A visit from the architects of the fly hourglass paper

Posted 13 December 2010 by

So, shortly after the first post on the hourglass model went up here on the Panda's Thumb, the senior author of one of the two featured papers (the article using fruit flies, titled "Gene expression divergence recapitulates the developmental hourglass model") contacted me, clearly enthused about our interest in the story. He's Pavel Tomancak, and together with the co-first author on the study, Alex Kalinka, he offered some useful feedback as well as some cool images. Here are some of their further thoughts, posted with their permission and edited slightly by me. Let's think of them as honored guest bloggers.

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I am indeed excited about the insightful blogging that has followed the publication of our work. It is great to see that people like you are genuinely trying to come to grips with the sometimes complex analysis we have put forward (a 55 page monograph accompanies the paper) and share their understanding with scientifically-inclined readers on the blogosphere.

The major challenge we had to overcome was to convince people that the evolutionary divergence of the Drosophila species we used is sufficient to make arguments about phylum-level morphological patterns. Many people thought that we could not possibly say something about the phylotypic stage by looking at closely related species. We made a number of arguments like: the species facilitate unambiguous comparisons, gene orthology is clear, timing of development is not so different (although we compensated for that) and so on. What really drives it home is the comparison of the Drosophila phylogeny to the vertebrate one. D. virilis is roughly as distant from D. melanogaster as lizards are from humans in terms of the molecular clock (see figure below, from Stark et al. 2007 Fig. 1). I take it that flies are more similar to each other morphologically than say human or mouse or elephant, but they also are rather different, living in very different environments that influence their embryonic strategies (Markow & O'Grady 2008).

dros_comparisons_vs_mammals_Pavel.jpg

However, in addition to these arguments, we believe that approaching evo-devo questions using a mixture of closely related species, such as D. persimilis and D. pseudoobscura, together with more distantly related species such as D. virilis, allows us to see both large accumulated differences between species that have accrued over tens of millions of years, together with the first steps that occur as two species diverge from one another. One of the advantages of such an approach is that it will enable us to infer whether most differences are the result of a large number of small changes, or whether they are the result of a small number of large changes. Moreover, this approach is essential if we are to integrate population genetics theory with comparative embryology, a synthesis that will greatly advance our understanding of how development evolves (Simpson 2002).

The dataset was actually massive even by today's standards; we had replicates which allowed us to do all the statistics. All together 200 array experiments on self-designed arrays.

Our ability to recapitulate the known phylogeny from the divergence data is in my opinion remarkable. As far as we know, the reconstruction of a phylogeny using expression data has not been attempted before. Karolina Varga, co-first author on the paper, with her impeccable sense of humor, wanted to coin the term 'expressogram' as a variation of 'phylogram', which follows the fine tradition of ‘eisengrams’ and such. Despite exhibiting the same topology as the molecular clock phylogram there are differences (See supplementary Figure 3 of our paper, included below) and these pointed us to the evolutionary modeling that suggests that the hourglass waist is maintained by stabilizing selection.

PavelSupplFig3.gif
Supplementary Figure 3. A comparison of the phylogenetic relationships between the six Drosophila species used in our study when drawn up using our gene expression data (based on normalised values from a linear model (see Methods)) - boxed in blue - and based on median dS values for ~ 10,000 orthologous genes - boxed in green. Red branches indicate terminal branches between sister species that are longer in the gene expression data.

The genes that conform to the hourglass pattern are enriched for genes involved in building up the body plan and could be in general referred to as 'developmental toolkit genes'. It will be interesting to compare these genes to the ones that drive the hourglass pattern in the other study by Domazet-Loso and Tautz. While there may be commonalities in the studies, it may also be the case that the evolution of new genes (through a process of duplication and divergence, for example) may be under a different set of constraints than the evolution of gene expression. Exploring such differences promises to be an exciting avenue for future research.

Finally, I think that both papers really open up new horizons for studying the developmental hourglass experimentally using the awesome power of Drosophila and fish genetics. That's what we worked towards from the beginning. We are developing fancy transgenic, imaging and image-analysis techniques to be able to compare gene expression in the different species quantitatively on the spatio-temporal level. It's well-funded (among others by HFSP and ERC) and these papers will be a huge boost to not only us but the entire field, which until recently was living on the fringes.

References:

Markow, T., & O'Grady, P. (2008). Reproductive ecology of Drosophila. Functional Ecology 22, 747-759.

Simpson, P. (2002). Evolution of development in closely related species of flies and worms. Nat Rev Genet 3:907-917.

Stark, A., et al. (2007). Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature 450, 219-232.

146 Comments

Kris · 14 December 2010

A similar study, including checkerspot butterflies, and especially the ones in the genus Euphydryas (like E. editha, E. colon, E. chalcedona, etc.) would also be very interesting.

DS · 14 December 2010

"The major challenge we had to overcome was to convince people that the evolutionary divergence of the Drosophila species we used is sufficient to make arguments about phylum-level morphological patterns."

But it appears that you have indeed accomplished that task. Now that you have developed the methods and types of analysis required, and demonstrated the molecular basis of the hour glass phenomena, there is nothing stopping anyone from applying this same technique to larger divergence times. Many whole genome sequences are already available. You may have founded the new field of evo devo temporal/spatial gene expression pattern analysis. OK, maybe that name could use a little work.

The next step might be to examine the evolution of the regulatory mechanisms responsible for producing this pattern. I am sure that when confronted with the scientific evidence for evolution at this level that every honest creationist will be convinced of the reality of evolution.

Paul Burnett · 14 December 2010

DS said: I am sure that when confronted with the scientific evidence for evolution at this level that every honest creationist will be convinced of the reality of evolution.
"Honest creationist" - wherever do you suppose something like that might be found? It's been pretty obvious the last few decades that there is no such thing.

Henry J · 14 December 2010

It’s been pretty obvious the last few decades that there is no such thing.

That's because to find one of those, you have to look among people who haven't been confronted with the evidence yet. The ones who have been so confronted, are now either (1) what's expected of Creationists, or (2) no longer one of them.

Cubist · 14 December 2010

To my knowledge there are exactly two Creationists who genuinely do understand evolution, Kurt Wise and Todd Wood. Both of these guys are very upfront about how evolution is scientifically valid... and Wise, at least, is equally upfront about rejecting evolution because it conflicts with his religious beliefs. Apart from that pair, however, it's honest; informed; Creationist -- pick two.

Dale Husband · 14 December 2010

Cubist said: To my knowledge there are exactly two Creationists who genuinely do understand evolution, Kurt Wise and Todd Wood. Both of these guys are very upfront about how evolution is scientifically valid... and Wise, at least, is equally upfront about rejecting evolution because it conflicts with his religious beliefs. Apart from that pair, however, it's honest; informed; Creationist -- pick two.
And they are both sell-outs and frauds I have no regard for.

Ichthyic · 14 December 2010

And they are both sell-outs and frauds I have no regard for.

Yay Dale!

you're absolutely right. to hold those two up as "honest" is to horribly malign the term "intellectual honesty".

I've looked at what they have written. Honesty in name only.

simply claiming you can deny evidence because your religion dictates it does NOT make for an intellectually honest argument.

DS · 14 December 2010

Paul Burnett said:
DS said: I am sure that when confronted with the scientific evidence for evolution at this level that every honest creationist will be convinced of the reality of evolution.
"Honest creationist" - wherever do you suppose something like that might be found? It's been pretty obvious the last few decades that there is no such thing.
True enough. But the statement still stands.

Rolf Aalberg · 14 December 2010

Ichthyic said: And they are both sell-outs and frauds I have no regard for. Yay Dale! you're absolutely right. to hold those two up as "honest" is to horribly malign the term "intellectual honesty". I've looked at what they have written. Honesty in name only. simply claiming you can deny evidence because your religion dictates it does NOT make for an intellectually honest argument.
Religious honesty trumps intellectual honesty?

Gary Hurd · 14 December 2010

I would like to thank, and welcome Pavel Tomancak. There have been years of attacks on evolution, and science teaching in general based on the perceived "fraud" of Haeckel's embryo drawing.

What I now hope we will see is a new, and independently derived set of science results from embryology giving further confirmation of evolution.

John Vanko · 14 December 2010

At the risk of being repetitive and boring, I resubmit an earlier post from June, that seems even more poignant here:

If AIG or CMI is one’s authority you might think that “Ontogeny recapitulates Phylogeny” (and the similarities of developmental forms in general) is a false concept long abandoned and dis-proven (now providing evidence against evolution), and therefore cannot be included in any biology textbook or classroom today.

But such is not the case. Stephen Jay Gould wrote a 500 page tome, Ontogeny and Phylogeny* where he says in his opening sentence on page 1, 'I am aware that I treat a subject currently unpopular.'

He continues, “I tell a colleague that I am writing a book about parallels between ontogeny and phylogeny. He takes me aside, makes sure that no one is looking, checks for bugging devices, and admits in markedly lowered voice: ‘You know, just between you, me, and that wall, I think there really is something to it after all.’ “

Because there is indeed something to it. It’s not a false concept. It just needs modification in light of what we know today about biology. And that’s what Gould did.

On page 213 he writes, “The embryonic features that we share with all vertebrates represent no previous adult state, only the unaltered identity of early development. Thought they do not allow us to trace the actual course of our descent in any way, they are full of evolutionary significance nonetheless; for, as Darwin argued, community of embryonic structure reveals community of descent.”

All you have to do is look at those photographs and you know he’s right.

*-Belknap Press of Harvard University Press, 1977

(PS-No one at AIG or CMI has the record of field work of Gould. No one at AIG or CMI has the scholarship to write an Ontogeny and Phylogeny like Gould. Yet they expect us to bow to their pronouncements.)

dmso74 · 14 December 2010

"Our ability to recapitulate the known phylogeny from the divergence data is in my opinion remarkable.."
"We are developing fancy transgenic.."
"It’s well-funded.."

you know, if you keep doing that, you're going to go blind.

harold · 14 December 2010

John Vanko -

Well, Gould was obviously correct, and even if embryoes were more divergent morphologically, what we now know about the conservation of basic major genes families in development across diverse lineages would prove that point.

However, to some degree, although Haeckel is probably excessively maligned, as Gould said in the quote you presented - "The embryonic features that we share with all vertebrates represent no previous adult state, only the unaltered identity of early development".

I haven't read Haeckel in the original and probably never will, but relying on summaries, I thought this was kind of the point. He thought that they did represent or recapitulate previous adult states.

They certainly do seem to resemble adult states of some members of the vertebrate lineage, and they certainly do often seem to resemble more ancient lineages closer to the beginning of development (I'm not sure if there are counter-examples), but at a vastly smaller physical scale. Without meaning to be unfair to someone whose work I have not read in the original, didn't Haeckel perhaps, unlike Gould, take this resemblance to literally?

John Vanko · 14 December 2010

harold said: ... didn't Haeckel perhaps, unlike Gould, take this resemblance too literally?
Yes, I think that's what happened. Haeckel was so struck by the resemblance of mammalian embryos that he carried it too far - formulating his biogenetic law of Ontogeny Recapitulates Phylogeny - and used drawings of embryos rescaled and 'touched-up' to prove his point. Apparently his 'law' stated that embryonic development recapitulated the adult ancestry of the phylum. That was going too far. Science, being self-correcting, discovered his over-enthusiasm and his 'law' fell into disrepute. Creationists didn't 'discover' the problems, legitimate scientists did. Now, creationists can't stop using Haeckel's touched-up drawings as 'proof' that Ontogeny Recapitulates Phylogeny is a fraud that invalidates all of evolutionary biology. Gould refused to toss Ontogeny into the dustbin of history and wrote his tome that more correctly restates, "The embryonic features that we share with all vertebrates represent no previous adult state, only the unaltered identity of early development. Though they do not allow us to trace the actual course of our descent in any way, they are full of evolutionary significance nonetheless; for, as Darwin argued, community of embryonic structure reveals community of descent.” That is the biogenetic law as it was meant to be.

Kris · 14 December 2010

Pavel Tomancak may well be disappointed in some of the people here right now. He and his associates probably did the study so as to learn something, and not so that the results would be used solely (or partly) as a weapon in the war on ID/creationism, unless he and his associates intended it to be solely (or partly) that weapon of course.

Since science "ignores religious beliefs" (yeah right) that of course couldn't be the case. But, that surely hasn't stopped some of you from instantly adding the study to your arsenal of weapons against ID/creationism.

So, whatever you do, don't just find the study interesting and informative for its own sake (which I hope is what the authors intended). Think of it only as another scientific weapon against ID/creationism, while you keep saying that "science ignores religious beliefs".

harold · 14 December 2010

Yep, that pretty much summarizes it.

Haeckel was working at a very early but very, very active time in the history of biology. I guess every period in biology since Linnaeus has been something of an explosive period of new knowledge, but the late nineteenth century still probably stands out in many ways.

Because the science was early, it was a time of brilliant minds forming rather extreme ideas, some of which turned out to be prescient, some of which were brilliant but wrong.

Golgi and Cajal supposedly came close to a fist fight at the Nobel Prize ceremonies (technically that was in the early twentieth century). Cajal realized that the central nervous system was made up of individual cells, Golgi thought it was some kind of syncitium. (Cajal was also an early weight training enthusiast; I have no idea what kind of shape Golgi would have been in for his age at the time - they were probably both about 60.)

In fact, I recently discovered to my amazement that some science-denying anti-medicine cranks are accurate advocates of once very important ideas from that time.

So in that context, Haeckel's admitted over-interpretation of his basically valid observations, and his mildly over-emphatic (but not grotesquely wrong) drawings, are really not that shocking. It's worth noting that before photomicrographs, artistic ability was an important scientific skill.

The real message is that the study of development, beside having applications to medical research, provides a lot of strong evidence for evolution and common descent.

Flint · 14 December 2010

So, whatever you do, don’t just find the study interesting and informative for its own sake (which I hope is what the authors intended). Think of it only as another scientific weapon against ID/creationism, while you keep saying that “science ignores religious beliefs”.

You are wallowing in a false dichotomy. ALL science, properly performed, is ipso facto a refutation of creationism. Science by its very nature cannot avoid being the inadvertent enemy of dishonesty, distortions, and general idiocy. This is certainly not the purpose of science, it's simply an unavoidable side-effect.

He and his associates probably did the study so as to learn something

But of course, the very act of learning is antithetical to creationism, which treats all claims as either absolutely true, or absolutely wrong, and judges all new claims by theological standards rather than against reality itself. You are having semantic issues. Science does indeed ignore religious beliefs, but this does not mean scientific understandings do not or can not refute religious beliefs - much in the sense that when you drive a car, you ignore the ants on the road even though you are killing them steadily. And while it may certainly SEEM to the ants that you are deliberately out to get them, in fact your purposes are entirely unrelated.

harold · 14 December 2010

Kris -
Pavel Tomancak may well be disappointed in some of the people here right now.
Indeed. I wonder who?
He and his associates probably did the study so as to learn something, and not so that the results would be used solely (or partly) as a weapon in the war on ID/creationism,
All science is always done to learn something, and no science is ever directly related to ID/creationism, which is irrelevant.
unless he and his associates intended it to be solely (or partly) that weapon of course.
Obviously they didn't.
Since science “ignores religious beliefs” (yeah right) that of course couldn’t be the case.
Science does ignore religious beliefs. However, religious beliefs that coincidentally happen to deny science are wrong. Therefore, your religious beliefs are wrong. I can't comment on the religious beliefs of the Pope, the Archbishop of Canterbury, or the Dalai Llama, because those guys have religious beliefs that don't deny science, but your religious beliefs are wrong. Therefore if people with wrong religious beliefs go to hell, which is not what I believe, but let's say that happens, well, global warming will be a useful practice session for you.
But, that surely hasn’t stopped some of you from instantly adding the study to your arsenal of weapons against ID/creationism.
Right. The study wasn't done to deny creationism, but it provides evidence against creationism. We don't use antibiotics to deny that demons cause disease instead of microbes, but when they work, they provide evidence that microbes, not demons, cause some diseases.
So, whatever you do, don’t just find the study interesting and informative for its own sake (which I hope is what the authors intended).
Why not?
Think of it only as another scientific weapon against ID/creationism, while you keep saying that “science ignores religious beliefs”.
But actually, it's both. I'm sorry that your science-denying religion is proven wrong by science. If it was spiritual enlightenment you were after, you'd probably adapt, but since science-denying religion tends to just be a superficial proxy for creepy authoritarian fantasies, you may find yourself frustrated.

Dale Husband · 14 December 2010

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Mike Elzinga · 14 December 2010

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Dale Husband · 15 December 2010

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Kris · 15 December 2010

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Dale Husband · 15 December 2010

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Michael Behe · 15 December 2010

Because Natural Selection can destroy, it can therefore build.

This is the central fallacy of Darwinism. Just because something can destroy does not mean it can build.

Ichthyic · 15 December 2010

This is the central fallacy of Darwinism

you mean your own personal fallacious strawman.

sounds catchy, but it makes no sense, and has nothing to do with evolution.

fail.

Dale Husband · 15 December 2010

Michael Behe said: Because Natural Selection can destroy, it can therefore build. This is the central fallacy of Darwinism. Just because something can destroy does not mean it can build.
Wrong. That is YOUR fallacy. Natural selection neither builds nor destroys. It CHANGES!

Ichthyic · 15 December 2010

here's a hint for you:

what's the most basic definition of the word: evolution?

change.

Ichthyic · 15 December 2010

heh.

jinx!

see, sometimes we DO think alike, Dale.

:)

Ichthyic · 15 December 2010

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Mike Elzinga · 15 December 2010

Michael Behe said: Because Natural Selection can destroy, it can therefore build. This is the central fallacy of Darwinism. Just because something can destroy does not mean it can build.
Actually this is THE Fundamental Misconception of ID/creationism brought to you by Henry Morris back in the 1970s, and further asserted in response to being told by the physics community that he was wrong. These misconceptions permeate ALL ID/creationist writings, including those of the one you impersonate. Here is Thomas Kindell repeating Morris’s arguments almost verbatim. This is your intellectual heritage; but we know it better than you do. And we also know why it is wrong.

Rolf Aalberg · 15 December 2010

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Kris · 15 December 2010

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Paul Burnett · 15 December 2010

harold said: We don't use antibiotics to deny that demons cause disease instead of microbes, but when they work, they provide evidence that microbes, not demons, cause some diseases.
Ah, but can you prove that demons don't cause microbes? (/snark) Some (most?) creationists attribute creative powers to their various devils and demons, committing a variant of the Manichaean Heresy (not that they have a clue).

eric · 15 December 2010

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Stanton · 15 December 2010

Paul Burnett said:
harold said: We don't use antibiotics to deny that demons cause disease instead of microbes, but when they work, they provide evidence that microbes, not demons, cause some diseases.
Ah, but can you prove that demons don't cause microbes? (/snark) Some (most?) creationists attribute creative powers to their various devils and demons, committing a variant of the Manichaean Heresy (not that they have a clue).
A large number of creationists often preach about how Satan is "prince" or even "god of this world." IBIG was especially fond of saying that. Yet, they always deny that this contradicts what the first of 10 Commandments in the Bible says.

RBH · 15 December 2010

Michael Behe said: Because Natural Selection can destroy, it can therefore build. This is the central fallacy of Darwinism. Just because something can destroy does not mean it can build.
Absent verification of IP and email, I strongly recommend that folks not uncritically or naively accept this commenter as the Michael Behe of Lehigh University. We do not have auto-verification of commenters, so anyone can post under that name.

DS · 15 December 2010

Anybody notice that the trolls here are not actually discussing the science? It's almost as if they don't really understand the paper at all. You know, it's almost as if they never even read the paper! Imagine that, going to a web site devoted to defending evolution and ridiculing people for defending evolution, all the while ignoring the science and still claiming you are on their side. Amazing.

If anyone thinks that this paper refutes religion, just ask yourself, what religion? If anyone thinks that this paper refutes a religious belief, just ask yourself, what belief? As Flint correctly pointed out, whenever anyone makes claims about the natural world, science can and should address those claims. The science should be used to refute the scientific claims, not the religious motivation behind them.

As for the authors being disappointed, well why not just ask them? You know, the authors who specifically came to a blog devoted to defending evolution against creationism. Ask them if they are disappointed that their paper has been used for such a vile purpose as defending evolution. Why not hear it straight from the scientists mouth?

Steve Matheson · 15 December 2010

Notice.

First, I'll go further than RBH: if you are assuming that the commenter who refers to him/herself as "Michael Behe" is in fact the author of Darwin's Black Box, then you're a lot dumber than he is.

Second, and related, all comments by Kris -- and responses to her/him -- are on their way to the Bathroom Wall, as are any and all comments far afield of the interesting topics discussed by our guest bloggers. Seriously, guys, do you not have any experience in dealing succinctly with trolls? I can demonstrate the use of href tags to create links if that would help.

DS · 15 December 2010

RBH said:
Michael Behe said: Because Natural Selection can destroy, it can therefore build. This is the central fallacy of Darwinism. Just because something can destroy does not mean it can build.
Absent verification of IP and email, I strongly recommend that folks not uncritically or naively accept this commenter as the Michael Behe of Lehigh University. We do not have auto-verification of commenters, so anyone can post under that name.
Thanks RBH, but we had kind of reached that conclusion already. After all, the guy used the probability calculation, you know, the one that means absolutely nothing, the one that was debunked decades ago, the one that even a brain dead syphilitic chimp wouldn't have to think twice about in order to realize that it was complete and utter horse puckey. Now the real Behe might be many things, but syphilitic he is not. Besides, the real Behe would not come to a thread discussing a real paper about real science and completely ignore the paper just to post some nonsense now would he? What kind of troll would do such a thing?

harold · 15 December 2010

Kris -

It doesn't really matter what your motivation is. The quality of your comments is what it is. This will be my last "feeding" of you.

Joe Felsenstein · 15 December 2010

Michael Behe said: Because Natural Selection can destroy, it can therefore build. This is the central fallacy of Darwinism. Just because something can destroy does not mean it can build.
Of course natural selection can destroy the alleles in some individuals, but doing so increases the frequency of those alleles that occur in the remaining genotypes in the population. And those surviving alleles, which are in the more fit genotypes, may or may not bring about phenotypes that “build”. It depends on whether the alleles eliminated “build” less or more than the ones that survive. I sense from your statement that because natural selection (by differential viability, say) eliminates some individuals, that therefore there is some scientific principle that says that it cannot be a constructive force. What would that scientific principle be? I can construct any sentence I want by writing down a set of columns, each of which has all 26 letters plus a space, and then eliminating all the 26 incorrect choices from each column. Am I therefore unable to “build” any sentence that I want to? An old-fashioned manual typesetter built pages of books by selecting metal type from a tray of possibilities. I am also reminded of Michaelangelo's famous statement that in sculpting his “David”
It’s simple. I just remove everything that doesn’t look like David.
Was Michaelangelo unable to “build”? Note that invoking your usual arguments about the unavailability of the necessary mutations is irrelevant here. Your statement implies that even if the mutations are available, they somehow can't be constructive. Why?

Joe Felsenstein · 15 December 2010

I was assuming (naïvely) that the poster “Michael Behe” really was Michael Behe. If he was, then he will expand on his argument and show us the logic underlying it.

If he behaves like a drive-by troll and just disappears and refuses to explain his argument then I will give the real Michael Behe the benefit of the doubt and assume that the commenter wasn't Michael Behe.

harold · 15 December 2010

Feel free to put this comment on the Bathroom Wall, but an important chance to highlight something about the history of ID presents itself.

ID was originally marketed as a means for getting some stealth creationism into public schools, without invoking court challenges. We can debate whether the DI ever intended for it to actually perform that function, but that's how it was marketed.

Hence, it was common during the pre-Dover era for science-denying trolls to ostentatiously claim not to be religious, to claim that ID/creationism wasn't religious, and so on. Simultaneous obsessive construction of a "discard science or discard all religious behavior" false dichotomy was characteristic of this. Canned remarks claiming persecution, often in ludicrous contexts, were also common (the "Expelled" strategy).

All of this was nothing more than a strategy that lying follower bots were instructed to observe.

We see a lot less of it since Dover, given that Judge Jones specifically called out people using this strategy for lying under oath, and wrote a decision making it almost impossible for this strategy to ever succeed.

However, there are a few dolts who haven't abandoned this grotesquely dishonest strategy yet, and Kris seems to be a "living fossil" of this type. If not, he is coincidentally a perfect mimic.

DS · 15 December 2010

Well, now that the trolls are taken care of we can get back to discussing the science. If the author is still around, I have some questions.

Is it necessary to use species specific microarrays? Would it be possible to design microarrays that would allow for this type of analysis using a greater divergence time, especially for phylogenetically conserved genes such as hox genes? If that were possible, it would make this approach much less costly and time consuming? If not, how difficult is it to design and construct such arrays? Do you have any plans for looking at more fly species or expanding the divergence time? Could such an approach be used for vertebrates as well? Could the molecular developmental hour glass be demonstrated in the organisms used for Haeckel's drawing? Would you be disappointed if your work was used to fight creationism?

Thanks for doing such ground breaking work and for helping us to understand it.

William Dembski · 15 December 2010

RBH said: Absent verification of IP and email, I strongly recommend that folks not uncritically or naively accept this commenter as the Michael Behe of Lehigh University. We do not have auto-verification of commenters, so anyone can post under that name.
Hey, anything's possible.

Kris · 15 December 2010

DS said: Anybody notice that the trolls here are not actually discussing the science? It's almost as if they don't really understand the paper at all. You know, it's almost as if they never even read the paper! Imagine that, going to a web site devoted to defending evolution and ridiculing people for defending evolution, all the while ignoring the science and still claiming you are on their side. Amazing. If anyone thinks that this paper refutes religion, just ask yourself, what religion? If anyone thinks that this paper refutes a religious belief, just ask yourself, what belief? As Flint correctly pointed out, whenever anyone makes claims about the natural world, science can and should address those claims. The science should be used to refute the scientific claims, not the religious motivation behind them. As for the authors being disappointed, well why not just ask them? You know, the authors who specifically came to a blog devoted to defending evolution against creationism. Ask them if they are disappointed that their paper has been used for such a vile purpose as defending evolution. Why not hear it straight from the scientists mouth?
Are YOU discussing the science????? You started the whole pile of shit about creationists with this remark: "I am sure that when confronted with the scientific evidence for evolution at this level that every honest creationist will be convinced of the reality of evolution." How exactly is THAT discussing the science, and how exactly is your post above discussing the science? You and most of the others are just up on your asinine soapboxes again and are ignoring the science of the study. I can't help but notice that selective comments were moved the BW while others that have NOTHING to do with discussing the science are still here. What a surprise! NOT!

Kris · 15 December 2010

Yeah, I would LOVE to hear from the authors of the study as to how they feel about the way some of you have totally detoured from the topic of the study. If they're smart, they're distancing themselves as far as possible from this website as fast as they can, unless of course if their study was simply intended to find and supply more weapons for the war on creationism/religious beliefs.

Steve Matheson · 15 December 2010

Kris, you seem not to be reading the thread. (What a surprise!) Your own opening comment about expanding the analysis has been left in. And your question about whether DS is "discussing the science" made me laugh out loud. (...ignoring the science of the study." LOL!)

So, Kris, we await your comments on "the science of the study." From this point on, comments on other topics by anyone will be sent straight to the wall. That means all other topics. There are plenty of threads around here where you can whine idiotically about mistreatment of "creationists." This is not one of them.

Stanton · 15 December 2010

If D. melanogaster and D. virilis are molecularly clocked as being as distant as humans are to lizards, would that quality alone, merit splitting the Drosophila subgenera (Sophophora, D. Drosophila spp, etc) into separate, distinct genera?

Kris · 15 December 2010

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eric · 15 December 2010

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DS · 15 December 2010

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Napolean Bonaparte · 15 December 2010

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Steve Matheson · 15 December 2010

To DS: I'll invite the authors to tackle some of the questions. I do think they're planning as similar analysis in other taxa, and for sure they plan to do the phylostratigraphic analysis of Domazet-Loso & Tautz on their fly data.

To everyone else: don't bother typing comments about trolls, creationists, deities, or ISPs on this thread. I'm quite sure that your time is better spent on other efforts, unless your buddies are really impressed when you cc them.

DS · 15 December 2010

Thanks Steve. I appreciate it.

Mike Elzinga · 15 December 2010

Steve Matheson said: I'll invite the authors to tackle some of the questions. I do think they're planning as similar analysis in other taxa, and for sure they plan to do the phylostratigraphic analysis of Domazet-Loso & Tautz on their fly data.
A variable that doesn’t seem appear explicitly in these studies is temperature. From a more general perspective of complex systems emerging from complex underlying systems that provide a “template,” one would expect that temperature would play an important role in the subsequent development of complexity on top of those templates. Just considering the responses of organisms to temperature is an important clue. For example, action potentials in the nervous systems of organisms are in the range of about 70 millivolts. Hyperthermia and hypothermia are strong indicators of the range of energies in which such thermally activated systems operate. There is a rough general rule of thumb in condensed matter systems that potential wells – and therefore binding energies – become increasingly shallower and more complex with increasing complexity. Complex systems that are comprised of composites of other complex systems would show different responses to different temperature ranges depending on which subsystems are being activated or shut down as temperature changes. So I suspect that since there is a common underlying template for all living organisms, whatever differences emerge as they develop are going to be strongly temperature dependent, and that the temperature dependence will become more sensitive with increasing complexity. We already know about sex differences that emerge in some species as temperature is changed during early development in the egg or womb. If living systems develop in accord with the general rules of development in other condensed matter systems, then it should be no surprise that an “underlying template” would be manifest in early developmental stages. But as the system develops further, sensitivities to “built-in initial conditions” will begin to affect further development; and these would be very temperature dependent.

harold · 15 December 2010

Mike Elzinga -

Interestingly - http://www.ncbi.nlm.nih.gov/pubmed/20512118

I don't at all know what the maximum range of temperatures that permit any viable development of drosophila embryos of any species is. I would guess that it is extremely narrow relative to the range of temperatures even that can be experienced on the surface of the earth, but relatively wide compared to the temperature range needed for viable mammalian development. But that would just be a guess.

Mike Elzinga · 15 December 2010

harold said: Mike Elzinga - Interestingly - http://www.ncbi.nlm.nih.gov/pubmed/20512118 I don't at all know what the maximum range of temperatures that permit any viable development of drosophila embryos of any species is. I would guess that it is extremely narrow relative to the range of temperatures even that can be experienced on the surface of the earth, but relatively wide compared to the temperature range needed for viable mammalian development. But that would just be a guess.
Fascinating. And it also indicates how natural selection picks out redundancy; given that non-redundant forms cannot survive a broader temperature range. Systems adjusting to environmental changes by making variable replicas of themselves to be sorted by the environment appears to be more flexible than systems that simply deform and adjust themselves to fit. It produces a “more robust fit” that is easily mistaken for design.

Paul Burnett · 15 December 2010

Mike Elzinga said: A variable that doesn’t seem appear explicitly in these studies is temperature.
Pressure is interesting, too - separate from but including partial pressures of the different atmospheric constituents. Atoms and molecules get mashed together better at higher pressures. Who's to say life didn't get kick-started at the bottom of the ocean - or too close to a meteor strike or lightning strike or some other pressure gradient-increasing event?

Paul Burnett · 15 December 2010

harold said: I don't at all know what the maximum range of temperatures that permit any viable development of drosophila embryos of any species is. I would guess that it is extremely narrow relative to the range of temperatures even that can be experienced on the surface of the earth, but relatively wide compared to the temperature range needed for viable mammalian development.
"Jack pine is well-adapted to fire. Serotinous cones, which have a waxy outer coating to protect the seeds, remain on the tree rather than dropping to the forest floor. Seeds can remain viable on the tree for 20 years or longer. When a fire occurs, the thick cone protects the jack pine seed from the intense heat. Jack pine seeds have been known to still be viable after exposure to heat at 1000 degrees Fahrenheit." http://www.nifc.gov/preved/comm_guide/wildfire/fire_6.html

harold · 15 December 2010

Yep, those plant embryos (seeds) can be amazingly hardy. There's a certain analogy to cysts. Some bacteria, and some eukaryotes like certain Amoeba species, can morph into hardy cysts when the environment becomes threatening and then transform back to their normal "adult" form when things return to ideal. I have no idea how long cysts can theoretically remain dormant but viable, but it's probably a very long time.

(For completeness, every beer enthusiast knows that brewer's yeast from bottles of beer recovered from 19th century shipwrecks has produced cultures that were used to brew excellent beer well over a century and a half later, but that's only because humans provided the sealed glass bottle environment.)

The last common ancestor of Jack Pine and Drosophila lived quite a while ago, of course :).

I'm no PZ Myers, but I do seem to recall that gravity plays a major role in early embryonic development of some animals - the contents of the actual zygotic cell become polarized, and that has a major impact on everything else.

Also, I think there are other Drosophila mutations that have an expression that is affected by temperature. That paper just happened to be a very elegant and in depth modern look at how this works for one example. I could be wrong, but I have a nagging feeling that I have heard of this before.

Flint · 15 December 2010

Michael Behe said: This is what Richard Dawkins believes: 1. I don't how life began 2. Therefore, I know it's not designed. That is a fallacy
No, it's an extrapolation. We recognize that no intelligent entity designed any life we DO know about, back in time for over half a billion years. It's not far-fetched to suppose that no such design happened before that as well, at least until some evidence otherwise should be found. You need some evidence to reject the null hypothesis. Produce it, and everyone will listen.

Joe Felsenstein · 15 December 2010

“Michael Behe” [sic] said:
Joe Felsenstein said: Was Michaelangelo unable to “build”?
Michelangelo was an intelligent designer
Irrelevant diversion from the main issue: does selection against some forms mean that evolution cannot be “constructive”? If so then Michaelangelo's activities in carving away stone could not be constructive either. Typical of a troll: the real MB would be ashamed of you for not addressing the real issue that you yourself raised.

John Harshman · 15 December 2010

Stanton said: If D. melanogaster and D. virilis are molecularly clocked as being as distant as humans are to lizards, would that quality alone, merit splitting the Drosophila subgenera (Sophophora, D. Drosophila spp, etc) into separate, distinct genera?
No, because a genus, like any other taxonomic rank, has no actual meaning. You could call the same clade a genus, a family, or even a phylum depending on your personal taste. Now, there have been occasional proposals to give ranks a real meaning. Charles Sibley proposed to do it based on genetic distance values, as you seem to imply. John Avise (and others before him) proposed to do it based on time of origin, which is not quite the same thing given that different genomes can evolve at different rates (not to mention different parts of the same genome). So far, though, none of these attempts has been popular, probably because they just aren't practical -- we don't have the necessary data to make the determinations in most cases -- and because if applied across a wide taxonomic scope it would require massive re-assignment of ranks. As with the case you raise: either Drosophila becomes a class (or higher), or Amniota becomes a genus. Neither of these is likely to be accepted.

John Kwok · 15 December 2010

This comment has been moved to The Bathroom Wall.

David Utidjian · 15 December 2010

This comment has been moved to The Bathroom Wall.

Dale Husband · 15 December 2010

This comment has been moved to The Bathroom Wall.

Steve Matheson · 15 December 2010

Then why are you feeding the troll? Please refrain, if not for me (I made it completely clear that this thread is not the place for off-topic bickering) then out of respect for our guest bloggers.

Joe Felsenstein · 15 December 2010

Steve Matheson said: Then why are you feeding the troll? Please refrain, if not for me (I made it completely clear that this thread is not the place for off-topic bickering) then out of respect for our guest bloggers.
You're right. I was dumb enough to think that this might really be Michael Behe until you guys pointed out the unlikelihood. (OK, I admit it, once I tumbled to it, I posted the one by “Napolean Bonaparte” too -- the only time I've ever posted under a pseudonym). As the troll is ducking and weaving rather than facing the issues they originally raised, I will not attempt to respond further to “Behe”, who will of course claim victory! On the issue of the original post, I would be curious whether the new work says anything about whether the explanation I posted in my comment on Part I is supported. It's an explanation that is often heard.

Kris · 16 December 2010

Once again a thread has turned into an ID/creationism/creationist bash fest. So much for the science.

I wonder why the authors of the study haven't been back and aren't participating in the 'discussion'. LOL!

Science Daily (and others) kicks this site's ass when it comes to providing interesting scientific information.

Kris · 16 December 2010

John Harshman said:
Stanton said: If D. melanogaster and D. virilis are molecularly clocked as being as distant as humans are to lizards, would that quality alone, merit splitting the Drosophila subgenera (Sophophora, D. Drosophila spp, etc) into separate, distinct genera?
No, because a genus, like any other taxonomic rank, has no actual meaning. You could call the same clade a genus, a family, or even a phylum depending on your personal taste. Now, there have been occasional proposals to give ranks a real meaning. Charles Sibley proposed to do it based on genetic distance values, as you seem to imply. John Avise (and others before him) proposed to do it based on time of origin, which is not quite the same thing given that different genomes can evolve at different rates (not to mention different parts of the same genome). So far, though, none of these attempts has been popular, probably because they just aren't practical -- we don't have the necessary data to make the determinations in most cases -- and because if applied across a wide taxonomic scope it would require massive re-assignment of ranks. As with the case you raise: either Drosophila becomes a class (or higher), or Amniota becomes a genus. Neither of these is likely to be accepted.
That's just one of the problems with science. Personal tastes have way too much to do with the way things are even named/labeled, let alone with how those things may be related to each other, or how they originated, or interact with their environment, etc., etc., etc. E.g., how many definitions of the word "species" are there? Yeah. Nothing in nature cares one iota what we humans call it. If we humans can't even agree on what the labels mean, how are we ever going to really figure out anything else, and agree on that too?

Just Bob · 16 December 2010

Kris said: That's just one of the problems with science. Personal tastes have way too much to do with the way things are even named/labeled, let alone with how those things may be related to each other, or how they originated, or interact with their environment, etc., etc., etc.
So...what science do YOU do, and how do you do it to avoid all of those "problems"?

DS · 16 December 2010

Well one of the best criteria for identification of species is genetic discontinuity. Any gene pools that are are isolated from each other and have little or no gene glow will undergo genetic divergence. Often times this occurs in a clock like manner, at least for certain portions of certain genes. So the same genetic data that can be used to reconstruct phylogenetic relationships can also be used to identify isolated gene pools, i.e. species. This is in fact why the Barcode of life project has been so successful. It provides a relatively consistent framework for species identification using the mitochondrial COI gene.

What is interesting to me is that the spatio-temporal patterns of gene expression in these species can be used to reconstruct the exact same phylogenetic pattern produced by other data sets. So, there is obviously phylogenetic information in this data as well. Once again, the same result, produced by independent data sets and different methods of analysis, increases confidence in the result.

I would end with a comment about how this is yet another stunning example of the predictions of the theory of evolution and how it represents yet another nail in the coffin of creationism. But then our resident troll would have yet another excuse to fixate on that and once again complete ignore the science in order to whine and moan about how we don't really understand anything so we might as well give up and let the butt heads win. So I won't do that.

DS · 16 December 2010

gene glow = gene flow obviously

gene glow is only for fireflies

Robin · 16 December 2010

Stanton said: If D. melanogaster and D. virilis are molecularly clocked as being as distant as humans are to lizards, would that quality alone, merit splitting the Drosophila subgenera (Sophophora, D. Drosophila spp, etc) into separate, distinct genera?
Actually, this was what I was wondering as well. I don't really know what molecular clocking is, so I have no feel for the practicality or validity of use such as a marker. It strikes me though that counting...say...the number of changes that have occurred between two species wouldn't necessarily correlate meaningfully to the number of changes between two other species. I understand evolution (as a process), and nature in general, to be more dynamic and irregular than that. For instance, I would expect (though I've not done any research on this personally) that some biological/behavioral characteristics in some species would manifest after but a few changes while other biological/behavior characteristics would only manifest after many varied changes in certain species. It think that a fair amount in terms of measuring change and determining genus level differentiation, as it were, would depend both on the species itself and the environment that species was in/pioneering into.

DS · 16 December 2010

Robin,

The concept of a molecular clock refers to the observation that there is a relatively constant rate of mutation for certain parts of certain genes for certain periods of time in certain groups of organisms. This can be determined by calibrating the times of divergence using the fossil record. For example, the rate of amino acid replacements in vertebrates can be shown to be relatively constant for hundreds of millions of years. So, if we can calibrate the clock, we can estimate divergence times based on genetic divergence.

However, you are correct. Things are usually a lot messier than this. that is why there are so many restrictions and qualifiers required. For example, the calibration used for vertebrates cannot be used for insects and the clock ticks at different rates for mitochondrial DNA than for nuclear genes and for different rates for different mitochondrial genes. So yes, things can get very messy.

Still, the mitochondrial COI gene has proven to be extraordinarily useful for many different groups. Thus it is currently the basis of the Barcode of Life project. However, the various taxonomic ranks are still somewhat arbitrary, due to rate heterogeneity in different groups. So even if we can agree on a definition of species, higher groups may still remain an artificial construct, regardless of degree of divergence or even phylogenetic relationships.

DS · 16 December 2010

The vertebrate example was for the hemoglobin gene.

DS · 16 December 2010

Shoot. I forgot to mention that creationists have no explanation for the molecular clock data, or for the nested hierarchy of genetic similarities that it produces. They lose again.

Robin · 16 December 2010

DS said: Robin, The concept of a molecular clock refers to the observation that there is a relatively constant rate of mutation for certain parts of certain genes for certain periods of time in certain groups of organisms. This can be determined by calibrating the times of divergence using the fossil record. For example, the rate of amino acid replacements in vertebrates can be shown to be relatively constant for hundreds of millions of years. So, if we can calibrate the clock, we can estimate divergence times based on genetic divergence.
Ahhh...interesting! Ok.
However, you are correct. Things are usually a lot messier than this. that is why there are so many restrictions and qualifiers required. For example, the calibration used for vertebrates cannot be used for insects and the clock ticks at different rates for mitochondrial DNA than for nuclear genes and for different rates for different mitochondrial genes. So yes, things can get very messy. Still, the mitochondrial COI gene has proven to be extraordinarily useful for many different groups. Thus it is currently the basis of the Barcode of Life project. However, the various taxonomic ranks are still somewhat arbitrary, due to rate heterogeneity in different groups. So even if we can agree on a definition of species, higher groups may still remain an artificial construct, regardless of degree of divergence or even phylogenetic relationships.
Thanks DS! Makes much more sense now.

eric · 16 December 2010

DS said: the calibration used for vertebrates cannot be used for insects and the clock ticks at different rates for mitochondrial DNA than for nuclear genes and for different rates for different mitochondrial genes. So yes, things can get very messy.
Is the latter messy, or is it a bonus? In radiochemistry and geochronology, having two clocks that run at different rates is more useful than having two clocks that run at the same rate. It can give you independent measurements of the same value (age). Moreover, you can detect changes in one of the clocks by looking at the ratio of the two rates. The ratio should remain constant; if its not, you know something affected one of your clocks but not the other.

Kris · 16 December 2010

Well, if you must know I do various things in science, mostly involving Paleontology, and Lepidoptera.

I really can't avoid most of the problems since most scientists won't listen to anything that might improve the status quo. They get angry and defensive when problems are pointed out and potentially helpful suggestions are made (not just by me). I have been dealing with it for a long time.

Some scientists would like to fix some of the problems but too many are entrenched in old, non-productive ways. In some cases it's the chaos and confusion that keeps them employed.

It's kind of like having a huge work crew but no one is in charge, or at least no one takes charge. The result? Chaos, waste, and confusion. You know, kind of like a typical government.

Have you ever noticed that religion is often called "organized religion"? Have you ever heard anyone call science 'organized science'? I haven't, and for good reason.

Think about this; throughout history many churches/religions have been very well organized. They have a hierarchy of people who hold certain positions of leadership within the church or religion and they answer to each other a lot like managerial employees do in a large company.

I'm sure you've heard of the "Salvation Army", and the words, "Onward Christian soldiers", and "Holy Wars", and other such things that imply organization and a common cause. Yeah, I know, religions and churches are often at war with each other but some of them are still way more organized than science is. Maybe that's part of the reason they're so successful and science is so poorly known and accepted by the masses.

Yep, it's all my fault. Just thought I'd say that before I'm viciously attacked for pointing out some realities.

Something else to think about: if the 'scientific method' is allegedly so standardized and is truly accepted and practiced by scientists, then why do so many scientists fight with each other so often, including over the methods and standards they use?

I won't be a bit surprised if someone comes along (not necessarily here) and challenges the standards and methods used in the study that is the original subject of this thread, and they might even have some legitimate complaints. Time will tell.

Think of the recent Mono Lake arsenic study. Oh sure, it will be "self correcting", someday. What a lame argument.

harold · 16 December 2010

So even if we can agree on a definition of species, higher groups may still remain an artificial construct, regardless of degree of divergence or even phylogenetic relationships.
But it is also important to note that the nested hierarchy that we acknowledge when we apply taxonomic labels is real, even though the labels necessarily subdivide it at somewhat arbitrary points, and even though not every single lineage's relationship with every other lineage is known. The imaginary "ideal" molecular clock is a shared region of DNA, present in all lineages of interest, that does not have any coding, regulatory, or sequence-related structural function (note that such a region of DNA could not, thus, even exist in prokaryotes). The idea would be that mutations in such an allele would occur at the frequency of mutation rates, and not be selected against. Looking at the sequence of the allele in different lineages, the approximate time of divergence from a common allele could be estimated. Obviously - 1) No such perfect allele exists. 2) DNA repair rates, exposure to environmental mutagens, and possibly even other factors impacting underlying mutation frequencies, vary in different cell types and lineages. 3) Other types of molecular clocks can be and have been used. Having said all that, molecular clock studies have proved very useful, are in strong fundamental agreement with other types of studies, and continue to be refined.

Kris · 16 December 2010

harold said:
So even if we can agree on a definition of species, higher groups may still remain an artificial construct, regardless of degree of divergence or even phylogenetic relationships.
But it is also important to note that the nested hierarchy that we acknowledge when we apply taxonomic labels is real, even though the labels necessarily subdivide it at somewhat arbitrary points, and even though not every single lineage's relationship with every other lineage is known. The imaginary "ideal" molecular clock is a shared region of DNA, present in all lineages of interest, that does not have any coding, regulatory, or sequence-related structural function (note that such a region of DNA could not, thus, even exist in prokaryotes). The idea would be that mutations in such an allele would occur at the frequency of mutation rates, and not be selected against. Looking at the sequence of the allele in different lineages, the approximate time of divergence from a common allele could be estimated. Obviously - 1) No such perfect allele exists. 2) DNA repair rates, exposure to environmental mutagens, and possibly even other factors impacting underlying mutation frequencies, vary in different cell types and lineages. 3) Other types of molecular clocks can be and have been used. Having said all that, molecular clock studies have proved very useful, are in strong fundamental agreement with other types of studies, and continue to be refined.
And sometimes they are in strong fundamental disagreement with other types of studies.

harold · 16 December 2010

Kris -

If you can get everything right the first time, more power to you. You are indeed superior to scientists and to everyone who posts here. It must be frustrating that lesser beings refuse to acknowledge your glory, but hey, that's life.

The rest of us need feedback and corrections to get things right, and that is why science is grounded in peer review and ultimate self-correction.

The Mono Lake bacterial study is a perfect example of the power of the self-correcting nature of science.

A useful discovery was made (arsenic resistant bacterial lineage), mildly excessive scientific claims were made, and the media reported irresponsibly. But in the end, the useful discovery will be what remains.

harold · 16 December 2010

And sometimes they are in strong fundamental disagreement with other types of studies.
What is a very precise and specific example of this? Point one out so that we can discuss in detail.

eric · 16 December 2010

Kris said: Something else to think about: if the 'scientific method' is allegedly so standardized and is truly accepted and practiced by scientists, then why do so many scientists fight with each other so often, including over the methods and standards they use?
You are confusing method writ large with method writ small. When creationists attack the scientific method, they are attacking basic principles like the limitation of evidence to empirical observables. The concept of reproducibility and the scientific rule of thumb that says irreproducible and unconfirmable results will not be give much weight (if any). They are not talking about whether in last Tuesday's extraction Bob should've held the pipette at 90 degrees instead of 45 degrees. That is also a scientific methodology question. Scientists can argue about those sorts of details until the cows come home and there is no real significance to the scientific method writ large. You are falling for a classic creationist argument which claims that disagreements between scientists about how an experiment was performed somehow invalidates major scientific findings. This argument is bogus. Its bogus first because findings like evolution and so on are the result of enormous numbers of independent experiments reaching the same conclusion; no individual experiment wipes the slate clean. Its bogus second because they have no alternative method to put in its place. When (my example) Alice and Bob argue about pipettes, Alice is proposing an alternative methodology that we can test. When Behe (in reality) argues that science should allow for supernatural causes, he proposes no method at all for doing so. Nothing we can test. He wants to sneak divine revelation in without ever going through the process of determining whether science + revelation is better than science - revelation.

stevaroni · 16 December 2010

Kris said: I really can't avoid most of the problems since most scientists won't listen to anything that might improve the status quo.
Huh? You do realize that true fame in science comes not maintaining the status quo, but from upending it, and proving that the current explanation is wrong, or at least incomplete, don't you? After all, Copernicus and Galileo are famous for demonstrating that, contrary to common belief, the Earth did move and orbited the Sun. Newton is famous for upending two millenia of "classical" mechanics. Einstein if famous for demonstrating that Newton wasn't all that and a bag of chips. And, of course, Darwin is famous for making an, ahem, slightly controversial observation about the origins of man. The way forward in science is to disturb the status quo. That's how you get famous.

Science Avenger · 16 December 2010

Kris said: Maybe that's part of the reason [religions are] so successful and science is so poorly known and accepted by the masses.
Religion tells people what they mostly want to hear, especially that if they look deep within themselves, they can know the truth (without having to do any icky work). Simple and sweet. Science mostly tells people what they do not want to hear, especially that their intuitions aren't worth a pipette of spit compared to actual, testable, experimental data. Complicated and bitter. In a nutshell, that's why religion is more popular than science. OTOH, its these very same properties that make science far more successful in actually, you know, figuring stuff out, than is religion. That you'd focus on PR rather than substantive results puts you very much in the ID camp, so you'll have to forgive experienced readers of these forums from concluding that's where your sympathies lie, pun intended.

DS · 16 December 2010

Don't worry, Kris will no doubt provide examples where scientific studies disagree with creationist claims. He will then go on to claim that the studies were done specifically to destroy creationism, so science is really religion after all. That will prove how close minded those awful scientists are. What can you expect from an amateur butterfly collector?

Apparently he still hasn't read the paper and yet he has the audacity to whine about how others ignore the science. Perhaps he has simply failed to notice that this is a stunning example of where independent data sets agree. I wonder what explanation he has for that?

Steve needs to purge this thread again. If Kris were banished to the bathroom wall permanently we could give him the type of feedback he so richly deserves.

jkc · 16 December 2010

Kris said: Nothing in nature cares one iota what we humans call it. If we humans can't even agree on what the labels mean, how are we ever going to really figure out anything else, and agree on that too?
This is precisely why the theory of evolution is so attractive. If life presented us with nice neat categories and easy definitions we might be inclined to conclude that everything was create a few thousand years ago according to those categories and had changed little since then. Since, in fact, life is not neat and clean, but rather, full of overlap and discontinuity (among many other evidences), we conclude that life has been changing for millions of years. The fact that science cannot neatly categorize all of life is more a function of the complexity of life than it is the fallibility of science. Oh, and if you have a better idea, let's hear it...

Stanton · 16 December 2010

John Harshman said:
Stanton said: If D. melanogaster and D. virilis are molecularly clocked as being as distant as humans are to lizards, would that quality alone, merit splitting the Drosophila subgenera (Sophophora, D. Drosophila spp, etc) into separate, distinct genera?
No, because a genus, like any other taxonomic rank, has no actual meaning. You could call the same clade a genus, a family, or even a phylum depending on your personal taste. Now, there have been occasional proposals to give ranks a real meaning. Charles Sibley proposed to do it based on genetic distance values, as you seem to imply. John Avise (and others before him) proposed to do it based on time of origin, which is not quite the same thing given that different genomes can evolve at different rates (not to mention different parts of the same genome). So far, though, none of these attempts has been popular, probably because they just aren't practical -- we don't have the necessary data to make the determinations in most cases -- and because if applied across a wide taxonomic scope it would require massive re-assignment of ranks. As with the case you raise: either Drosophila becomes a class (or higher), or Amniota becomes a genus. Neither of these is likely to be accepted.
Actually, I'm expressing curiosity over the implications this paper has on the current taxonomy of Drosophila, I was wondering whether or not it would be split up into different genera as a result. Do recall that while the term "genus," along with the rest of taxonomy, is a human construct, taxonomic terms were constructed to help people understand the degrees of related-ness between all organisms. Plus, then there is the fact that the taxonomy of Drosophila is a tangled, contentious affair, and I want to see the hopefully profound affect this paper will have on this situation.

Flint · 16 December 2010

Religion tells people what they mostly want to hear...In a nutshell, that’s why religion is more popular than science.

I suggest this is only part of the story. Religion offers Absolute Truths, and the best science can do is offer conditional, tentative, probabilistic statements. One of the most common religious critiques of science revolves around this issue. Scientific "truths" are not guaranteed, they don't hold still, they are generally wrong or incomplete, scientific theories must be in principle subject to change at any time. Even when science self-corrects, it doesn't replace Wrong with Right, but rather replaces a little more wrong with a little less wrong. What organized religions are organized around is arbitrary tenets of doctrine DEFINED to be Absolute Truth, not subject to change no matter what new evidence should turn up. Scientists squabble with one another because in their territory, "probably correct" is (at least at the cutting edge of research) NOT known. Science is forever, inherently, necessarily a group of blind men examining an elephant. The elephant-examination methodology can make a critical difference ONLY when the whole elephant is unknown to anyone. If all of the blind men agreed on a single methodology, the wall-like (or tree-liie, or rope-like) nature of the whole elephant would become Absolute Truth, which would warm the hearts of the religious but unfortunately not describe the elephant very well.

eric · 16 December 2010

Flint said: I suggest this is only part of the story. Religion offers Absolute Truths, and the best science can do is offer conditional, tentative, probabilistic statements. One of the most common religious critiques of science revolves around this issue. Scientific "truths" are not guaranteed, they don't hold still, they are generally wrong or incomplete, scientific theories must be in principle subject to change at any time. Even when science self-corrects, it doesn't replace Wrong with Right, but rather replaces a little more wrong with a little less wrong.
I tend to agree. People hate loose ends. Given the choice between a useful explanation with a lot of loose ends and a less useful explanation with fewer loose ends, some folks with gravitate towards the latter out of an almost aesthetic desire for completeness. This is not just a religious thing; people have the same preference for pat, complete solutions in public policy. What do you think is better: a policy that sets a specific emission standard for a facility based on what we know about the environmental impact of that facility, or a policy which says every time you upgrade, you have to replace your old crap with the most efficient current technology available? Seems like the first policy should be better, right? Wrong. It turns out to be less effective at reducing pollution (at least in the U.S. from the 1970s to today). IIRC (I studied this a long time ago), the second policy is not just a little better, its dramatically better at reducing pollution. Even knowing that, however, part of my mind says the first policy is preferrable because a specified limit and specified penalties etc... is better than a fairly vague command to keep improving your equipment. There's something about a loose end that is just unappealing, even when it works.

harold · 16 December 2010

Although some individual religions offer claims of absolute truth and rules for every aspect of life, taken together, a collection of untestable and contradictory claims of "absolute truth" is the result. In short, even if you think that one "absolute truth" based religion is true, you still have to randomly pick the right one. So the "absoluteness" is illusionary. At best your chances are as absolute as a lottery ticket. (My subjectively belief is that there is absolutely no risk of going to hell after you die no matter what you do, but that's another matter.)

This is much less of a problem for religions that are more ecumenical and more grounded in the idea of universal ethical standards.

Although science deals only with measurement and description of the physical world, and does not claim absolute truth (which is not the same thing as saying that it does not claim that some things are well-established), the result of scientific activity is an ever-expanding understanding of the physical world, and a high degree of consensus about many things.

Flint · 16 December 2010

Although some individual religions offer claims of absolute truth and rules for every aspect of life, taken together, a collection of untestable and contradictory claims of “absolute truth” is the result.

Once again, you can be certain or you can be probably correct, but you can't be both. People want clear answers. The human mind, as eric implies, is a dichotomizing engine. It divides the world into two classes - those who divide the world into two classes, and those who don't! And science, falling into the second group, is very much in the minority. The absoluteness of religious belief is not illusory at all. What is believed in may be an illusion, but the belief itself is fixed. Science has faith that the universe is consistent, and that scientific disputes can ALWAYS be resolved by appropriately focused research. Conversely, the religious live in an arbitrary and capricious world made understandable only through the absolute guarantees of the right god (the god of one's parents, 98% of the time). Disputes are "resolved" by schism.

Henry J · 16 December 2010

Science has faith that the universe is consistent, and that scientific disputes can ALWAYS be resolved by appropriately focused research.

IMO it's not so much that scientists have faith that everything is resolvable, but that when things that can be resolved using evidence, that resolution is a better bet than the resolution obtained by somebody just making something up. (On a side note, IMO instead of saying "science has faith ..." it might be more accurate to say "the people involved in science have faith ...".)

harold · 16 December 2010

Flint -

Since we mainly agree on things, I won't belabor the point, but I will make one more comment.

I can't read the minds of religious people, nor of anyone else.

There is kind of a fashion on the internet of insisting that the religious are brainwashed automatons who are convinced of some arbitrary "absolute truth", in a way so hard-wired and unchangeable as to resemble the fly-snapping neural circuitry of a frog.

The appeal of this claim is obvious. It allows a strong sense of superiority, while simultaneously declaring creationists to be innocent of machinations, thus avoiding the awkwardness of confronting potentially ugly underlying motivations.

I personally think this oversimplifies.

I think many religious behaviors are beneficial to those who choose them (although they aren't what I choose) and harmless to others, and are emotional in nature. Singing inspiring songs in church, praying in symbolic empathy with those who face some hardship, and so on. However, these behaviors ultimately rely on the idea of an invisible friend, who may or may not be able to affect things here on earth, but who is infinitely sympathetic and trustworthy. Science denial isn't really necessary. Certainly that's the kind of religion I was raised with. My grandparents went to Baptist church on every possible occasion, and would have gone more often if it had been possible (which, mercifully, it was not). The emphasis was almost entirely on what a wonderful, kind man Jesus was, how people mistreated him but know better now, how much Jesus cares whenever people or warm-blooded animals that aren't raised for food are suffering, and in general, how much better he is than everyone else but how much he likes us anyway, and what a good idea it is to try to be more like him. Which it generally was, as he was presented as being compassionate, honest, forgiving, intelligent, perceptive, tolerant, standing up for the underdog, making bad people decide to be good, etc. This was not a "liberal" church except by decadent post-modern standards that label any criticism of infantile narcissistic self-indulgence as "liberal"; it was deservedly considered very strict and austere by other denominations.

Another type of "religious behavior", which is not mutually exclusive, is to identify with a group or political movement and adopt religious views associated with that group or ideology, partly for group identity and partly as a defense against ethical criticisms ("since Gawd sed to kill teh gayz it must be moral to discriminate against them"). This can be done somewhat sincerely, grossly insincerely (Tom Tancredo, Bobby Jindal, Ann Coulter), or in a manner indicating a profoundly disturbed psyche (Christine O'Donnell). I'm sorry for mentioning politicians, but they make such great examples. Plenty of repulsive politicians have been communist or ostentatiously, hypocritically "liberal", let's not side track any further than the side track we're already on.

Yet another type is to attempt to indulge authoritarian fantasies up by self-identifying as the "one true prophet". Examples of this abound, and are often associated with violent events.

While it's true that people are unlikely to easily give up these reinforcing behaviors easily, many creationists would switch in a flash. Tom Tancredo probably "converted" from Catholicism to creationism because the Pope is only hard core right wing on issues that have something to do with sex, and can be outright "progressive" on issues like war, torture, death penalty, health care, programs for the needy, etc. Meanwhile, you can find a Protestant clergyman who is right wing on every issue (or "progressive" on every issue), so Tancredo presumably found someone whose God coincidentally commands exactly what you need to support to get elected in some designer-forsaken gated community and "converted".

A lot of the other creationists, from the trolls here on up, are just wanna-be authoritarian rulers or the like, and their sincerity is about as deep as I perceive that of some of those I have mentioned here to be.

Flint · 16 December 2010

harold, Yes, I'm aware that religious experience encompasses a wide and rich territory in direction as well as degree. Generalizations about Believers are much like generalizations about scientists. Yet even within the generalization, the evident need for absolutes, for clear bright universal lines between right and wrong, the comfort in certainty, etc. seem pretty applicable across the board. The criticism strikes me as sincerely felt, that science is unreliable because it "keeps changing its mind" in contrast with the Rock of Ages. I don't try to read minds, but I do try to find consistent patterns in the statements made. I think this is possible, despite the recognition that creationists are, like any large group of people, made up of introverts and extroverts, leaders and followers, sincere and dishonest, seeking power and allergic to power. And that, being people, they will steer their faith in support of personal comfort and goals. I doubt there are many statements one can make about any large group of people, that applies fully to all of them. For all I know, there are creationists who sincerely doubt that their imaginary friend is any more than imaginary. But I haven't seen any of them actually write this.

(On a side note, IMO instead of saying “science has faith …” it might be more accurate to say “the people involved in science have faith …”.)

Well, I meant what I wrote, but I could have phrased it differently. Maybe we can say that science operates on certain axioms, accepted as true without test. And one of those axioms is that all scientific disputes are in principle capable of being resolved, even if the means of conducting the necessary tests may be forever beyond our capabilities.

Kris · 16 December 2010

DS said: Robin, The concept of a molecular clock refers to the observation that there is a relatively constant rate of mutation for certain parts of certain genes for certain periods of time in certain groups of organisms. This can be determined by calibrating the times of divergence using the fossil record. For example, the rate of amino acid replacements in vertebrates can be shown to be relatively constant for hundreds of millions of years. So, if we can calibrate the clock, we can estimate divergence times based on genetic divergence. However, you are correct. Things are usually a lot messier than this. that is why there are so many restrictions and qualifiers required. For example, the calibration used for vertebrates cannot be used for insects and the clock ticks at different rates for mitochondrial DNA than for nuclear genes and for different rates for different mitochondrial genes. So yes, things can get very messy. Still, the mitochondrial COI gene has proven to be extraordinarily useful for many different groups. Thus it is currently the basis of the Barcode of Life project. However, the various taxonomic ranks are still somewhat arbitrary, due to rate heterogeneity in different groups. So even if we can agree on a definition of species, higher groups may still remain an artificial construct, regardless of degree of divergence or even phylogenetic relationships.
On the usefulness (or lack thereof) of mitochondrial DNA: http://en.wikipedia.org/wiki/DNA_barcoding Yep, very messy.

Kris · 16 December 2010

stevaroni said:
Kris said: I really can't avoid most of the problems since most scientists won't listen to anything that might improve the status quo.
Huh? You do realize that true fame in science comes not maintaining the status quo, but from upending it, and proving that the current explanation is wrong, or at least incomplete, don't you? After all, Copernicus and Galileo are famous for demonstrating that, contrary to common belief, the Earth did move and orbited the Sun. Newton is famous for upending two millenia of "classical" mechanics. Einstein if famous for demonstrating that Newton wasn't all that and a bag of chips. And, of course, Darwin is famous for making an, ahem, slightly controversial observation about the origins of man. The way forward in science is to disturb the status quo. That's how you get famous.
So then, you're saying that scientists are or should be motivated by a desire for fame? I would say that some scientists are motivated by that but some just want to stay employed (or keep the grant money coming in). Either can cause a scientist to accept or rebuke any criticisms of, or proposed changes to, the status quo. Their status quo. Was Darwin's work really about the "origins of man"?

Kris · 16 December 2010

Robin said:
Stanton said: If D. melanogaster and D. virilis are molecularly clocked as being as distant as humans are to lizards, would that quality alone, merit splitting the Drosophila subgenera (Sophophora, D. Drosophila spp, etc) into separate, distinct genera?
Actually, this was what I was wondering as well. I don't really know what molecular clocking is, so I have no feel for the practicality or validity of use such as a marker. It strikes me though that counting...say...the number of changes that have occurred between two species wouldn't necessarily correlate meaningfully to the number of changes between two other species. I understand evolution (as a process), and nature in general, to be more dynamic and irregular than that. For instance, I would expect (though I've not done any research on this personally) that some biological/behavioral characteristics in some species would manifest after but a few changes while other biological/behavior characteristics would only manifest after many varied changes in certain species. It think that a fair amount in terms of measuring change and determining genus level differentiation, as it were, would depend both on the species itself and the environment that species was in/pioneering into.
Good points.

Kris · 17 December 2010

DS said: Robin, The concept of a molecular clock refers to the observation that there is a relatively constant rate of mutation for certain parts of certain genes for certain periods of time in certain groups of organisms. This can be determined by calibrating the times of divergence using the fossil record. For example, the rate of amino acid replacements in vertebrates can be shown to be relatively constant for hundreds of millions of years. So, if we can calibrate the clock, we can estimate divergence times based on genetic divergence. However, you are correct. Things are usually a lot messier than this. that is why there are so many restrictions and qualifiers required. For example, the calibration used for vertebrates cannot be used for insects and the clock ticks at different rates for mitochondrial DNA than for nuclear genes and for different rates for different mitochondrial genes. So yes, things can get very messy. Still, the mitochondrial COI gene has proven to be extraordinarily useful for many different groups. Thus it is currently the basis of the Barcode of Life project. However, the various taxonomic ranks are still somewhat arbitrary, due to rate heterogeneity in different groups. So even if we can agree on a definition of species, higher groups may still remain an artificial construct, regardless of degree of divergence or even phylogenetic relationships.
Are you saying that the rate of amino acid replacements in vertebrates can be shown to be relatively constant for hundreds of millions of years by using the fossil record? Yeah, if only we could agree on a definition of "species". This seems to be the appropriate time to insert this (form another thread): Stuart Weinstein replied to comment from darwinism.dogbarf() December 16, 2010 2:45 PM darwinism.dogbarf() said: "None of those essays explains how complex specified information rises in a cognitively isloated system." Stuart Weinstein said: "To do that we require the formula to compute what the complex specified information is.You can’t explain something if you can’t define it. “Complex specification” is the Zen of ID theory. IDists can’t explain it, but they know what is. If you’re punking us, very well done. “cognitively isolated”. Unfortunately ID proponents suffer cognitive disbaility." Notice this sentence: "You can’t explain something if you can’t define it." Seems to me that that applies (or at least should) to ID/creationism AND science.

Kris · 17 December 2010

Kris said:
DS said: Robin, The concept of a molecular clock refers to the observation that there is a relatively constant rate of mutation for certain parts of certain genes for certain periods of time in certain groups of organisms. This can be determined by calibrating the times of divergence using the fossil record. For example, the rate of amino acid replacements in vertebrates can be shown to be relatively constant for hundreds of millions of years. So, if we can calibrate the clock, we can estimate divergence times based on genetic divergence. However, you are correct. Things are usually a lot messier than this. that is why there are so many restrictions and qualifiers required. For example, the calibration used for vertebrates cannot be used for insects and the clock ticks at different rates for mitochondrial DNA than for nuclear genes and for different rates for different mitochondrial genes. So yes, things can get very messy. Still, the mitochondrial COI gene has proven to be extraordinarily useful for many different groups. Thus it is currently the basis of the Barcode of Life project. However, the various taxonomic ranks are still somewhat arbitrary, due to rate heterogeneity in different groups. So even if we can agree on a definition of species, higher groups may still remain an artificial construct, regardless of degree of divergence or even phylogenetic relationships.
Are you saying that the rate of amino acid replacements in vertebrates can be shown to be relatively constant for hundreds of millions of years by using the fossil record? Yeah, if only we could agree on a definition of "species". This seems to be the appropriate time to insert this (form another thread): Stuart Weinstein replied to comment from darwinism.dogbarf() December 16, 2010 2:45 PM darwinism.dogbarf() said: "None of those essays explains how complex specified information rises in a cognitively isloated system." Stuart Weinstein said: "To do that we require the formula to compute what the complex specified information is.You can’t explain something if you can’t define it. “Complex specification” is the Zen of ID theory. IDists can’t explain it, but they know what is. If you’re punking us, very well done. “cognitively isolated”. Unfortunately ID proponents suffer cognitive disbaility." Notice this sentence: "You can’t explain something if you can’t define it." Seems to me that that applies (or at least should) to ID/creationism AND science.
That's supposed to be 'from' another thread.

Kris · 17 December 2010

eric said:
Kris said: Something else to think about: if the 'scientific method' is allegedly so standardized and is truly accepted and practiced by scientists, then why do so many scientists fight with each other so often, including over the methods and standards they use?
You are confusing method writ large with method writ small. When creationists attack the scientific method, they are attacking basic principles like the limitation of evidence to empirical observables. The concept of reproducibility and the scientific rule of thumb that says irreproducible and unconfirmable results will not be give much weight (if any). They are not talking about whether in last Tuesday's extraction Bob should've held the pipette at 90 degrees instead of 45 degrees. That is also a scientific methodology question. Scientists can argue about those sorts of details until the cows come home and there is no real significance to the scientific method writ large. You are falling for a classic creationist argument which claims that disagreements between scientists about how an experiment was performed somehow invalidates major scientific findings. This argument is bogus. Its bogus first because findings like evolution and so on are the result of enormous numbers of independent experiments reaching the same conclusion; no individual experiment wipes the slate clean. Its bogus second because they have no alternative method to put in its place. When (my example) Alice and Bob argue about pipettes, Alice is proposing an alternative methodology that we can test. When Behe (in reality) argues that science should allow for supernatural causes, he proposes no method at all for doing so. Nothing we can test. He wants to sneak divine revelation in without ever going through the process of determining whether science + revelation is better than science - revelation.
I'm not falling for any creationist argument. I'm not Behe or any other creationist. When considering, claiming, or referring to the 'scientific method', the scientific methods should be standardized (as much as possible) if scientists want anyone else to take 'scientific method' seriously. The standards and/or methods scientists use is foundational to the 'scientific method'. Of course different people have different ways of defining standards, methods, and the 'scientific method', but that's one of the problems in science. There are too many 'personal tastes', even with some of the most basic things. Obviously, many scientists (and most people here whether scientists or not) expect ID/creationists to use very strict standards and methods to support or prove their claims. I don't think it's unreasonable to expect the same from scientists. I am not a creationist, but I am also not a blind follower of science. I actually expect more from scientists than from non-scientific, religion pushing ID/creationists. Religion is a matter of faithful belief, whereas science says it's based on verifiable, reproducible, material evidence. Religious beliefs really don't need material support or proof since they're not material. Science, on the other hand, does need material support or proof of its claims, if it wants to be taken seriously. If any claim by science is based on non-standardized methods, or variable standards, don't be too surprised when people are reluctant to accept those claims. I think you'd find that the average person will usually accept claims by science that have strong evidence in their favor AND fit into how that person perceives strong evidence. If a scientist says that a cement sidewalk is 'hard', the average person will agree and quickly accept it. But, if a scientist says that studies of mitochondrial DNA help prove evolutionary theory, the average person (and other scientists) may not be so quick to agree and accept it, especially if that person (or scientist) has studied some or all of the standards and/or methods used by the scientists making the claim, and finds them questionable or faulty. (Think arsenic/bacteria for example, in regard to methods/standards.) There are many scientific studies that contradict each other, even though the same things were studied and allegedly with the same methods and/or standards. There are also many scientific studies that contradict each other simply because they didn't use the same standards and/or methods, yet each study claims to have used accepted or proven methods and/or standards, and of course each scientist or team of scientists vouches for the quality and veracity of their study. It's hard enough to figure out nature without disagreeing or fighting about the standards and/or methods used to do so. I want to add that I don't think that all standards and/or methods used in science are inconsistent, debatable, or unreliable, but some are.

Kris · 17 December 2010

DS said: Don't worry, Kris will no doubt provide examples where scientific studies disagree with creationist claims. He will then go on to claim that the studies were done specifically to destroy creationism, so science is really religion after all. That will prove how close minded those awful scientists are. What can you expect from an amateur butterfly collector? Apparently he still hasn't read the paper and yet he has the audacity to whine about how others ignore the science. Perhaps he has simply failed to notice that this is a stunning example of where independent data sets agree. I wonder what explanation he has for that? Steve needs to purge this thread again. If Kris were banished to the bathroom wall permanently we could give him the type of feedback he so richly deserves.
I didn't start the crap that has nothing to do with the original topic, so if anything should be purged, or anyone sent to the BW, it should be the off topic comments and the people making them.

Kris · 17 December 2010

jkc said:
Kris said: Nothing in nature cares one iota what we humans call it. If we humans can't even agree on what the labels mean, how are we ever going to really figure out anything else, and agree on that too?
This is precisely why the theory of evolution is so attractive. If life presented us with nice neat categories and easy definitions we might be inclined to conclude that everything was create a few thousand years ago according to those categories and had changed little since then. Since, in fact, life is not neat and clean, but rather, full of overlap and discontinuity (among many other evidences), we conclude that life has been changing for millions of years. The fact that science cannot neatly categorize all of life is more a function of the complexity of life than it is the fallibility of science. Oh, and if you have a better idea, let's hear it...
I don't have any problem with the complexity of life. In fact, I'm glad it's complex. I'll always have something new to observe and learn. One of my complaints though, is that science claims to be able to "neatly categorize all of life" (or at least strongly comes across that way) but makes a pretty big mess of it. A possible example of something I'd like to see adopted by 'science' just popped into my head but I'm going to put more thought into it before presenting it.

Kris · 17 December 2010

harold said: Flint - Since we mainly agree on things, I won't belabor the point, but I will make one more comment. I can't read the minds of religious people, nor of anyone else. There is kind of a fashion on the internet of insisting that the religious are brainwashed automatons who are convinced of some arbitrary "absolute truth", in a way so hard-wired and unchangeable as to resemble the fly-snapping neural circuitry of a frog. The appeal of this claim is obvious. It allows a strong sense of superiority, while simultaneously declaring creationists to be innocent of machinations, thus avoiding the awkwardness of confronting potentially ugly underlying motivations. I personally think this oversimplifies. I think many religious behaviors are beneficial to those who choose them (although they aren't what I choose) and harmless to others, and are emotional in nature. Singing inspiring songs in church, praying in symbolic empathy with those who face some hardship, and so on. However, these behaviors ultimately rely on the idea of an invisible friend, who may or may not be able to affect things here on earth, but who is infinitely sympathetic and trustworthy. Science denial isn't really necessary. Certainly that's the kind of religion I was raised with. My grandparents went to Baptist church on every possible occasion, and would have gone more often if it had been possible (which, mercifully, it was not). The emphasis was almost entirely on what a wonderful, kind man Jesus was, how people mistreated him but know better now, how much Jesus cares whenever people or warm-blooded animals that aren't raised for food are suffering, and in general, how much better he is than everyone else but how much he likes us anyway, and what a good idea it is to try to be more like him. Which it generally was, as he was presented as being compassionate, honest, forgiving, intelligent, perceptive, tolerant, standing up for the underdog, making bad people decide to be good, etc. This was not a "liberal" church except by decadent post-modern standards that label any criticism of infantile narcissistic self-indulgence as "liberal"; it was deservedly considered very strict and austere by other denominations. Another type of "religious behavior", which is not mutually exclusive, is to identify with a group or political movement and adopt religious views associated with that group or ideology, partly for group identity and partly as a defense against ethical criticisms ("since Gawd sed to kill teh gayz it must be moral to discriminate against them"). This can be done somewhat sincerely, grossly insincerely (Tom Tancredo, Bobby Jindal, Ann Coulter), or in a manner indicating a profoundly disturbed psyche (Christine O'Donnell). I'm sorry for mentioning politicians, but they make such great examples. Plenty of repulsive politicians have been communist or ostentatiously, hypocritically "liberal", let's not side track any further than the side track we're already on. Yet another type is to attempt to indulge authoritarian fantasies up by self-identifying as the "one true prophet". Examples of this abound, and are often associated with violent events. While it's true that people are unlikely to easily give up these reinforcing behaviors easily, many creationists would switch in a flash. Tom Tancredo probably "converted" from Catholicism to creationism because the Pope is only hard core right wing on issues that have something to do with sex, and can be outright "progressive" on issues like war, torture, death penalty, health care, programs for the needy, etc. Meanwhile, you can find a Protestant clergyman who is right wing on every issue (or "progressive" on every issue), so Tancredo presumably found someone whose God coincidentally commands exactly what you need to support to get elected in some designer-forsaken gated community and "converted". A lot of the other creationists, from the trolls here on up, are just wanna-be authoritarian rulers or the like, and their sincerity is about as deep as I perceive that of some of those I have mentioned here to be.
I'm not necessarily agreeing or disagreeing with this but you may find it interesting: http://www.sciencedaily.com/releases/2010/12/101207091802.htm

Kris · 17 December 2010

Here's something else you all may find interesting:

http://www.sciencedaily.com/releases/2010/12/101216142523.htm

Stuart Weinstein · 17 December 2010

Kris said:
John Harshman said:
Stanton said: If D. melanogaster and D. virilis are molecularly clocked as being as distant as humans are to lizards, would that quality alone, merit splitting the Drosophila subgenera (Sophophora, D. Drosophila spp, etc) into separate, distinct genera?
No, because a genus, like any other taxonomic rank, has no actual meaning. You could call the same clade a genus, a family, or even a phylum depending on your personal taste. Now, there have been occasional proposals to give ranks a real meaning. Charles Sibley proposed to do it based on genetic distance values, as you seem to imply. John Avise (and others before him) proposed to do it based on time of origin, which is not quite the same thing given that different genomes can evolve at different rates (not to mention different parts of the same genome). So far, though, none of these attempts has been popular, probably because they just aren't practical -- we don't have the necessary data to make the determinations in most cases -- and because if applied across a wide taxonomic scope it would require massive re-assignment of ranks. As with the case you raise: either Drosophila becomes a class (or higher), or Amniota becomes a genus. Neither of these is likely to be accepted.
That's just one of the problems with science. Personal tastes have way too much to do with the way things are even named/labeled, let alone with how those things may be related to each other, or how they originated, or interact with their environment, etc., etc., etc. E.g., how many definitions of the word "species" are there? Yeah. Nothing in nature cares one iota what we humans call it. If we humans can't even agree on what the labels mean, how are we ever going to really figure out anything else, and agree on that too?
Unfortunately nature doesn't always oblige us by putting objects into nice neat categories. Its not a problem of Science, but a problem for Science. Putting things into categories and understanding patterns is how humans come to understand the world. Similar problem in geology is characterizing rocks. You harp on the disagreement above, but ignore the thousands of points of agreement that exist. Isn't it past your bed time?

Stuart Weinstein · 17 December 2010

Kris said:
stevaroni said:
Kris said: I really can't avoid most of the problems since most scientists won't listen to anything that might improve the status quo.
Huh? You do realize that true fame in science comes not maintaining the status quo, but from upending it, and proving that the current explanation is wrong, or at least incomplete, don't you? After all, Copernicus and Galileo are famous for demonstrating that, contrary to common belief, the Earth did move and orbited the Sun. Newton is famous for upending two millenia of "classical" mechanics. Einstein if famous for demonstrating that Newton wasn't all that and a bag of chips. And, of course, Darwin is famous for making an, ahem, slightly controversial observation about the origins of man. The way forward in science is to disturb the status quo. That's how you get famous.
So then, you're saying that scientists are or should be motivated by a desire for fame?
No. He's pointing out that your claim that scientists don't want to upset the *status quo* is stupid. For if that were the case, momentous discoveries would never happen or be acknowledged. Science is about challenging the status quo. That is why tests upon tests have been performed on fundamental theory like Quantum Mechanics or GR. Even though QM has in some cases been tested to a precision of one part in a billion billions, new and more precise experiments will be done in the future. Why? cuz any deviation from theory would be important. If science was overly concerned with status quo, such research would have ended decades ago.
I would say that some scientists are motivated by that but some just want to stay employed (or keep the grant money coming in).
You have completely missed the point.
Either can cause a scientist to accept or rebuke any criticisms of, or proposed changes to, the status quo. Their status quo. Was Darwin's work really about the "origins of man"?
You are familiar with Darwin's work, "Descent of Man"? Isn't it past your bed time?

Kris · 17 December 2010

Stuart Weinstein said:
Kris said:
John Harshman said:
Stanton said: If D. melanogaster and D. virilis are molecularly clocked as being as distant as humans are to lizards, would that quality alone, merit splitting the Drosophila subgenera (Sophophora, D. Drosophila spp, etc) into separate, distinct genera?
No, because a genus, like any other taxonomic rank, has no actual meaning. You could call the same clade a genus, a family, or even a phylum depending on your personal taste. Now, there have been occasional proposals to give ranks a real meaning. Charles Sibley proposed to do it based on genetic distance values, as you seem to imply. John Avise (and others before him) proposed to do it based on time of origin, which is not quite the same thing given that different genomes can evolve at different rates (not to mention different parts of the same genome). So far, though, none of these attempts has been popular, probably because they just aren't practical -- we don't have the necessary data to make the determinations in most cases -- and because if applied across a wide taxonomic scope it would require massive re-assignment of ranks. As with the case you raise: either Drosophila becomes a class (or higher), or Amniota becomes a genus. Neither of these is likely to be accepted.
That's just one of the problems with science. Personal tastes have way too much to do with the way things are even named/labeled, let alone with how those things may be related to each other, or how they originated, or interact with their environment, etc., etc., etc. E.g., how many definitions of the word "species" are there? Yeah. Nothing in nature cares one iota what we humans call it. If we humans can't even agree on what the labels mean, how are we ever going to really figure out anything else, and agree on that too?
Unfortunately nature doesn't always oblige us by putting objects into nice neat categories. Its not a problem of Science, but a problem for Science. Putting things into categories and understanding patterns is how humans come to understand the world. Similar problem in geology is characterizing rocks. You harp on the disagreement above, but ignore the thousands of points of agreement that exist. Isn't it past your bed time?
I must say I'm surprised at you Stuart, well, maybe not all that much, based on what I've seen around here. I thought you might see how your statement about defining something applies (or at least should) to science as well as ID/creationism. I'll bet you regret ever making that statement now, because it can be reasonably held against you, or pretty much anyone else who expects ID/creationists to define something and instantly bashes them when they don't or won't do it to your satisfaction. Actually, I haven't and don't ignore the thousands of points of agreement that exist in science. I agree with many of those points but not just because others agree with them. The amount of people agreeing or disagreeing about something doesn't necessarily have an effect on me. If it did, I'd probably be religious. What if a creationist were to say that you ignore the points of agreement (whether thousands or otherwise) that exist between creationists? Would that change your mind about the veracity, reputation, and/or trustworthiness of the concept or practice of ID/creationism, either in whole or in part? I believe that science has proven many things and that it is WAY, WAY better than religion when it comes to explaining nature and generating useful information, but I also feel that science has some work to do to clean up its own act. Would any of you reading this like to define what a "species" is and exactly how it can be determined?

Robin · 17 December 2010

Kris said:
stevaroni said:
Kris said: I really can't avoid most of the problems since most scientists won't listen to anything that might improve the status quo.
Huh? You do realize that true fame in science comes not maintaining the status quo, but from upending it, and proving that the current explanation is wrong, or at least incomplete, don't you? After all, Copernicus and Galileo are famous for demonstrating that, contrary to common belief, the Earth did move and orbited the Sun. Newton is famous for upending two millenia of "classical" mechanics. Einstein if famous for demonstrating that Newton wasn't all that and a bag of chips. And, of course, Darwin is famous for making an, ahem, slightly controversial observation about the origins of man. The way forward in science is to disturb the status quo. That's how you get famous.
So then, you're saying that scientists are or should be motivated by a desire for fame?
No, I don't think he's saying that at all. The paragraph is pretty straight forward to me - great scientists - those society recognizes as being representative (famously so in these examples) of good science - went against the grain and broke boundaries. They didn't seek to go against the grain for the sake of disproving the boundaries (a la creationism), they just came up explanations that better fit the data, and were able to come up with more in depth and detailed evidence. Great scientists become famous *because* they provide better, more accurate answers.
Was Darwin's work really about the "origins of man"?
Not according to the evidence.

Kris · 17 December 2010

Stuart Weinstein said:
Kris said:
stevaroni said:
Kris said: I really can't avoid most of the problems since most scientists won't listen to anything that might improve the status quo.
Huh? You do realize that true fame in science comes not maintaining the status quo, but from upending it, and proving that the current explanation is wrong, or at least incomplete, don't you? After all, Copernicus and Galileo are famous for demonstrating that, contrary to common belief, the Earth did move and orbited the Sun. Newton is famous for upending two millenia of "classical" mechanics. Einstein if famous for demonstrating that Newton wasn't all that and a bag of chips. And, of course, Darwin is famous for making an, ahem, slightly controversial observation about the origins of man. The way forward in science is to disturb the status quo. That's how you get famous.
So then, you're saying that scientists are or should be motivated by a desire for fame?
No. He's pointing out that your claim that scientists don't want to upset the *status quo* is stupid. For if that were the case, momentous discoveries would never happen or be acknowledged. Science is about challenging the status quo. That is why tests upon tests have been performed on fundamental theory like Quantum Mechanics or GR. Even though QM has in some cases been tested to a precision of one part in a billion billions, new and more precise experiments will be done in the future. Why? cuz any deviation from theory would be important. If science was overly concerned with status quo, such research would have ended decades ago.
I would say that some scientists are motivated by that but some just want to stay employed (or keep the grant money coming in).
You have completely missed the point.
Either can cause a scientist to accept or rebuke any criticisms of, or proposed changes to, the status quo. Their status quo. Was Darwin's work really about the "origins of man"?
You are familiar with Darwin's work, "Descent of Man"? Isn't it past your bed time?
I said: "I really can’t avoid most of the problems since most scientists won’t listen to anything that might improve the status quo." And: "Some scientists would like to fix some of the problems but too many are entrenched in old, non-productive ways." From the rest of that post it's pretty easy to tell that I was referring to the disorganization, inconsistencies, and disagreements in science, as they pertain to standards (including definitions), methods, and the so-called 'scientific method' when I said status quo, and it's also obvious that I didn't say or mean ALL scientists. I'm not complaining about scientists who use new or refined methods to find new information or to verify old information, unless it's redundant and wasteful. Something you guys seem to be oblivious to is that much, if not most of science is not done in laboratories with test tubes and electron microscopes, or with sophisticated satellites in space. In other words, a lot of science is done using rather crude methods and often even cruder, widely variable standards. And, a lot of science is done by people who have agendas or are inept and/or poorly educated or trained, no matter how fancy the gear is. There's also the fact that 'personal tastes' and/or entrenched, unproductive, selfish, antiquated thinking comes into play way too often when it comes to defining scientific terms, deciding on which methods and standards will be used, and the way results are viewed and reported. Even religious beliefs could be a factor. I'm not condemning all of science. Why are you guys so defensive? You act like a gung-ho, angry, religious zealot who just had someone tell him/her there's no such thing as God and that absolutely everything he/she ever believed in is false. Regarding the Descent of Man: I honestly didn't think of that book when I posed the question about Darwin's work. I could argue that Darwin didn't become famous because of his work on the descent of man (or origin of man) and that his fame is based on evolutionary theory as it applies to all organisms. However, I will just withdraw the question and will try to be more mindful.

SWT · 17 December 2010

Kris, you keep writing that science has "messes" and needs to "clean up its act."

What specific changes do you advocate?

eric · 17 December 2010

Kris said: When considering, claiming, or referring to the 'scientific method', the scientific methods should be standardized (as much as possible) if scientists want anyone else to take 'scientific method' seriously.
I don't get that at all. There are times when I may want to run experiments that can be directly compared to other people's experiments in all details. In these cases I may adopt their methods or they may adopt mine. However, I may also actively choose to use a different method to measure the same quantity. This is extremely valuable as a means of eliminating systemic errors. If there are no systemic errors, two entirely different methods should yield the same result (within their respective margins of error). Good scientists sometimes intentionally choose to use multiple methods to gather the same information because it helps you identify any biases in the methods used. So your thing about being taken seriously makes no sense to me. Moreover, using different methods may help you identify something you would've never discovered with any single method. Without GALLEX and Super Kamiokande yielding different results, we may not have discovered the oscillation of solar neutrinos.
Of course different people have different ways of defining standards, methods, and the 'scientific method', but that's one of the problems in science. There are too many 'personal tastes', even with some of the most basic things.
Its not a problem, its a feature. If I discover a new way of measuring X, I test it. Then I publish it. My peers read it. Someone else or several other people try it and publish their results and comments. Once the community has ironed out the wrinkles and is reasonably confident the method works, we now have two tools for measuing X where we used to have one. Or, in testing my alternative my peers discover a flaw I didn't see and the whole community puts it away as a lesson learned. While the former is preferrable, both results yield knowledge. Its only when I don't publish my method and it doesn' go through the vetting process that multiple methods become a detriment. That is what happens in pseudoscience. That is what Behe and Dembski do.
Obviously, many scientists (and most people here whether scientists or not) expect ID/creationists to use very strict standards and methods to support or prove their claims. I don't think it's unreasonable to expect the same from scientists.
I have herad no one make the argument you claim. It would be sufficient if Dembski published his definition of CSI and his method of calculating it. Heck, he can publish 8 different methods if he feels like it - we already have Shannon entropy and Kolmogorov complexity, a few more different attempts to define information are welcome as long as they are defined well enough to test and use. But the bottom line is he has published no such methods, no such definitions. Its not that he is not living up to some strict methodology, its that he refuses to meet even the most basic, taking-a-math-test form of showing one's work.

ben · 17 December 2010

SWT said: Kris, you keep writing that science has "messes" and needs to "clean up its act." What specific changes do you advocate?
Kris isn't here to advocate specific changes, Kris is here to cast as much aspersion as possible on science while pretending to value it. Note that although Kris has claimed to be a scientist, "science" and "scientists" are always referred to in 3rd person, and not a single example of anything has been offered from his/her own work or experience. Dishonest concern troll. Nothing to see here, move along.

Stuart Weinstein · 17 December 2010

Kris said:
Stuart Weinstein said:
Kris said:
John Harshman said:
Stanton said: If D. melanogaster and D. virilis are molecularly clocked as being as distant as humans are to lizards, would that quality alone, merit splitting the Drosophila subgenera (Sophophora, D. Drosophila spp, etc) into separate, distinct genera?
No, because a genus, like any other taxonomic rank, has no actual meaning. You could call the same clade a genus, a family, or even a phylum depending on your personal taste. Now, there have been occasional proposals to give ranks a real meaning. Charles Sibley proposed to do it based on genetic distance values, as you seem to imply. John Avise (and others before him) proposed to do it based on time of origin, which is not quite the same thing given that different genomes can evolve at different rates (not to mention different parts of the same genome). So far, though, none of these attempts has been popular, probably because they just aren't practical -- we don't have the necessary data to make the determinations in most cases -- and because if applied across a wide taxonomic scope it would require massive re-assignment of ranks. As with the case you raise: either Drosophila becomes a class (or higher), or Amniota becomes a genus. Neither of these is likely to be accepted.
That's just one of the problems with science. Personal tastes have way too much to do with the way things are even named/labeled, let alone with how those things may be related to each other, or how they originated, or interact with their environment, etc., etc., etc. E.g., how many definitions of the word "species" are there? Yeah. Nothing in nature cares one iota what we humans call it. If we humans can't even agree on what the labels mean, how are we ever going to really figure out anything else, and agree on that too?
Unfortunately nature doesn't always oblige us by putting objects into nice neat categories. Its not a problem of Science, but a problem for Science. Putting things into categories and understanding patterns is how humans come to understand the world. Similar problem in geology is characterizing rocks. You harp on the disagreement above, but ignore the thousands of points of agreement that exist. Isn't it past your bed time?
I must say I'm surprised at you Stuart, well, maybe not all that much, based on what I've seen around here. I thought you might see how your statement about defining something applies (or at least should) to science as well as ID/creationism. I'll bet you regret ever making that statement now, because it can be reasonably held against you, or pretty much anyone else who expects ID/creationists to define something and instantly bashes them when they don't or won't do it to your satisfaction.
Don't hold your breath. First off with respect to species, there are several definitions, each appropriate for different circumstances. The BSC concept for example, works well enough for species that use sexual reproduction. Not so well for Ameobas. However no IDist has ever given a formula to compute the CSI of anything. There, there, its your nappy time. And here's your bottle..

Robin · 17 December 2010

Kris said:
eric said:
Kris said: Something else to think about: if the 'scientific method' is allegedly so standardized and is truly accepted and practiced by scientists, then why do so many scientists fight with each other so often, including over the methods and standards they use?
You are confusing method writ large with method writ small. When creationists attack the scientific method, they are attacking basic principles like the limitation of evidence to empirical observables. The concept of reproducibility and the scientific rule of thumb that says irreproducible and unconfirmable results will not be give much weight (if any). They are not talking about whether in last Tuesday's extraction Bob should've held the pipette at 90 degrees instead of 45 degrees. That is also a scientific methodology question. Scientists can argue about those sorts of details until the cows come home and there is no real significance to the scientific method writ large. You are falling for a classic creationist argument which claims that disagreements between scientists about how an experiment was performed somehow invalidates major scientific findings. This argument is bogus. Its bogus first because findings like evolution and so on are the result of enormous numbers of independent experiments reaching the same conclusion; no individual experiment wipes the slate clean. Its bogus second because they have no alternative method to put in its place. When (my example) Alice and Bob argue about pipettes, Alice is proposing an alternative methodology that we can test. When Behe (in reality) argues that science should allow for supernatural causes, he proposes no method at all for doing so. Nothing we can test. He wants to sneak divine revelation in without ever going through the process of determining whether science + revelation is better than science - revelation.
When considering, claiming, or referring to the 'scientific method', the scientific methods should be standardized (as much as possible) if scientists want anyone else to take 'scientific method' seriously. The standards and/or methods scientists use is foundational to the 'scientific method'.
You are describing two different concepts here and seem to be implying that they are directly related to one another. As Eric noted above, the Scientific Method (e.g., observe phenomenon, come up with an hypothesis to explain the mechanics of the phenomenon, test the hypothesis, report findings, peer review findings, rinse and repeat) is not directly related to the standards of how thermometers are manufactured or incremented. Further, whether two or more scientists and researchers squabble over taxonomic vagaries, semantics, or minute similarities and differences has nothing to do with the Scientific Method. For example, whether groups of astronomers disagree on refining and narrowing the definition of "planet" such that Pluto no longer fits the category isn't an argument about the SM. Similarly, the disagreements on whether the species megalodon should fall under Carcharodon or Carcharocles is rather irrelevant to the SM.
Obviously, many scientists (and most people here whether scientists or not) expect ID/creationists to use very strict standards and methods to support or prove their claims. I don't think it's unreasonable to expect the same from scientists.
Well, we expect that if creationists are going to claim that ID/Creationism is science that they use the Scientific Method as described above. The fact that they don't makes the claim of science dubious at best. The fact that their explanations, analyses and calculation contain numerous errors and outright distortions is another matter entirely.
If any claim by science is based on non-standardized methods, or variable standards, don't be too surprised when people are reluctant to accept those claims.
Using the thread's subject research, is there something non-standard in the methodology used by Pavel Tomancak in his analysis of the divergence of Drosophila gene expression recapitulating the hour glass model? If not, can you cite an example of such on the bathroom wall where we can discuss such without derailing this thread entirely?
I think you'd find that the average person will usually accept claims by science that have strong evidence in their favor AND fit into how that person perceives strong evidence. If a scientist says that a cement sidewalk is 'hard', the average person will agree and quickly accept it. But, if a scientist says that studies of mitochondrial DNA help prove evolutionary theory, the average person (and other scientists) may not be so quick to agree and accept it, especially if that person (or scientist) has studied some or all of the standards and/or methods used by the scientists making the claim, and finds them questionable or faulty. (Think arsenic/bacteria for example, in regard to methods/standards.)
Since there was nothing wrong with the methodology used in the arsenic/bacteria research, I have really have no idea what your statement here is suppose to mean. Please explain the issues you have with the methodology used in the arsenic.bacteria research on the bathroom wall. I'd be interested in reading why you think it's a problem.
There are many scientific studies that contradict each other, even though the same things were studied and allegedly with the same methods and/or standards. There are also many scientific studies that contradict each other simply because they didn't use the same standards and/or methods, yet each study claims to have used accepted or proven methods and/or standards, and of course each scientist or team of scientists vouches for the quality and veracity of their study.
Making general or generic claims is worthless in any discussion, but particularly discussions of science. Please cite two or more specific examples of conflicting studies in science on the bathroom wall. I'll be happy to discuss them there, but it would be inappropriate to get into such here.

DS · 17 December 2010

Kris said:
DS said: Robin, The concept of a molecular clock refers to the observation that there is a relatively constant rate of mutation for certain parts of certain genes for certain periods of time in certain groups of organisms. This can be determined by calibrating the times of divergence using the fossil record. For example, the rate of amino acid replacements in vertebrates can be shown to be relatively constant for hundreds of millions of years. So, if we can calibrate the clock, we can estimate divergence times based on genetic divergence. However, you are correct. Things are usually a lot messier than this. that is why there are so many restrictions and qualifiers required. For example, the calibration used for vertebrates cannot be used for insects and the clock ticks at different rates for mitochondrial DNA than for nuclear genes and for different rates for different mitochondrial genes. So yes, things can get very messy. Still, the mitochondrial COI gene has proven to be extraordinarily useful for many different groups. Thus it is currently the basis of the Barcode of Life project. However, the various taxonomic ranks are still somewhat arbitrary, due to rate heterogeneity in different groups. So even if we can agree on a definition of species, higher groups may still remain an artificial construct, regardless of degree of divergence or even phylogenetic relationships.
Are you saying that the rate of amino acid replacements in vertebrates can be shown to be relatively constant for hundreds of millions of years by using the fossil record? Yeah, if only we could agree on a definition of "species".
Yes Kris, that is exactly what I am saying. The molecular clock is calibrated using the fossil record. If you were a real paleontologist instead of just some amateur hacker you would know that already. And the molecular clock does not depend on any definition of the term species. I already explained why. Apparently you were too stupid to understand it. Yes that was a personal attack. If you could understand the science it wouldn't be necessary, but apparently it is. If you don't like it go away and don't come back. As for mitochondrial DNA, once again you seem to be completely ignorant of an entire branch of science. Mitochondrial is one of the most useful and powerful tools used in evolutionary genetics and phylogenetics. It has been used to trace everything from human origins and migrations to the origin and relationships between the Arthropods and other phyla. It has been used very successfully on butterflies as well, so even an amateur collector should be familiar with it. Now if you can describe, in your own words, exactly what you think some of the problems are with mitochondrial DNA, rather than just some crap wiki site that you really don't understand, then maybe "someone" would care to discuss it with you in a vain attempt to educate you. Now dipstick, are you going to read the paper that is the subject of this thread or not? Can you even understand it, or are you just interested in whining about how those more qualified than you and how mean they are? YOu can piss and moan about the shortcomings of science until the cows come home and bite you on your ignorant ass, but unless you offer some concrete suggestions for improvement or some viable alternative you are just blowing smoke in the wind. This troll is obviously just trying to walk the fine line between actually discussing real science and being banished to the bathroom wall. I say it doesn't deserve the benefit of the doubt. It should be banished permanently. In fact, it probably already was under a different name.

Robin · 17 December 2010

eric said:
Kris said: When considering, claiming, or referring to the 'scientific method', the scientific methods should be standardized (as much as possible) if scientists want anyone else to take 'scientific method' seriously.
However, I may also actively choose to use a different method to measure the same quantity. This is extremely valuable as a means of eliminating systemic errors. If there are no systemic errors, two entirely different methods should yield the same result (within their respective margins of error). Good scientists sometimes intentionally choose to use multiple methods to gather the same information because it helps you identify any biases in the methods used. So your thing about being taken seriously makes no sense to me. Moreover, using different methods may help you identify something you would've never discovered with any single method. Without GALLEX and Super Kamiokande yielding different results, we may not have discovered the oscillation of solar neutrinos.
Here's an example, Eric. In a study I was involved in concerning passerine species dynamics, one of the methods we chose to use to analyze and understand eating, perching, singing, and interaction characteristics was to record flight times to the various habit zones (ponds and streams, orchards, fields, forests, etc) and across zone borders. Could we have measured distance? Yep...and many researchers do, but someone in our group came up with (what I think was rather a brilliant) notion that since distance doesn't necessarily mean the same thing to birds and humans, maybe their flight times would be more meaningful. Does our data vary from other research data? Yeah, but that doesn't make it any less useful.

DS · 17 December 2010

Of course every real scientist knows that the scientific method is "standardized" as much as it possible already. Now matter what the study question or the methods, the same important issues are always addressed in any good study:

1) Testable hypothesis

2) Good experimental design

3) Appropriate methods

4) Ability to be reproduced

5) Sufficient sample size

6) Appropriate analysis and statistical significance

7) Peer review

If "someone" has a problem with any particular scientific study. then"someone" can publish a rebuttal paper. Whining and moaning about things you don't understand isn't really going to help now is it?

Now if "someone" has any suggestions for improvement, then "someone" might take that other "someone" seriously. Until then, "someone" can piss off.

Robin · 17 December 2010

Kris said: I'm not condemning all of science. Why are you guys so defensive? You act like a gung-ho, angry, religious zealot who just had someone tell him/her there's no such thing as God and that absolutely everything he/she ever believed in is false.
I'll tell you why I've become so defensive when it comes to your posts: 1) With but infinitesimal exceptions, your posts have nothing to do with the subject thread. Go post on the bathroom wall. 2) Your posts are almost all vague, generalized complaints without any examples pertaining specifically to the complaints when you make them. 3) You equivocate rather regularly, making your claims fallacious and irrelevant. Your complaint about the inconsistency of scientific methodology (vs the Scientific Method) comes to mind here. 4) You make a number of complaints that are irrelevant or "no duh". Your complaint that science and scientists make mistakes or are sometimes greedy or selfish comes to mind here. Why should this be surprising to anyone or relevant to any discussion? 5) You make a number of complaints against strawmen or claims nobody has ever made. Your complaint about science claiming or implying that it will “neatly categorize all of life” comes to mind. When has anyone in science implied such? 6) You refuse to explain a point or elaborate with detail when asked. The rather consistent questions regarding your insistence that the Mono Lake research and the Ivory-billed Woodpecker investigations were somehow a black mark on the science (contrary to actual evidence in science) come to mind here. 7) Your insistence on deflating scientific analyses while inflating ID claims and actually comparing them at all when they are but apples and oranges. Your numerous claims comparing scientific output with creationist output comes to mind. To be more specific, here's a great example:
Kris: Actually, I haven’t and don’t ignore the thousands of points of agreement that exist in science. I agree with many of those points but not just because others agree with them. The amount of people agreeing or disagreeing about something doesn’t necessarily have an effect on me. If it did, I’d probably be religious. What if a creationist were to say that you ignore the points of agreement (whether thousands or otherwise) that exist between creationists? Would that change your mind about the veracity, reputation, and/or trustworthiness of the concept or practice of ID/creationism, either in whole or in part?
Creationists don't have "a thousand points of agreement" that science does, so there's no comparison. In fact, creationists have done nothing scientific at all, so the point is actually moot - it's comparing apples and oranges. You harp on scientific disagreements while ignore the literally thousands of agreements on a given subject and then imply the science is doing the same thing to creationism, but clearly that is impossible since creationism doesn't have any points of agreement since they've done no research specific to creationism/ID at all. That's why I'm defensive.

harold · 17 December 2010

Robin -

You are not being "defensive".

The term "defensive" implies unreasonable objection to valid criticism.

Kris is defensive.

I can note objectively that every post Kris puts up consists of some combination of the following - worthlessly vague claims that "science" is somehow horribly flawed, worthlessly vague claims that he could tell "scientists" what to do, an uproariously evasive lack of specifics, and an implied worthless post-modern argument that creationism is "just as good" as science because science is so bad.

I will stick to that objective observation.

stevaroni · 17 December 2010

Kris said: So then, you're saying that scientists are or should be motivated by a desire for fame?
Actually, I don't believe used the word "motivated" anywhere in my comments. That's your reading, once again, a conclusion unsupported by any evidence. I did point out that, in science, the accolades tend to come to those who discover something new and innovative. After all, 400 years later, the names "Copernicus" and "Galileo" are still household words. Those of their contemporaries who defended geocentrism.... not so much. Although, to answer your question bluntly, would most scientists be pleased to become famous for advancing their field? Sure. Why not? Most people would be happy with a touch of professional recognition, and scientists are certainly no different.

I would say that some scientists are motivated by that but some just want to stay employed (or keep the grant money coming in). Either can cause a scientist to accept or rebuke any criticisms of, or proposed changes to, the status quo. Their status quo.

In my experience with scientists (largely electronics and semiconductors, with a smattering of geology) most of the many scientists I know don't work in academia. Instead, they get their paycheck from actually producing results. If, for example, flood geology were actually a useful method for finding oil, I have no doubt that the geologists I know, being practical people who know what a large strike is worth, and desiring to explore questions like "just how many sports cars is too many?", would quickly embrace the Noahchian model as the preferred tool.
Was Darwin's work really about the "origins of man"?
Well, his work was about common descent, so ultimately, yes, it was, though he was careful to avoid the subject if he could. I don't really know if anybody really stood on the issue. On the one hand, the logical conclusion tha tman was just another animal and subject to the same rules as a fruit fly was (and is) inescapable. On the other hand, Darwin was, paradoxically, a deeply religious man, and seemed hesitant to make that final leap, and disolve the idea of human exceptionalism. His contemporaries, however, had no such qualms, quickly painting him as the despoiler of man, even in the early days.

mrg · 17 December 2010

harold said: ... that creationism is "just as good" as science because science is so bad.
"Science is worthless, and we're just as good as it is." Which is the bottom line of all "argument from authority" objections.

Kris · 17 December 2010

ben said:
SWT said: Kris, you keep writing that science has "messes" and needs to "clean up its act." What specific changes do you advocate?
Kris isn't here to advocate specific changes, Kris is here to cast as much aspersion as possible on science while pretending to value it. Note that although Kris has claimed to be a scientist, "science" and "scientists" are always referred to in 3rd person, and not a single example of anything has been offered from his/her own work or experience. Dishonest concern troll. Nothing to see here, move along.
I don't have much time right now so I'll respond to some comments and questions from others later, but I simply have to respond to you right now. You're not the first one who has said or implied that I'm not a scientist, or has asked me where I work or what kind of science I work at. Does it matter who I am, or what I do, or where I work, or what my credentials are? Why would it matter? Is it so that you or someone else can compare me to themselves and see if they can beat my credentials, degrees, GPA, or some other irrelevant 'qualification' and then try to use it against me in a debate? Would you also ask who my teachers, associates, or mentors are or were, or which books or papers I have read, for the same reason? If I said I graduated from Harvard, or Princeton, or MIT, or some obscure community college, would it make any relevant difference? If I told you the size of my dick would you compare it to yours and hope to beat me there too? Unlike many (most?) people I don't rely on my credentials, including GPA, places of employment, mentors, teachers, degrees, schools, cited articles/papers/books, etc., just to impress others, or to use in a blustering attempt to bolster what I say. If I bring up any of that stuff it will be because it's relevant at the time and to the points I'm making. I know and have met people with tons of fancy credentials who are dumber than a post and I also know and have met people with no fancy credentials who are very sharp and knowledgeable. I pay attention to what people say, not how many diplomas they have on their walls. I don't worship anyone and I'm not intimidated by anyone. I know some things and there are lots of things I don't know. I have an insatiable thirst for knowledge about nature and I try very hard to keep as open a mind as possible. I don't care which or how many degrees you or anyone has or which schools you or they attended or graduated from. I don't care how many times someone's writings have been cited. I don't care where you or anyone else has worked or what your title is. I care about substance, not braggadocios fluff.

Robin · 17 December 2010

Kris said: Does it matter who I am, or what I do, or where I work, or what my credentials are?
Only in so far as supporting vs contradicting your claim. You made the claim that you are a scientist, without any prompting from anyone here. If it doesn't matter (and it is certainly irrelevant to most folks here) why did you bring it up? And the fact is, your posts demonstrate you are unfamiliar with basic concepts and structures in science. That leads to the impression that your claim is dubious and speaks to your credibility as a whole. But...perhaps there's an honest reason for the inconsistency. Revealing your actual scientific association might explain the inconsistency and restore your credibility. Of course, that's up you.
I pay attention to what people say, not how many diplomas they have on their walls.
Me too. The issue to consider, however, is that what you've said in your posts indicates that you don't really know much about what you are posting on.

SWT · 17 December 2010

Kris said:
ben said:
SWT said: Kris, you keep writing that science has "messes" and needs to "clean up its act." What specific changes do you advocate?
Kris isn't here to advocate specific changes, Kris is here to cast as much aspersion as possible on science while pretending to value it. Note that although Kris has claimed to be a scientist, "science" and "scientists" are always referred to in 3rd person, and not a single example of anything has been offered from his/her own work or experience. Dishonest concern troll. Nothing to see here, move along.
I don't have much time right now so I'll respond to some comments and questions from others later, but I simply have to respond to you right now. You're not the first one who has said or implied that I'm not a scientist, or has asked me where I work or what kind of science I work at. Does it matter who I am, or what I do, or where I work, or what my credentials are? Why would it matter? Is it so that you or someone else can compare me to themselves and see if they can beat my credentials, degrees, GPA, or some other irrelevant 'qualification' and then try to use it against me in a debate? Would you also ask who my teachers, associates, or mentors are or were, or which books or papers I have read, for the same reason? If I said I graduated from Harvard, or Princeton, or MIT, or some obscure community college, would it make any relevant difference? If I told you the size of my dick would you compare it to yours and hope to beat me there too? Unlike many (most?) people I don't rely on my credentials, including GPA, places of employment, mentors, teachers, degrees, schools, cited articles/papers/books, etc., just to impress others, or to use in a blustering attempt to bolster what I say. If I bring up any of that stuff it will be because it's relevant at the time and to the points I'm making. I know and have met people with tons of fancy credentials who are dumber than a post and I also know and have met people with no fancy credentials who are very sharp and knowledgeable. I pay attention to what people say, not how many diplomas they have on their walls. I don't worship anyone and I'm not intimidated by anyone. I know some things and there are lots of things I don't know. I have an insatiable thirst for knowledge about nature and I try very hard to keep as open a mind as possible. I don't care which or how many degrees you or anyone has or which schools you or they attended or graduated from. I don't care how many times someone's writings have been cited. I don't care where you or anyone else has worked or what your title is. I care about substance, not braggadocios fluff.
Kris, you found time to respond to ben's response to my post ... perhaps you can find a moment to respond to my actual question.

harold · 17 December 2010

I can note objectively that every post Kris puts up consists of some combination of the following - worthlessly vague claims that “science” is somehow horribly flawed, worthlessly vague claims that he could tell “scientists” what to do, an uproariously evasive lack of specifics, and an implied worthless post-modern argument that creationism is “just as good” as science because science is so bad.
I don’t have much time right now so I’ll respond to some comments and questions from others later, but I simply have to respond to you right now. You’re not the first one who has said or implied that I’m not a scientist, or has asked me where I work or what kind of science I work at. Does it matter who I am, or what I do, or where I work, or what my credentials are? Why would it matter? Is it so that you or someone else can compare me to themselves and see if they can beat my credentials, degrees, GPA, or some other irrelevant ‘qualification’ and then try to use it against me in a debate? Would you also ask who my teachers, associates, or mentors are or were, or which books or papers I have read, for the same reason? If I said I graduated from Harvard, or Princeton, or MIT, or some obscure community college, would it make any relevant difference? If I told you the size of my dick would you compare it to yours and hope to beat me there too? Unlike many (most?) people I don’t rely on my credentials, including GPA, places of employment, mentors, teachers, degrees, schools, cited articles/papers/books, etc., just to impress others, or to use in a blustering attempt to bolster what I say. If I bring up any of that stuff it will be because it’s relevant at the time and to the points I’m making. I know and have met people with tons of fancy credentials who are dumber than a post and I also know and have met people with no fancy credentials who are very sharp and knowledgeable. I pay attention to what people say, not how many diplomas they have on their walls. I don’t worship anyone and I’m not intimidated by anyone. I know some things and there are lots of things I don’t know. I have an insatiable thirst for knowledge about nature and I try very hard to keep as open a mind as possible. I don’t care which or how many degrees you or anyone has or which schools you or they attended or graduated from. I don’t care how many times someone’s writings have been cited. I don’t care where you or anyone else has worked or what your title is. I care about substance, not braggadocios fluff.
Yep. Let me add one more - worthlessly vague and over-generalized declarations that other peoples' degrees and achievements don't mean anything. I'm objectively noting the small number of repetitive elements that comprise Kris's posts so that, if I have time, I can point them out in his future posts.

DS · 17 December 2010

So the answer is no, Kris is not a real scientist as he claimed. ANd the answer is no, he has no intention of actually reading the paper that is the topic of this thread or actually discussing any of the science in it. Glad he cleared that up once and for all.

Now Kris, if you want to argue about the molecular clock, you really should understand what you are talking about. Here area few references to get you started. If you are a real scientist you will read them. If not, you will be admitting that you cannot. In that case, my original diagnosis about you just having a bad case of science envy will once again be confirmed.

Goodman (1987) Globins: A case study in molecular phylogeny. Cold Spring Harbor Symp Quant Biol 52:875-890.

Ayala et. al. (1998) Origin of the Metazoan phyla: Molecular clocks confirm paleontological estimates. PNAS 95(2):606-611.

Lynch (1993) A method for calibrating molecular clocks and its application to animal mitochondrial DNA. 135:1197-1208.

ben · 17 December 2010

Kris said:
ben said:
SWT said: Kris, you keep writing that science has "messes" and needs to "clean up its act." What specific changes do you advocate?
Kris isn't here to advocate specific changes, Kris is here to cast as much aspersion as possible on science while pretending to value it. Note that although Kris has claimed to be a scientist, "science" and "scientists" are always referred to in 3rd person, and not a single example of anything has been offered from his/her own work or experience. Dishonest concern troll. Nothing to see here, move along.
I don't have much time right now so I'll respond to some comments and questions from others later, but I simply have to respond to you right now. You're not the first one who has said or implied that I'm not a scientist...etc., etc.
I didn't say that whether or not you were an actual scientist was relevant in evaluating any specific argument you may have made. I was just pointing out that you appear to be dishonest. I think you're probably the only one who missed my point.
I care about substance
So show us some. You've got a lot of vague complaints about science and scientists (all of which are resolved neatly in your own alleged scientific practices, no doubt), but you strenuously resist ever suggesting any concrete improvements that might be made, while spewing pages and pages of general crap.
I don’t have much time right now so I’ll respond to some comments and questions from others later, but I simply have to respond to you right now.
Ever notice how the trolls so often preface their comments with pretense about how busy they are? Off doing science the right way, no doubt. Are you growing mushrooms on your houseboat, or researching whether ticks are more attracted to watermelon rinds than they are to orange peels?

John Vanko · 17 December 2010

Robin said, quoting Chris the Creationist Christmas troll: "You made the claim that you are a scientist, without any prompting from anyone here. If it doesn't matter (and it is certainly irrelevant to most folks here) why did you bring it up?"
I think Chris the Creationist Christmas troll collects butterflies. That's his claim to being a scientist. But he ain't no scientist, as we all know. Unless he's one of those fake 'scientists' at AiG or ICR.

John Vanko · 17 December 2010

"Robin said, in response to..."

fnxtr · 17 December 2010

Anybody wanna bet he's either an engineer or a "computer scientist"? Anyone?

mrg · 17 December 2010

fnxtr said: Anybody wanna bet he's either an engineer or a "computer scientist"? Anyone?
Now be nice to engineers ... BTW, I minored in computer science.

Robin · 17 December 2010

John Vanko said: "Robin said, in response to..."
??? Was this a misfire, John?

Robin · 17 December 2010

Robin said:
John Vanko said: "Robin said, in response to..."
??? Was this a misfire, John?
Oops...nevermind. I see what you did there... ;)

stevaroni · 17 December 2010

fnxtr said: Anybody wanna bet he's either an engineer or a "computer scientist"? Anyone?
Hey! Lay off the engineers! I assure you, most of us realize that the earth really is a big ball of rock that's been looping around the sun for billions of years while amoebas evolved the ability to blog.

Henry J · 17 December 2010

while amoebas evolved the ability to blog.

And pseudo-pods evolved into pseudo-science?

harold · 17 December 2010

stevaroni -

In defense of engineers -

1) Many creationist trolls who claim to be or imply that they are engineers or computer scientists are outright lying. They simply hope that biomedical people won't know enough about engineering to know that they are lying. They are usually wrong.

2) Many are technically doing a task with an occupational description of "(something) engineer" but don't have, and would not be able to obtain, an actually engineering degree.

That's not to say that there aren't some creationist engineers, but the numbers are exaggerated by the pretenders.

I have never seen an amoeba blogging, and I rotated through a clinical parasitology lab - although that was in the early days of the internet.

harold · 17 December 2010

That should be "actual engineering degree" of course.

mrg · 17 December 2010

harold said: 1) Many creationist trolls who claim to be or imply that they are engineers or computer scientists are outright lying.
I would say some of them really are engineers, but as a person with an engineering background that gives them them about the same qualifications on evo science that I do, or for that matter a plumber or carpenter does.

harold · 17 December 2010

mrg -

Yes, it is indeed true that even the self-proclaimed engineers who actually are engineers are not qualified.

However, self-declaration of "engineer" or "computer scientist" status in trolls should be viewed with great skepticism.

John Vanko · 17 December 2010

Robin said: ??? Was this a misfire, John?
(hoping you are a ma'am): "My Dear, I never misfire."

Robin · 20 December 2010

John Vanko said:
Robin said: ??? Was this a misfire, John?
(hoping you are a ma'am): "My Dear, I never misfire."
Heh! Well, though I'm a guy, that's still funny. I teed that one up without thinking about it.

John Vanko · 20 December 2010

Robin said:
John Vanko said:
Robin said: ??? Was this a misfire, John?
(hoping you are a ma'am): "My Dear, I never misfire."
Heh! Well, though I'm a guy, that's still funny. I teed that one up without thinking about it.
Aw Shit! My comeback was going to be, "I only fire exactly when I mean to." Oh well. Back to the business of slamming these damn creationists!