Junk in the Trunk
Sadly I don't have time for a full blog, but PT readers should read a caustic paper by Dan Graur et al. (Graur of chicken entrails fame), which is doing the most thorough take-down to date of the ENCODE project's widely-advertised claim last year that 80% of the human genome is functional and that the junk DNA concept has been debunked. It's open access, and the media is starting to pick it up: http://gbe.oxfordjournals.org/content/early/2013/02/20/gbe.evt028.full.pdf+html
The major weakness is that Graur et al. do not discuss the huge variability in eukaryote genome size much, although they do cite Ryan Gregory's Onion Test. And the tone is such that tone itself is becoming an issue. On the other hand, many of us feel that ENCODE steamrolled basic, well-known scientific facts when it shot the "80% functional" claim around the world's media. Certainly there's a lot to discuss!
305 Comments
Flint · 23 February 2013
More discussion here:
http://talkrational.org/showthread.php?t=55051
harold · 24 February 2013
The entire "controversy" is grounded in the use of imprecise language, particularly imprecise use of the term "functional". I am on the side of those who think the ENCODE press releases greatly misused the term "functional", but until people actually agree to use the term to mean the same thing, all dialogue is just people insulting each other for using the same word in different ways.
I think just using the term "active" instead of "functional" might have helped a great deal.
"Functional" and "junk" are both subjective terms which need to be carefully defined if conflicts about their use are to be resolved. There also needs to be some effort to be honest and consistent, though, because there will always be gray areas. If "functional" means "does something for the cell which facilitates cell survival and/or reproduction", then mutations with negative impact, recessive alleles, and even alleles that code for proteins that work but perform a totally redundant function might not make the grade as "functional". On the other hand, if we define "functional" as "potentially does something that impacts on cell survival and/or reproduction", all sorts of "junk" like transposable elements meets the definition of "functional".
Complicating it all is that it is extremely important to understand what such potentially active junk might do, whether we call what it does "functional" or not. Nothing could be more absurd than - not to imply anyone would do this - inhibiting or disparaging study of the role of genome elements validly considered junk, in things like causing neoplasms or infection, susceptibility, by affecting protein or RNA expression, or chromosome stability, through recombination, transposition, etc, out of fear that creationists might claim that such study means that something is "functional".
I will illustrate what I am talking about with the example of TURF13.
As readers here may recall, the TURF13 story goes approximately like this (feedback welcome if corrections or elaborations are relevant). Some loci in the genome of a strain of maize recombined to come together in one or more events. Prior to the recombination these loci represented functionless junk by reasonable standards. Now they are a single locus which codes for an expressed protein. But here's the real catch - so far, all the new protein has been shown to do is to make the maize strains that carry it susceptible to a particular fungal infection. It may have some sort of beneficial activity as well, but that hasn't been detected, to the best of my knowledge.
Is the TURF13 gene functional? It codes for a protein. Were the loci that recombined to create it functional? Almost certainly not, but they were "active".
Frank J · 24 February 2013
https://me.yahoo.com/a/JxVN0eQFqtmgoY7wC1cZM44ET_iAanxHQmLgYgX_Zhn8#57cad · 24 February 2013
DS · 24 February 2013
Nick,
Bozo Joe is once again infesting these threads using a different name. As you know, he was permanently banned for threatening violence against anyone who disagreed with his insane ideas. Pleas dump all of his posts to the bathroom wall immediately until he can once again be banned. If you don't do this, this thread will become filled with the most vile and insane nonsense imaginable. Joe is psychotic and completely irrational, he simply cannot handle the truth. Do him a favor and put him out of our misery.
Nick Matzke · 24 February 2013
Nick Matzke · 24 February 2013
For added fun & excitement, see the twitter discussion: https://twitter.com/DanGraur
Nick Matzke · 24 February 2013
DS · 24 February 2013
Anything by a Masked Panda (1686), such as the one directly prior to my post. Joe has been using that name for a few days now. And he will undoubtedly change names once again when he is banned. He is absolutely obsessed over the idea of junk DNA. He is not emotionally capable of letting the discussion continue without trying to interrupt it.
DS · 24 February 2013
harold · 24 February 2013
DS · 24 February 2013
Well the definition of "functional" cannot be that it could one day take on some function. We know that any random sequence can mutate into something "functional". All DNA represents the raw material on which natural selection can act. But then again, creationists can't use this definition, not without admitting that random mutaion and natural selection can produce new information, new genes, new functions and new structures. And that was the reason for all this bluff and bluster about "junk DNA" in the first place. So for once it's heads evolution wins and tails creationism fails.
https://me.yahoo.com/a/UIFqpY46nexUlCvhZ8zfKDh3zX4VO81SHItDeWm6L4agSA6W#dd2ba · 24 February 2013
Wolfhound · 24 February 2013
Nick, see the above post for Bozo Joe.
DS · 24 February 2013
I called it. This guy is as predictable as the next number in the Fibonacci series.
John Harshman · 24 February 2013
I think you guys should all read Graur et al., which as Nick mentions is open-access. Everything anyone has said so far was addressed in that paper, and pretty well, I think.
Nick Matzke · 24 February 2013
Looks like I don't have sufficient admin status for doing bannings, so try to ignore him, I'll BW as able.
DS · 24 February 2013
phhht · 24 February 2013
Hear, hear.
DS · 24 February 2013
DS · 24 February 2013
From page 31:
"Third, numerous researchers use teleological reasoning according to which the function of a stretch of DNA lies in its future potential. Such researchers (e.g., Makalowski 2003; Wen et al. 2012) use the term “junk DNA” to denote a piece of DNA that can never, under any evolutionary circumstance, be useful. Since any piece of DNA may become functional, many are eager to get rid of the term “junk DNA” altogether. This type of reasoning is false. Of course, pieces of junk DNA may be coopted into function, but that does not mean that they presently are functional."
Man these guys are smart.
DS · 24 February 2013
From page 32:
"It has been pointed to us that junk DNA, garbage DNA, and functional DNA may not add up to 100% because some parts of the genome may be functional but not under constraint with respect to nucleotide composition. We tentatively call such genomic segments “indifferent DNA.” Indifferent DNA refers to DNA sites that are functional, but show no evidence of selection against point mutations. Deletion of these sites, however, is deleterious, and is subject to purifying selection. Examples of indifferent DNA are spacers and flanking elements whose presence is required but whose sequence is not important. Another such case is the third position of four-fold redundant codons, which needs to be present to avoid a downstream frameshift."
Now where have I heard that before?
harold · 24 February 2013
DS · 24 February 2013
Or perhaps they just wanted their results to be controversial and generate some publicity. Unfortunately, it seems to have backfired.
In any event, the rebuttal paper seems to agree with me. So I conclude that they got it right. :)
harold · 24 February 2013
Flint · 24 February 2013
I enjoyed the suggested parallels between the genome and "bloatware", which generally refers to humongous software projects written by many different people over an extended period of time, all of which is ideosyncratically documented (if at all). During this period, features are dropped or de-emphasized, debugged, patched, worked around, extended, and otherwise mangled.
Graur's programming contacts divided such computer code into categories - functional and useful, dead, and useless. The functional useful part is obvious. But dead (that is, unreachable via any path) code nonetheless sometimes ends up performing the equivalent of spacing or alignment utility (masking bugs elsewhere).
Useless code, now, is fascinating and seems very like much of what ENCODE identified. Useless code is reached during execution, and performs functions - it can produce values, modify data structures or files, etc. What makes it useless is that nothing elsewhere in the system uses or even notices these functions. It can also be essential for spacing and alignment (like dead code), for consuming bus cycles that can mask potential race conditions, for introducing delays that let IO operations complete, and so on (and on and on. BTDT.)
I think it would be a mistake to dismiss useless code as non-functional. Perhaps like a pseudogene, it might someday do something useful again. For now, it's just noise but it DOES execute, it DOES perform functions, it's expensive to try to identify it and weed it out, so over time it just keeps growing.
DS · 24 February 2013
Actually, as the paper points out, only about ten percent of pseudogenes are transcribed. So most are not "executed" at all and none perform any "function". Not a very good design really.
https://www.google.com/accounts/o8/id?id=AItOawm-WhebH0itIDDTj06EQo2vtiF0BBqF10Q · 24 February 2013
IMHO some of you guys are too lenient towards the ENCODE guys especially towards Ewan Birney. I don't know if re-defining "funcrional" was just a cheap trick or if he really wasn't aware of 40 years of population genetics, molecular and evolutionary biology. I tend to think the later is true because he seemingly didn't grasp the C-value paradox.
https://www.google.com/accounts/o8/id?id=AItOawm-WhebH0itIDDTj06EQo2vtiF0BBqF10Q · 24 February 2013
Mike Elzinga · 24 February 2013
Watching the Discovery Institute and UD cluster with glee around the ENCODE project's claims is like watching flies cluster. You know something is rotten already.
Gary_Hurd · 25 February 2013
Thanks Nick. That was a great read.
https://me.yahoo.com/a/UIFqpY46nexUlCvhZ8zfKDh3zX4VO81SHItDeWm6L4agSA6W#dd2ba · 25 February 2013
harold · 25 February 2013
DS · 25 February 2013
You can change names all you want Joe, we still know it's you. Looks like my claims have more support than your mamas bra.
And just for your information, introns make up nearly fifty percent of the human genome and mobile genetic elements such as SINES and LINES make up about 45 percent. There are over a million and a half SINES alone. Not really a very efficient design. So, the majority of the human genome serves no function whatsoever. You lose again.
Nick,
You are going to have to closely examine every post made by A Masked Panda, since Joe seems to be switching names more often than a convict on the run. I sure hop it costs him money every time he does it. But don't ban others using Yahoo accounts such as Glen Davidson. Like a breast without nipples, that would be pointless.
https://me.yahoo.com/a/UIFqpY46nexUlCvhZ8zfKDh3zX4VO81SHItDeWm6L4agSA6W#dd2ba · 25 February 2013
DS · 25 February 2013
DS · 25 February 2013
Oh and thanks for confirming that some mobile genetic elements can change due to random mutation and natural selection to take on some regulatory function. That was the conclusion of the reference you cited. You didn't cite a reference that disproved the claim you were trying to make again did you Joe?
https://me.yahoo.com/a/UIFqpY46nexUlCvhZ8zfKDh3zX4VO81SHItDeWm6L4agSA6W#dd2ba · 25 February 2013
DS · 25 February 2013
Well let's see what the paper in question has to say about these elements:
"Hence, regardless of their transcriptional or translational status, pseudogenes are nonfunctional!"
"Thus, in the vast majority of cases, introns evolve neutrally, while a small fraction of introns are under selective constraint (Ponjavic et al. 2007). Of course, we recognize that some human introns harbor regulatory sequences (Tishkoff et al. 2006), as well as sequences that produce small RNA molecules (Hirose 2003; Zhou et al. 2004). We note, however, that even those few introns under selection are not constrained over their entire length."
"Whether transcribed or not, the vast majority of transposons in the human genome are merely parasites, parasites of parasites, and dead parasites, whose main “function” would appear to be causing frameshifts in reading frames, disabling RNA-specifying sequences, and simply littering the genome."
So there you have it, some small proportion of junk DNA may evolve through random mutation and natural selection to take on some "function". But those are the exceptions that prove the rule. The human genome is filled with inactive genes, mobile elements that jump and mobile elements that don't, introns that may or may not do anything at all, usually they don't serve any function either. It's mostly junk. It's not designed, it's not efficient and you can't claim otherwise without admitting that evolution can and does produce new genes and new functions from random mutation and natural selection.
You can't have it both ways Joe. In fact, you can't have it either way. Now if you disagree with the published article, you know what you can do about it. But of course, that usually doesn't work out for you either now does it Joe?
harold · 25 February 2013
https://me.yahoo.com/a/UIFqpY46nexUlCvhZ8zfKDh3zX4VO81SHItDeWm6L4agSA6W#dd2ba · 25 February 2013
DS · 25 February 2013
Well at least he didn't deny having claimed there were no beneficial mutations. Joe is at least consistently wrong. By the way, in case no one noticed, he just admitted to using different names. That alone is grounds for banishment.
gnome de net · 25 February 2013
Is A Masked Panda (d2ba) the same as A Masked Panda (1686)?
DS · 25 February 2013
Do you see anyone else around her claiming that there are no beneficial mutations?
glipsnort · 25 February 2013
May I ask which Joe this is?
harold · 25 February 2013
DS · 25 February 2013
I believe his is the Joe that was permanently banned for threatening to bring a machine gun to a scientific conference and "reeducate" anyone who disagreed with him. Now he is reduced to claiming that a rearrangement or a transposition event is not a "mutation" and that evolution of a novel mechanism of regulation of gene expression can never be "beneficial". I think everyone can see he is still full of the same crap, no matter what name he tries to use.
And yes, Joe ran away from several hundred questions last time as well.
Ron Okimoto · 26 February 2013
Joe Felsenstein · 26 February 2013
DS · 26 February 2013
harold · 26 February 2013
diogeneslamp0 · 26 February 2013
diogeneslamp0 · 26 February 2013
harold · 26 February 2013
DS · 26 February 2013
matthew.s.ackerman · 26 February 2013
harold · 26 February 2013
rog.shrubber · 26 February 2013
There a foundational problem here and that's the misconception about function. One has to expect that DNA binding proteins will bind in useless ways, that RNA transcriptase will transcribe useless bits of DNA, and this will also occur in tissue specific ways. It's expected. It is not functional by any remotely sensible notion of "function". Energetically, RNA transcription accounts for very little of an Eukaryotic cell's energy budget. Even 10% non-functional transciption would be too little a cost to provide for a noticeable selective disadvantage. This is not arcane knowledge. I learned it as an undergraduate many decades ago. The authors of ENCODE publications seem unaware of this basic biological knowledge. They promote an absurd misconception: that everything that happens in a cell happens for a functional reason. They deserve ridicule for promoting that misconception.
harold · 26 February 2013
Flint · 26 February 2013
rog.shrubber · 26 February 2013
EvoDevo · 27 February 2013
Ron Okimoto · 27 February 2013
DS · 27 February 2013
diogeneslamp0 · 27 February 2013
Ron Okimoto · 28 February 2013
DS · 28 February 2013
This is of course the whole point. If the genome were intelligently designed, one would expect that it would function efficiently with a minimum of waste. If on the other hand it were the product of billions of years of random processes such as mutations, duplications, transpositions and other events that were then subjected to selection, one would expect to see an inefficient mess composed mostly of junk, some of which could sometimes become functional due to random mutation and natural selection. This is in fact exactly what is observed.
So the discoveries of modern genetics correspond precisely to what one would expect if evolution is true and are inconsistent with the hypothesis of intelligent design. That's why the IDiots are so eager to jump on any suggestion to the contrary.
Steve P. · 1 March 2013
DS · 1 March 2013
So that would be a no Stevie PP. YOu have no explanation whatsoever for the decrepitude of the human genome. That's what I thought.
Rolf · 1 March 2013
TomS · 1 March 2013
DS · 1 March 2013
We've been through this before with Stevie. In his analogy, a brand new car has extra plastic embedded right in the middle of every plastic part, plastic that must all be removed in order for the car to function properly. The new car has over two million broken radios in it, almost none of which will ever be able to do anything at all other than slow down the car. Because of all of this the car gets extremely poor gas mileage and no one wants to buy it. But hey, it's not a poor design. No it's what happens when a car if left alone too long! Got it.
Mike Elzinga · 1 March 2013
As usual, Steve P. recites a variant of the hackneyed argument originated by Henry Morris back in the 1970s; namely, evolution violates the second law of thermodynamics.
John Sanford’s “genetic entropy,” Dembski’s calculations of the probabilities of molecular assemblies, Behe’s “irreducible complexity,” and every ID/creationist misconception about complex organic molecules all have their roots in Henry Morris’s teachings.
ID/creationism can’t even explain the existence of solids and liquids, let alone complex molecules.
All ID/creationist camp followers stopped learning science back in middle school. They no longer have a clue about what they don’t know.
phhht · 1 March 2013
SWT · 1 March 2013
Hey Steve P. --
Based on your posts, you probably share my interest in complexity and the limits of self-organization. I sure hope you're joining in the fun in the free MOOC "Introduction to Complexity" offered by the Santa Fe Institute. Some good stuff there so far, so far with no scary calculations of entropy.
Steve P. · 1 March 2013
Steve P. · 1 March 2013
Steve P. · 1 March 2013
PA Poland · 1 March 2013
Steve P. · 1 March 2013
Keelyn · 1 March 2013
phhht · 1 March 2013
SWT · 1 March 2013
DS · 1 March 2013
apokryltaros · 1 March 2013
apokryltaros · 1 March 2013
Just Bob · 1 March 2013
Look Stevie, you go on about the "Second Law" and then insist that something "violates" it. Here's news: in science, a law is something that's ALWAYS true. It cannot be broken. That's why it's called a "law", and not just "the usual thing" or "the average".
So, do you think the Second Law of Thermodynamics actually is a law of the physical universe? Or do you think something can "violate" it? If so, then it's not really a law, and you need to quit calling it that.
So is the Second Law truly a law or not?
phhht · 1 March 2013
Steve P. · 2 March 2013
Steve P. · 2 March 2013
Steve P. · 2 March 2013
Dave Luckett · 2 March 2013
Oh, dear me. A violation of the Second Law of Thermodynamics.
What's next, perpetual motion? I imagine that would come in very useful in the fabrics manufacturing business.
Malcolm · 2 March 2013
So basically what SteveP is trying to tell us is that his understanding of the second law thermodynamics is no better than FL's understanding of "objective evidence".
DS · 2 March 2013
Time to move another troll to the bathroom wall. These guys are just playing their own version of dumb and dumber. What a waste of protoplasm.
SWT · 2 March 2013
apokryltaros · 2 March 2013
apokryltaros · 2 March 2013
DS · 2 March 2013
phhht · 2 March 2013
phhht · 2 March 2013
https://me.yahoo.com/a/FGBzQUZtsemthPseqYzKYHG1950GVQdQElnix0p2OwOZDtFTmQ--#98415 · 2 March 2013
https://me.yahoo.com/a/FGBzQUZtsemthPseqYzKYHG1950GVQdQElnix0p2OwOZDtFTmQ--#98415 · 2 March 2013
phhht · 2 March 2013
DS · 2 March 2013
Henry J · 2 March 2013
Does life violate the 2nd law of thermodynamics? If it did, that rule wouldn't have been called a "law" in the first place. We know that cells grow or divide to make more cells, so obviously this process doesn't violate any laws of nature.
How to distinguish designed object from non-designed object?
(1) Compare the object to similar objects that are known to have been constructed (engineered) by people (or maybe animals other than people); see if it matches.
(2) Compare the object to similar objects that are known to be producible by known natural processes; see if it matches.
On failure of both (1) and (2), further research is required to reach a reliable conclusion. (Of course, biology in general falls into (2), since natural mechanisms for it are known.)
On success of both (1) and (2), further research is again required, since in this case it might be natural or somebody might have done it on purpose. (I reckon people in forensics deal with this case a lot. )
Keep in mind that failure of either (1) or (2) can result from lack of knowledge of ways either nature or people might do things. (Remember how neutron stars were discovered? )
Does that about sum up the general principles?
Henry
PA Poland · 2 March 2013
https://me.yahoo.com/a/FGBzQUZtsemthPseqYzKYHG1950GVQdQElnix0p2OwOZDtFTmQ--#98415 · 2 March 2013
https://me.yahoo.com/a/FGBzQUZtsemthPseqYzKYHG1950GVQdQElnix0p2OwOZDtFTmQ--#98415 · 2 March 2013
DS · 2 March 2013
https://me.yahoo.com/a/FGBzQUZtsemthPseqYzKYHG1950GVQdQElnix0p2OwOZDtFTmQ--#98415 · 2 March 2013
phhht · 2 March 2013
https://me.yahoo.com/a/FGBzQUZtsemthPseqYzKYHG1950GVQdQElnix0p2OwOZDtFTmQ--#98415 · 2 March 2013
https://me.yahoo.com/a/FGBzQUZtsemthPseqYzKYHG1950GVQdQElnix0p2OwOZDtFTmQ--#98415 · 2 March 2013
phhht · 2 March 2013
phhht · 2 March 2013
prongs · 2 March 2013
How do I separate the designed from the non-designed?
I have two quartz crystals. One is natural, the other grown in a laboratory. The laboratory crystal looks nothing like a natural one. The laboratory crystal has certain key features, manifestly obvious, that identify it.
Just Bob has natural diamond crystals, and man-made diamond crystals. Can he tell the difference? I dare say he can. Can a man-made diamond be made that looks just like a natural crystal? Perhaps. In that case I suppose you could conclude all diamonds are man-made, but you would be wrong.
I found a pocket watch on the heath. I declare it is designed because I am familiar with human technology, and I am a keen student of natural history. Pocket watches are not found in nature, at least not so far. Knowing the answer beforehand I declare the watch designed. (Bully for me.)
Every example of design I am aware of is human design. (Okay, birds design nests, spiders design webs, if you like. And there are other exceptions.) I judge 'design' in the context in which I know it - human technology, because that's all I know (I don't really know Klingon technology very well, or Santa Claus' technology for that matter).
Complex things, like a pocket watch, with all its intricate parts, are beyond my ability to manufacture or design. Therefore anything that is complex, and beyond my own abilities, must be designed. Almost everything in the natural world is complex beyond my ability to comprehend. Therefore it must be designed by some human smarter than me.
Since I can't explain it, Big Daddy In The Sky must have made it.
Simple.
See how easy that was that?
Aren't simple-minded answers easier?
Thanks for listening.
SWT · 2 March 2013
Suppose a truck carrying bricks has an accident, and the entire load of bricks is dumped out of the truck onto the shoulder of the road. Overnight, an obsessive artist purchases a truckload of bricks indistinguishable from the load that fell onto the shoulder of the road and painstakingly builds an exact replica of the heap of bricks that resulted from the chance accident.
The original pile of bricks is not designed.
The second pile of bricks was painstakingly designed and constructed.
How do I tell, strictly by looking at the two indistinguishable piles of bricks, which was designed and which was the result of chance?
Mike Elzinga · 2 March 2013
Mike Elzinga · 2 March 2013
phhht · 2 March 2013
phhht · 2 March 2013
prongs · 2 March 2013
Mike Elzinga, do you have a good source for the criteria used to judge electromagnetic signals from space? Too periodic or too random a signal doesn't make for a good "Hello Universe" message. Unmodulated signals are pretty much useless as identifiers of 'intelligence'. Modulated signals with a combination of some periodicity and pseudo-randomness seem to me to be the best candidates. Got any useful links?
DS · 2 March 2013
Just Bob · 2 March 2013
phhht · 2 March 2013
Henry J · 2 March 2013
apokryltaros · 2 March 2013
Mike Elzinga · 3 March 2013
Rolf · 3 March 2013
prongs · 3 March 2013
Mike, thanks for the link and the summary.
Since human technology is all we know and understand, that's what we look for, with a slight variation. We are looking for ourselves "out there."
Biblical SETI might look for signs and "miracles" such as we see in the Old Testament - handwriting in the stars, burning bushes, wheels of light, angels, fantastic beasts, and demons flying through space. Remember looking out into space is looking back in time. Old Testament times, under the old covenant, when those kinds of miracles were still in force, are only 2,000 light years out there in outer space. We should be able to see them.
I have seen a purported image of a 'genuine' angel in outer space amongst the stars, hanging on the wall in the home of true believers. It was claimed to have been taken by an ordinary person with an ordinary camera, at night. It was in reality a greatly magnified view of a planetary nebula with a classical painting of an angel printed as a double exposure. None of this could dissuade the faithful from their belief. You can see it here: http://www.angelsghosts.com/angel_in_the_night_sky_angel_picture.html
(I wonder if FLuvius Oris accepts all the eyewitness evidence at www.angelsghosts.com as proof of angels and ghosts? What are the chances he'll answer? None.)
By the way, I've searched for the classical painting of the angel used in the double exposure but have never found it.
Now that we can detect extra-solar planets, LDS SETI should be looking for the planet Kolob. You know, the planet where Joseph Smith said, under divine inspiration, Jesus lives today while waiting for his second coming.
Wonder why the Discovery Institute doesn't spend their money on Biblical SETI?
It's a great opportunity for them to make their first 'discovery.'
DS · 3 March 2013
DS · 3 March 2013
Nick,
This is at least the fourth user name used by Joe on this thread. Is anyone going to do something about it or not?
DS · 3 March 2013
prongs · 3 March 2013
The design vs. non-design "controversy" doesn't exist for mainstream science, only for its religiously motivated proponents. Everyone knows who they mean by the 'designer.' They don't mean aliens from outer space.
To pretend that the design vs. non-design "controversy" is a scientific issue is manifestly false when you see it is a scientifically-worded extension of the inspired vs. non-inspired "controversy" surrounding ancient texts.
Replace "inspired" by "contains words and concepts designed by The Almighty" and you can see how easy it is to move from a controversy about which texts should be included into the Bible, to a controversy about which features of the natural universe are 'designed.'
And if anyone says, "It's all designed." How does that help further investigations of Nature?
I, for one, do not want to step backwards in time a thousand years.
phhht · 3 March 2013
phhht · 3 March 2013
phhht · 3 March 2013
Feign laughter all you like. There are no arsenic bacteria. There is no Harry Potter, wizard. There is no second lunar satellite. Right? We know these claims are true because when we look, we find no such bacteria, no such person, no such satellite.
And when we look for gods, we don't find them either. Your pitiful claims of evidence for the existence of gods do not provide empirical evidence for the existence of gods. You know, evidence like that for the existence of apples, or zebras, or cosmic rays, or the Higgs boson. Something someone who is not a loony can actually test for himself.
But for gods, you got nothing but natural processes, personal incredulity, and god-of-the-gaps. No gods are required to explain or understand the Big Bang, or biological complexity, for that matter. And how can I, myself, test to show that physical constants are finely tuned? It's all standard Christian-crazy apologist bafflegab.
And that snowflake bullshit. Is a snowflake designed, or not? Are the rings of Saturn designed, or not? You cannot say. All you can do is weasel and squirm and dodge.
Really, can't you do better than that?
Mike Elzinga · 3 March 2013
PA Poland · 3 March 2013
phhht · 3 March 2013
Just Bob · 3 March 2013
prongs · 3 March 2013
Scott F · 3 March 2013
Scott F · 3 March 2013
phhht · 3 March 2013
stevaroni · 3 March 2013
prongs · 3 March 2013
prongs · 3 March 2013
Henry J · 3 March 2013
Mike Elzinga · 3 March 2013
Scott F · 4 March 2013
Scott F · 4 March 2013
stevaroni · 4 March 2013
Steve P. · 4 March 2013
Steve P. · 4 March 2013
Steve P. · 4 March 2013
Steve P. · 4 March 2013
Frank J · 4 March 2013
SWT · 4 March 2013
SWT · 4 March 2013
DS · 4 March 2013
Just Bob · 4 March 2013
"Organisms don’t violate the 2nd law, Life does."
Then it's not a law (in your world).
Unlike human-made laws, scientific laws (really, laws of the universe) CANNOT BE VIOLATED. If they can, then they're not laws.
If you think "life violates the 2nd Law", then YOU can't keep calling it a "law". It's NOT a law, in your formulation. Your argument is actually that the 2nd Law is not really a law.
So why do you persist in calling it a law, when, by your own statements, you don't believe it's a law?
apokryltaros · 4 March 2013
apokryltaros · 4 March 2013
Kevin B · 4 March 2013
co · 4 March 2013
Rolf · 4 March 2013
Mike Elzinga · 4 March 2013
stevaroni · 4 March 2013
phhht · 4 March 2013
stevaroni · 4 March 2013
eric · 4 March 2013
So much fail. So little time. I'm curious in hearing just what part of reproduction Steve P. thinks violates the 2LOT. DNA duplication? Every cell does that, not just sex cells! Production of egg and sperm? Insemination? Early stages of development of blastocyst? Later stages? Puberty? As far as I know, every single one of those processes relies on using chemically stored energy and putting out waste, and obeys the laws of thermo just fine.
C'mon Steve, enquiring minds want to know. At what point does the 2LOT violation take place?
prongs · 4 March 2013
"Dementropy" - A condition suffered by creationists and cdesign proponentists when they try to work out the details of Life divinely disobeying their Law of Conservation of Entropy and Information.
PA Poland · 4 March 2013
GODDESIGNERDIDIT !!!!!' is irrational and illogical. IF YOU WERE CONSISTENT WITH DESIGN PHILOSOPHY, YOU WOULD. Good thing that, IN REALITY, few are STUPID enough to think that computer programs have imperfect replication, heritable variation and selection. Sane and rational folk know they are artifacts - things CREATED BY intelligent beings (ie, humans). THE SAME CANNOT BE SAID OF LIVING THINGS; true, gibbering f*ckwits see complexity and immediately leap to the conclusion 'IT BE DESIGNED BY A MAGICAL SKY PIXIE !!!!!!!!!', but sane and rational folk figured out (about 150+ years ago) that evolution can produce the APPEARANCE of design. Complexity can arise without a mind to guide it. And I see you (as expected) FAILED to deal with the actual issue : Since YOU are the one flatulating that a Designer exists and did this, that, and the other thing, IT IS UP TO YOU TO PROVIDE POSITIVE EVIDENCE TO SUPPORT YOUR POSITION. Given the FACT that evolution has many known and observed mechanisms that completely explain what is observed in real-world creatures, there is no point in invoking the unknowable whim of an unknowable being that somehow did stuff sometime in the past for some reason. You got something besides your boundless ignorance to support your blubberings about 'intelligent designers' ? Or do you just expect everyone to fall for the idiotic "Me can't figure it out, therefore GODDIDIT !!!!!!" routine ?Just Bob · 4 March 2013
prongs · 4 March 2013
stevaroni · 4 March 2013
stevaroni · 4 March 2013
Henry J · 4 March 2013
Steve P. · 5 March 2013
Dave Luckett · 5 March 2013
Mike Elzinga · 5 March 2013
Steve P. · 5 March 2013
SWT · 5 March 2013
Steve P. · 5 March 2013
Steve P. · 5 March 2013
prongs · 5 March 2013
Steve P. · 5 March 2013
Rolf · 5 March 2013
I don't know much about obstructing laws, but we routinely violate the laws of nature; we resist gravity, we pump water and drive our cars uphill. We even send stuff so far out it never will return to earth again; the ultimate insult to God.
There remains one law that can't be obstructed, namely the law of stupidity, as Schiller observed.
Dave Luckett · 5 March 2013
DS · 5 March 2013
Stevie Pee Pee wrote:
"Imperfect replication results in death unless the organism recognizes the imperfection and makes the requisite corrections. In fact, that is actually what we observe organisms doing; continually making the necessary corrections to keep the genome viable. And that is no thanks to imperfect replication. Far from being an engine of growth and development, imperfect replication is a clear obstacle that organisms bend over backwards to avoid."
RIght. There are no beneficial mutations Stevie, just keep repeating that over and over. Funny you should say that on a thread that is about the fact that the majority of the human genome is just so much junk. You seem to have misunderstandings of the basic nature of reality. Why you want to display them is a mystery.
TIme to dump this troll and his off topic bullshit to the bathroom wall. Any further response by me will be found there.
Keelyn · 5 March 2013
Keelyn · 5 March 2013
DS · 5 March 2013
PA Poland · 5 March 2013
eric · 5 March 2013
phhht · 5 March 2013
Mike Elzinga · 5 March 2013
Mike Elzinga · 5 March 2013
phhht · 5 March 2013
Malcolm · 5 March 2013
phhht · 5 March 2013
...You lay claim to "a huge body of collective human experience,' but your purported "experience" has no backing whatsoever in the real world. It's all stories, SpevieT, just like Harry Potter, just like The Avengers. Your religious illness impairs your ability to tell the real from the imaginary.
SWT · 5 March 2013
prongs · 5 March 2013
SWT · 5 March 2013
prongs · 5 March 2013
Steve P. · 6 March 2013
Steve P. · 6 March 2013
Steve P. · 6 March 2013
Steve P. · 6 March 2013
Steve P. · 6 March 2013
Steve P. · 6 March 2013
SWT · 6 March 2013
The careful reader will note that Steve P. has now completely abandoned any pretense of following up on the thermodynamic discussion. Color me shocked.
Keelyn · 6 March 2013
Keelyn · 6 March 2013
Dave Lovell · 6 March 2013
apokryltaros · 6 March 2013
So did Steve P ever get around to showing anyone those magical explanations that Intelligent Design can provide about life that Darwinian (sic) Evolution can not?
apokryltaros · 6 March 2013
Or was he just too busy insulting everyone for kissing his ass and not swallowing his bullshit without question, as usual?
PA Poland · 6 March 2013
Dave Luckett · 6 March 2013
phhht · 6 March 2013
Frank J · 7 March 2013
Just Bob · 7 March 2013
Steve P. · 13 March 2013
https://www.google.com/accounts/o8/id?id=AItOawm-WhebH0itIDDTj06EQo2vtiF0BBqF10Q · 13 March 2013
Ford Doolittle just published his ENCODE critique in PNAS
SPARC
Dave Luckett · 13 March 2013
Steve has just spent half a dozen paragraphs demonstrating that he hasn't a clue what the second law says or what its application is.
eric · 13 March 2013
SWT · 13 March 2013
prongs · 13 March 2013
Oh Steve understands 2LOT all right, at least his version anyway.
Living things wear down, wear out, just like car engines.
"Entropy", whatever that is, must be like friction and wear. Don't need no pesky equations and definitions - Elzinga be damned.
Without reproduction, all living things would disappear from the Earth in one generation. Reproduction cheats Death. "Entropy", whatever that is, must be like Death. (I know it is because thermodynamic people talk about "Heat Death.")Therefore Reproduction cheats the 2LOT. Praise the Designer.
See how easy that was? What's wrong with you people? Such a simple concept.
phhht · 13 March 2013
Mike Elzinga · 13 March 2013
Scott F · 13 March 2013
eric · 13 March 2013
Mike Elzinga · 13 March 2013
prongs · 13 March 2013
apokryltaros · 13 March 2013
prongs · 13 March 2013
DS · 13 March 2013
apokryltaros · 14 March 2013
JesusTHE DESIGNER said so," is strictly prohibited according to Steve P's religion. That, and Steve P isn't obligated to prove or provide anything beyond inanity and inane insults because he already knows he knows more about science and biology and thermodynamics than all of the evil, stupid, God-hating and puppy-hating scientists in the whole wide world, and it's wrong and a sin for any of us to question Steve P's immaculate, divinely inspired proclamations.Rolf · 14 March 2013
Cells divide. That's the key to sustained life, and evolution. If cells didn't divide, life soon would become extinct. That's a fact of life. There are many ways in which an organism, unicellular or not, may be destroyed, become dead. Without reproduction, life would be doomed. No need for appeals to the 2LOT.
I don't think Steve P is as smart as he seem to think he is.
prongs · 14 March 2013
Mike Elzinga · 14 March 2013
apokryltaros · 14 March 2013
Scott F · 14 March 2013
Scott F · 14 March 2013
SWT · 15 March 2013
I totally agree the Steve P. is in a fundamentally different class than for example, FL and Biggy.
However, I'd describe him differently and perhaps less charitably: Steve P. is a crank. He's misunderstood some basic concepts, convinced himself that his understanding is superior to that of people who work in the field, and convinced himself that those who disagree with him are blinded by their prejudiced fealty to the old way of thinking.
Try scoring him on this well-known index.
For extra credit, score atheistoclast on the same scale.
Dave Luckett · 15 March 2013
I think you're on to something there, Scott. There are, as Frank J says, many flavours of evolution deniers. Most of them are fundamentalists of one of the Abrahamic religions - in the west, generally, that would mean that most of them are Christian fundamentalists of various sorts, but most of those are YEC or simply ignorant. Steve P would seem to be a different "kind", and there are a few more of them. They're a minor moiety within denialism, but they're present. As you say, Steve P's take is some kind of cellular or chemical-level self-awareness and ability to self-direct. Borzorgmehr plumps for an invisible, immaterial "morphic field". Other outliers have various, equally vapid, equally nonsensical ideas.
As Frank J remarks, the only thing they have in common with the fundies is that they deny evolution. (The fundies, as he also says, are of various and often incompatible opinions among themselves.) But that's output. The input for their ideas also seems to have one salient feature in common with the fundies: it doesn't consist of evidence. Denialists don't get evidence. They don't know what it is, or of what it consists, or what it is used for, or of how it is interpreted.
FL simply sees God everywhere (or at least, that's what he says he sees. Actually, he sees himself.) Biggy (remember him?) thinks the Bible is evidence (Actually, he doesn't. He thinks that whatever some authority has told him about the Bible is evidence.) Steve P sees whatever he sees. He can't describe it, and he gets deeply frustrated when he's asked to demonstrate it, but he knows - knows - that it's there.
It really makes me wonder how much of the human mind, or perhaps how many humans, are similarly afflicted. The placebo effect is real, and whatever it consists of, it involves a basic self-delusion. There is also the ganzfeld effect - show an absolutely blank white field to a subject and suggest that this is a visual acuity test, and the test subject will begin to describe the shapes and figures they see on it. Is this a root cause for Steve P's delusions - simply seeing something that isn't there?
But it is one thing to see what you want to see, or what you think you should see. It's another to refuse to see what is plainly evident. Denial of evolution requires both. The first is explicable. The second is far more difficult to explain.
Mike Elzinga · 15 March 2013
One never gets the impression that ID/creationists – or people like Steve P. – ever grasp the significance of physics and chemistry in biology. To them apparently, physics and chemistry are irrelevant and can’t explain anything.
What ID/creationists and Steve P cannot know – because they never look – is that biophysics and biochemistry are very active areas of research that are demonstrating very concisely that physics and chemistry are central to the operations of biological mechanisms and systems.
There is a report in the recent March issue of Physics Today about the work of Michael Levin and colleagues at Tufts University in the area of “bioelectric signaling.” By manipulating the transmembrane voltage differences to influence the behaviors of cells, they can cause cells to turn on growth in the amputated legs of frogs and cause legs to regenerate, complete with toes and nails. Planarian flatworms can regrow new tails or new heads; or be made to grow two tails or two heads.
This kind of stuff has been known for decades; and even Galvani in 1771 discovered that electricity can make the legs of dead frogs move.
Phenomena like hypothermia and hyperthermia are dramatic demonstrations of the importance of ambient temperature (average kinetic energies per degree of freedom) to the proper functioning of the central nervous system. We know what that implies about the relative magnitudes of kinetic energy and binding energies in these systems; and that is all physics and chemistry.
We know why ID/creationists need “organizational principles” and “informational instructions.” Not one of them knows about the energies of interaction among atoms and molecules that even high school students learn about in physics and chemistry.
ID/creationism is not just bad biology; it wrecks all of science, physics and chemistry in particular.
Mike Elzinga · 15 March 2013
bbennett1968 · 15 March 2013
Malcolm · 16 March 2013
Not only does StevieP think that bacteria are intelligent, he thinks that there is no such thing as competition. He says that less fit organisms sacrifice themself to preditors so that the fitter individuals can live. Or something.
apokryltaros · 16 March 2013
Henry J · 16 March 2013
Mike Elzinga · 16 March 2013
Steve P. · 18 March 2013
Steve P. · 18 March 2013
Steve P. · 18 March 2013
Steve P. · 18 March 2013
phhht · 18 March 2013
Steve P. · 18 March 2013
phhht · 18 March 2013
Steve P. · 18 March 2013
Steve P. · 18 March 2013
phhht · 18 March 2013
Steve P. · 18 March 2013
phhht · 18 March 2013
Steve P. · 18 March 2013
ha, phhht calls me SkevieP in 5th grade fashion and turns around and tries to paste me with the grade-schooler label.
....and he keeps on talking about God for some silly reason.
phhht · 18 March 2013
phhht · 18 March 2013
C'mon, might warrior for whatever-it-is you're trying to profess, give us a hint! Tell us why you repeat and repeat again and again that there is something we don't know! So what? So what, blusterer?
phhht · 18 March 2013
PA Poland · 18 March 2013
SWT · 18 March 2013
SWT · 18 March 2013
SWT · 18 March 2013
SWT · 18 March 2013
phhht · 18 March 2013
Malcolm · 18 March 2013
Just to be clear; Even in modern cells, RNA preplicates RNA. The proteins in the ribosome are structural. The catalysis is carried out by the ribosomal RNA.
Mike Elzinga · 19 March 2013
Malcolm · 19 March 2013
fnxtr · 19 March 2013
Oh, yeah, Mike? Well... well... how come sulfur is yellow, huh? And why is mercury liquid at room temperature? Huh? Huh? Your materialistic reductionist philosophy can't explain that, can it, you baby-eater!
Therefore design.
Henry J · 19 March 2013
Mike Elzinga · 19 March 2013
Steve P. · 21 March 2013
SWT · 21 March 2013
bbennett1968 · 22 March 2013
phhht · 22 March 2013
DS · 22 March 2013
Steve P. · 28 March 2013
SWT · 28 March 2013
So, Steve P., not interested in discussing thermodynamics any more?
apokryltaros · 28 March 2013
claimslies, though. So where is the research you've done to prove that reproduction magically violates the 2nd Law of Thermodynamics? Or, are you just pulling more lies out of your butt, as usual? What makes you think that "doing experiments and searching for evidence for 150 years" is tantamount to "not answering questions"? I mean, besides possible brain damage.Because saying DESIGNERDIDIT does absolutely nothing to explain anything. Occam's Razor refers to how the most parsimonious explanation is probably the correct explanation. Intelligent Design is not an explanation, let alone science. Therefore, you can not invoke Occam's Razor because Intelligent Design is not an explanation to begin with. Well, you can, but, doing so makes you look like a fool. As usual.apokryltaros · 28 March 2013
RPST · 29 March 2013
Steve P. · 29 March 2013
Steve P. · 29 March 2013
DS · 29 March 2013
So the asshole thinks that he can get everyone to magically forget that he was completely wrong about birds and gravity by somehow trying to argue about the beginning of life or some such nonsense., Come on guys, you have to realize by now that he is incapable of any coherent thought let alone reasoned argument.
None of this bullshit has anything whatsoever to do with the subject of the thread. Like so many ignorant trolls before him, all further responses by me to Stevie PP will be on the bathroom wall. I suggest that others do the same. He doesn't deserve the respect of replying here.
prongs · 29 March 2013
Dave Lovell · 29 March 2013
SWT · 29 March 2013
co · 29 March 2013
Malcolm · 29 March 2013
So, SteveP has no understanding of thermodynamics or biochemistry.
I wonder what he thinks happens when a protein in a cell gets damaged.
It is as if he thinks that the cell is doomed. That would make photosynethsis a little tricky.
prongs · 4 April 2013
apokryltaros · 4 April 2013
prongs · 4 April 2013
Mike Elzinga · 5 April 2013
prongs · 5 April 2013
Mike,
Yes, I think that's a good summary.
I do like Carl Sagan's depiction of the alien message in the movie Contact. On the simplest level it has a pattern perceptible at a human scale of listening that repeats a sequence of prime numbers. Further inspection reveals human television transmissions embedded more deeply. This tells them that the aliens recognize us and acknowledge us. Even more deeply are embedded the designs to construct a communications device.
Now this is very clever. What it really represents is what we humans might do if we received television signals from another planet orbiting a distant (but not too far) star.
It is precisely the way we might respond to them. In this movie Sagan created the aliens in our own image. That's because we have no other image with which to create aliens or gods.
I remember an article Sagan wrote for Parade magazine, the one that comes with your Sunday paper. In it he wrote that in medieval times people feared demons coming at night, paralyzing them, and transporting them out of their beds for unspeakable abominations. Now that we have 'aliens', people imagine them coming in the middle of the night, paralyzing them, and transporting them out of their beds to the alien ships for unspeakable abominations. Might there be a connection here?
You've been around long enough to recognize there are precious few creationist arguments, and none of them are really new.
Thanks for your comments.