adds anything new and yet it produces the most beautiful works of art, all from the stone that just happened to be there all along.
Except that this is not a fitting analogy when describing proteins (like collagen) encoded in genes that were not in any form present in the genome of the primordial organism.
Instead of a sculptor, I would suggest the analogy of a topiary artist, or a bonsai artist. Same kind of creativity, but with a living medium. The topiary artist can only use those features that already exist, or might exist. The same with Bonsai Mountains. :-)

DS · 18 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
DS said: Natural selection is like a sculpter. By itself it never adds anything new and yet it produces the most beautiful works of art, all from the stone that just happened to be there all along.
Except that this is not a fitting analogy when describing proteins (like collagen) encoded in genes that were not in any form present in the genome of the primordial organism.
Now you got it asshole. Your analogy is completely inappropriate and has no biological relevance whatsoever.

DS · 18 February 2013

Joe has been provided with references that demonstrate that all of his hand waving and and baseless assertions are meaningless. He refuses to learn and simply repeats his mistakes over and over. He is not concerned with evidence or reality, he has only his own incredulity. Well Joe, I'm incredulous as well. I can't believe that anyone could actually believe anything so stupid, so I have concluded that you don't. Piss off.

Richard B. Hoppe · 18 February 2013

The anonymous commenter said:
Richard B. Hoppe said: Well, of course. Variation is the raw material on which selection operates. But that statement doesn't imply that there was insufficient variation over billions of years to produce the biogical diversity we see.
Well, we may not know much about variation that occurred in the distant past, but we do know enough about random variation as it occurs today. We know that mutations in our own DNA are either harmful, and so cause disease, or else contribute to largely neutral and non-adaptive differences among us. What these random variations do not seem to provide is any raw material for significant evolutionary change by way of natural selection.
Most mutations in already fit populations in relatively stable selective environments will be neutral or more-or-less deleterious. That's a consequence of the topography of fitness landscapes: populations near peaks can't get much higher on average. However, in varying fitness landscapes, more mutations will be advantageous. In humans, for example, the change in the fitness landscape occasioned by the advent of pastoral farming, with the attendant availability of milk beyond infancy, has enabled the occurrence and spread of lactose tolerance mutations. And I note the weasel word "significant." "Significant evolutionary change" almost always comes as the consequence of a series of incremental changes, none in itself necessarily particularly striking, but in the aggregate generating significant change. (An exception, perhaps, is polyploidy, which particularly in plants can produce single-generation speciation.)
Richard B. Hoppe said: What specific examples are you referring to here?
(1) enzyme catalysis by the rate of diffusion of substrates to the active site, (2) mutation rate by the thermodynamics of base pairing, (3) reaction times by the speed of propagation of nerve impulses, and (4) the acuity of the eye by spherical aberration.
A copy and paste from the referenced article. Note that the article does not refer to them as "... some examples of where this is a real problem", as the anonymous commenter claims, but as a list of the various constraints on variation. But one more time, no one has claimed that variation is unlimited, and in fact like any good scientific theory, evolutionary theory actually considers the constraints on what will be observed, rendering it testable. That's very dissimilar to the various creationist alternatives: there is no limitation on the magic invoked by creationists. As I said earlier
Once again, of course there are limits: not everything is possible to be evolved by natural selection operating on random variation, and we don't see pigs flying precisely because of constraints on what is possible. Evolution is descent with modification.
The anonymous commenter replied
Yes. And the question that has been posed since Darwin's time is whether the accumulation of "slight modifications" can (at least in principle) generate the manifold "endless forms most beautiful and wonderful" evident in the living world. There is scant evidence for this.
The evidence from paleontology, molecular biology, comparative genetics, and evolutionary developmental biology is very far from "scant."
RBH said: But once again, the authors do not suggest that precludes accounting for the diversity of biological life that we observe.
I would be shocked if they did, considering that the authors are both eminent evolutionary biologists. What is noteworthy is that they are prepared to admit this limitation in a way in which the NCSE does not appear to be prepared to acknowledge.
Where'd the reference to NCSE come from? Eminent evolutionary biologists have not been reluctant to study the issue. As the history of biology since the resurrection of Mendel's work just after the turn of the 20th centurt shows, that's been a question that's absorbed a good deal of attention. See, for example, the debates between mutationists and selectionists in the early part of that century.
RBH said: Pigs don't fly, but their evolutionary cousins do. And we know why extant pigs won't evolve to fly. Intelligent design "theory" gives us no reason to suppose that some intelligent agent couldn't produce flying pigs. After all, an intelligent agent could skip over all those pesky intermediate forms.
Anonymous replied: There are mechanics involved that make some designs good and others less than optimal. A flying pig would, for simple physical reasons, be a flawed engineering design and would thus not be viable. You build things to last, not to fail (hence intelligent design).
Which, of course, utterly fails to explain why roughly 99% of the allegedly designed critters have gone extinct. Some designer!
Anonymous said:
RBH said: In addition, we're back to the "if it's an experimental outcome, it's intelligent design" foolishness. And I'll also note that "human experience" spans a tiny fraction of the time available for the diversification of life.
Some of the best evidence for evolution comes through a directed process of design by artificial selection rather than by the blind working of natural selection: http://www.nature.com/nrm/journal/v10/n12/abs/nrm2805.html ftp://ftp.dbkgroup.org/pub/pdf_direvol/jackel_arb08.pdf
Yup. That's known as "doing experiments": modeling hypothesized processes in the lab to see if the variables operate as predicted. In contrast to ID proponents, that's what genuine scientists do. The source of the selective pressure is irrelevant; the process works whether that source is humans or nature.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 18 February 2013

Scott F said: Why do you characterize "artificial selection" as "directed", yet you characterize "natural selection" as "blind"? The adjectives appear to be arbitrary bias on your part.
If I may quote from the Nature paper: http://www.nature.com/nrm/journal/v10/n12/execsumm/nrm2805.html "Directed evolution circumvents our profound ignorance of how a protein's sequence encodes its function by using iterative rounds of random mutation and artificial selection to discover new and useful proteins."
In "natural selection", the implicit selection criteria (or rather one of the many selection criteria) is "reproduces more offspring in the current environment". In what sense is this criteria "blind"? "Blind" to what? How is such selection not "directed" by reproductive success?
Well, you could indeed see natural selection as being "directed" by the environment. However, environmental pressures tend to fluctuate and so are directionless.
Also, the adjective "Blind" would suggest that there is some Living Being with "Sight", and that this "Sight" is somehow inhibited from working. No one characterizes rocks or rain as "blind", for example. Why would you anthropomorphize a non-living process such as "Natural Selection" as "Blind"?
It is the "Blind Watchmaker" analogy of Richard Dawkins: "Natural selection, the blind, unconscious automatic process which Darwin discovered, and which we now know is the explanation for the existence and apparently purposeful form of all life, has no purpose in mind. It has no mind and no mind's eye. It does not plan for the future. It has no vision, no foresight, no sight at all. If it can be said to play the role of watchmaker in nature, it is the blind watchmaker." The Blind Watchmaker (1996) p.5
In general, how could humans possibly "direct" that certain mutations come into existence, and "direct" that other mutations not come into existence? Specifically, how did humans "direct" the creation of the original mutation for Belgian Blue cattle? Sure, human breeders can ensure that such cattle survive by artificial means (such as caesareans), but are you saying that humans "directed" the mutation to occur in the first place? In 1807?
Artificial selection, just like natural selection, avails of random variations. However, artificial selection works by directing evolution and choosing variations to meet a goal or objective. Natural selection, however, has no goal or target.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 18 February 2013

Richard B. Hoppe said: Most mutations in already fit populations in relatively stable selective environments will be neutral or more-or-less deleterious. That's a consequence of the topography of fitness landscapes: populations near peaks can't get much higher on average. However, in varying fitness landscapes, more mutations will be advantageous. In humans, for example, the change in the fitness landscape occasioned by the advent of pastoral farming, with the attendant availability of milk beyond infancy, has enabled the occurrence and spread of lactose tolerance mutations.
An ability to drink milk beyond infancy (through the loss of a control mechanism) is hardly evidence that there exist natural variations that can explain the diversity of life.
And I note the weasel word "significant." "Significant evolutionary change" almost always comes as the consequence of a series of incremental changes, none in itself necessarily particularly striking, but in the aggregate generating significant change. (An exception, perhaps, is polyploidy, which particularly in plants can produce single-generation speciation.)
We all agree that some change can happen in living organisms. Only the limits to which this happens (naturally) is in dispute.
The evidence from paleontology, molecular biology, comparative genetics, and evolutionary developmental biology is very far from "scant."
And what evidence specifically? To date, I have seen no detailed explanation for how such and such a structure or part came to be through the accumulation of random mutations.
Eminent evolutionary biologists have not been reluctant to study the issue. As the history of biology since the resurrection of Mendel's work just after the turn of the 20th centurt shows, that's been a question that's absorbed a good deal of attention. See, for example, the debates between mutationists and selectionists in the early part of that century.
Yes. And the NCSE glosses over the fact that many evolutionary biologists are not as comfortable with the idea that natural selection can explain diversity as they imply.
Which, of course, utterly fails to explain why roughly 99% of the allegedly designed critters have gone extinct. Some designer!
This is a really silly argument to make. Extinction does not occur because organisms are badly designed or maladapted, but because of factors that include competition for resources, excessive predation or catastrophes. The dinosaurs weren't badly designed because an asteroid hit the earth and killed them any more than we would be badly designed if we became extinct through nuclear warfare.
The source of the selective pressure is irrelevant; the process works whether that source is humans or nature.
Wrong. So wrong. Artificial selection has no constraints other than the availability of the variation itself. Darwinian natural selection, however, requires that variation should improve reproductive success/fitness whereas artificial selection does not. Hence, artificial selection is more effective.

Mike Elzinga · 18 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: Wrong. So wrong. Artificial selection has no constraints other than the availability of the variation itself. Darwinian natural selection, however, requires that variation should improve reproductive success/fitness whereas artificial selection does not. Hence, artificial selection is more effective.
Just where did you get the notion that animal traits attractive to humans, and produced by "artificial" selection, are "more effective" than traits produced by "natural" selection? What are your criteria for "more effective?" Why should that be so? Where is your evidence?

Gsparky2004 · 18 February 2013

Okay, why is "A Masked Panda (1686)" using that particular screen name? Doesn't this forum already have "A Masked Panda"? Who is very obviously not "AMP (1686)" (whoever he is)? This isn't someone pulling "a Poe". This is someone pulling "a con". And a really bad one, at that.

apokryltaros · 18 February 2013

Gsparky2004 said: Okay, why is "A Masked Panda (1686)" using that particular screen name? Doesn't this forum already have "A Masked Panda"? Who is very obviously not "AMP (1686)" (whoever he is)? This isn't someone pulling "a Poe". This is someone pulling "a con". And a really bad one, at that.
"A Masked Panda" is a catch-all pseudonym for people who use yahoo mail accounts to sign in.

Mike Elzinga · 18 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: Wrong. So wrong. Artificial selection has no constraints other than the availability of the variation itself. Darwinian natural selection, however, requires that variation should improve reproductive success/fitness whereas artificial selection does not. Hence, artificial selection is more effective.
Let me ask the question a different way. Are you suggesting that “artificial” selection is “more effective” at producing traits than “natural” selection? What about the proboscis monkey or the platypus? Some humans might like such exaggerated features or such a bizarre mix of features; but there weren’t any humans who produced the proboscis monkey or the platypus.

Flint · 18 February 2013

Mike Elzinga said:
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: Wrong. So wrong. Artificial selection has no constraints other than the availability of the variation itself. Darwinian natural selection, however, requires that variation should improve reproductive success/fitness whereas artificial selection does not. Hence, artificial selection is more effective.
Let me ask the question a different way. Are you suggesting that “artificial” selection is “more effective” at producing traits than “natural” selection? What about the proboscis monkey or the platypus? Some humans might like such exaggerated features or such a bizarre mix of features; but there weren’t any humans who produced the proboscis monkey or the platypus.
I think he's saying that artificial selection is more efficient. And there's no question that it is far more efficient. Of course, "artificial" selection is nothing more than a reproductive environment, where the desired traits most emphatically "improve reproductive success/fitness". Artificial selection is like natural selection on steroids. Under artificial selection, ALL variants (and mutations) meeting the breeding goal are selected, and ALL variants (and mutations) not doing so are culled. The difference from natural selection IS efficiency, pretty much nothing else (except insofar as natural selection takes so much longer than more mutations will become available for selection).

Richard B. Hoppe · 18 February 2013

The anonymous yahoo poster wrote
An ability to drink milk beyond infancy (through the loss of a control mechanism) is hardly evidence that there exist natural variations that can explain the diversity of life.
It precisely refutes your claim that
We know that mutations in our own DNA are either harmful, and so cause disease, or else contribute to largely neutral and non-adaptive differences among us.
The anonymous poster further wrote
And what evidence specifically? To date, I have seen no detailed explanation for how such and such a structure or part came to be through the accumulation of random mutations.
Ah, yes. The "explain precisely how this rock in a landslide came to occupy this particular position" demand of Behe. Dealt with here. The anon commenter wrote
Yes. And the NCSE glosses over the fact that many evolutionary biologists are not as comfortable with the idea that natural selection can explain diversity as they imply.
Citation required. The anon poster wrote
This is a really silly argument to make. Extinction does not occur because organisms are badly designed or maladapted, but because of factors that include competition for resources, excessive predation or catastrophes. The dinosaurs weren’t badly designed because an asteroid hit the earth and killed them any more than we would be badly designed if we became extinct through nuclear warfare.
All three of the variables he identifies are changes in the selective environment of populations that may occur too rapidly for natural processes to allow a population track the changing environment. Thus the population becomes maladapted and goes extinct. A genuinely good design would have mechanisms to allow populations to deal with those changes more effectively and rapidly. Some designer. The anon commenter wrote
Wrong. So wrong. Artificial selection has no constraints other than the availability of the variation itself. Darwinian natural selection, however, requires that variation should improve reproductive success/fitness whereas artificial selection does not. Hence, artificial selection is more effective.
Pure B.S. Artificial selection employs strong controls on reproductive success. Try to artificially select for some trait in a population without controlling the reproductive success of variants. You'll fail miserably. Artificial selection is more effective (i.e., faster) precisely because it controls reproductive success more stringently than natural selection generally does. Selection is generally stronger in artificial selection than in nature. The anon commenter has not yet provided any evidence that the constraints on variation identified in the linked review prevent the theory of evolution from accounting for the diversity of life we see. That there are constraints is obvious; that the constraints are too narrow is not.

Dave Luckett · 18 February 2013

"However, environmental pressures tend to fluctuate and so are directionless."

There. Right there. Read that, and straight away you're in fruitloop territory.

That's like saying that ocean levels tend to fluctuate and so are directionless, so littoral animals can't evolve to exploit the tides. Winds tend to fluctuate and so are directionless, so birds can't use wind patterns for migration. Patterns that fluctuate don't select for lifeforms that exploit the fluctuations. It's so wrong that it's idiotic, even at that level.

But it's also wrong at another level. "Environmental pressures tend to fluctuate." That's to say, there are no long-term trends in the environment. Climates don't change in one direction (out of several) over the long term. There are no such things as ice ages. There is no such thing as relief rainfall patterns which change according to continental drift. No mountains ever rose or were eroded down. There is no such thing as long-term global warming. The Earth's ice caps were always there, just as they are today.

There is no such thing as the appearance of new environmental niches, newly created by other living things. Couldn't happen. Never happened. Forests can't replace grasslands and start selecting for living things that climb trees. Vice-versa, and the grasslands can't select for living animals that did climb trees, but now must move over open terrain. Can't happen.

Nonsense on stilts. Ignorance taken to the level of dismissal of reality.

Mike Elzinga · 19 February 2013

Flint said: I think he's saying that artificial selection is more efficient. And there's no question that it is far more efficient. Of course, "artificial" selection is nothing more than a reproductive environment, where the desired traits most emphatically "improve reproductive success/fitness". Artificial selection is like natural selection on steroids. Under artificial selection, ALL variants (and mutations) meeting the breeding goal are selected, and ALL variants (and mutations) not doing so are culled. The difference from natural selection IS efficiency, pretty much nothing else (except insofar as natural selection takes so much longer than more mutations will become available for selection).
His comment seems pretty muddled; and I wasn’t sure if he was claiming artificial selection could produce extreme traits and natural selection couldn’t or if, as you say, artificial selection is more efficient. I think both you and Richard have unpacked the muddle and answered it. Extreme traits like those of the proboscis monkey, or the extreme tails or plumage of some birds, are products of natural selection. So both natural and artificial selection can do that also.

Scott F · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
The source of the selective pressure is irrelevant; the process works whether that source is humans or nature.
Wrong. So wrong. Artificial selection has no constraints other than the availability of the variation itself. Darwinian natural selection, however, requires that variation should improve reproductive success/fitness whereas artificial selection does not. Hence, artificial selection is more effective.
So what? Your statement in no way makes the previous statement "wrong". Everyone agrees that Natural Selection is slower than Artificial Selection. Nature has millions of years to do what humans want to do in a single human life time. Nature isn't in any hurry. First, your statement is false. Natural selection does not strictly require that "variation should improve reproductive success/fitness", only that such variation is not detrimental enough to outright kill the host. There are other means of "Natural Selection", besides slight variations selected over long periods of time. You explicitly identified several of them. Catastrophe, for one. While dinosaurs were well adapted for their environment, the environment changed radically, and rapidly. The environment naturally selected for smaller, warm blooded creatures who didn't require as much food. "Natural Selection" selected against the large, voracious dominant life forms. How is that not "Natural Selection"? Or, perhaps you are instead suggesting that the "Intelligent Designer" sent the asteroid to do some "Artificial Selection" for him? "Natural Selection" requires serendipity and contingency. Those little warm blooded creatures just happened to be in the right place at the right time (serendipity) and with the right set of metabolic features (contingency) necessary to survive in the new environment. Up until the asteroid strike, such variation wasn't successful enough to overcome and replace the dominant lifeforms. But that variation was adequate to keep them alive in their ecological niche long enough so that they were there to take advantage of the new environment. Second, how do you think that (historically*) breeders have implemented "Artificial Selection"? The breeders breed their stock. They control the "reproductive success" of the animals or plants they are breeding. That's what animal husbandry is all about. That's exactly what "Natural Selection" is all about: the environment controls the "reproductive success" of the plants or animals in question, just as breeders do. How does "Natural Selection" control "reproductive success"? You yourself identified the means, but seem blind to the implications:
Extinction does not occur because organisms are badly designed or maladapted, but because of factors that include competition for resources, excessive predation or catastrophes.
For some odd reason you see no connection between weather, predation, and competition for food, and "reproductive success". What do you think "Natural Selection" is? Those creatures that are better adapted, better "designed" to survive changes in weather, to survive predation, to survive competition for food, then survive long enough to create the next generation. Creatures that are maladapted to the stresses in the environment tend not to do so. That's what "reproductive success" means. You identify the mechanisms that drive "Natural Selection", but don't seem to realize that that is exactly what "Natural Selection" is. (*) I use the term "historically", because with advancements in genetic engineering, we can now bypass even "Artificial Selection", and go directly to "Intelligent Design", creating new features in plants and animals directly, without having to go through the historical tedious breeding processes.)

Scott F · 19 February 2013

As an analogy, saying that "Natural Selection" can't produce novel features because "Artificial Selection" is so much more effective, is like saying that rivers can't use "Natural Erosion" to find a way to transport water to lower elevations, because only "Intelligent Designers" can use "Artificial Earth Moving" to carve the land just so, in order to create aqueducts that use gradual changes in elevation to take advantage of gravity to move the water. It takes an "Intelligence" to understand how water behaves and to direct that water to where it is needed as "effectively" as possible. Obviously, "Natural Erosion" can't possibly move water to where it is needed, therefore the whole idea of "Natural" rivers is "silly". Heck, if left to "Nature", such water might end up puddling in valleys, or falling over sheer cliffs. Where's the effectiveness in that?

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

Richard B. Hoppe said: It precisely refutes your claim.
No. Being able to drink milk beyond infancy is probably not good for us despite the hype to the contrary: http://www.naturalnews.com/031255_milk_health.html Even if it were, it represents a loss of regulatory function which is hardly evidence for an increase in diversity and complexity.
Ah, yes. The "explain precisely how this rock in a landslide came to occupy this particular position" demand of Behe. Dealt with here.
Yes. Because good science is based on the ability to demonstrate, and not to speculate. The PNAS paper does indeed describe the changes that happened in a copy of a sialic acid synthase (SAS) gene. However, this gene was bifunctional (promiscuous) to begin with and already had some antifreeze capability. The main change described is the complete destruction of the N-terminus coding for the SAS function which allowed the C-terminus with the antifreeze residues to be more properly deployed. In any case, I asked for an explanation of the evolutionary origin of the structures and parts of living organisms with reference to random variation, not molecules.
Citation required.
"Natural selection is the only mechanism known to cause the evolution of adaptations, so many biologists would simply define an adaptation as a characteristic that has evolved by natural selection." http://ncse.com/files/pub/evolution/Evolution--Futuyma--chap11.pdf
Thus the population becomes maladapted and goes extinct. A genuinely good design would have mechanisms to allow populations to deal with those changes more effectively and rapidly. Some designer.
LOL. If the air suddenly changed from being oxygen-rich to chlorine-rich, we would not be maladapted or badly designed because we could no longer survive. The dinosaurs ruled the earth for millions of years, and would have carried on, were it not for a cataclysmic event 65 million years ago. The fact is that many species are going extinct or at risk of extinction because of human expansion within their ecosystems. Just because they can't compete with us does not mean that they are badly designed.
Pure B.S. Artificial selection employs strong controls on reproductive success. Try to artificially select for some trait in a population without controlling the reproductive success of variants.
Poppycock. We have generated lots of breeds of dog that wouldn't have any chance of surviving in the wild. A bulldog can't even breathe properly as everyone knows. Artificial selection methods are used in the directed evolution of proteins which in vivo would not be viable. This is because artificial selection can overcome fitness barriers.
You'll fail miserably. Artificial selection is more effective precisely because it controls reproductive success more stringently than natural selection generally does. Selection is generally stronger in artificial selection than in nature.
No. Artificial selection does not have to take into account reproductive success at all! How do you think we have managed to generate seedless fruit? Next time you eat a banana, you should note that it is just a clone of an infertile banana plant.
The anon commenter has not yet provided any evidence that the constraints on variation identified in the linked review prevent the theory of evolution from accounting for the diversity of life we see. That there are constraints is obvious; that the constraints are too narrow is not.
I think you should read the review's points in detail: 1. Absence of fit intermediates "The difficulty in establishing multiple changes, all of which are apparently required to give a selective advantage, has long been seen as a key objection to adaptation by simple natural selection, and has stimulated elaborate alternative explanations." 2. The cost of natural selection "Haldane argued that selection is costly, relative to the ideal alternative in which all genes are instantaneously changed to the currently optimal allele." 3. Random drift "Since different genes produce different numbers of offspring by chance, allele frequencies inevitably fluctuate. This process of random genetic drift interferes with selection in several ways." 4. Evolvability "Kirschner and Gerhart define ``evolvability'' as ``the capacity to generate heritable, selectable phenotypic variation'', a definition that relates to both ``selective'' and ``developmental'' constraints.....Discussions of ``evolvability'' concentrate on limits on the production of ``selectable variation''""

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

Mike Elzinga said: Let me ask the question a different way. Are you suggesting that “artificial” selection is “more effective” at producing traits than “natural” selection?
OK. Let me clearly explain this for the benefit of all: 1. Artificial selection refers to the way humans choose variations and traits because of the breeder's or society's needs. 2. Natural selection refers to the way in which the environment "chooses" variations because of their effect on reproduction. Since many variations are harmful with respect to reproductive success, natural selection will tend to discard them. However, artificial selection is not constrained by the need for reproduction. We have generated fruit without seed for reasons that have nothing to do with fertility. In Nature, such variations would just not survive. Therefore, the breeder is much freer to work with variations that natural selection would reject. In the case of directed evolution by artificial selection, we can choose variations not because of their immediate benefit (as natural selection does) but because they might represent a path towards a target which does prove to be beneficial. By choosing unfit intermediates, artificial selection can overcome a "rough fitness landscape" that otherwise would represent a formidable barrier to natural evolution. Richard Dawkins showed just how effective artificial selection (but not natural selection) can be with his "Weasel" program, as described in the Blind Watchmaker. He selected variations not based on reproductive fitness, but because they matched a target.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

Just Bob said: I would like to ask you what kind of barrier exists that prevents one species from varying enough, over time, to give rise to a distinctly separate species. Is it: A) some physical barrier, perhaps a code in the DNA, that allows only minor variation and "knows" to prevent variation beyond a predetermined(?) point; or B) a supernatural (spiritual, divine, miraculous, magical, etc.) effect that observes all reproduction events and 1) prevents ones with too much variation, or 2) aborts all offspring with too much variation, or 3) repairs any DNA variation beyond the allowable limit, or 4) some combination of the above; or C) some other barrier? If the barrier is in fact physical, is it in principal detectable? Should we be able to discover the DNA barrier that is in every species which prevents an impermissible degree of variation?
Our experience with breeding plants and animals shows us that there are indeed real limits to the way in which we can change them. This is likely because of developmental constraints due to the complex relationship between interacting gene networks. We can alter the size and color of a dog, for example, but we can't modify it to the point where it becomes something other than a dog. I would suggest that you read the "Edge of Evolution" by Michael Behe that properly describes the limits I refer to.

harold · 19 February 2013

A Masked Panda 1686 -

Although you show misunderstanding of the theory of evolution, I would like to know what your explanation for the diversity of the biosphere is, and what positive evidence - not arguments against evolution, positive evidence - you have to support it.

1) Could any evidence convince you of the theory of evolution, and if so, what type of evidence is now lacking, that would convince you, if present?

2) The Supreme Court ruled against the direct teaching of Biblical Young Earth Creationism as science in public schools; however, if that ruling were overturned, which would you support more, teaching of ID, or direct teaching of Bible-based YEC?

3) Do you think it is important for opponents of the theory of evolution to fully understand the theory of evolution? If so, can you explain it, and if not, can you explain why not?

4) Who or what is the designer? How can we test your answer?

5) What did that designer do? How can we test your answer?

6) How did the designer do it? How can we test your answer?

7) When did the designer do it? How can we test your answer?

8) What is an example of something that was not designed by the designer?

9) If you claim that "CSI" or "irreducible complexity" is proof of design, how do you define those terms, and how do you show that those traits can never be the result of evolution?

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

harold said: A Masked Panda 1686 - Although you show misunderstanding of the theory of evolution, I would like to know what your explanation for the diversity of the biosphere is, and what positive evidence - not arguments against evolution, positive evidence - you have to support it.
I disagree. I think those who do not recognize the natural and real limits to biological change don't understand evolution. I personally don't know what is the correct scientific explanation for the diversity of the biosphere - I think this is something yet to be discovered. What I do know is that we can safely rule out random genetic variation and natural selection as the creative source for the complexity and diversity displayed in the living world.

DS · 19 February 2013

I told you it was worthless arguing with the invincibly deluded. This guy will never change his tune no matter what.

I also think it is interesting that it has been allowed to troll up this thread with page after page of irrelevant off-topic crap. This kind of jackass is precisely what the bathroom wall was created for.

Is there anyone who doesn't think that this is once again Bozo Joe, flaunting his ignorance and antisocial pseudo personality? Same old arguments from incredulity, same old avoidance of any real evidence, same old lack of any viable alternative.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

DS said: I told you it was worthless arguing with the invincibly deluded. This guy will never change his tune no matter what.
What would convince me is evidence based on demonstrable, testable and falsifiable investigation. What will not convince me is speculation, extrapolation and a profound lack of empirical evidence that natural selection can explain biodiversity and complexity. I think that the likes of Doug Futuyma, and other Darwinians, say it all when they claim that evolution by natural selection is "one of the most important ideas in the history of human thought—“Darwin’s dangerous idea,” as the philosopher Daniel Dennett (1995) has called it—for it explains the apparent design of the living world without recourse to a supernatural, omnipotent designer." http://ncse.com/files/pub/evolution/Evolution--Futuyma--chap11.pdf The IDEA appeals to their atheistic and naturalistic prejudices more than any actual evidence in support of it. The NCSE does not want to admit its own atheistic/non-theistic agenda, but that is what it is trying to sell to the public through its "educational" efforts.

Scott F · 19 February 2013

DS said: I told you it was worthless arguing with the invincibly deluded. This guy will never change his tune no matter what. I also think it is interesting that it has been allowed to troll up this thread with page after page of irrelevant off-topic crap. This kind of jackass is precisely what the bathroom wall was created for. Is there anyone who doesn't think that this is once again Bozo Joe, flaunting his ignorance and antisocial pseudo personality? Same old arguments from incredulity, same old avoidance of any real evidence, same old lack of any viable alternative.
This guy keeps referring to Behe's books as his source of information. If he's reading from the same play book, he ought to have the same "arguments", and the same misunderstandings. He's somewhat condescending, but less so that FL. But I wouldn't be surprised that Creationists willing to post to PT would probably have similar profiles, so I wouldn't ascribe his comments to the same person, especially after just a few pages. Even so, the BW may be appropriate. OTOH, he's more articulate than most.

Scott F · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
DS said: I told you it was worthless arguing with the invincibly deluded. This guy will never change his tune no matter what.
What would convince me is evidence based on demonstrable, testable and falsifiable investigation. What will not convince me is speculation, extrapolation and a profound lack of empirical evidence that natural selection can explain biodiversity and complexity. I think that the likes of Doug Futuyma, and other Darwinians, say it all when they claim that evolution by natural selection is "one of the most important ideas in the history of human thought—“Darwin’s dangerous idea,” as the philosopher Daniel Dennett (1995) has called it—for it explains the apparent design of the living world without recourse to a supernatural, omnipotent designer." http://ncse.com/files/pub/evolution/Evolution--Futuyma--chap11.pdf The IDEA appeals to their atheistic and naturalistic prejudices more than any actual evidence in support of it. The NCSE does not want to admit its own atheistic/non-theistic agenda, but that is what it is trying to sell to the public through its "educational" efforts.
Ah, so now we come back to the true Creationist. It's not "skepticism". It's not "evidence". It's just good old fashioned religion, isn't it. It's not "Intelligent Design". It's about "God". So, you don't like Evolution because it is "dangerous". You don't like it because "atheists" like it. Do you believe in God? Do you believe that Jesus is the son of God? Show us the evidence. So "atheists" like the Theory of Evolution. So what? Why even bother bringing it up, when you claim to care about "evidence"? (And you brought it up out of thin air. We were originally talking about "evidence", remember?) Perhaps you'll next grace us a massive conspiracy theory, where 99.9% of all the scientists are in on the "scam" to deny a place for God at the table. Even when 20-30% of those scientists are strongly religious. You know, because the "evidence" shows that scientists are evil. So now, instead of "evidence", you argue that an idea is "wrong" because people you don't like believe it. Sorry, but you just lost whatever slim shred of credibility that you had.

DS · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
DS said: I told you it was worthless arguing with the invincibly deluded. This guy will never change his tune no matter what.
What would convince me is evidence based on demonstrable, testable and falsifiable investigation. What will not convince me is speculation, extrapolation and a profound lack of empirical evidence that natural selection can explain biodiversity and complexity. I think that the likes of Doug Futuyma, and other Darwinians, say it all when they claim that evolution by natural selection is "one of the most important ideas in the history of human thought—“Darwin’s dangerous idea,” as the philosopher Daniel Dennett (1995) has called it—for it explains the apparent design of the living world without recourse to a supernatural, omnipotent designer." http://ncse.com/files/pub/evolution/Evolution--Futuyma--chap11.pdf The IDEA appeals to their atheistic and naturalistic prejudices more than any actual evidence in support of it. The NCSE does not want to admit its own atheistic/non-theistic agenda, but that is what it is trying to sell to the public through its "educational" efforts.
Right back at you twinkle toes. You have presented absolutely no evidence whatsoever. You have ignored all of the evidence ever presented to you. You lose. Get a life and go away, not necessarily in that order.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

Scott F said: So now, instead of "evidence", you argue that an idea is "wrong" because people you don't like believe it.
No. What I am explaining is that the IDEA that natural selection can explain "apparent design" (without need for a supernatural designer) matters more to some ideologically-driven scientists than any evidence for it. Without Darwinian selectionism, the case for atheism becomes much harder to sustain, and Paley's argument becomes irrefutable.

Just Bob · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
Just Bob said: I would like to ask you what kind of barrier exists that prevents one species from varying enough, over time, to give rise to a distinctly separate species. Is it: A) some physical barrier, perhaps a code in the DNA, that allows only minor variation and "knows" to prevent variation beyond a predetermined(?) point; or B) a supernatural (spiritual, divine, miraculous, magical, etc.) effect that observes all reproduction events and 1) prevents ones with too much variation, or 2) aborts all offspring with too much variation, or 3) repairs any DNA variation beyond the allowable limit, or 4) some combination of the above; or C) some other barrier? If the barrier is in fact physical, is it in principal detectable? Should we be able to discover the DNA barrier that is in every species which prevents an impermissible degree of variation? [emphasis added]
Our experience with breeding plants and animals shows us that there are indeed real limits to the way in which we can change them. This is likely because of developmental constraints due to the complex relationship between interacting gene networks. We can alter the size and color of a dog, for example, but we can't modify it to the point where it becomes something other than a dog. I would suggest that you read the "Edge of Evolution" by Michael Behe that properly describes the limits I refer to.
Now answer the question. Is it A)? B1) 2) or 3)? C?

harold · 19 February 2013

DS said: I told you it was worthless arguing with the invincibly deluded. This guy will never change his tune no matter what. I also think it is interesting that it has been allowed to troll up this thread with page after page of irrelevant off-topic crap. This kind of jackass is precisely what the bathroom wall was created for. Is there anyone who doesn't think that this is once again Bozo Joe, flaunting his ignorance and antisocial pseudo personality? Same old arguments from incredulity, same old avoidance of any real evidence, same old lack of any viable alternative.
I thoroughly agree. I discourse with them solely for the sake of third party observers. In the case of most creationists, the emotional barriers and authoritarian personality structure together probably mean that only illegal, unethical tactics akin to the kidnapping of Patty Hearst would be sufficient to change their minds. (Even normal people massively resist imposed change of emotionally charged biases, and it is probable that such change can only occur either when it is truly self-driven, or when it is imposed by unusual circumstances.) Joe is probably even more unchangeable than a typical merely biased creationist. He's probably made of the stuff that heretics who would not give up some random claim about "the nature of the trinity" or some such thing, even in the face of torture and death, were made of. In this case, I hadn't inserted my usual questions, so I decided to do so for completeness.

Henry J · 19 February 2013

natural selection can explain “apparent design”

Selection is only one of the components. Variation and feedback loops are also necessary.

Flint · 19 February 2013

From the viewpoint of the organism undergoing artificial selection, the distinction with "natural" selection is moot. Some variations survive to breed again, some do not. The fact that human breeding decisions ARE the environment is irrelevant to them. The fact that other environments exists, in which they couldn't cope well, is also irrelevant to them.

The only thing natural selection can do that artificial selection does not, is wait for new mutations for selection. If one wished to breed cats to glide like flying squirrels, they could breed for small size and tree climbing ability, since those variations already exist. But for the webbed skin between limbs, they might have to wait a while.

apokryltaros · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: The IDEA appeals to their atheistic and naturalistic prejudices more than any actual evidence in support of it. The NCSE does not want to admit its own atheistic/non-theistic agenda, but that is what it is trying to sell to the public through its "educational" efforts.
And yet, one of the bigger problems you are ignoring is to explain why it is necessary to resort to postulating that the diversities of life are the direct result of the magical tinkering of a supernatural "Intelligent Designer" who literally works in magically mysterious ways beyond the puny ken of stupid mortal scientists, ala GODDIDIT? That, and why is it "atheistic" to not automatically resort to parroting GODDIDIT in place of doing actual science or research?

DS · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
Scott F said: So now, instead of "evidence", you argue that an idea is "wrong" because people you don't like believe it.
No. What I am explaining is that the IDEA that natural selection can explain "apparent design" (without need for a supernatural designer) matters more to some ideologically-driven scientists than any evidence for it. Without Darwinian selectionism, the case for atheism becomes much harder to sustain, and Paley's argument becomes irrefutable.
What I am explaining is that the theoretical and empirical evidence for the importance of natural selection has been well established by the last one hundred and fifty years of research. You have presented no evidence for the existence of any barrier that prevents this process from producing the diversity of life and no reason to suppose that one exists. You have presented no alternative, let alone any evidence for any alternative. In short, all you got is "I don't wanna believe it so it ain't true". You want to quote mine scientists who disagree with you, fine, just don't expect anyone to be fooled. You don't like atheists, fine, the evidence is clear no matter who presents it. You got some religious agenda to push, fine, just don't pretend it's scientifically motivated. You need to believe that natural selection doesn't work, fine, no one cares what you think. You want to have a discussion, go to the bathroom wall where you belong, at least until they ban you again.

apokryltaros · 19 February 2013

I would suggest that you read the “Edge of Evolution” by Michael Behe that properly describes the limits I refer to.
You mean Behe's 2nd book on Intelligent Design where he once again neglects to describe how to identify Irreducible Complexity beyond "being too complex for (Behe) to care about understanding"? Or how Behe mentions the phenomenon of Plasmodium sp. evolving quinine resistance as an example of how the Intelligent Design, strongly implied to be God as described in the Bible, hates the collective guts of humans?

eric · 19 February 2013

A masked panda said: The NCSE does not want to admit its own atheistic/non-theistic agenda, but that is what it is trying to sell to the public through its "educational" efforts.
Good lord, the NCSE falls all over itself to be accommodationist. I believe they have released multiple PR statements that it is entirely possible to be theist and accept evolution. If you're calling them atheistic, you really are out on the extreme.
Just Bob said: I would like to ask you what kind of barrier exists that prevents one species from varying enough, over time, to give rise to a distinctly separate species...
Repeated for relevancy. How can what happens in development prevent a mutation from occurring? What's the mechanism? As far as I can tell, Behe's limitation requires the physics of DNA replication to have some form of time-traveling knowledge about what a mis-replication will do in the future. If some duplication does nothing, its allowed, but if it results in a future developmental change to the organism that starts it down the path of speciation, not allowed.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

DS said: What I am explaining is that the theoretical and empirical evidence for the importance of natural selection has been well established by the last one hundred and fifty years of research.
It has been researched, and real limits and constraints to natural selection have been found. I am not arguing that Darwinian evolution is false, but that its explanatory power is limited and has been greatly exaggerated. Like I say, natural selection far better explains why things don't change rather than why they do.
You have presented no evidence for the existence of any barrier that prevents this process from producing the diversity of life and no reason to suppose that one exists.
I think you should read the paper I cited which outlines all of the major arguments and evidence against the power of natural selection. If you choose to ignore them, then so be it. I can't help you. But I would encourage you to read something a little simpler: The limitations of natural selection http://evolution.berkeley.edu/evolibrary/article/0_0_0/misconcep_03 Those of you with more patience may want to read this: http://www.pnas.org/content/99/21/13616.full.pdf
You have presented no alternative, let alone any evidence for any alternative. In short, all you got is "I don't wanna believe it so it ain't true". You want to quote mine scientists who disagree with you, fine, just don't expect anyone to be fooled.
Well, there is a viable alternative - directed evolution. But finding evidence in the past for its application is not feasible.

Dave Lovell · 19 February 2013

Flint said: From the viewpoint of the organism undergoing artificial selection, the distinction with "natural" selection is moot.
Where is the boundary between the two anyway? Even a perfectly run breeding establishment will have an element of natural selection imposed upon it by disease, birth defects, infertility and accidents. And is an unintended decrease in the typical adult size of fish due to larger ones being less likely to slip through fishermen's nets natural or artificial selection?

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

apokryltaros said: And yet, one of the bigger problems you are ignoring is to explain why it is necessary to resort to postulating that the diversities of life are the direct result of the magical tinkering of a supernatural "Intelligent Designer" who literally works in magically mysterious ways beyond the puny ken of stupid mortal scientists, ala GODDIDIT?
It is really quite simple. Life exhibits the appearance of being designed (see Dawkins and Futuyma) and for a purpose. The most parsimonious inference is therefore that life has a designer. The more convoluted and less plausible inference is that there is no designer (just chance and necessity) and that any appearance of design is merely illusory

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

Flint said: From the viewpoint of the organism undergoing artificial selection, the distinction with "natural" selection is moot.
Let me just repeat this point one more time. Artificial selection is not constrained by reproductive fitness, only the mind of the breeder. This means that "unfit intermediates" can be selected for that natural selection would discard. It means that traits that have no reproductive benefit to the organism can be preserved. This means that artificial selection can explore the full extent of heritable variation while NS cannot.

Scott F · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
Scott F said: So now, instead of "evidence", you argue that an idea is "wrong" because people you don't like believe it.
No. What I am explaining is that the IDEA that natural selection can explain "apparent design" (without need for a supernatural designer) matters more to some ideologically-driven scientists than any evidence for it. Without Darwinian selectionism, the case for atheism becomes much harder to sustain, and Paley's argument becomes irrefutable.
So, are you saying that scientists espouse the IDEA of natural selection, not because they think it is true, or correct, or (you know) useful, but instead because it makes them feel better about being atheists? Weak. Very weak. When you have no "evidence" on your side, you attack the motives of the people on the other side. How about sticking to the "evidence", as you claim. You know. The "evidence" that you don't have. Remember, the question isn't just about "Design". If someone "Designed" life, then someone had to "Implement" that design. They actually had to "Make" something, not just a bunch of blueprints for "Life". There is absolutely no "evidence" for any such implementation, unless perhaps you are saying that the "Intelligent Designer" used Evolution to implement that design. Remember, the Theory of Evolution explains not only the "Design" of life, it also explains the "how", the "what", the "where", the "when", and the "who" of life. "Intelligent Design" doesn't address any of those questions. It doesn't even address the question of "why". In fact, "Intelligent Design" intentionally avoids asking any of those questions, let alone answering them. Why is that, do you think? So, without any "evidence", without any "answers", even without any "questions", all you can come up with is conspiracy theories and, "I can't imagine how it works, therefore 'God Intelligent Designer'".

bplurt · 19 February 2013

We are skeptical of claims for the ability of random mutation and natural selection to account for the complexity of life. Careful examination of the evidence for Darwinian theory should be encouraged.
A real compendium of creo-babble, non? Leaving aside the fact that its straw-man version of evilooshun is laughably wrong, there's nothing too objectionable about that statement. I don't think that any serious biologist maintains that "random mutation and natural selection" are able to "account for the complexity of life", at least on their own! Does any scientist disagree with the need for scepticism, even of well-supported theories? Indeed, "the evidence for Darwinian theory" [sic] should be carefully examined: as I understand it, that is pretty much what scientists have been doing since 1859. I have argued before that, because this ridiculous statement is drafted around a parody of evolution that would never be taken seriously in any Science Department, a crowd of prominent biologists (preferably including the most vocal creo-baiters, of course!) should pound on the door of the Disco-Tute demanding to sign it and have their names prominently displayed as supporting it. Richard Dawkins should hang a copy of it on the podium whenever he gives a speech. PZ Myers should put it up as a banner on his web site. The discombobulation of the creonauts would be delectable.

Henry J · 19 February 2013

And is an unintended decrease in the typical adult size of fish due to larger ones being less likely to slip through fishermen’s nets natural or artificial selection?

Yes.

Scott F · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
Flint said: From the viewpoint of the organism undergoing artificial selection, the distinction with "natural" selection is moot.
Let me just repeat this point one more time. Artificial selection is not constrained by reproductive fitness, only the mind of the breeder. This means that "unfit intermediates" can be selected for that natural selection would discard. It means that traits that have no reproductive benefit to the organism can be preserved. This means that artificial selection can explore the full extent of heritable variation while NS cannot.
And "Natural Selection" can do the same. Genetic drift. Neutral mutations. You still haven't addressed the questions presented earlier. Surviving changes in weather, surviving predation, surviving competition for food are all means to "reproductive benefit". But this all gets back to the question of "intent". The difference you keep coming back to between "Natural" and "Artificial" selection is a difference of "intent", of "need", of "effectiveness", of "purpose", of "direction". Agreed. "Natural" selection has no "intent", or "need", or "purpose", or "direction". A river has no "intent" of delivering large amounts of water to the ocean, nor does it have a "need" to, nor does it "know" its "purpose", nor is it as "effective" at it as an "intelligently designed" aqueduct built for the same purpose, nor did anyone "direct" it to do so. Yet, somehow magically, the river effectively delivers water to the ocean. Perhaps some "Intelligent Designer" drew a line in the ground for the river to follow?

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

Scott F said:
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
Flint said: From the viewpoint of the organism undergoing artificial selection, the distinction with "natural" selection is moot.
Let me just repeat this point one more time. Artificial selection is not constrained by reproductive fitness, only the mind of the breeder. This means that "unfit intermediates" can be selected for that natural selection would discard. It means that traits that have no reproductive benefit to the organism can be preserved. This means that artificial selection can explore the full extent of heritable variation while NS cannot.
And "Natural Selection" can do the same. Genetic drift. Neutral mutations.
Er...no. Random genetic drift is not natural selection and often interferes with natural selection. Neutral variations are liable to be lost as they confer no reproductive benefit.

eric · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: It has been researched, and real limits and constraints to natural selection have been found.
None of your citations support the notion that speciation falls outside of what evolution can do. Its like some mainstream biologist says "pigs can't fly" and you infer that they said "pigs can't speciate." The idea of some general limits does not support your argument about the specific limit you claim exists.
Well, there is a viable alternative - directed evolution. But finding evidence in the past for its application is not feasible.
Unless your "directed evolution" can create mutational events that are physically impossible for nature to produce, then its limited to doing what evolution can do, just doing it faster. And if it can, I'd like to know how your Directing Evolutionist is doing the mutation. What is your hypothesis? Lab on the moon? Magic?

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

Scott F said: So, are you saying that scientists espouse the IDEA of natural selection, not because they think it is true, or correct, or (you know) useful, but instead because it makes them feel better about being atheists?
More or less. I think natural selection for them represents a naturalistic/atheistic alternative to that of a divine Creator. It doesn't really matter to them that natural selection cannot replace the need for a creative agency in evolution, but the idea appeals to them more than the actual evidence for it. If you read how most evolutionary biologists came to believe in Darwinism, you will find it wasn't through a careful examination of the evidence but because they found the idea to be so appealing:
"It's arguably the best idea that anyone has ever had.". Richard Dawkins
I admit it is an intriguing idea that a blind and purposeless process could generate the diversity and complexity of life on earth....but it's also an idea that belongs in the realm of imagination and speculation, and not that of observation and demonstration.

Just Bob · 19 February 2013

Er...no. Random genetic drift is not natural selection and often interferes with natural selection. Neutral variations are liable to be lost as they confer no reproductive benefit.
...until the environment changes.

Flint · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
Flint said: From the viewpoint of the organism undergoing artificial selection, the distinction with "natural" selection is moot.
Let me just repeat this point one more time. Artificial selection is not constrained by reproductive fitness, only the mind of the breeder. This means that "unfit intermediates" can be selected for that natural selection would discard. It means that traits that have no reproductive benefit to the organism can be preserved. This means that artificial selection can explore the full extent of heritable variation while NS cannot.
The mind of the breeder is what is behind the imposition of a standard of reproductive fitness. If the breeder considers an organism fit to breed, it breeds. If the breeder decices it's not fit to breed, it does not breed. Why is this so hard to understand? Whatever traits the breeder wants are precisely those traits conferring reproductive benefit. Artificial selection can explore anything that varies. Anything. Sheesh.

Flint · 19 February 2013

"It's arguably the best idea that anyone has ever had.". Richard Dawkins
I admit it is an intriguing idea that a blind and purposeless process could generate the diversity and complexity of life on earth....but it's also an idea that belongs in the realm of imagination and speculation, and not that of observation and demonstration.
Except, of course, unlike religion where doctrine comes first and observation must be forced to fit whether it does or not, the idea of natural selection was posited to explain the evidence. Which is to say, the observations and demonstrations. You don't seem to grasp that science is not religion. In science, theories are based on facts. In religion, facts are whatever fits the doctrine even if they must be fabricated. You have it backwards. Evolution is a fact. Gods themselves are purely speculative.

phhht · 19 February 2013

Just as I suspected. Another religious loony, very much like FL and IBelieveInGod and all those other sad, obsessed, deluded people who cannot tell the real from the imaginary. I continue to hypothesize that religious belief occurs because of some cognitive mechanism failure(s) which impair the accuracy of that distinction. The commenter attacks the theory of evolution as a stand-in for rational, natural scientific thought, which has no use for the notion of the supernatural. He thinks that the ToE is somehow more susceptible to personal incredulity and denial than, say, the theory of gravity. I cannot understand this tunnel vision on the part of faitheists. Why the ToE? Why not the germ theory of disease, or classical thermodynamics? NO scientific field is any more or less atheistic than evolution, but the obsessives target it exclusively.
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
Scott F said: So, are you saying that scientists espouse the IDEA of natural selection, not because they think it is true, or correct, or (you know) useful, but instead because it makes them feel better about being atheists?
More or less. I think natural selection for them represents a naturalistic/atheistic alternative to that of a divine Creator. It doesn't really matter to them that natural selection cannot replace the need for a creative agency in evolution, but the idea appeals to them more than the actual evidence for it. If you read how most evolutionary biologists came to believe in Darwinism, you will find it wasn't through a careful examination of the evidence but because they found the idea to be so appealing:
"It's arguably the best idea that anyone has ever had.". Richard Dawkins
I admit it is an intriguing idea that a blind and purposeless process could generate the diversity and complexity of life on earth....but it's also an idea that belongs in the realm of imagination and speculation, and not that of observation and demonstration.

TomS · 19 February 2013

apokryltaros said:
I would suggest that you read the “Edge of Evolution” by Michael Behe that properly describes the limits I refer to.
You mean Behe's 2nd book on Intelligent Design where he once again neglects to describe how to identify Irreducible Complexity beyond "being too complex for (Behe) to care about understanding"? Or how Behe mentions the phenomenon of Plasmodium sp. evolving quinine resistance as an example of how the Intelligent Design, strongly implied to be God as described in the Bible, hates the collective guts of humans?
What interested me most about "The Edge of Evolution" was his extended discussion about how the malaria parasite repeatedly evolved resistance to every intelligent design of drugs, which he contrasted with the long-lasting effectiveness of the evolved sickle-cell trait.

PA Poland · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
apokryltaros said: And yet, one of the bigger problems you are ignoring is to explain why it is necessary to resort to postulating that the diversities of life are the direct result of the magical tinkering of a supernatural "Intelligent Designer" who literally works in magically mysterious ways beyond the puny ken of stupid mortal scientists, ala GODDIDIT?
It is really quite simple. Life exhibits the appearance of being designed (see Dawkins and Futuyma) and for a purpose. The most parsimonious inference is therefore that life has a designer. The more convoluted and less plausible inference is that there is no designer (just chance and necessity) and that any appearance of design is merely illusory.
"Most parsimonious" in this case being "most simple-minded, intellectually lazy, and willfully ignorant of reality" ? "An unknowable designer somehow did stuff for some reason sometime in the past !!!" is useless, so no sane or rational person invokes it. IDiots, creationuts and theoloons (being arrogant enough to 'think' that they represent the pinnacle of human knowledge and understanding) figure if *** THEY *** can't figure out how something happened, no one can, therefore : GodIntelligent Designer DIDIT !!!1!!!11! You seem to 'think' that 'APPEARANCE of design' = 'design'. Too bad for you that the effects of selection GENERATE THE APPEARANCE OF DESIGN. Again (for the slow-witted imbeciles that are unable/unwilling to understand any process of more than one step) : Mutations CREATE VARIATIONS. Some variants are more useful at living long enough to reproduce than others (ie, the 'purpose' of life in this context). These variants tend to become more common. End result of many iterations of these simple FACTS OF REALITY : the appearance of design. It will look like the critters were 'designed' SINCE THE LESS EFFICIENT VARIANTS WENT EXTINCT, LEAVING ONLY THE 'BETTER' ONES. If you truly are unable or unwilling to understand (or accept) so simple an idea, you really have no place whining about how 'inferior' evolution is, or how superior your evidence-free, untestable gibberings are.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

Flint said: Except, of course, unlike religion where doctrine comes first and observation must be forced to fit whether it does or not, the idea of natural selection was posited to explain the evidence. Which is to say, the observations and demonstrations.
"Natural theology", of the Paleyan traditon, is based chiefly upon an observation of the natural world and the inference of a signature of intelligence within it.
You don't seem to grasp that science is not religion. In science, theories are based on facts. In religion, facts are whatever fits the doctrine even if they must be fabricated. You have it backwards. Evolution is a fact. Gods themselves are purely speculative.
"Scientism" is indeed a modern pseudo-religion and wordlview, replete with its own dogmas, assumptions and tenets. I would urge you to read "Science Set Free" by Dr. Rupert Sheldrake (a biologist formerly at the University of Cambridge) who argues that science has become a belief system more than a system or open inquiry: http://www.amazon.com/dp/0770436706

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

PA Poland said: End result of many iterations of these simple FACTS OF REALITY : the appearance of design. It will look like the critters were 'designed' SINCE THE LESS EFFICIENT VARIANTS WENT EXTINCT, LEAVING ONLY THE 'BETTER' ONES. If you truly are unable or unwilling to understand (or accept) so simple an idea, you really have no place whining about how 'inferior' evolution is, or how superior your evidence-free, untestable gibberings are.
Thanks for the recap about what natural selection is all about. Mutations create sub-optimal variations which natural selection filters out. The end result of this process is conservation and stasis, not change and evolution. Natural selection keeps things as they are.

phhht · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
PA Poland said: End result of many iterations of these simple FACTS OF REALITY : the appearance of design. It will look like the critters were 'designed' SINCE THE LESS EFFICIENT VARIANTS WENT EXTINCT, LEAVING ONLY THE 'BETTER' ONES. If you truly are unable or unwilling to understand (or accept) so simple an idea, you really have no place whining about how 'inferior' evolution is, or how superior your evidence-free, untestable gibberings are.
Thanks for the recap about what natural selection is all about. Mutations create sub-optimal variations which natural selection filters out. The end result of this process is conservation and stasis, not change and evolution. Natural selection keeps things as they are.
Completely baseless assertion. Denial, the number-one tool of the deluded.

phhht · 19 February 2013

Can you, yourself, tell us how empirically to distinguish the designed from the non-designed? I think you personally can't tell the difference. You assert that design is evident in nature. I assert that you cannot back up that claim with any objective methodology to detect or measure the distinction. Go ahead, tell us how you can detect the presence or absence of design in a tornado. Tell us to find out how little or how much design goes into the production of a snowflake. But you can't, can you? All you can do is to wave your baseless religious delusions and shout Look! Design!
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
Flint said: Except, of course, unlike religion where doctrine comes first and observation must be forced to fit whether it does or not, the idea of natural selection was posited to explain the evidence. Which is to say, the observations and demonstrations.
"Natural theology", of the Paleyan traditon, is based chiefly upon an observation of the natural world and the inference of a signature of intelligence within it.
You don't seem to grasp that science is not religion. In science, theories are based on facts. In religion, facts are whatever fits the doctrine even if they must be fabricated. You have it backwards. Evolution is a fact. Gods themselves are purely speculative.
"Scientism" is indeed a modern pseudo-religion and wordlview, replete with its own dogmas, assumptions and tenets. I would urge you to read "Science Set Free" by Dr. Rupert Sheldrake (a biologist formerly at the University of Cambridge) who argues that science has become a belief system more than a system or open inquiry: http://www.amazon.com/dp/0770436706

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

phhht said: You assert that design is evident in nature. I assert that you cannot back up that claim with any objective methodology to detect or measure the distinction.
I didn't assert that design is evident in Nature - Doug Futuyma and Richard Dawkins did. The only difference is that I maintain that the design is real whereas they think it is illusory. Extraordinary claims require extraordinary evidence. If you want to refute the design inference, you need to provide compelling evidence both against it and for natural selection.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

phhht said: Completely baseless assertion. Denial, the number-one tool of the deluded.
If it were not for natural selection, all sorts of diseases and maladies would be present in a population. By weeding out harmful traits, natural selection maintains reproductive fitness.

Mike Elzinga · 19 February 2013

phhht said: Completely baseless assertion. Denial, the number-one tool of the deluded.
As is the case with every one of these ID/creationist camp followers, they don’t even understand high school science. It is glaringly obvious from the way he expresses himself; and all he can do is copy/paste the thoughts of others. Unfortunately, that also means that he doesn’t have the tools to understand what he is copy/pasting; and that makes his misconceptions all the more obvious. The leaders of ID/creationism really know their rubes.

phhht · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
phhht said: Can you, yourself, tell us how empirically to distinguish the designed from the non-designed? I think you personally can’t tell the difference. You assert that design is evident in nature. I assert that you cannot back up that claim with any objective methodology to detect or measure the distinction. Go ahead, tell us how you can detect the presence or absence of design in a tornado. Tell us to find out how little or how much design goes into the production of a snowflake. But you can’t, can you? All you can do is to wave your baseless religious delusions and shout Look! Design!
I maintain that the design is real whereas they think it is illusory.
Ah the classic FLian "dodge 'm, duck 'em, got no answer so fuck 'em" move. You, yourself, the great advocate of the reality of design in nature, cannot tell the designed from the non-designed. Just as I thought.

Mike Elzinga · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
phhht said: You assert that design is evident in nature. I assert that you cannot back up that claim with any objective methodology to detect or measure the distinction.
I didn't assert that design is evident in Nature - Doug Futuyma and Richard Dawkins did. The only difference is that I maintain that the design is real whereas they think it is illusory. Extraordinary claims require extraordinary evidence. If you want to refute the design inference, you need to provide compelling evidence both against it and for natural selection.
All ID/creationists claim that crystals are not designed but living organisms are. Yet they never explain where along the chain of increasing complexity in condensing matter that the laws of physics and chemistry stop and a designer has to take over. Perhaps you can be the first ID/creationist in history to explain to us why crystals are not designed and things like proteins and the building blocks of life are. Where is the “barrier” to evolution? What is the mechanism by which this "barrier" operates? How do you prove that it exists, and at what level of complexity does it start to operate? You have no clue what is being asked here, do you.

eric · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: "Natural theology", of the Paleyan traditon, is based chiefly upon an observation of the natural world and the inference of a signature of intelligence within it.
No, its based on the analogy between a watch and a bug. On the inference that since non-replicating, nonmutating machines that we know through independent evidence to be design have designers, organisms that descend with modification must have them too. Quite a bad inference. Well, I guess not bad for mid-1800s, but once someone comes along and points out the critically important differences between watches and cows, which completely undermines the analogy, any reasonable person should abandon it.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

phhht said: You, yourself, the great advocate of the reality of design in nature, cannot tell the designed from the non-designed. Just as I thought.
William Paley does so profoundly in "Natural Theology". http://web.ecologia.unam.mx/laboratorios/evolucionmolecular/homes/pdfs/WilliamPaley_1802_NaturalTheology.pdf Why don't you read it?

Dave Lovell · 19 February 2013

Mike Elzinga said: As is the case with every one of these ID/creationist camp followers, they don’t even understand high school science. It is glaringly obvious from the way he expresses himself; and all he can do is copy/paste the thoughts of others. Unfortunately, that also means that he doesn’t have the tools to understand what he is copy/pasting; and that makes his misconceptions all the more obvious.
And also his talent for seeing support for his ideas in articles that refute them.
In an earlier post, MP1686 suggested a reference: The limitations of natural selection http://evolution.berkeley.edu/evoli[…]misconcep_03
The "limits" described on that page are limits imposed by the properties of materials. They would apply to natural and artificial selection equally.

Richard B. Hoppe · 19 February 2013

This thread is getting to the point of diminishing returns for lurkers, which is why I left it open. I'll soon move a post or two to the BW and close it here.

60187mitchells · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
Flint said: From the viewpoint of the organism undergoing artificial selection, the distinction with "natural" selection is moot.
Let me just repeat this point one more time. Artificial selection is not constrained by reproductive fitness, only the mind of the breeder. This means that "unfit intermediates" can be selected for that natural selection would discard. It means that traits that have no reproductive benefit to the organism can be preserved. This means that artificial selection can explore the full extent of heritable variation while NS cannot.
"reproductive fitness": that phrase doesn't mean what you think it means (apparently). Fitness in the context of animal husbandry is allowing whichever livestock that exhibit desired traits to breed (fertility/fecundity CAN be among those traits) and preventing others from breeding - if a 'breed' has traits that lower thier fitness in a different context (bulldogs would have a hard time breeding 'in the wild') or litter size, or number of young/year , or whatever- those are among the traits that artificial selection (in the vernacular = animal husbandry) can compensate for - big headed bulldogs sell/are desireble so selecting for a trait that would otherwise decreases fitness (in a different environment/context/niche) is compensated for by decreasing the relative fitness of other dogs (by not allowing access to the bitch) in agriculture/horticulture the case is parallel. We compensate for traits that would lower fitness "in the wild" by changing the niche (pesticides, fertilizers, plowing etc.) and/or by facilitating asexual/vegitative reproduction techniques (grafting is very common in fruit trees and vines for example where a root stock has traits for disease/pest resistance and the stem/rest of the tree produces fruit with desired characteristics (yeild/taste/whatever) - HUMANS become part of the fitness landscape, Humans are natural enteties - it's still natural selection and all the rules apply (just a special case)

Richard B. Hoppe · 19 February 2013

Or put another way, "fitness" is not a property of an organism; it's a property of an organism in a particular environmental context.

phhht · 19 February 2013

But YOU can't, can you? Despite having studied all the ID fiction, despite professing the obvious reality of design in nature, you yourself still can't say how objectively to tell the designed from the non-designed. You still can't say how empirically to measure the design in a tornado or a snowflake. Neither can any of your fellow loonies.
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
phhht said: You, yourself, the great advocate of the reality of design in nature, cannot tell the designed from the non-designed. Just as I thought.
William Paley does so profoundly in "Natural Theology".

Rolf · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
phhht said: Completely baseless assertion. Denial, the number-one tool of the deluded.
If it were not for natural selection, all sorts of diseases and maladies would be present in a population. By weeding out harmful traits, natural selection maintains reproductive fitness.
What is preventing natural selection from preserving beneficial mutations? You better prove your bold claim:
Mutations create sub-optimal variations which natural selection filters out. The end result of this process is conservation and stasis, not change and evolution. Natural selection keeps things as they are.
What mechanism is reponsible for ensuring that variations always are sub-optimal, never the other way around? You are postulating an impossible mechanism. If there is anything we know, it is that life is not static! Never was, never will be.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 19 February 2013

Rolf said: What mechanism is reponsible for ensuring that variations always are sub-optimal, never the other way around? You are postulating an impossible mechanism. If there is anything we know, it is that life is not static! Never was, never will be.
Rolf said: What mechanism is reponsible for ensuring that variations always are sub-optimal, never the other way around? You are postulating an impossible mechanism. If there is anything we know, it is that life is not static! Never was, never will be.
Nature uses two ways of ensuring that gene variations (i.e copying mistakes) are filtered out. The first is the direct approach of deploying editing and proofreading enzymes to correct these mistakes in the gene sequence. The second is that of natural selection which tends to eliminate those variations that are the most harmful in terms of fitness. Now, as regards "beneficial mutations", you should realize that the wild or normal type of a gene is the one which by default has the optimal function. Any variations in it either make no difference to the function or degrade it. However, in some extreme environments, a variation that reduces or even destroys the function of a gene can confer a survival advantage. An obvious example of this is a mutation in a bacterium which deletes a gene that is the target of an antibiotic. It is this flexibility/versatility which is necessary for life to adapt to adverse conditions. But it does comes at a cost.

Mike Elzinga · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: The first is the direct approach of deploying editing and proofreading enzymes to correct these mistakes in the gene sequence.
Here is another clue. All ID/creationists reify metaphors. Explain the mechanism that “deploys editing and proofreading enzymes to correct mistakes in the gene sequence.” How do these enzymes know what a mistake is, and how do they know what the correct sequence is? How do they correct the "mistake?"

phhht · 19 February 2013

Mike Elzinga said: All ID/creationists reify metaphors.
They imbue the natural world with teleological agency where none exists. That's thunder! Hear that? There must be a Thunderer! That's design! Whaddya mean you don't see it? We would detect it and measure it if only we knew how, we're working on that, it'll be ready real soon now, but in the meantime it IS there, ergo Jesus. Oh, and evolution sucks. That's pretty much the ID platform as I understand it.

phhht · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: Nature uses two ways...
But you have no way at all to distinguish the designed from the non-designed, do you, Masky. You spout a lot of hot air, but when it comes time to put up or shut up, you shut up, just like FL. Dodge 'em, duck 'em, got no answer so fuck 'em. Right Masky?

Dave Lovell · 19 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: Now, as regards "beneficial mutations", you should realize that the wild or normal type of a gene is the one which by default has the optimal function. Any variations in it either make no difference to the function or degrade it. However, in some extreme environments, a variation that reduces or even destroys the function of a gene can confer a survival advantage.
So which is the "wild or normal type" for the Sickle-Cell gene? Does this change if the carrier moves into or out of a region where malaria is a problem?

raven · 19 February 2013

creationist: Thanks for the recap about what natural selection is all about. Mutations create sub-optimal variations which natural selection filters out.
This is false. It is just a lie. Mutations can and often do create beneficial mutations. Our whole agricultural system depends on this. Mutations beneficial to their hosts are a huge problem in medicine and frequently treatment limiting, e.g. drug resistance of microbial pathogens. I skipped this entire thread up till the end and it doesn't look like I missed much, creationist bingo from a meat robot.

Dave Luckett · 19 February 2013

This loon is Ray Martinez. Ray's the one who thinks that Paley is just the bee's knees.

Two hundred years ago, his fellow natural philosophers pointed out the basic error in logic that Paley had made, viz, "Design is characterised by a purposeful arrangement of parts; living things exhibit a purposeful arrangement of parts; therefore, living things are designed."

The gaping hole in that is childishly obvious; Paley did not demonstrate that "a purposeful arrangement of parts" is necessarily produced only by design, and unless that is demonstrated, the argument breaks down. Paley was destroyed by that criticism alone; Darwin's contribution was (at this level) to demonstrate another mechanism that produces this apparently purposeful arrangement, but is not design.

The current loon's statement that William Paley had "profoundly" given a way to tell design from non-design is simply false.

John_S · 19 February 2013

Natural selection keeps things as they are.
... are when?

harold · 19 February 2013

I continue to hypothesize that religious belief occurs because of some cognitive mechanism failure(s) which impair the accuracy of that distinction.
I'm no more religious than you are, but do you have any evidence for this rather extraordinary assertion? Not evidence of neurobiological substrates of religious belief, which trivially must exist, evidence that, in all human populations, there is a significant association of religious belief, broadly defined, with cognitive deficits? Also not an argument that supernatural beliefs aren't really true, which I already agree with. Evidence that all people who hold such beliefs, whether true or not, have some kind of cognitive problem? According to recent polls, a strong majority of Americans want less religion in politics, but 92% of Americans claim some kind of belief in a god. http://www.pollingreport.com/religion.htm Incidentally, I think you might get a surprisingly similar result in "less religious" societies; you certainly would in Canada. A lot of very progressive and intelligent people have some kind of "spiritual" belief. I'm not one of them, but they do. You make a lot of good points here, and there is certainly a strong association between authoritarian religious beliefs, bigotry, disrespect for the rights of others, and denial of scientific reality in favor of self-serving deluded. However, that is a specific type of religious belief that attracts and creates a specific type of person. It is quite unfair to generalize from the likes of Joe, IBIG, FL, and so on to all religious people. I realize that you personally have been massively over-exposed to the most obnoxious type of authoritarian religious bigotry. Let me make it clear; I don't consider anybody's religious beliefs convincing. Otherwise I would be religious, obviously. But for whatever reason, a vast number of people do have some sort of religious belief. What is cognitively normal is defined by comparison to the human norm, not to some imaginary standard of philosophical purity. Chimpanzees can't talk or do basic math; that doesn't mean that they all have cognitive deficits, it means that most of them are cognitively normal chimpanzees. Humans are primates with a few extra layers of frontal cortex, primarily motivated by seething emotional and instinctive drives that we take so completely for granted that we almost forget that they are there. A set of perfectly logically defensible beliefs is not the norm.

Gsparky2004 · 19 February 2013

apokryltaros said: "A Masked Panda" is a catch-all pseudonym for people who use yahoo mail accounts to sign in.
Okay, I'm an idiot. Apologies, all. I'll go back to my Lurking Corner now...

stevaroni · 19 February 2013

Richard B. Hoppe said: Or put another way, "fitness" is not a property of an organism; it's a property of an organism in a particular environmental context.
This is an important point. Gray wolves are a "more fit" organism than chihuahuas in almost every conceivable way, yet there are probably 1000 chihuahuas in North America for every wolf. Why? Because chihuahuas exploit an environmental niche - that of urban fashion accessory - for which wolves are extremely ill suited.

phhht · 19 February 2013

I understand that you object to the word failure. Should I say idiosyncracy instead?
harold said:
I continue to hypothesize that religious belief occurs because of some cognitive mechanism failure(s) which impair the accuracy of that distinction.
I'm no more religious than you are, but do you have any evidence for this rather extraordinary assertion? Not evidence of neurobiological substrates of religious belief, which trivially must exist, evidence that, in all human populations, there is a significant association of religious belief, broadly defined, with cognitive deficits? Also not an argument that supernatural beliefs aren't really true, which I already agree with. Evidence that all people who hold such beliefs, whether true or not, have some kind of cognitive problem? According to recent polls, a strong majority of Americans want less religion in politics, but 92% of Americans claim some kind of belief in a god. http://www.pollingreport.com/religion.htm Incidentally, I think you might get a surprisingly similar result in "less religious" societies; you certainly would in Canada. A lot of very progressive and intelligent people have some kind of "spiritual" belief. I'm not one of them, but they do. You make a lot of good points here, and there is certainly a strong association between authoritarian religious beliefs, bigotry, disrespect for the rights of others, and denial of scientific reality in favor of self-serving deluded. However, that is a specific type of religious belief that attracts and creates a specific type of person. It is quite unfair to generalize from the likes of Joe, IBIG, FL, and so on to all religious people. I realize that you personally have been massively over-exposed to the most obnoxious type of authoritarian religious bigotry. Let me make it clear; I don't consider anybody's religious beliefs convincing. Otherwise I would be religious, obviously. But for whatever reason, a vast number of people do have some sort of religious belief. What is cognitively normal is defined by comparison to the human norm, not to some imaginary standard of philosophical purity. Chimpanzees can't talk or do basic math; that doesn't mean that they all have cognitive deficits, it means that most of them are cognitively normal chimpanzees. Humans are primates with a few extra layers of frontal cortex, primarily motivated by seething emotional and instinctive drives that we take so completely for granted that we almost forget that they are there. A set of perfectly logically defensible beliefs is not the norm.

phhht · 19 February 2013

harold said:
I continue to hypothesize that religious belief occurs because of so me cognitive mechanism failure(s) which impair the accuracy of that distinction.
I'm no more religious than you are, but do you have any evidence for this rather extraordinary assertion?
I'm not sure what you think I am asserting, beyond what I said. I understand that you object to the word failure. Should I say idiosyncracy instead? Perhaps you find the word hypothesizing too strong. I could say speculating. I could live with the following paraphrase:
I continue to speculate that religious belief occurs because of some cognitive mechanism idiosyncracy which impairs the accuracy of that distinction .
The distinction in question is the capacity to tell the real from the imaginary. To distinguish fact from fiction. To tell chicken shit from chicken salad. Just like any other cognitive capacity, it exists on a continuum, and depending on the degree to which you value the capacity, you may or may not find its impairment a deficit.
According to recent polls, a strong majority of Americans want less religion in politics, but 92% of Americans claim some kind of belief in a god. http://www.p ollingreport.com/religion.htm Incidentally, I think you might get a surprisingl y similar result in "less religious" societies; you certainly would in Canada. A lot of very progressive and intelligent people have some kind of "spiritual" b elief. I'm not one of them, but they do.
If you expect an argument about the prevalence of mental illness, loosely interpreted, you won't get one from me. I think the current state of the art puts mental illness at about the epistimelogical niche of the rat flea in Europe in the fourteenth century. Everybody's got one or more, nobody is without at least one, and I speculate that religious belief is the common cold of delusional illnesses. Of course, there is nothing more mundane, nothing more common, nothing more normal than the common cold. But I think even you will concede that it is a deficit to have one.

Dave Luckett · 19 February 2013

No. An idiosyncrasy is an oddity, a peculiar or individual quirk or habit. Harold was at pains to show evidence that a belief in God, if not participation in formal religion, is held by a large majority of Americans, and therefore cannot be so described. That is, it might be false, but it is not idiosyncratic.

What you mean is something like "error" or "falsehood" or "illogicality" or "incapacity". Hence, perhaps:

"I continue to hypothesize that religious belief occurs because of some error in the cognitive mechanism which impair(s) the accuracy of that distinction." (ie, between "the real and the imaginary".)

phhht · 19 February 2013

Dave Luckett said: No. An idiosyncrasy is an oddity, a peculiar or individual quirk or habit. Harold was at pains to show evidence that a belief in God, if not participation in formal religion, is held by a large majority of Americans, and therefore cannot be so described. That is, it might be false, but it is not idiosyncratic. What you mean is something like "error" or "falsehood" or "illogicality" or "incapacity". Hence, perhaps: "I continue to hypothesize that religious belief occurs because of some error in the cognitive mechanism which impair(s) the accuracy of that distinction." (ie, between "the real and the imaginary".)
I don't think error will do for harold. It's too pejorative. And besides, there is a secondary meaning for idiosyncratic: "the idiosyncrasies of the prison system", as St Wiki puts it.

phhht · 19 February 2013

phhht said:
Dave Luckett said: No. An idiosyncrasy is an oddity, a peculiar or individual quirk or habit. Harold was at pains to show evidence that a belief in God, if not participation in formal religion, is held by a large majority of Americans, and therefore cannot be so described. That is, it might be false, but it is not idiosyncratic. What you mean is something like "error" or "falsehood" or "illogicality" or "incapacity". Hence, perhaps: "I continue to hypothesize that religious belief occurs because of some error in the cognitive mechanism which impair(s) the accuracy of that distinction." (ie, between "the real and the imaginary".)
I don't think error will do for harold. It's too pejorative. And besides, there is a secondary meaning for idiosyncratic: "the idiosyncrasies of the prison system", as St Wiki puts it.
So what I would say is

I continue to hypothesize that religious belief occurs because of some idiosyncracies in the cognitive mechanism which impair(s) the accuracy of that distinction." (ie, the capacity to distinguish between "the real and the imaginary".)

phhht · 19 February 2013

One more time:

I speculate that religious belief occurs because of idiosyncracies in cognitive mechanisms which impair the capacity to distinguish between "the real and the imaginary".

Richard B. Hoppe · 19 February 2013

we're starting to wander pretty far afield, folks.

phhht · 19 February 2013

Richard B. Hoppe said: we're starting to wander pretty far afield, folks.
I'll put my back to the Wall. See ya.

prongs · 19 February 2013

phhht said: ... the capacity to distinguish between "the real and the imaginary". .
In quadrature there is both beauty and satisfaction. (Off to the BW)

Henry J · 19 February 2013

Why? Because chihuahuas exploit an environmental niche

Acting in advertisements for Taco Bell?

Rolf · 20 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
Rolf said: What mechanism is reponsible for ensuring that variations always are sub-optimal, never the other way around? You are postulating an impossible mechanism. If there is anything we know, it is that life is not static! Never was, never will be.
Rolf said: What mechanism is reponsible for ensuring that variations always are sub-optimal, never the other way around? You are postulating an impossible mechanism. If there is anything we know, it is that life is not static! Never was, never will be.
Nature uses two ways of ensuring that gene variations (i.e copying mistakes) are filtered out. The first is the direct approach of deploying editing and proofreading enzymes to correct these mistakes in the gene sequence. The second is that of natural selection which tends to eliminate those variations that are the most harmful in terms of fitness. Now, as regards "beneficial mutations", you should realize that the wild or normal type of a gene is the one which by default has the optimal function. Any variations in it either make no difference to the function or degrade it. However, in some extreme environments, a variation that reduces or even destroys the function of a gene can confer a survival advantage. An obvious example of this is a mutation in a bacterium which deletes a gene that is the target of an antibiotic. It is this flexibility/versatility which is necessary for life to adapt to adverse conditions. But it does comes at a cost.
I note that you make wild assumptions about genetics. Please substantiate your claims with any quotes you may find from reliable, (i.e. non-creationist sources), that says you know what you are talking about. Do you have a proper knowlede of how genetic work? Gene duplication, multiple copies of genes, re-use of genes = the same gene used for differnt puirposes, old genes being put to new uses? Duplicated genes available for new purposes. Random, or point mutations are just one of the many sources of both positive and negative genetic changes. I believe you are poorly educated in this field. I am an amateur myself but I have been doing my best to learn the facts. Please name your sources so we can check that you are not just parrotting creotalk. Here is your hero, Michael J. Behe speaking, something I found at the ARN ID site many years ago:
http://www.arn.org/cgi-bin/ubb/ultimatebb.cgi?ubb=get_topic;f=13;t=000261 From a transcript made at the DDD3 conference in 2002: Question from the audience: I’d be interested in hearing you tell us a little bit about what your theory of intelligent design is, as opposed to what evolution isn’t. Behe replies: Well, that’s a great question, and I know folks on the other side who are sceptical of intelligent design often get frustrated, but I try to be as conservative as I can and I don’t go out beyond what the data can support because I think overreaching is the bane of theories of design. You say that flagellum looks designed so everything is designed, or that everything that looks complex was designed, or something like that. I think the short answer to your question is, for all of those things, I don’t know. There not enough data. For the elephant, we have primelephus, the ancestral elephant of the Asian and African elephant, and mammoth. Well, could that happened by random mutation and natural selection? My instinctive answer is sure - it sure looks like it. It doesn’t look like any big deal. The more careful answer, the actual answer, is I don’t know - cause I don’t know what’s involved in making one versus the other. I don’t know what molecular changes are necessary to make the small anatomical differences in those different species. Suppose one believed that those things could have happened by natural selection, but maybe the origination of mammals needed some extra information - how would that have happened - how would the designer have done that? Would it have been, say, information embedded into nature at the big bang, or whenever nature started, or might it have been manipulations along the way, or some sort of input along the way? The short answer is “I don’t know.”
(Bolding by me)

stevaroni · 20 February 2013

Henry J said:

Why? Because chihuahuas exploit an environmental niche

Acting in advertisements for Taco Bell?
Not unique enough - wolf puppies are shilling for Carmax these days.

Rolf · 20 February 2013

Here is a real life example of how genetics really work.

TomS · 20 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
phhht said: You, yourself, the great advocate of the reality of design in nature, cannot tell the designed from the non-designed. Just as I thought.
William Paley does so profoundly in "Natural Theology". http://web.ecologia.unam.mx/laboratorios/evolucionmolecular/homes/pdfs/WilliamPaley_1802_NaturalTheology.pdf Why don't you read it?
I wonder whether you have read it. You see, there is a puzzle that Paley raised, and tried to give a solution. But, as I suggest, there is a problem with Paley's solution. First, Paley's problem and his attempt at a solution:
One question may possibly have dwelt in the reader's mind during the perusal of these observations, namely, Why should not the Deity have given to the animal the faculty of vision at once? Why this circuitous perception; the ministry of so many means; an element provided for the purpose; reflected from opaque substances, refracted through transparent ones; and both according to precise laws; then, a complex organ, an intricate and artificial apparatus, in order, by the operation of this element, and in conformity with the restrictions of these laws, to produce an image upon a membrane communicating with the brain? Wherefore all this? Why make the difficulty in order to surmount it? If to perceive objects by some other mode than that of touch, or objects which lay out of the reach of that sense, were the thing proposed; could not a simple volition of the Creator have communicated the capacity? Why resort to contrivance, where power is omnipotent? Contrivance, by its very definition and nature, is the refuge of imperfection. To have recourse to expedients, implies difficulty, impediment, restraint, defect of power. This question belongs to the other senses, as well as to sight; to the general functions of animal life, as nutrition, secretion, respiration; to the economy of vegetables; and indeed to almost all the operations of nature. The question, therefore, is of very wide extent; and amongst other answers which may be given to it; beside reasons of which probably we are ignorant, one answer is this: It is only by the display of contrivance, that the existence, the agency, the wisdom of the Deity, could be testified to his rational creatures. From pages 38-40 of William Paley, Natural Theology; or Evidences of the Existence and Attributes of the Deity, Collected from the Appearance of Nature (12th edition)
I don't know how Paley knew that limitation on the power of God, that God could only achieve his goals by the display of contrivance. Why could not the existence, the agency, the wisdom of the Deity be testified without contrivance? And why, in the 200 years since Paley, has no one answered this rather obvious question?

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 20 February 2013

raven said: This is false. It is just a lie. Mutations can and often do create beneficial mutations. Our whole agricultural system depends on this. Mutations beneficial to their hosts are a huge problem in medicine and frequently treatment limiting, e.g. drug resistance of microbial pathogens.
No, it is not a lie. Mutations are always harmful in some way to an organism. In a cruel and unusual environment, however, some mutations prove to be harmful but at the same time allow the organism to survive. Antibiotic resistance in microbes often occurs the deletion of the gene targeted by the antibiotic so that it cannot bind to it and induce death.Thus, they are only "beneficial" in that they cause defects that fortuitously allow the organism to survive. It is a bit like saying that a man born without an arm is at less risk of dying from malaria because there is less chance of him being bitten by a mosquito.

DS · 20 February 2013

And there you have it folks, the old "no beneficial mutations" bullshit. It's only one hundred years behind the times. Still no references, still no evidence, just "I says it so it's true bullshit.

And of course the asshole completely ignores the fact that the exact same objection applies to artificial selection and that the main benefit of longer term selection is that it can take advantage of BENEFICIAL mutations that eventually do arise. But who cares? All you have to do is warp the definition of "beneficial" enough so you can ignore all of that. The fact that mutations have an effect relative to the environment and that the environment can change means that, by definition, beneficial mutations must occur. But just forget all that and take to word of a liar and charlatan with no evidence whatsoever.

Any further responses by me to anything Joe has to say will be on the bathroom wall. IF he ever attempts to provide any evidence that is. Until then, all I have to do is say he's wrong and that makes it true.

Karen S. · 20 February 2013

And there you have it folks, the old “no beneficial mutations” bullshit.
So that's why we don't have corn, only teosinte. I was wondering about that.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 20 February 2013

DS said: And there you have it folks, the old "no beneficial mutations" bullshit. It's only one hundred years behind the times. Still no references, still no evidence, just "I says it so it's true bullshit.
You want references? http://www.discoverymedicine.com/R-Craig-MacLean/2010/08/04/the-evolution-of-antibiotic-resistance-insight-into-the-roles-of-molecular-mechanisms-of-resistance-and-treatment-context/
"All known mechanism of antibiotic resistance are associated with costs that cause a reduction in competitive ability, transmission and virulence in the absence of antibiotics (Andersson, 2006; Andersson and Hughes , 2010; Andersson and Levin 1999)."
You see, folks, there is no such thing as a "free lunch" in biochemistry - see Dembski. If these "beneficial mutations" were so beneficial then they would have become fixed in the genome by now. But they are only "beneficial" in an extreme environment where defective mutants have a reproductive advantage over the non-defective wild types.

eric · 20 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: Mutations are always harmful in some way to an organism.
So, if an animal has a copy number variation that changes sequences ABC to ABBC has undegone a mutation. That must be harmful. Its kid then undergoes a copy number variation that changes sequence ABBC to ABC, another mutation. That must also be harmful too, eh? Your argument doesn't even pass the low low bar of logical consistency, let alone the higher bar of empirical support.

Scott F · 20 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
DS said: And there you have it folks, the old "no beneficial mutations" bullshit. It's only one hundred years behind the times. Still no references, still no evidence, just "I says it so it's true bullshit.
You want references? http://www.discoverymedicine.com/R-Craig-MacLean/2010/08/04/the-evolution-of-antibiotic-resistance-insight-into-the-roles-of-molecular-mechanisms-of-resistance-and-treatment-context/
"All known mechanism of antibiotic resistance are associated with costs that cause a reduction in competitive ability, transmission and virulence in the absence of antibiotics (Andersson, 2006; Andersson and Hughes , 2010; Andersson and Levin 1999)."
You see, folks, there is no such thing as a "free lunch" in biochemistry - see Dembski. If these "beneficial mutations" were so beneficial then they would have become fixed in the genome by now. But they are only "beneficial" in an extreme environment where defective mutants have a reproductive advantage over the non-defective wild types.
I see you missed the point again. I have not read the paper, but even the sentence that you quote out of context supports exactly the opposite of what you claim it does. Here, let me help you out a bit:
"All known mechanism of antibiotic resistance are associated with costs that cause a reduction in competitive ability, transmission and virulence in the absence of antibiotics (Andersson, 2006; Andersson and Hughes , 2010; Andersson and Levin 1999)."
Notice the newly underlined part: "in the absence of antibiotics". No one has ever claimed that changes to genes come "without cost". It costs the cell energy to create any protein. It costs the cell energy to divide. It costs the cell energy to move. But the point you missed is that the environment in which the cell lives had changed. Now, there are antibiotics that the cell has to contend with. In the absence of antibiotics, the resistance gene has a cost, a cost that other cells don't have to pay. But in the new environment, the mutated cell with the resistance gene can suddenly survive and out-compete its neighbors in the new environment. The new environment has "naturally selected" the resistant cell. Thus, "Natural Selection" wins again, as demonstrated by the very quote that you have provided.

j. biggs · 20 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
raven said: This is false. It is just a lie. Mutations can and often do create beneficial mutations. Our whole agricultural system depends on this. Mutations beneficial to their hosts are a huge problem in medicine and frequently treatment limiting, e.g. drug resistance of microbial pathogens.
No, it is not a lie. Mutations are always harmful in some way to an organism. In a cruel and unusual environment, however, some mutations prove to be harmful but at the same time allow the organism to survive. Antibiotic resistance in microbes often occurs the deletion of the gene targeted by the antibiotic so that it cannot bind to it and induce death.Thus, they are only "beneficial" in that they cause defects that fortuitously allow the organism to survive. It is a bit like saying that a man born without an arm is at less risk of dying from malaria because there is less chance of him being bitten by a mosquito.
Here is an example of a beneficial mutation in humans. It also happens that it isn't particularly susceptible to natural selection because its benefits are experienced primarily later in life when reproduction is not necessarily a priority. None the less, this is a prime example in humans of a beneficial mutation. Also you are woefully unaware of how beneficial mutations in bacteria work. Penicillinase production in bacteria, for example, is not analogous to a person cutting off their arm in order not to be bitten by a mosquito. Penicillinase is an enzyme that hydrolizes the beta lactam ring in penicillin. This disables penicillin from inhibiting peptidoglycan cross links which degrade the bacterial cell wall. I would say that penicillinase is quite beneficial to the bacteria. You should also consider nylonase. Nylon is an artificial substrate only recently produced by humans, yet there are now bacteria which have evolved this enzyme which can use nylon as a growth medium. Also nylonase enzymes are known to have evolved separately in both flavobacterium and Pseudomonas aeruginosa. So your argument that beneficial mutations don't happen or have some otherwise deleterious effect is patently false, and these are three well documented counter examples to your mendacious claim.

raven · 20 February 2013

“All known mechanism of antibiotic resistance are associated with costs that cause a reduction in competitive ability, transmission and virulence in the absence of antibiotics (Andersson, 2006; Andersson and Hughes , 2010; Andersson and Levin 1999).”
This is BTW, also false.
sbc.ubc.ca Reversal of resistance by removal of antibiotics from use was an idea that was put forth. Generally mutation in a bacterial gene to confer resistance often results in a loss of fitness leading to slower growth. Therefore it was believed that removal of antibiotics would cause selection against these bacteria when competing with non-resistant, fit bacteria. Unfortunately, for the most part, this has been shown to be ineffective. Bacteria often acquire compensatory mutations that allow them to grow as fast as or even faster than wild type, non-resistant bacteria. Consequently, the selective advantage of the non-resistant bacteria and the selection against the resistance mutation is eliminated.
One strategy to cope with the Darwinian treadmill of antibiotic resistance is to just stop using antibiotics that have become ineffective and hope that nonresistant strains take over again. That hasn't really worked. The fitness cost minus antibiotics is often slight or nonexistent. What one commonly sees when selecting antibiotic resistant mutants is a decrease in growth rate. Then the microbes pick up a compensatory mutation and end up growing at the same rate they were before the antibiotic mutation.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 20 February 2013

raven said: What one commonly sees when selecting antibiotic resistant mutants is a decrease in growth rate. Then the microbes pick up a compensatory mutation and end up growing at the same rate they were before the antibiotic mutation.
Compensatory mutations simply reverse or mitigate the harmful effect of the previous mutation that conferred the resistance to the antibiotic. However, the organism is still likely to have compromised some of its original functionality despite the compensatory effect identified.

j. biggs · 20 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
raven said: What one commonly sees when selecting antibiotic resistant mutants is a decrease in growth rate. Then the microbes pick up a compensatory mutation and end up growing at the same rate they were before the antibiotic mutation.
Compensatory mutations simply reverse or mitigate the harmful effect of the previous mutation that conferred the resistance to the antibiotic. However, the organism is still likely to have compromised some of its original functionality despite the compensatory effect identified.
You are good at making claims, not so good at providing references that back them up.

raven · 20 February 2013

FEMS Microbiol Ecol. 2013 Mar;83(3):622-31. doi: 10.1111/1574-6941.12019. Epub 2012 Nov 6. Escherichia coli adapts to tetracycline resistance plasmid (pBR322) by mutating endogenous potassium transport: in silico hypothesis testing. Hellweger FL. SourceDepartment of Civil and Environmental Engineering, Northeastern University, Boston, MA, USA. Abstract Antibiotic resistance exerts a metabolic cost on bacteria and presumably a fitness disadvantage in the absence of antibiotics. However, several studies have shown that bacteria can evolve to eliminate this cost. Escherichia coli can adapt to the plasmid pBR322 carrying the tetA tetracycline-resistance gene (codes for the TetA efflux pump) by a chromosome mutation, which requires an intact tetA gene on the plasmid. The TetA pump can mediate potassium uptake. Here, the hypothesis that TetA replaces the endogenous K(+) uptake system Trk is explored using a multi-level modeling approach that explicitly resolves relevant intracellular processes (e.g., metabolism and K(+) uptake) and simulates individual bacteria in competition. The general behavior of the model is consistent with observations from the literature (e.g., growth rate and K(+) limitation). In competition experiments without tetracycline, the model correctly predicts the fitness advantage of naive susceptible over naive resistant, evolved resistant over naive resistant and evolved resistant over evolved susceptible strains. Trk takes up about 10 times the K(+) required, which costs energy. TetA takes up less K(+) , which is more efficient and leads to the evolution of the Trk mutant. The evolved Trk mutant relies on TetA to take up K(+) , and thus, carrying the plasmid is advantageous even in the absence of the antibiotic.
Here is one example of antibiotic resistance not resulting in a fitness cost. 1. E. coli acquiring tet resistance by plasmid shows a fitness cost. 2. It then picks up a compensatory beneficial mutation that restores fitness. These are two examples of beneficial mutations and demonstrate a common evolutionary pathway. BTW, the creationist is likely to be Ray Martinez. He is known to be immune to logic or reason so don't expect anything from him.

j. biggs · 20 February 2013

raven said:
FEMS Microbiol Ecol. 2013 Mar;83(3):622-31. doi: 10.1111/1574-6941.12019. Epub 2012 Nov 6. Escherichia coli adapts to tetracycline resistance plasmid (pBR322) by mutating endogenous potassium transport: in silico hypothesis testing. Hellweger FL. SourceDepartment of Civil and Environmental Engineering, Northeastern University, Boston, MA, USA. Abstract Antibiotic resistance exerts a metabolic cost on bacteria and presumably a fitness disadvantage in the absence of antibiotics. However, several studies have shown that bacteria can evolve to eliminate this cost. Escherichia coli can adapt to the plasmid pBR322 carrying the tetA tetracycline-resistance gene (codes for the TetA efflux pump) by a chromosome mutation, which requires an intact tetA gene on the plasmid. The TetA pump can mediate potassium uptake. Here, the hypothesis that TetA replaces the endogenous K(+) uptake system Trk is explored using a multi-level modeling approach that explicitly resolves relevant intracellular processes (e.g., metabolism and K(+) uptake) and simulates individual bacteria in competition. The general behavior of the model is consistent with observations from the literature (e.g., growth rate and K(+) limitation). In competition experiments without tetracycline, the model correctly predicts the fitness advantage of naive susceptible over naive resistant, evolved resistant over naive resistant and evolved resistant over evolved susceptible strains. Trk takes up about 10 times the K(+) required, which costs energy. TetA takes up less K(+) , which is more efficient and leads to the evolution of the Trk mutant. The evolved Trk mutant relies on TetA to take up K(+) , and thus, carrying the plasmid is advantageous even in the absence of the antibiotic.
Here is one example of antibiotic resistance not resulting in a fitness cost. 1. E. coli acquiring tet resistance by plasmid shows a fitness cost. 2. It then picks up a compensatory beneficial mutation that restores fitness. These are two examples of beneficial mutations and demonstrate a common evolutionary pathway. BTW, the creationist is likely to be Ray Martinez. He is known to be immune to logic or reason so don't expect anything from him.
Strangely enough the very article this bozo quoted mentioned the effect of compensatory mutations right under the paragraph that was quote-mined. In fact it stated unequivocally that even though the genes that confer antibiotic resistance initially have a cost to the organism, this cost is quickly compensated for resulting in antibiotic resistance becoming fixed in bacterial populations. This compensation explains why, antibiotics are quickly becoming ineffective, when it was previously assumed that intermittent use of certain antibiotics would cause antibiotic resistance to disappear which has not been the case. How disingenuous is it to use an article explaining the evolution of antibiotic resistance in bacteria as evidence against evolution? This very possibly could be Ray, because he is good at not reading past the introduction of any piece of literature he quotes or else he conveniently ignores the parts he finds inconvenient. Then again this ability seems to be prevalent in most creationists.

raven · 20 February 2013

J Antimicrob Chemother. 2005 Sep;56(3):544-51. Epub 2005 Jul 22. Assessment of the fitness impacts on Escherichia coli of acquisition of antibiotic resistance genes encoded by different types of genetic element. Enne VI, Delsol AA, Davis GR, Hayward SL, Roe JM, Bennett PM. SourceBristol Centre for Antimicrobial Research, Department of Pathology and Microbiology, University of Bristol, Medical Sciences Building, Bristol BS8 1TD, UK. v.i. Abstract OBJECTIVES: Little is known of the fitness cost that antibiotic resistance exerts on wild-type bacteria, especially in their natural environments. We therefore examined the fitness costs that several antibiotic resistance elements imposed on a wild-type Escherichia coli isolate, both in the laboratory and in a pig gut colonization model. METHODS: Plasmid R46, Tn1 and Tn7 and a K42R RpsL substitution were separately introduced into E. coli 345-2 RifC, a rifampicin-resistant derivative of a recent porcine isolate. The insertion site of Tn1 was determined by DNA sequencing. The fitness cost of each resistance element was assessed in vitro by pairwise growth competition and in vivo by regularly monitoring the recovery of strains from faeces for 21 days following oral inoculation of organic piglets. Each derivative of 345-2 RifC carrying a resistance element was grown in antibiotic-free broth for 200 generations and the experiments to assess fitness were repeated. RESULTS: RpsL K42R was found to impose a small fitness cost on E. coli 345-2 RifC in vitro but did not compromise survival in vivo. R46 imposed a cost both before and after laboratory passage in vitro, but only the pre-passage strain was at a disadvantage in vivo. The post-passage isolate had an advantage in pigs. Acquisition of Tn7 had no impact on the fitness of E. coli 345-2 RifC. Two derivatives containing Tn1 were isolated and, in both cases, the transposon inserted into the same cryptic chromosomal sequence. Acquisition of Tn1 improved fitness of E. coli 345-2 RifC in vitro and in vivo in the case of the first derivative, but in the case of a second, independent derivative, Tn1 had a neutral effect on fitness. CONCLUSIONS: The fitness impact imposed on E. coli 345-2 RifC by carriage of antibiotic resistance elements was generally low or non-existent, suggesting that once established, resistance may be difficult to eliminate through reduction in prescribing alone.
and
Enhancement of host fitness by the sul2-coding plasmid p9123 in the absence of selective pressure. Enne VI, Bennett PM, Livermore DM, Hall LM. J Antimicrob Chemother. 2004 Jun; 53(6):958-63. Epub 2004 Apr 21.
FYI. It's self explanatory.

raven · 20 February 2013

J Antimicrob Chemother. 2004 Jun;53(6):958-63. Epub 2004 Apr 21. Enhancement of host fitness by the sul2-coding plasmid p9123 in the absence of selective pressure. Enne VI, Bennett PM, Livermore DM, Hall LM. SourceBristol Centre for Antimicrobial Research, Department of Pathology and Microbiology, University of Bristol, Medical Sciences Building, University Walk, Bristol BS8 1TD. v.i. Abstract OBJECTIVES: Despite a 97% reduction in clinical sulphonamide usage, the prevalence of sulphonamide resistance among Escherichia coli has remained constant in the UK. Genetic linkage of sulphonamide resistance to other resistances is thought important for this maintenance, but the finding also implies that sulphonamide resistance exerts little fitness cost. To test this hypothesis, we examined the fitness impact of four naturally occurring sul2-coding plasmids upon their hosts. METHODS: The fitness impact of the plasmids upon E. coli was determined by pairwise growth competition in a minimal medium. The DNA sequence of plasmid p9123 was obtained by primer walking and PCR. RESULTS: Three of the four sul2-coding plasmids studied imposed fitness costs on their hosts. The fourth plasmid, a 6.2 kb resistance element carrying sul2, strA and strB designated p9123, conferred a 4% fitness advantage upon its original clinical host and also on E. coli K12 JM109. The complete sequence of p9123 revealed eight open reading frames, including five of unknown function. There was no obvious gene to which the fitness advantage might be attributed. CONCLUSIONS: The novel finding that p9123 can improve host fitness may explain why this plasmid and its close relatives are so widespread among enteric bacteria. In addition to other factors such as co-selection of sulphonamide resistance by other agents, the fitness advantage conferred by plasmids such as p9123 may have contributed to the maintenance of sulphonamide resistance in the UK in the absence of clinical selection pressure. These data indicate that once antibiotic resistance has been established on mobile genetic elements, it may be difficult to eliminate.
This is interesting enough to post the entire abstract. Drug resistance plasmids are autonomous replicators and susceptible to selection for their own survival. This plasmid is capable of conferring a selective advantage on its hosts even in the absence of antibiotics. It also carries a sulphonamide resistant determinant. Since it is beneficial by itself, it persists even after sulphonamide drug use has stopped.

harold · 20 February 2013

eric said:
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: Mutations are always harmful in some way to an organism.
So, if an animal has a copy number variation that changes sequences ABC to ABBC has undegone a mutation. That must be harmful. Its kid then undergoes a copy number variation that changes sequence ABBC to ABC, another mutation. That must also be harmful too, eh? Your argument doesn't even pass the low low bar of logical consistency, let alone the higher bar of empirical support.
I can't restrain myself from adding this final comment. 1) It is, as Eric points out, logically impossible that there are no beneficial mutations. You can be a YEC creationist and realize this. "Beneficial" is a subjective term, but in the context of evolution, we nearly alway use it to refer to a trait that predisposes to greater individual reproductive success, than would be the case without the trait. Therefore what is beneficial depends on the environment and also on zygosity and interaction with other alleles. Heterozygosity for sickle hemoglobin. Beneficial in low altitude, high malaria environments, especially if effective therapy is imperfectly available. Mildly deleterious in high altitude environments (heterozygous state can lead to death or incapacity under these conditions). Homozygosity almost always deleterious. But there is a spectrum of severity of disease. "No beneficial mutations" does not make logical sense. The clear underlying assumption is that everything was perfect once (in the Garden of Eden?) and that all changes since have been for the worse. That has to be the assumption, because a "mutation" is only mutation relative to a baseline that is defined as "wild type". However, even someone who believes in a literall Garden of Eden 6000 years ago should be able to get this one right. If mutations happen at all some of them sometimes have to lead to phenotypic changes that improve expected reproductive success. Yet creationists still repeat the "no beneficial mutations" line. (And speaking of sickle hemoglobin, how about those malaria parasites with their drug resistance? Deliberate miracle by the designer? If so, why did the designer favor malaria parasites over humans?)

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 20 February 2013

j. biggs said: You should also consider nylonase. Nylon is an artificial substrate only recently produced by humans, yet there are now bacteria which have evolved this enzyme which can use nylon as a growth medium. Also nylonase enzymes are known to have evolved separately in both flavobacterium and Pseudomonas aeruginosa. So your argument that beneficial mutations don't happen or have some otherwise deleterious effect is patently false, and these are three well documented counter examples to your mendacious claim.
Your knowledge of this is pretty poor. The mutated enzyme does not degrade nylon as such, but rather oligomers associated with the production of nylon. Nylonase happens to be a mutated esterase with enhanced Ald-hydorlytic activity. This most likely adversely affects the specificity of the enzyme by altering its catalytic chemistry. In an extreme or unusual environment, like that near a factory, these mutants will thrive but likely with some biochemical cost. In a normal environment they will be selected against. Like I say, there is no free lunch.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 20 February 2013

raven said: Here is one example of antibiotic resistance not resulting in a fitness cost. 1. E. coli acquiring tet resistance by plasmid shows a fitness cost. 2. It then picks up a compensatory beneficial mutation that restores fitness. These are two examples of beneficial mutations and demonstrate a common evolutionary pathway.
Compensatory mutations don't restore the organism to the same level of fitness as they originally had. They are just stop gaps which help to mitigate the deleterious effect of the previous "beneficial" mutation. They almost certainly produce some other deleterious effect, although not one which is greater than the effect they compensate for. Backmutations, however, do restore the original function but also reverse any adaptive benefit.

60187mitchells · 20 February 2013

how is lactose tolerance in adult humans not a beneficial mutation?
IF a mutation is beneficial or not is relative. relative to the environment, relative to competing organisms, etc.

to say mutaions can ONLY decrease fitness is just silly - as fitness is also a relative term.

eric · 20 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: In an extreme or unusual environment, like that near a factory, these mutants will thrive but likely with some biochemical cost. In a normal environment they will be selected against. Like I say, there is no free lunch.
So what you're saying is: this mutation provides a net benefit in certain environmental conditions. In others, it doesn't. This is absolutely correct. Fitness is local. And this is one of the reasons why your "no mutation is beneficial" claim is not just empirically wrong but logically impossible.

j. biggs · 20 February 2013

eric said:
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: In an extreme or unusual environment, like that near a factory, these mutants will thrive but likely with some biochemical cost. In a normal environment they will be selected against. Like I say, there is no free lunch.
So what you're saying is: this mutation provides a net benefit in certain environmental conditions. In others, it doesn't. This is absolutely correct. Fitness is local. And this is one of the reasons why your "no mutation is beneficial" claim is not just empirically wrong but logically impossible.
It's quite funny that the troll ignores this fact while he says natural selection can not lead to diversity but only maintains genetic characteristics. It is well known that selection can do both. Natural selection causes stasis when the environment is stable but can also lead to diversity because the environment changes. Also populations can move into different environments and exploit new ecological niches. Who cares if flavobacteria with nylonase can't do as well in the environment their predecessors thrived in. They are now exploiting a beneficial mutation in order to exploit a new ecological niche of which their predecessors couldn't take advantage. You say my understanding of nylonase is lacking dolt, but just because I didn't expound on which man made organic compounds (such as 6-aminohexanoate) flavobacteria exploits doesn't change the fact that this is an example of a beneficial mutation that exploits a previously non-existent ecological niche. Your entire understanding of how evolution works is laughably wrong and everyone here knows it.

j. biggs · 20 February 2013

BTW, the last paragraph was addressed to the troll not eric.

Mike Elzinga · 20 February 2013

FL is just taunting and throwing feces; he has no clue what he is talking about.

He doesn’t even have a middle school or high school understanding of science; it’s all bluff and bluster. He can’t do any calculations because he doesn’t know any high school algebra. He doesn’t know what to do with a formula. He didn’t learn anything in any science or math course ever.

He needs to go back to the Bathroom Wall and have his nose rubbed in his claim that the television program Unsolved Mysteries proves faith healing. That program is the highest level of science he has ever been exposed to; and he didn’t even learn anything from that.

Tenncrain · 20 February 2013

Mike Elzinga said: FL is just taunting and throwing feces; he has no clue what he is talking about. He doesn’t even have a middle school or high school understanding of science; it’s all bluff and bluster. He can’t do any calculations because he doesn’t know any high school algebra. He doesn’t know what to do with a formula. He didn’t learn anything in any science or math course ever. He needs to go back to the Bathroom Wall and have his nose rubbed in his claim that the television program Unsolved Mysteries proves faith healing. That program is the highest level of science he has ever been exposed to; and he didn’t even learn anything from that.
Perhaps you meant to post this in the "Montana Creationism Bill: dead in committee" thread. Otherwise, we couldn't agree with you more.

Tenncrain · 20 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: You are aware that the subject of this thread is precisely about an appeal to scientific authority by the NCSE?
You ignore that Project Steve describes itself as a spoof. In NCSE's own words from the webpage,
"Project Steve" is a tongue-in-cheek parody of a long-standing creationist tradition of amassing lists of "scientists who doubt evolution"
[my bold above] If anything, it's the Discovery Institute list that is trying to appeal to authority, but you conveniently look the other way about this matter as well.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 20 February 2013

60187mitchells said: how is lactose tolerance in adult humans not a beneficial mutation? IF a mutation is beneficial or not is relative. relative to the environment, relative to competing organisms, etc.
Actually drinking milk beyond infancy is probably not good for us at all. Hence the loss of (what I see) as a designed control mechanism to disable production of lactase beyond suckling age is most likely harmful. We are not supposed to tolerate lactose in adulthood but this mutation allows us to harm our health by eating ice cream. http://www.naturalnews.com/031255_milk_health.html http://saveourbones.com/osteoporosis-milk-myth/ The term "beneficial mutation" is somewhat of a contradiction due to the fact that copying errors in code that is designed to be optimal can only ever mess things up. Only in bizarre, unusual or extreme situations can a mutation prove to be advantageous. Once this situation is removed, the mutation then becomes useless.

Mike Elzinga · 20 February 2013

Tenncrain said:
Mike Elzinga said: FL is just taunting and throwing feces; he has no clue what he is talking about. He doesn’t even have a middle school or high school understanding of science; it’s all bluff and bluster. He can’t do any calculations because he doesn’t know any high school algebra. He doesn’t know what to do with a formula. He didn’t learn anything in any science or math course ever. He needs to go back to the Bathroom Wall and have his nose rubbed in his claim that the television program Unsolved Mysteries proves faith healing. That program is the highest level of science he has ever been exposed to; and he didn’t even learn anything from that.
Perhaps you meant to post this in the "Montana Creationism Bill: dead in committee" thread. Otherwise, we couldn't agree with you more.
Yup. I must have had two windows open. It’s ok though. Even if he saw it he wouldn’t know what it meant.

Scott F · 20 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
60187mitchells said: how is lactose tolerance in adult humans not a beneficial mutation? IF a mutation is beneficial or not is relative. relative to the environment, relative to competing organisms, etc.
Actually drinking milk beyond infancy is probably not good for us at all. Hence the loss of (what I see) as a designed control mechanism to disable production of lactase beyond suckling age is most likely harmful. We are not supposed to tolerate lactose in adulthood but this mutation allows us to harm our health by eating ice cream. http://www.naturalnews.com/031255_milk_health.html http://saveourbones.com/osteoporosis-milk-myth/ The term "beneficial mutation" is somewhat of a contradiction due to the fact that copying errors in code that is designed to be optimal can only ever mess things up. Only in bizarre, unusual or extreme situations can a mutation prove to be advantageous. Once this situation is removed, the mutation then becomes useless.
It's called "calories". In northern winters, with scarce food supplies, the ability to digest lactose (a sugar) provided a source of energy for those peoples, using a "renewable" resource. That is, you didn't have to kill the cow (or goat), and the cow could live off of plant resources that the humans could not. You could also store the cheese for long periods of time without refrigeration. Even if there are some undesirable side effects, being able to get more calories might avoid the undesirable side effect of death. Also, the osteoporosis problem is something that shows up mostly in the later years of life, typically after menopause, meaning after the point where natural selection has any noticeable effect. Reproductive fitness kind of ends after you can no longer reproduce. (This ignores the indirect effects of natural selection provided by kin relationships, especially the "grandmother" hypothesis.) The point is, that Natural Selection would select for the strong benefit of being able to use a new food source (hence avoiding early death), while it would not be too concerned with the weak cost of brittle bones in our dotage. The point is that there is always a trade off between the benefit and the cost. When the benefit is strong, and the cost is weak, Natural Selection will select for the "strong". But let's say for the sake of argument that you are right, that Natural Selection is wrong, and had no effect on our ability to digest lactose. How do *you* explain the presence and prevalence of the mutated lactose gene(s) in Caucasian populations? Did God magically give that mutation to all white-skinned peoples? I also note that the referenced web sites are against eating animal proteins of any kind, they are against any processed foods, and they tend to be full of conspiracy theories: "What else aren't "they" telling us about drinking milk?" They also don't seem to understand that both "cows" and "humans" are "mammals". The reason that we get any benefit at all from cows milk is that our respective biologies are very closely related, because of common ancestry. But of course, you (and most likely they) don't believe in common ancestry. You believe in unique and special creation of all animals separately. Therefore, any similarities in biology are all (to you) simple accidents, or unintended by-products of the separate and unique "designs" of God. So while I can't (yet) discount their hypothesis based on the underlying studies (which I haven't yet read), the general information that is presented is not persuasive. (And I will read them, because I consume a lot of dairy products.)

Scott F · 20 February 2013

Scott F said:
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
60187mitchells said: how is lactose tolerance in adult humans not a beneficial mutation? IF a mutation is beneficial or not is relative. relative to the environment, relative to competing organisms, etc.
Actually drinking milk beyond infancy is probably not good for us at all. Hence the loss of (what I see) as a designed control mechanism to disable production of lactase beyond suckling age is most likely harmful. We are not supposed to tolerate lactose in adulthood but this mutation allows us to harm our health by eating ice cream. http://www.naturalnews.com/031255_milk_health.html http://saveourbones.com/osteoporosis-milk-myth/ The term "beneficial mutation" is somewhat of a contradiction due to the fact that copying errors in code that is designed to be optimal can only ever mess things up. Only in bizarre, unusual or extreme situations can a mutation prove to be advantageous. Once this situation is removed, the mutation then becomes useless.
It's called "calories". In northern winters, with scarce food supplies, the ability to digest lactose (a sugar) provided a source of energy for those peoples, using a "renewable" resource. That is, you didn't have to kill the cow (or goat), and the cow could live off of plant resources that the humans could not. You could also store the cheese for long periods of time without refrigeration. Even if there are some undesirable side effects, being able to get more calories might avoid the undesirable side effect of death. Also, the osteoporosis problem is something that shows up mostly in the later years of life, typically after menopause, meaning after the point where natural selection has any noticeable effect. Reproductive fitness kind of ends after you can no longer reproduce. (This ignores the indirect effects of natural selection provided by kin relationships, especially the "grandmother" hypothesis.) The point is, that Natural Selection would select for the strong benefit of being able to use a new food source (hence avoiding early death), while it would not be too concerned with the weak cost of brittle bones in our dotage. The point is that there is always a trade off between the benefit and the cost. When the benefit is strong, and the cost is weak, Natural Selection will select for the "strong". But let's say for the sake of argument that you are right, that Natural Selection is wrong, and had no effect on our ability to digest lactose. How do *you* explain the presence and prevalence of the mutated lactose gene(s) in Caucasian populations? Did God magically give that mutation to all white-skinned peoples? I also note that the referenced web sites are against eating animal proteins of any kind, they are against any processed foods, and they tend to be full of conspiracy theories: "What else aren't "they" telling us about drinking milk?" They also don't seem to understand that both "cows" and "humans" are "mammals". The reason that we get any benefit at all from cows milk is that our respective biologies are very closely related, because of common ancestry. But of course, you (and most likely they) don't believe in common ancestry. You believe in unique and special creation of all animals separately. Therefore, any similarities in biology are all (to you) simple accidents, or unintended by-products of the separate and unique "designs" of God. So while I can't (yet) discount their hypothesis based on the underlying studies (which I haven't yet read), the general information that is presented is not persuasive. (And I will read them, because I consume a lot of dairy products.)
Nope. Sorry. While lactose intolerance is a normal genetic occurrence for most mammals, even in non-humans lactose tolerance in adulthood runs about 10% (in dogs and cats). But just because lactose intolerance is "normal", that does not mean that lactase production in adulthood is a "harmful" mutation. There are some potential side effects (particularly with milk allergies), but these vary considerably by individual. As with all of genetics, there is a broad range of expression of lactase over all ages. From what I can tell, while some individuals may have health issues related to lactose and some of the proteins in non-human milk, overall the ability to consume milk into adulthood is overwhelmingly positive for the species as a whole. (The complaints of certain vegans notwithstanding.) And that's the hallmark of a "positive" mutation: the positives outweighs the negatives. Besides, production of lactase in humans (as in all mammals) is a normal thing. It's what defines "mammals". So, the mutation that does not disable the production of lactase is, by itself, neither "positive" nor "negative". Lactase is only produced in quantity when it is needed; that is, when milk is consumed. So, if no milk is consumed, then there are no negative health effects. There is essentially no cost to the individual nor to the species to maintain the ability to produce lactase. If there is no cost to have the mutation when it is not needed, and there are strong benefits when the mutation is useful, then by any definition it is a "positive" mutation. http://www.nbcnews.com/id/22349307/#.USWMst3w8Sw http://www.myhealthnewsdaily.com/2781-experts-explain-milk-health-benefits-risks.html http://en.wikipedia.org/wiki/Milk http://www.petwave.com/Dogs/Dog-Health-Center/Digestive-Disorders/Lactose-Intolerance/Overview.aspx

Matt Bright · 21 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
raven said: Here is one example of antibiotic resistance not resulting in a fitness cost. 1. E. coli acquiring tet resistance by plasmid shows a fitness cost. 2. It then picks up a compensatory beneficial mutation that restores fitness. These are two examples of beneficial mutations and demonstrate a common evolutionary pathway.
Compensatory mutations don't restore the organism to the same level of fitness as they originally had. They are just stop gaps which help to mitigate the deleterious effect of the previous "beneficial" mutation. They almost certainly produce some other deleterious effect, although not one which is greater than the effect they compensate for. Backmutations, however, do restore the original function but also reverse any adaptive benefit.
Also worth remembering that while they're generally quite helpful plasmids can, to a certain extent, be viewed as independent genetic entities with their own agenda - a sort of bacterial equivalent of gut flora. They may impose a bit of a fitness cost, but they've also evolved mechanisms (which look like they've been duplicated and repurposed from the bacterial chromosome) that ensure they're maintained in the population even if they're not being challenged by whatever they protect against. So there's another 'pathetic level of detail' these people are going to have to glibly ignore if they want to try this route of argument...

Rolf · 21 February 2013

Interesting, A Masked Panda (1686) ignored my two posts on page 5.

BTW, I don't think it my be Ray. He doesn't even recognize natural selection, his position has always been "The concept of natural selection is not seen in nature." I haven't checked talkorigins the past few months, though.

DS · 21 February 2013

Rolf said: Interesting, A Masked Panda (1686) ignored my two posts on page 5. BTW, I don't think it my be Ray. He doesn't even recognize natural selection, his position has always been "The concept of natural selection is not seen in nature." I haven't checked talkorigins the past few months, though.
Joe has previously argued, (before he was permanently banned), that genes can never take on new functions. When presented with a paper that documented just such an occurrence, he denied it, even though the term "neofunctionalization" was in the title of the paper. He is notorious for claiming that papers that refute his insane ideas actually support them. He has no concept whatsoever of how genetics works, it's worthless to argue with him about it. He literally cannot comprehend that the evidence is against him. He will desperately cling to his delusions, even in the face of overwhelming evidence to the contrary. It is a mystery why such a person is still allowed to post here.

ogremk5 · 21 February 2013

Thanks guys. I'm doing a series on debunking the weaknesses of evolution as presented by Texas creationists. This discussion covered 3 of the 'weaknesses' and provided me with some excellent references and links.

I for one am most appreciative.

And for a blatant plug: http://skepticink.com/smilodonsretreat/

harold · 21 February 2013

ogremk5 said: Thanks guys. I'm doing a series on debunking the weaknesses of evolution as presented by Texas creationists. This discussion covered 3 of the 'weaknesses' and provided me with some excellent references and links. I for one am most appreciative. And for a blatant plug: http://skepticink.com/smilodonsretreat/
I also found this a surprisingly good thread. At this point it is, of course, in permanent loop mode. We all, including Joe, define "mutation" as a change in nucleotide sequence, relative to parent sequence. The problem is the definition of "beneficial". As I noted above, "beneficial" is a subjective term, but the science supporters here are implicitly using an objective definition. A mutation is beneficial if it can, in a given environment, be associated with greater expected reproductive rate, relative to expected reproductive rate in the same individual, in the absence of the mutation. Joe isn't using that definition. His definition of "beneficial" is "Joe will say that it looks beneficial to Joe". And by that standard, no mutation can ever, ever look beneficial to Joe. In this way, unlike some of his idols at the DI, he is internally consistent, but absurd. Joe can be presented with an infinite number of beneficial mutation examples. But they can never be "beneficial" in his mind. Period.

DS · 21 February 2013

harold said:
ogremk5 said: Thanks guys. I'm doing a series on debunking the weaknesses of evolution as presented by Texas creationists. This discussion covered 3 of the 'weaknesses' and provided me with some excellent references and links. I for one am most appreciative. And for a blatant plug: http://skepticink.com/smilodonsretreat/
I also found this a surprisingly good thread. At this point it is, of course, in permanent loop mode. We all, including Joe, define "mutation" as a change in nucleotide sequence, relative to parent sequence. The problem is the definition of "beneficial". As I noted above, "beneficial" is a subjective term, but the science supporters here are implicitly using an objective definition. A mutation is beneficial if it can, in a given environment, be associated with greater expected reproductive rate, relative to expected reproductive rate in the same individual, in the absence of the mutation. Joe isn't using that definition. His definition of "beneficial" is "Joe will say that it looks beneficial to Joe". And by that standard, no mutation can ever, ever look beneficial to Joe. In this way, unlike some of his idols at the DI, he is internally consistent, but absurd. Joe can be presented with an infinite number of beneficial mutation examples. But they can never be "beneficial" in his mind. Period.
Correct. According to Joe, a mutation cannot be "beneficial" if: 1) It has some cost (even if the benefit is greater than the cost) 2) If it is not beneficial in every environment 3) If it does not make you better than some theoretical previous version of the organism ( you know, before all those nasty mutations degraded it in the first place) So, given those constraints, no mutation can ever be beneficial, no new function or new structure can ever arise and no gene can ever get any better than it was at some unspecified time in the past. And the justification for all of this, everything was designed perfect in the first place and reality can only make things worse. No evidence, no reason, no logic, just an unsubstantiated claim. Why he finds the prospect of "beneficial" mutations so frightening i don't know and I don't care. He's more divorced form reality than a loon in a cuckoo factory.

harold · 21 February 2013

In this way, unlike some of his idols at the DI, he is internally consistent, but absurd.
Just to clarify, the fellows at the DI are just as absurd as Joe, but less internally consistent. I may have phrased that in a way that implied that I think that they are less internally consistent, but also less absurd. That is not the case. They are equally absurd. Some science supporters have disagreed with me on this, but in my view, the arguments made by the creationist regulars here are absolutely as good as, or better than, the arguments from "official" creationist sites and institutions. I am not saying this as a complement to the creationist regulars. And I realize that in terms of grammar, Casey Luskin is better than Robert Byers (but not than Joe or FL). Rather, I am merely pointing out that total crap is total crap. Whether it comes from Dembski in the form of a pseudo-scholarly book published by Regnery, or it comes from IBIG as a rant on the BW, it all has the same value.

ogremk5 · 21 February 2013

I'm actually kind of surprised Joe didn't pull out the 'no new function' card. Of course, that's easily refuted by Lenski's work. Indeed, citrate metabolism is not only a new function, but it's massively beneficial.

I argued with Joe about this a year or so back and his claim was that the reproduction rate of the citrate consuming bacteria was lower than the non-cit+ bacteria means that the cit+ mutation wasn't beneficial.

Obviously, he has a vested interested in proclaiming it to be non-beneficial. Anytime a population (or organism) can utilize a completely untapped energy source, then it's massively beneficial. Competition would be non-existent and the population would face no significant pressures other than itself.

Just Bob · 21 February 2013

DS said: So, given those constraints, no mutation can ever be beneficial, no new function or new structure can ever arise and no gene can ever get any better than it was at some unspecified time in the past. And the justification for all of this, everything was designed perfect in the first place and reality can only make things worse.
Hmm, I guess that would mean that all those dinosaurs and other ancient extinct creatures were more perfect than modern creatures, since they weren't as far removed from the original perfection of creation! And Homo habilis and Neanderthals were more perfect (had fewer harmful mutations) than we do. Damn.

Dave Lovell · 21 February 2013

DS said: Why he finds the prospect of "beneficial" mutations so frightening i don't know...
Presumably because his entire world view is predicated upon the idea that only an intelligent creator can inject an organism with the information required to "improve" it. He sees that conceding a beneficial outcome, however small, can arise through a random process can only lead him to the impossible conclusion that he is wrong.

DS · 21 February 2013

Just Bob said:
DS said: So, given those constraints, no mutation can ever be beneficial, no new function or new structure can ever arise and no gene can ever get any better than it was at some unspecified time in the past. And the justification for all of this, everything was designed perfect in the first place and reality can only make things worse.
Hmm, I guess that would mean that all those dinosaurs and other ancient extinct creatures were more perfect than modern creatures, since they weren't as far removed from the original perfection of creation! And Homo habilis and Neanderthals were more perfect (had fewer harmful mutations) than we do. Damn.
That's exactly the point. Joes nonsense is inconsistent with the genetic evidence, but also with the fossil record. If he were correct, what one would expect to see would be a maximum number of species six thousand years ago, followed by a reduction in species numbers due to extinctions since. This is of course completely contrary to the actual fossil record. But so what? If you can ignore one entire field of science, it isn't much more work to ignore them all.

DS · 21 February 2013

Dave Lovell said:
DS said: Why he finds the prospect of "beneficial" mutations so frightening i don't know...
Presumably because his entire world view is predicated upon the idea that only an intelligent creator can inject an organism with the information required to "improve" it. He sees that conceding a beneficial outcome, however small, can arise through a random process can only lead him to the impossible conclusion that he is wrong.
Sure. And he doesn't want to start down the slippery slope to reality. That could lead to dancing.

Rolf · 21 February 2013

Only in bizarre, unusual or extreme situations can a mutation prove to be advantageous. Once this situation is removed, the mutation then becomes useless
And the reliable source(s) of claims like that are? So what if the "situation is removed", say because the population in question becomes isolated, as for example by a river taking a new course, territory, habitat, earthquakes or a lot of other options; if you'd been interested you'd know but I don't see you as having a genuine interest in learning, only an ingrained creationism. The fact that life is spread out all over the planet, from the ocean depths to the highest mountains, the coldest or hottest places on earth, even what looks like the most inhospitable places thinkable, they have life because of the adaptability offered by natural gentic mechanisms at work. Not because a benign designer is on standby at every risk or challenge for survival that populations are continuously faced with. Sorry, you don't impress anybody except maybe your fellow creationists.

Rolf · 21 February 2013

Sorry, should be “situation is not removed or maybe even aggravated", ...

Henry J · 21 February 2013

Only in bizarre, unusual or extreme situations can a mutation prove to be advantageous. Once this situation is removed, the mutation then becomes useless

I have to wonder, what about a mutation that only increases or decreases the amount of some protein (e.g., melanin), or increases or decreases the rate of growth of some body part (or the length of time it spends growing) (e.g., amount of hair, arm length, skin flaps between fingers or limbs)? Besides which, so what if the thus modified lineage doesn't do quite as well in the environment that its unmodified relatives still live in; if it thrives in a different environment, then that makes it successful, even if its relatives are still doing well where they are (i.e., why shouldn't there still be monkeys? What would zoos do without them?). Henry

Scott F · 22 February 2013

DS said:
Just Bob said:
DS said: So, given those constraints, no mutation can ever be beneficial, no new function or new structure can ever arise and no gene can ever get any better than it was at some unspecified time in the past. And the justification for all of this, everything was designed perfect in the first place and reality can only make things worse.
Hmm, I guess that would mean that all those dinosaurs and other ancient extinct creatures were more perfect than modern creatures, since they weren't as far removed from the original perfection of creation! And Homo habilis and Neanderthals were more perfect (had fewer harmful mutations) than we do. Damn.
That's exactly the point. Joes nonsense is inconsistent with the genetic evidence, but also with the fossil record. If he were correct, what one would expect to see would be a maximum number of species six thousand years ago, followed by a reduction in species numbers due to extinctions since. This is of course completely contrary to the actual fossil record. But so what? If you can ignore one entire field of science, it isn't much more work to ignore them all.
That's an excellent point. You should lead with that one next time. :-)

Rolf · 22 February 2013

A Masked Panda (1686) said:
Compensatory mutations don’t restore the organism to the same level of fitness as they originally had. They are just stop gaps which help to mitigate the deleterious effect of the previous “beneficial” mutation. They almost certainly produce some other deleterious effect, although not one which is greater than the effect they compensate for. Backmutations, however, do restore the original function but also reverse any adaptive benefit.
How comee you never cite your sources and tell us where you have your information from? Am I supposed to believe whatever you say? Not good enough, I don't believe a word of what you say, it looks very suspiciously like creationist misconceptions, distortions and straight ignorance.

DS · 22 February 2013

Rolf said: A Masked Panda (1686) said:
Compensatory mutations don’t restore the organism to the same level of fitness as they originally had. They are just stop gaps which help to mitigate the deleterious effect of the previous “beneficial” mutation. They almost certainly produce some other deleterious effect, although not one which is greater than the effect they compensate for. Backmutations, however, do restore the original function but also reverse any adaptive benefit.
How comee you never cite your sources and tell us where you have your information from? Am I supposed to believe whatever you say? Not good enough, I don't believe a word of what you say, it looks very suspiciously like creationist misconceptions, distortions and straight ignorance.
That's because whenever he does cite his sources, they turn out to refute his preposterous contentions.

Rolf · 22 February 2013

I am afraid the thought that he might be wrong never enters his mind. We are offtopic, but for the noble purpose of educating a creationist.

Kevin B · 22 February 2013

DS said: Sure. And he doesn't want to start down the slippery slope to reality. That could lead to dancing.
You don't reality for dancing. You just need a pin and the right number of angels. Q: Is 1686 the "right number of angels"?

Kevin B · 22 February 2013

Drat. "You don't need reality...."

Malcolm · 22 February 2013

DS said:
Rolf said: A Masked Panda (1686) said:
Compensatory mutations don’t restore the organism to the same level of fitness as they originally had. They are just stop gaps which help to mitigate the deleterious effect of the previous “beneficial” mutation. They almost certainly produce some other deleterious effect, although not one which is greater than the effect they compensate for. Backmutations, however, do restore the original function but also reverse any adaptive benefit.
How comee you never cite your sources and tell us where you have your information from? Am I supposed to believe whatever you say? Not good enough, I don't believe a word of what you say, it looks very suspiciously like creationist misconceptions, distortions and straight ignorance.
That's because whenever he does cite his sources, they turn out to refute his preposterous contentions.
He is probably having difficulty working out the correct format with which to cite that end of his elimentary tract.

Frank J · 23 February 2013

Rolf said: I am afraid the thought that he might be wrong never enters his mind. We are offtopic, but for the noble purpose of educating a creationist.
As you know, the way the word "creationist" is defined on these boards, a "creationist" is either too hopelessly compartmentalized to be educated, or is educated already and knows he's lying. Unless the purpose is to inform fence-sitting lurkers, and correct their misconceptions, these boards are 100% a waste of time.

Rolf · 23 February 2013

Indeed.

Richard B. Hoppe · 23 February 2013

Frank J said: As you know, the way the word "creationist" is defined on these boards, a "creationist" is either too hopelessly compartmentalized to be educated, or is educated already and knows he's lying. Unless the purpose is to inform fence-sitting lurkers, and correct their misconceptions, these boards are 100% a waste of time.
That last is indeed the purpose. I hold no illusions that the creationists who post here can be persuaded that they're wrong; that's a very infrequent occurrence (it happened maybe a couple of times--once for sure--in my 10+ years on Internet Infidels Discussion Board). But we get several thousand readers a day here, and well thought out refutations of the nonsense propagated by our resident creationists is a service to those readers.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 23 February 2013

Rolf said: How come you never cite your sources and tell us where you have your information from? Am I supposed to believe whatever you say? Not good enough, I don't believe a word of what you say, it looks very suspiciously like creationist misconceptions, distortions and straight ignorance.
In this particular case, there is very little information about the full effects of so-called "compensatory" mutations. However, my belief is based on the fact that mutations can only ever degrade the highly specified and complex functionality found in genes. The notion that a compensatory mutation can be entirely beneficial is theoretically unsound. There is a cost associated with all mutations, although this is variable.
Proteins are finicky molecules; they are barely stable and are prone to aggregate, but they must function in a crowded environment that is full of degradative enzymes bent on their destruction. It is no surprise that many common diseases are due to missense mutations that affect protein stability and aggregation.
http://www.ncbi.nlm.nih.gov/pubmed/16074985 The idea of a mutation with no functional cost is plain nonsense. If you mess about with the sequence of finely-designed and carefully-crafted molecules, shit happens.

phhht · 23 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: If you mess about with the sequence of finely-designed and carefully-crafted molecules, shit happens.
But the molecules which make up our bodies ARE NOT finely-designed. They ARE NOT carefully-crafted. This fallacy is called "begging the question."

Frank J · 23 February 2013

Richard B. Hoppe said:
Frank J said: As you know, the way the word "creationist" is defined on these boards, a "creationist" is either too hopelessly compartmentalized to be educated, or is educated already and knows he's lying. Unless the purpose is to inform fence-sitting lurkers, and correct their misconceptions, these boards are 100% a waste of time.
That last is indeed the purpose. I hold no illusions that the creationists who post here can be persuaded that they're wrong; that's a very infrequent occurrence (it happened maybe a couple of times--once for sure--in my 10+ years on Internet Infidels Discussion Board). But we get several thousand readers a day here, and well thought out refutations of the nonsense propagated by our resident creationists is a service to those readers.
I hope so. The catch-22 is that lurkers are unlikely to post, especially if they realize how they have been misled. I tried to coax some on Talk.Origins a few years back, just to get an idea of the demographics. Unfortunately the few who "delurked" mostly had no problems with evolution before lurking, leading me to suspect that they were not representative of lurkers as a whole. The one exception was obviously an anti evolution activist (or troll) in-training. I have had much greater, albeit still modest, success in personal life, where I convinced a few people that the "weaknesses" they had been fed were nothing but misrepresentations. Even the few committed deniers admitted that the evidence was not there for their brand of creationism, thus baclpedaling into Omphalism.

W. H. Heydt · 23 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:However, my belief is based on the fact that mutations can only ever degrade the highly specified and complex functionality found in genes. The notion that a compensatory mutation can be entirely beneficial is theoretically unsound. There is a cost associated with all mutations, although this is variable.
The universe doesn't care what you "believe". Empirical data is the touch stone of reality. What you've been proposing is thinly disguised pseudo-Biblical "everything has gotten worse wince The Fall." Dressing it up in the language of science (without the actual scientific work to back it up) isn't going to fool anybody with two neurons connected to make a synapse.

DS · 23 February 2013

My belief is based on the fact that your belief is full of shit. I don't have a reference so you'll just have to take my word for it. And I can easily ignore all references to the contrary, even claiming that they actually support my beliefs if I think I that no one will notice they actually don't.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 23 February 2013

DS said: My belief is based on the fact that your belief is full of shit. I don't have a reference so you'll just have to take my word for it. And I can easily ignore all references to the contrary, even claiming that they actually support my beliefs if I think I that no one will notice they actually don't.
I supplied a very good reference discussing the biophysical reasons why mutations in genes/proteins disturb a finely-balanced stability. If you choose to ignore the evidence for this, that's your problem. Only a backmutation for a deleterious change can be truly beneficial. All other mutations involve some sort of cost.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 23 February 2013

Richard B. Hoppe said: I hold no illusions that the creationists who post here can be persuaded that they're wrong.
I do have confidence that some lurkers sitting on the fence can be persuaded that the current paradigm of evolution is just plain wrong in so many ways.

DS · 23 February 2013

Oh what the hell. HEre is a reference that proves Joe wrong, again.

http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2958.2002.03173.x/full

There is a hight frequency of compensatory mutations and many different types are known. They increase the fitness of the bacteria in certain environments. They are, by any reasonable definition, beneficial, at least to the bacteria. They are not all associated with overwhelming costs, in fact most of them increase in frequency due to selection.

Now of course these bacteria might have eaten the magic apple and fallen form bacterial grace, but they are still better off than they used to be and all due to random mutations. Imagine that!

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 23 February 2013

phhht said: But the molecules which make up our bodies ARE NOT finely-designed. They ARE NOT carefully-crafted. This fallacy is called "begging the question."
If they were not, you would be probably be dead by now...you might even spontaneously explode. Your body's catalytic chemistry has to be just right for you to live.

stevaroni · 23 February 2013

A brave, nameless, yahoo lurker yelps... I do have confidence that some lurkers sitting on the fence can be persuaded that the current paradigm of evolution is just plain wrong in so many ways.
Like Einstein said, all it takes is one good piece of evidence. Um... so... got any of that?

phhht · 23 February 2013

Absolutely unsupported assertion. You're begging the question again. And water has to be just the right shape to fit in a particular puddle.
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
phhht said: But the molecules which make up our bodies ARE NOT finely-designed. They ARE NOT carefully-crafted. This fallacy is called "begging the question."
If they were not, you would be probably be dead by now...you might even spontaneously explode. Your body's catalytic chemistry has to be just right for you to live.

Scott F · 23 February 2013

Frank J said:
Richard B. Hoppe said:
Frank J said: As you know, the way the word "creationist" is defined on these boards, a "creationist" is either too hopelessly compartmentalized to be educated, or is educated already and knows he's lying. Unless the purpose is to inform fence-sitting lurkers, and correct their misconceptions, these boards are 100% a waste of time.
That last is indeed the purpose. I hold no illusions that the creationists who post here can be persuaded that they're wrong; that's a very infrequent occurrence (it happened maybe a couple of times--once for sure--in my 10+ years on Internet Infidels Discussion Board). But we get several thousand readers a day here, and well thought out refutations of the nonsense propagated by our resident creationists is a service to those readers.
I hope so. The catch-22 is that lurkers are unlikely to post, especially if they realize how they have been misled. I tried to coax some on Talk.Origins a few years back, just to get an idea of the demographics. Unfortunately the few who "delurked" mostly had no problems with evolution before lurking, leading me to suspect that they were not representative of lurkers as a whole. The one exception was obviously an anti evolution activist (or troll) in-training. I have had much greater, albeit still modest, success in personal life, where I convinced a few people that the "weaknesses" they had been fed were nothing but misrepresentations. Even the few committed deniers admitted that the evidence was not there for their brand of creationism, thus baclpedaling into Omphalism.
The other use of these posts is to help those of us who don't have the experience in biology to be able to recognize the creationist clap trap when it comes up in real life, and so to be able to knowledgeably defend science when the issues arise. It's frustrating to be able to know they're wrong, but not know how to explain why they're wrong. Without some preparation, it's difficult to refute, "Well, this scientist said X about evolution." These boards help quite a lot with that. One can even see the give and take here, stroke by stroke. Since creationists tend to use the same arguments over and over, it helps to have the responses "scripted out" ahead of time. What's nice is that the science side has actual explanations. Once understood, there's no need to memorize the talking points, and you can delve into the questions as deeply as you want. It gets you thinking about the questions, leading to more questions. The problem with the creationist side is that it's all cut-and-paste. Memorize the apologetics, and you're done. Except, once the orthodoxy is questioned, they don't have anything beyond repeating the same talking points. "I already told you how to test for SC." The creationist apologetics are intended to stop the never ending stream of questions, not to answer them and to create more. Please don't feel your efforts are in vain.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 23 February 2013

DS said: Oh what the hell. HEre is a reference that... http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2958.2002.03173.x/full
From the paper you cited (but clearly did not read):
The biological cost conferred by chromosomal mutations causing antibiotic resistance can be reduced by additional mutations.
I accept that there are "compensatory" mutations that can antagonistically interfere in order to reduce the cost of an "adaptive" mutation, but where in the paper does it state that these compensatory mutations do not themselves incur some sort of cost?

phhht · 23 February 2013

I gotta say I love it. What next, an episode of The X-Files as evidence for spontaneous combustion?
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: If they were not, ... you might even spontaneously explode.

DS · 23 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
DS said: Oh what the hell. HEre is a reference that... http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2958.2002.03173.x/full
From the paper you cited (but clearly did not read):
The biological cost conferred by chromosomal mutations causing antibiotic resistance can be reduced by additional mutations.
I accept that there are "compensatory" mutations that can antagonistically interfere in order to reduce the cost of an "adaptive" mutation, but where in the paper does it state that these compensatory mutations do not themselves incur some sort of cost?
Doesn't have to. It show the mutations are beneficial. Deal with it.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 23 February 2013

stevaroni said: Like Einstein said, all it takes is one good piece of evidence. Um... so... got any of that?
There is no one silver bullet that can kill the monster of Darwinism.Its demise will be slow and gradual.

phhht · 23 February 2013

And magic bullets! This guy just gets better!
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: There is no one silver bullet that can kill the monster of Darwinism.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 23 February 2013

DS said: Doesn't have to. It show the mutations are beneficial. Deal with it.
BUT NOT WITHOUT A COST. Deal with that. All "beneficial" mutations turn out to be examples of antagonistic pleiotropy. They only improve fitness by messing up something else.

phhht · 23 February 2013

And you just can't mess around with finely-tuned molecules! You're liable to burst into flames!
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said: All "beneficial" mutations ... improve fitness by messing up something else.

DS · 23 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
DS said: Doesn't have to. It show the mutations are beneficial. Deal with it.
BUT NOT WITHOUT A COST. Deal with that. All "beneficial" mutations turn out to be examples of antagonistic pleiotropy. They only improve fitness by messing up something else.
It doesn't matter Joe. The bacteria had a beneficial mutation that increased their ability to survive in an environment with antibiotics. They then had another mutation that reduced the cost of that mutation in an environment without antibiotics. So now they are better in two ways because of two beneficial mutations. In order to try to claim that they are not in some way, you must demonstrate that ALL 77 of the mutations are less fit than the original bacteria in every environment. You can just assume whatever you want, but you have no evidence and quite frankly only a meaningless semantic argument. You are wrong. Admit ti and go away. No one is fooled by your nonsense.

Scott F · 23 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
phhht said: But the molecules which make up our bodies ARE NOT finely-designed. They ARE NOT carefully-crafted. This fallacy is called "begging the question."
If they were not, you would be probably be dead by now...you might even spontaneously explode. Your body's catalytic chemistry has to be just right for you to live.
Surprisingly, except for the first clause, your statement is mostly correct. Do you have any idea what the rates of mutations are between generations of humans? Do you have any idea what the rate of spontaneous abortions is? What the rates of sperm failures are? The point is that you are looking at and discoursing with the ones who survived their various mutations. Those "individuals" with the truly deleterious mutations didn't get past the blastocyst stage. Heck, they probably didn't even get past the separate sperm and egg stage. We, the ones with the beneficial or neutral mutations, are the ones who are left. We are the ones whom Evolution and Natural Selection have arbitrarily and haphazardly chosen to survive. That's the whole point. (Caveat: Naturally, this is a generalization, and there are exceptions on both sides of the "survival" sieve.) If there was ever any "careful crafting" or "fine design", it was all done through natural means by evolution. Did you ever look at a picture of a protein? "Finely-designed" my ass. I've seen pictures drawn by elephants that were more "carefully crafted" than a Ribosome.

apokryltaros · 23 February 2013

1686 said:
DS said: Oh what the hell. HEre is a reference that... http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2958.2002.03173.x/full
From the paper you cited (but clearly did not read):
The biological cost conferred by chromosomal mutations causing antibiotic resistance can be reduced by additional mutations.
I accept that there are "compensatory" mutations that can antagonistically interfere in order to reduce the cost of an "adaptive" mutation, but where in the paper does it state that these compensatory mutations do not themselves incur some sort of cost?
Antibiotic resistance is metabolically expensive: no one is denying that. Originally, before the manufacture and misuse of antibiotics by humans, antibiotic-resistant bacteria tended to occur only near natural sources of antibiotics, such as Penicillium sp molds, and Streptomyces aureofaciens bacteria, and these resistant bacteria would be unable to compete with their non-resistant relatives outside of such environments. Of course, now that humans have supersaturated almost all environments with antibiotics, more and more antibiotic-resistant bacteria are appearing. Now having said that, how does your request/demand for the identity of the cost of the compensatory mutations supposed to disprove evolution while simultaneously prove Intelligent Design? Especially since not a single Intelligent Design proponent has ever done any sort of research beyond armchair navel contemplation.

DS · 23 February 2013

Think of it this way Joe. It is well established that whales evolved from terrestrial ancestors. The mutations that transformed their forelimbs into flippers had a cost, whales can no longer walk on land. Now Joe, are you seriously trying to claim that those mutations are not beneficial to the whales? Really? Really? Give it up Joe, you're a loony and everybody knows it.

apokryltaros · 23 February 2013

1686 said:
stevaroni said: Like Einstein said, all it takes is one good piece of evidence. Um... so... got any of that?
There is no one silver bullet that can kill the monster of Darwinism.Its demise will be slow and gradual.
Making impossible demands over inconsequential quibbles will do absolutely nothing to harm Evolutionary Biology.
1686 quibbled vociferously:
DS said: Doesn't have to. It show the mutations are beneficial. Deal with it.
BUT NOT WITHOUT A COST. Deal with that. All "beneficial" mutations turn out to be examples of antagonistic pleiotropy. They only improve fitness by messing up something else.
And how is this supposed to magically disprove Evolution? If anything it demonstrates that the Intelligent Designer is supremely inefficient and incompetent to boot.

apokryltaros · 23 February 2013

DS said: Think of it this way Joe. It is well established that whales evolved from terrestrial ancestors. The mutations that transformed their forelimbs into flippers had a cost, whales can no longer walk on land. Now Joe, are you seriously trying to claim that those mutations are not beneficial to the whales? Really? Really? Give it up Joe, you're a loony and everybody knows it.
And that this somehow magically disproves Evolution. Yes, that's what he's saying. But, then again, when you're a raving, science/reality denying idiot, well...

Scott F · 23 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
DS said: Doesn't have to. It show the mutations are beneficial. Deal with it.
BUT NOT WITHOUT A COST. Deal with that. All "beneficial" mutations turn out to be examples of antagonistic pleiotropy. They only improve fitness by messing up something else.
It doesn't matter what the cost is. As long as the benefit outweighs the cost, it is a net benefit. It costs the cell energy to make any protein. But if the benefit of the protein brings more energy into the cell than it costs to make (overall), then the cell will continue to make that protein. Similarly, if the benefit of the protein saves the cell more energy than it costs to make the protein, then it will continue to make the protein. Or rather, in the evolutionary sense, cells which make the protein will be at a competitive advantage, while cells that do not make the protein will be at a competitive disadvantage. But what you've already admitted is that the "compensatory" mutation is, even by your definition, a "beneficial" mutation. The bacterium is better off with the "compensatory" mutation than it is without. You have admitted this. Even if the "compensatory" mutation doesn't bring the cell back to it's "ground state", it is still better off with the "compensatory" mutation than without it. Even by your definition, that is a "benefit". The problem is that you then move the goal posts. "Well, it's not beneficial enough. Therefore beneficial mutations don't exist." I believe that's an example of the "No True Scotsman" logical fallacy.

DS · 23 February 2013

What about the blow hole Joe. You know it would have a significant cost on the golf course. A dolphin could be in serious trouble if a golf ball got caught in there. So I guess there is a cost to the blow hole, right?. So, according to you, the position of the blowhole is not beneficial in dolphins, right?

Why don't you shut your own blow hole Joe? The cost is way too high.

stevaroni · 23 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
stevaroni said: Like Einstein said, all it takes is one good piece of evidence. Um... so... got any of that?
There is no one silver bullet that can kill the monster of Darwinism.Its demise will be slow and gradual.
So then... no. No evidence. Thought so. Just checking.

apokryltaros · 23 February 2013

stevaroni said:
1686 said:
stevaroni said: Like Einstein said, all it takes is one good piece of evidence. Um... so... got any of that?
There is no one silver bullet that can kill the monster of Darwinism.Its demise will be slow and gradual.
So then... no. No evidence. Thought so. Just checking.
What did you expect from a group of science-hating science-deniers who whine that they're actually not obligated to do science/explain anything with Intelligent Design? Magic bullets? Sorcerery spitballs?

stevaroni · 23 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
stevaroni said: Like Einstein said, all it takes is one good piece of evidence. Um... so... got any of that?
There is no one silver bullet that can kill the monster of Darwinism.Its demise will be slow and gradual.
Now, here's the non-smart answer. The thing is, 51686, that there are things like magic bullets that would kill evolution as a theory. A rabbit fossil from the Precambrian. The discovery that there was a unique rip-up-and-rewrite in human DNA. A truly de-novo feature for which there is no incremental precursor. There are lots of things science can think up that would send conventional darwinian evolution to the dustbin of history to take its place alongside the aether, phlogiston, and Piltdown man. Problem is, that in 150 years of testing, often by rabidly biased investigators that want to discredit evolution at all cost, nobody has ever found that scrap of evidence. Creationists are left with inventing math that nobody else can duplicate (Dembski) or claiming with a straight face that certain structures don't have antecedents when simple research clearly shows they do (Behe). This is simple barnyard biology. If it doesn't work as described "magic bullets" to demonstrate so should be everywhere. Magic bullets should be downright mundane. It should be no harder to disprove Darwinian evolution that is is to disprove geocentrism. And yet... you can't. You side has been trying for fifteen decades. Since steam locomotives and telegraphs were cutting-edge technology. And after a century and a half... you got nuthin. Speaks volumes right there.

DS · 23 February 2013

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
DS said: Doesn't have to. It show the mutations are beneficial. Deal with it.
BUT NOT WITHOUT A COST. Deal with that. All "beneficial" mutations turn out to be examples of antagonistic pleiotropy. They only improve fitness by messing up something else.
Wrong again Joe. Remember this reference: Lenski, et.al. (2005) Pleiotrophic effects of beneficial mutations in E. coli. Evolution 59(11)2343-52. From the abstract: Our results show that the majority of mutations had significant fitness effects in alternative resources, such that pleiotropy was common. The predominant form of this pleiotropy was positive--that is, most mutations that conferred increased fitness in glucose also conferred increased fitness in novel resources. We did detect some deleterious pleiotropic effects, but they were primarily limited to one of the five resources, and within this resource, to only a subset of mutants. So some mutations can have beneficial effects in almost every environment. What you have to do is provide evidence that everyone of them has some negative effect in some environment. And even if you can do that, so what? The mutations are still beneficial, probably even beneficial in most environments, if not all. The fact that some of them might have some cost in some environment that is never encountered is irrelevant.

Dave Luckett · 23 February 2013

There is no one silver bullet that can kill the monster of Darwinism.Its demise will be slow and gradual.
I thought this was Ray Martinez, but that pronouncement sounds like Joe, all right. It has the ring of his grandiloquent florid lunacy, the delusions of grandeur that he trails around like the smell of a well-used sneaker. Ray's more into blank flat prosaic denial of reality, without the flourishes. Isn't it fun, playing "spot the troll"? Is it loony one, loony two, or loony three?

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 23 February 2013

apokryltaros said: What did you expect from a group of science-hating science-deniers who whine that they're actually not obligated to do science/explain anything with Intelligent Design? Magic bullets? Sorcerery spitballs?
I think Darwinism will collapse due to its own internal contradictions and failures, rather like how Communism collapsed. When the end/liberation does come, I expect it to happen quite quickly. Thereafter, a new paradigm and scientific regime will take hold.

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 23 February 2013

DS said: What about the blow hole Joe. You know it would have a significant cost on the golf course. A dolphin could be in serious trouble if a golf ball got caught in there. So I guess there is a cost to the blow hole, right?. So, according to you, the position of the blowhole is not beneficial in dolphins, right? Why don't you shut your own blow hole Joe? The cost is way too high.
You really ought to read more science, DS, and watch less Seinfeld. You are no marine biologist.

phhht · 23 February 2013

Why don't you hold your breath?
https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 said:
apokryltaros said: What did you expect from a group of science-hating science-deniers who whine that they're actually not obligated to do science/explain anything with Intelligent Design? Magic bullets? Sorcerery spitballs?
I think Darwinism will collapse due to its own internal contradictions and failures, rather like how Communism collapsed. When the end/liberation does come, I expect it to happen quite quickly. Thereafter, a new paradigm and scientific regime will take hold.

DS · 23 February 2013

So that would be a no. Joe has no answer for the reference I provided. Funny, since he provided none of his own. You lose again Joe. You should stick to watching the Flintstones. Your are no biologist of any kind.

apokryltaros · 23 February 2013

Banned Troll bullshitted:
apokryltaros said: What did you expect from a group of science-hating science-deniers who whine that they're actually not obligated to do science/explain anything with Intelligent Design? Magic bullets? Sorcerery spitballs?
I think Darwinism will collapse due to its own internal contradictions and failures, rather like how Communism collapsed. When the end/liberation does come, I expect it to happen quite quickly. Thereafter, a new paradigm and scientific regime will take hold.
Can the Administrators re-ban Atheistoclast?

Rolf · 24 February 2013

This thread is a good example of Schiller’s famous observation "Against stupidity the gods themselves contend in vain.". Googling around I also found an old favourite, the great Isaac Asimov and a novel I would like to read. Think I deserve a relief from the stoopid.

rob · 24 February 2013

His name is not Steve. The insanity of Joe Bozorgmehr:

Joe says: “Btw, just killing is part of my religion. Did not the prophet Elijah slaughter 450 priests of the false god, Ba’al (1 Kings 18:40)?”

Joe says: ”…wiping out a conference of evolutionary biologists but reasoned that it would not produce the intended result.”

Joe says: “I will admit that it did occur to my mind that conferences were ideal places to wipe out all of the current dinosaurs within the scientific establishment in one fell swoop”.

Joe fails on the age of the Earth: “By my calculations, there is a disparity between the age of the planet and the material it is made from. …But if you had to press me, I would say the planet is between 0.8bn to 1.5 bn years old. … It is based on iridum dating for isotopes 191Ir and 193Ir. I have also studied lava flows and rock formations. The figure of 4.6bn years is much too high. … The math is beyond the ken of everyone here. I can’t reduce it to baby steps. There is some serious calculus involved with double integrals and the like. … Like I say. It is complicated. I would need 4 pages of pure math just to explain it to you. It also involves some very taxing stochastic differentiation.”

Foolish Joe: Where is the math? Where is the evidence?

Joe says: “… The fusion of chromosome 2a and 2b, again, does not indicate common ancestry. It could so easily refer to the fact that Adam had 48 chromosomes but Noah and his descendants had 46 thanks to a translocation…”

Joe says: “Morphogenetic fields are non-energetic organizing principles that impose order on otherwise indeterminate structures.”

Joe says: “… I am not here to be liked - I am here to shatter the idols of ignorance and to pave the way for a new era in science and philosophy. Like it or not, I represent the future of humanity whereas you represent only the fossilized remains you examine.”

Joe says: “I’m gloating, all right. I just can’t wait to see the full data when it is made available. I am giggling like a little girl.”

Joe jokes: “I am not just some guy who rattles his keyboard on talk forums. I am a bigtime player and I’m playing to win.”

Joe says: “So what if I have a healthy sense of self-confidence? I know I’m right, but it is hard to convince everyone here to think the way I do.”

Years ago Joe says: “… Bozorgmehrism is going to take just a few years to become mainstream. You’ll see.”

Merriam-Webster’s definition of megalomania: a delusional mental disorder that is marked by feelings of personal omnipotence and grandeur.

prongs · 24 February 2013

Outstanding summary rob.

DS · 24 February 2013

Until Joe can once again be banned, any responses by me to him will be on the bathroom wall. If the administrators cannot or will not ban him permanently and make it stick. they might as well close down the site. No more discussion of science will ever occur here.

stevaroni · 24 February 2013

1686 said: For example, natural selection has acted fairly stringently to preserve the sequence of the ubiquitin protein among all eukaryotes: the protein in yeast is 96% identical with that of humans. -snip- What Natural selection does not do is explain the diversity of the protein repertoire and, more importantly, the diversity of form and patterns of behavior among organisms.
HuH? Evolution fails because a) there is too much commonality to explain and b) there is too much diversity to explain. Do you actually read what you write, 1686?

stevaroni · 24 February 2013

DS said: No more discussion of science will ever occur here.
Does any discussion of science ever occur with the creaobots?

https://me.yahoo.com/a/HVJnIBo.k9XNMUFdkYB_RBnH84qDk9rLK_k-#51686 · 24 February 2013

stevaroni said: HuH? Evolution fails because a) there is too much commonality to explain and b) there is too much diversity to explain. Do you actually read what you write, 1686?
It is very simple. Natural selection has acted against change in the vast majority of protein sequences. It is an anti-evolutionary force. It keeps things, like ubiquitin, as they are. Unfortunately, the Neo-Darwinists don't view natural selection as the conserving force in biology that it really is, but instead as a creative agency that (although blind and dumb) can somehow circumvent the need for an intelligent designer.

apokryltaros · 24 February 2013

And yet, you make this pronouncement without ever having done any research, Atheistoclast. Too busy writing up your list of people to murder publicly execute when you take power at the universities?

gnome de net · 24 February 2013

1686 said: Natural selection has acted against change in the vast majority of protein sequences. It is an anti-evolutionary force. It keeps things, like ubiquitin, as they are.
Natural selection does not prevent change; it permits change when change is necessary. As long as a protein sequence like ubiquitin is beneficial to the organism/species, there is no need for change. You know — if it ain't broke, don't fix it.

stevaroni · 24 February 2013

1686 said: It is very simple. Natural selection has acted against change in the vast majority of protein sequences.
True. It is very difficult for evolution to produce a beneficial mutation. The vast majority of mutations are neutral (because the largest fraction of DNA is broken junk) but of the vast majority of the remainder are harmful. DNA is a fragile system. It's now estimated that half of all fertilized human eggs fail to develop because, essentially, of an "unbootable program". But the key word is "vast majority". That means that some beneficial mutations do happen. Given the enormous number of times mother nature rolls the dice, even tiny probabilities add up. Michael Behe was famous for asserting that certain mutations were too infrequent to ever happen. Then was forced to run the actual numbers during the Dover trial an - surprise - when you do the math it turns out that his "impossible" mutations were statistically happening every 50 minutes or so with just the cells present inside the courtroom. Lenski's long term e-coli experiment is similar. He took 20,000 generations to evolve citrate-eating bacteria. Each generation involved hundreds of millions of organisms. That was because evolution is inefficient. It is sloppy. Most mutations are neutral of harmful. But evolution has numbers on it's side. It rolls the dice trillions of times a second. More importantly, it has feedback. Nature viciously selects against harmful mutations and generously rewards useful ones. While humans tend to think of 20,000 generations as a "long time", it's a blink of the eye to mother nature (and nature evolved the eye in various incarnations about 16 separate times). It is an anti-evolutionary force. It keeps things, like ubiquitin, as they are. Unfortunately, the Neo-Darwinists don't view natural selection as the conserving force in biology that it really is, but instead as a creative agency that (although blind and dumb) can somehow circumvent the need for an intelligent designer.

stevaroni · 25 February 2013

Um... sorry... This got trapped on the bottom of my last comment, because I was sloppy with my cutting and pasting
stevaroni said: It is an anti-evolutionary force. It keeps things, like ubiquitin, as they are. Unfortunately, the Neo-Darwinists don't view natural selection as the conserving force in biology that it really is, but instead as a creative agency that (although blind and dumb) can somehow circumvent the need for an intelligent designer.
That's actually a quote from 1686. I, on the other hand, have no problem at all with blind, dumb agents circumventing the need for an intelligent designer. In fact, I'll put money on it.

Henry J · 25 February 2013

This got trapped on the bottom of my last comment, because I was sloppy with my cutting and pasting

The Designer did it!!111!!!one!!!!

Rolf · 26 February 2013

It is an anti-evolutionary force. It keeps things, like ubiquitin, as they are. Unfortunately, the Neo-Darwinists don’t view natural selection as the conserving force in biology that it really is, but instead as a creative agency that (although blind and dumb) can somehow circumvent the need for an intelligent designer.
I know it is useless to say anything, but when you weed out the less fortunate from a population - and you are of course aware there is fierce competition in nature, Q: who remains alive and kicking (in lieu of the more folksy f'word) to enjoy propagating the species? A: The more competitive. Or are you telling us that they all share the same genes 100%? That the entire process, from mating behaviors to all that follows, are of no comsewuence, that by doing away with the way life is played in real life is of noe consequences whatosever? So why do they do it, why waste so much energy and resources on a bird's tail, a moose's horns, deer antlers, all the fantasic features, appendages, intricate bird dances and so on and on? Wherever I look at nature, I find evidence of natural evolution. Although in some places, only creationistic narrowmindedness, if not even worse.

Rolf · 26 February 2013

For the record: I missed the review button for proofreading.

Pierce R. Butler · 26 February 2013

I find it both ironic and irritating that a troll using the name "... panda ..." has derailed this thread from more important issues and personages obviously germane to the topic at hand.

To wit: why has it been so long since we've seen posts by and/or reports on the activities, researches, and adventures of Prof. Steve Steve?

eric · 27 February 2013

Pierce R. Butler said: I find it both ironic and irritating that a troll using the name "... panda ..." has derailed this thread
By all means be annoyed by the derailing, but anyone posting as a guest (vs. a login account) is called "a masked panda" followed by a string. So don't be annoyed about that. :)