So, shortly after the first post on the hourglass model went up here on the Panda's Thumb, the senior author of one of the two featured papers (the article using fruit flies, titled "Gene expression divergence recapitulates the developmental hourglass model") contacted me, clearly enthused about our interest in the story. He's Pavel Tomancak, and together with the co-first author on the study, Alex Kalinka, he offered some useful feedback as well as some cool images. Here are some of their further thoughts, posted with their permission and edited slightly by me. Let's think of them as honored guest bloggers.
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I am indeed excited about the insightful blogging that has followed the publication of our work. It is great to see that people like you are genuinely trying to come to grips with the sometimes complex analysis we have put forward (a 55 page monograph accompanies the paper) and share their understanding with scientifically-inclined readers on the blogosphere.
The major challenge we had to overcome was to convince people that the evolutionary divergence of the Drosophila species we used is sufficient to make arguments about phylum-level morphological patterns. Many people thought that we could not possibly say something about the phylotypic stage by looking at closely related species. We made a number of arguments like: the species facilitate unambiguous comparisons, gene orthology is clear, timing of development is not so different (although we compensated for that) and so on. What really drives it home is the comparison of the Drosophila phylogeny to the vertebrate one. D. virilis is roughly as distant from D. melanogaster as lizards are from humans in terms of the molecular clock (see figure below, from Stark et al. 2007 Fig. 1). I take it that flies are more similar to each other morphologically than say human or mouse or elephant, but they also are rather different, living in very different environments that influence their embryonic strategies (Markow & O'Grady 2008).
However, in addition to these arguments, we believe that approaching evo-devo questions using a mixture of closely related species, such as D. persimilis and D. pseudoobscura, together with more distantly related species such as D. virilis, allows us to see both large accumulated differences between species that have accrued over tens of millions of years, together with the first steps that occur as two species diverge from one another. One of the advantages of such an approach is that it will enable us to infer whether most differences are the result of a large number of small changes, or whether they are the result of a small number of large changes. Moreover, this approach is essential if we are to integrate population genetics theory with comparative embryology, a synthesis that will greatly advance our understanding of how development evolves (Simpson 2002).
The dataset was actually massive even by today's standards; we had replicates which allowed us to do all the statistics. All together 200 array experiments on self-designed arrays.
Our ability to recapitulate the known phylogeny from the divergence data is in my opinion remarkable. As far as we know, the reconstruction of a phylogeny using expression data has not been attempted before. Karolina Varga, co-first author on the paper, with her impeccable sense of humor, wanted to coin the term 'expressogram' as a variation of 'phylogram', which follows the fine tradition of ‘eisengrams’ and such. Despite exhibiting the same topology as the molecular clock phylogram there are differences (See supplementary Figure 3 of our paper, included below) and these pointed us to the evolutionary modeling that suggests that the hourglass waist is maintained by stabilizing selection.
Supplementary Figure 3. A comparison of the phylogenetic relationships between the six Drosophila species used in our study when drawn up using our gene expression data (based on normalised values from a linear model (see Methods)) - boxed in blue - and based on median dS values for ~ 10,000 orthologous genes - boxed in green. Red branches indicate terminal branches between sister species that are longer in the gene expression data.
The genes that conform to the hourglass pattern are enriched for genes involved in building up the body plan and could be in general referred to as 'developmental toolkit genes'. It will be interesting to compare these genes to the ones that drive the hourglass pattern in the other study by Domazet-Loso and Tautz. While there may be commonalities in the studies, it may also be the case that the evolution of new genes (through a process of duplication and divergence, for example) may be under a different set of constraints than the evolution of gene expression. Exploring such differences promises to be an exciting avenue for future research.
Finally, I think that both papers really open up new horizons for studying the developmental hourglass experimentally using the awesome power of Drosophila and fish genetics. That's what we worked towards from the beginning. We are developing fancy transgenic, imaging and image-analysis techniques to be able to compare gene expression in the different species quantitatively on the spatio-temporal level. It's well-funded (among others by HFSP and ERC) and these papers will be a huge boost to not only us but the entire field, which until recently was living on the fringes.
References:
Markow, T., & O'Grady, P. (2008). Reproductive ecology of Drosophila. Functional Ecology 22, 747-759.
Simpson, P. (2002). Evolution of development in closely related species of flies and worms. Nat Rev Genet 3:907-917.
Stark, A., et al. (2007). Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature 450, 219-232.
146 Comments
Kris · 14 December 2010
A similar study, including checkerspot butterflies, and especially the ones in the genus Euphydryas (like E. editha, E. colon, E. chalcedona, etc.) would also be very interesting.
DS · 14 December 2010
"The major challenge we had to overcome was to convince people that the evolutionary divergence of the Drosophila species we used is sufficient to make arguments about phylum-level morphological patterns."
But it appears that you have indeed accomplished that task. Now that you have developed the methods and types of analysis required, and demonstrated the molecular basis of the hour glass phenomena, there is nothing stopping anyone from applying this same technique to larger divergence times. Many whole genome sequences are already available. You may have founded the new field of evo devo temporal/spatial gene expression pattern analysis. OK, maybe that name could use a little work.
The next step might be to examine the evolution of the regulatory mechanisms responsible for producing this pattern. I am sure that when confronted with the scientific evidence for evolution at this level that every honest creationist will be convinced of the reality of evolution.
Paul Burnett · 14 December 2010
Henry J · 14 December 2010
Cubist · 14 December 2010
To my knowledge there are exactly two Creationists who genuinely do understand evolution, Kurt Wise and Todd Wood. Both of these guys are very upfront about how evolution is scientifically valid... and Wise, at least, is equally upfront about rejecting evolution because it conflicts with his religious beliefs. Apart from that pair, however, it's honest; informed; Creationist -- pick two.
Dale Husband · 14 December 2010
Ichthyic · 14 December 2010
And they are both sell-outs and frauds I have no regard for.
Yay Dale!
you're absolutely right. to hold those two up as "honest" is to horribly malign the term "intellectual honesty".
I've looked at what they have written. Honesty in name only.
simply claiming you can deny evidence because your religion dictates it does NOT make for an intellectually honest argument.
DS · 14 December 2010
Rolf Aalberg · 14 December 2010
Gary Hurd · 14 December 2010
I would like to thank, and welcome Pavel Tomancak. There have been years of attacks on evolution, and science teaching in general based on the perceived "fraud" of Haeckel's embryo drawing.
What I now hope we will see is a new, and independently derived set of science results from embryology giving further confirmation of evolution.
John Vanko · 14 December 2010
At the risk of being repetitive and boring, I resubmit an earlier post from June, that seems even more poignant here:
If AIG or CMI is one’s authority you might think that “Ontogeny recapitulates Phylogeny” (and the similarities of developmental forms in general) is a false concept long abandoned and dis-proven (now providing evidence against evolution), and therefore cannot be included in any biology textbook or classroom today.
But such is not the case. Stephen Jay Gould wrote a 500 page tome, Ontogeny and Phylogeny* where he says in his opening sentence on page 1, 'I am aware that I treat a subject currently unpopular.'
He continues, “I tell a colleague that I am writing a book about parallels between ontogeny and phylogeny. He takes me aside, makes sure that no one is looking, checks for bugging devices, and admits in markedly lowered voice: ‘You know, just between you, me, and that wall, I think there really is something to it after all.’ “
Because there is indeed something to it. It’s not a false concept. It just needs modification in light of what we know today about biology. And that’s what Gould did.
On page 213 he writes, “The embryonic features that we share with all vertebrates represent no previous adult state, only the unaltered identity of early development. Thought they do not allow us to trace the actual course of our descent in any way, they are full of evolutionary significance nonetheless; for, as Darwin argued, community of embryonic structure reveals community of descent.”
All you have to do is look at those photographs and you know he’s right.
*-Belknap Press of Harvard University Press, 1977
(PS-No one at AIG or CMI has the record of field work of Gould. No one at AIG or CMI has the scholarship to write an Ontogeny and Phylogeny like Gould. Yet they expect us to bow to their pronouncements.)
dmso74 · 14 December 2010
"Our ability to recapitulate the known phylogeny from the divergence data is in my opinion remarkable.."
"We are developing fancy transgenic.."
"It’s well-funded.."
you know, if you keep doing that, you're going to go blind.
harold · 14 December 2010
John Vanko -
Well, Gould was obviously correct, and even if embryoes were more divergent morphologically, what we now know about the conservation of basic major genes families in development across diverse lineages would prove that point.
However, to some degree, although Haeckel is probably excessively maligned, as Gould said in the quote you presented - "The embryonic features that we share with all vertebrates represent no previous adult state, only the unaltered identity of early development".
I haven't read Haeckel in the original and probably never will, but relying on summaries, I thought this was kind of the point. He thought that they did represent or recapitulate previous adult states.
They certainly do seem to resemble adult states of some members of the vertebrate lineage, and they certainly do often seem to resemble more ancient lineages closer to the beginning of development (I'm not sure if there are counter-examples), but at a vastly smaller physical scale. Without meaning to be unfair to someone whose work I have not read in the original, didn't Haeckel perhaps, unlike Gould, take this resemblance to literally?
John Vanko · 14 December 2010
Kris · 14 December 2010
Pavel Tomancak may well be disappointed in some of the people here right now. He and his associates probably did the study so as to learn something, and not so that the results would be used solely (or partly) as a weapon in the war on ID/creationism, unless he and his associates intended it to be solely (or partly) that weapon of course.
Since science "ignores religious beliefs" (yeah right) that of course couldn't be the case. But, that surely hasn't stopped some of you from instantly adding the study to your arsenal of weapons against ID/creationism.
So, whatever you do, don't just find the study interesting and informative for its own sake (which I hope is what the authors intended). Think of it only as another scientific weapon against ID/creationism, while you keep saying that "science ignores religious beliefs".
harold · 14 December 2010
Yep, that pretty much summarizes it.
Haeckel was working at a very early but very, very active time in the history of biology. I guess every period in biology since Linnaeus has been something of an explosive period of new knowledge, but the late nineteenth century still probably stands out in many ways.
Because the science was early, it was a time of brilliant minds forming rather extreme ideas, some of which turned out to be prescient, some of which were brilliant but wrong.
Golgi and Cajal supposedly came close to a fist fight at the Nobel Prize ceremonies (technically that was in the early twentieth century). Cajal realized that the central nervous system was made up of individual cells, Golgi thought it was some kind of syncitium. (Cajal was also an early weight training enthusiast; I have no idea what kind of shape Golgi would have been in for his age at the time - they were probably both about 60.)
In fact, I recently discovered to my amazement that some science-denying anti-medicine cranks are accurate advocates of once very important ideas from that time.
So in that context, Haeckel's admitted over-interpretation of his basically valid observations, and his mildly over-emphatic (but not grotesquely wrong) drawings, are really not that shocking. It's worth noting that before photomicrographs, artistic ability was an important scientific skill.
The real message is that the study of development, beside having applications to medical research, provides a lot of strong evidence for evolution and common descent.
Flint · 14 December 2010
harold · 14 December 2010
Dale Husband · 14 December 2010
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Mike Elzinga · 14 December 2010
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Dale Husband · 15 December 2010
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Kris · 15 December 2010
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Dale Husband · 15 December 2010
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Michael Behe · 15 December 2010
Because Natural Selection can destroy, it can therefore build.
This is the central fallacy of Darwinism. Just because something can destroy does not mean it can build.
Ichthyic · 15 December 2010
This is the central fallacy of Darwinism
you mean your own personal fallacious strawman.
sounds catchy, but it makes no sense, and has nothing to do with evolution.
fail.
Dale Husband · 15 December 2010
Ichthyic · 15 December 2010
here's a hint for you:
what's the most basic definition of the word: evolution?
change.
Ichthyic · 15 December 2010
heh.
jinx!
see, sometimes we DO think alike, Dale.
:)
Ichthyic · 15 December 2010
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Mike Elzinga · 15 December 2010
Rolf Aalberg · 15 December 2010
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Kris · 15 December 2010
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Paul Burnett · 15 December 2010
eric · 15 December 2010
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Stanton · 15 December 2010
RBH · 15 December 2010
DS · 15 December 2010
Anybody notice that the trolls here are not actually discussing the science? It's almost as if they don't really understand the paper at all. You know, it's almost as if they never even read the paper! Imagine that, going to a web site devoted to defending evolution and ridiculing people for defending evolution, all the while ignoring the science and still claiming you are on their side. Amazing.
If anyone thinks that this paper refutes religion, just ask yourself, what religion? If anyone thinks that this paper refutes a religious belief, just ask yourself, what belief? As Flint correctly pointed out, whenever anyone makes claims about the natural world, science can and should address those claims. The science should be used to refute the scientific claims, not the religious motivation behind them.
As for the authors being disappointed, well why not just ask them? You know, the authors who specifically came to a blog devoted to defending evolution against creationism. Ask them if they are disappointed that their paper has been used for such a vile purpose as defending evolution. Why not hear it straight from the scientists mouth?
Steve Matheson · 15 December 2010
Notice.
First, I'll go further than RBH: if you are assuming that the commenter who refers to him/herself as "Michael Behe" is in fact the author of Darwin's Black Box, then you're a lot dumber than he is.
Second, and related, all comments by Kris -- and responses to her/him -- are on their way to the Bathroom Wall, as are any and all comments far afield of the interesting topics discussed by our guest bloggers. Seriously, guys, do you not have any experience in dealing succinctly with trolls? I can demonstrate the use of href tags to create links if that would help.
DS · 15 December 2010
harold · 15 December 2010
Kris -
It doesn't really matter what your motivation is. The quality of your comments is what it is. This will be my last "feeding" of you.
Joe Felsenstein · 15 December 2010
Joe Felsenstein · 15 December 2010
I was assuming (naïvely) that the poster “Michael Behe” really was Michael Behe. If he was, then he will expand on his argument and show us the logic underlying it.
If he behaves like a drive-by troll and just disappears and refuses to explain his argument then I will give the real Michael Behe the benefit of the doubt and assume that the commenter wasn't Michael Behe.
harold · 15 December 2010
Feel free to put this comment on the Bathroom Wall, but an important chance to highlight something about the history of ID presents itself.
ID was originally marketed as a means for getting some stealth creationism into public schools, without invoking court challenges. We can debate whether the DI ever intended for it to actually perform that function, but that's how it was marketed.
Hence, it was common during the pre-Dover era for science-denying trolls to ostentatiously claim not to be religious, to claim that ID/creationism wasn't religious, and so on. Simultaneous obsessive construction of a "discard science or discard all religious behavior" false dichotomy was characteristic of this. Canned remarks claiming persecution, often in ludicrous contexts, were also common (the "Expelled" strategy).
All of this was nothing more than a strategy that lying follower bots were instructed to observe.
We see a lot less of it since Dover, given that Judge Jones specifically called out people using this strategy for lying under oath, and wrote a decision making it almost impossible for this strategy to ever succeed.
However, there are a few dolts who haven't abandoned this grotesquely dishonest strategy yet, and Kris seems to be a "living fossil" of this type. If not, he is coincidentally a perfect mimic.
DS · 15 December 2010
Well, now that the trolls are taken care of we can get back to discussing the science. If the author is still around, I have some questions.
Is it necessary to use species specific microarrays? Would it be possible to design microarrays that would allow for this type of analysis using a greater divergence time, especially for phylogenetically conserved genes such as hox genes? If that were possible, it would make this approach much less costly and time consuming? If not, how difficult is it to design and construct such arrays? Do you have any plans for looking at more fly species or expanding the divergence time? Could such an approach be used for vertebrates as well? Could the molecular developmental hour glass be demonstrated in the organisms used for Haeckel's drawing? Would you be disappointed if your work was used to fight creationism?
Thanks for doing such ground breaking work and for helping us to understand it.
William Dembski · 15 December 2010
Kris · 15 December 2010
Kris · 15 December 2010
Yeah, I would LOVE to hear from the authors of the study as to how they feel about the way some of you have totally detoured from the topic of the study. If they're smart, they're distancing themselves as far as possible from this website as fast as they can, unless of course if their study was simply intended to find and supply more weapons for the war on creationism/religious beliefs.
Steve Matheson · 15 December 2010
Kris, you seem not to be reading the thread. (What a surprise!) Your own opening comment about expanding the analysis has been left in. And your question about whether DS is "discussing the science" made me laugh out loud. (...ignoring the science of the study." LOL!)
So, Kris, we await your comments on "the science of the study." From this point on, comments on other topics by anyone will be sent straight to the wall. That means all other topics. There are plenty of threads around here where you can whine idiotically about mistreatment of "creationists." This is not one of them.
Stanton · 15 December 2010
If D. melanogaster and D. virilis are molecularly clocked as being as distant as humans are to lizards, would that quality alone, merit splitting the Drosophila subgenera (Sophophora, D. Drosophila spp, etc) into separate, distinct genera?
Kris · 15 December 2010
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eric · 15 December 2010
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DS · 15 December 2010
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Napolean Bonaparte · 15 December 2010
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Steve Matheson · 15 December 2010
To DS: I'll invite the authors to tackle some of the questions. I do think they're planning as similar analysis in other taxa, and for sure they plan to do the phylostratigraphic analysis of Domazet-Loso & Tautz on their fly data.
To everyone else: don't bother typing comments about trolls, creationists, deities, or ISPs on this thread. I'm quite sure that your time is better spent on other efforts, unless your buddies are really impressed when you cc them.
DS · 15 December 2010
Thanks Steve. I appreciate it.
Mike Elzinga · 15 December 2010
harold · 15 December 2010
Mike Elzinga -
Interestingly - http://www.ncbi.nlm.nih.gov/pubmed/20512118
I don't at all know what the maximum range of temperatures that permit any viable development of drosophila embryos of any species is. I would guess that it is extremely narrow relative to the range of temperatures even that can be experienced on the surface of the earth, but relatively wide compared to the temperature range needed for viable mammalian development. But that would just be a guess.
Mike Elzinga · 15 December 2010
Paul Burnett · 15 December 2010
Paul Burnett · 15 December 2010
harold · 15 December 2010
Yep, those plant embryos (seeds) can be amazingly hardy. There's a certain analogy to cysts. Some bacteria, and some eukaryotes like certain Amoeba species, can morph into hardy cysts when the environment becomes threatening and then transform back to their normal "adult" form when things return to ideal. I have no idea how long cysts can theoretically remain dormant but viable, but it's probably a very long time.
(For completeness, every beer enthusiast knows that brewer's yeast from bottles of beer recovered from 19th century shipwrecks has produced cultures that were used to brew excellent beer well over a century and a half later, but that's only because humans provided the sealed glass bottle environment.)
The last common ancestor of Jack Pine and Drosophila lived quite a while ago, of course :).
I'm no PZ Myers, but I do seem to recall that gravity plays a major role in early embryonic development of some animals - the contents of the actual zygotic cell become polarized, and that has a major impact on everything else.
Also, I think there are other Drosophila mutations that have an expression that is affected by temperature. That paper just happened to be a very elegant and in depth modern look at how this works for one example. I could be wrong, but I have a nagging feeling that I have heard of this before.
Flint · 15 December 2010
Joe Felsenstein · 15 December 2010
John Harshman · 15 December 2010
John Kwok · 15 December 2010
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David Utidjian · 15 December 2010
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Dale Husband · 15 December 2010
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Steve Matheson · 15 December 2010
Then why are you feeding the troll? Please refrain, if not for me (I made it completely clear that this thread is not the place for off-topic bickering) then out of respect for our guest bloggers.
Joe Felsenstein · 15 December 2010
Kris · 16 December 2010
Once again a thread has turned into an ID/creationism/creationist bash fest. So much for the science.
I wonder why the authors of the study haven't been back and aren't participating in the 'discussion'. LOL!
Science Daily (and others) kicks this site's ass when it comes to providing interesting scientific information.
Kris · 16 December 2010
Just Bob · 16 December 2010
DS · 16 December 2010
Well one of the best criteria for identification of species is genetic discontinuity. Any gene pools that are are isolated from each other and have little or no gene glow will undergo genetic divergence. Often times this occurs in a clock like manner, at least for certain portions of certain genes. So the same genetic data that can be used to reconstruct phylogenetic relationships can also be used to identify isolated gene pools, i.e. species. This is in fact why the Barcode of life project has been so successful. It provides a relatively consistent framework for species identification using the mitochondrial COI gene.
What is interesting to me is that the spatio-temporal patterns of gene expression in these species can be used to reconstruct the exact same phylogenetic pattern produced by other data sets. So, there is obviously phylogenetic information in this data as well. Once again, the same result, produced by independent data sets and different methods of analysis, increases confidence in the result.
I would end with a comment about how this is yet another stunning example of the predictions of the theory of evolution and how it represents yet another nail in the coffin of creationism. But then our resident troll would have yet another excuse to fixate on that and once again complete ignore the science in order to whine and moan about how we don't really understand anything so we might as well give up and let the butt heads win. So I won't do that.
DS · 16 December 2010
gene glow = gene flow obviously
gene glow is only for fireflies
Robin · 16 December 2010
DS · 16 December 2010
Robin,
The concept of a molecular clock refers to the observation that there is a relatively constant rate of mutation for certain parts of certain genes for certain periods of time in certain groups of organisms. This can be determined by calibrating the times of divergence using the fossil record. For example, the rate of amino acid replacements in vertebrates can be shown to be relatively constant for hundreds of millions of years. So, if we can calibrate the clock, we can estimate divergence times based on genetic divergence.
However, you are correct. Things are usually a lot messier than this. that is why there are so many restrictions and qualifiers required. For example, the calibration used for vertebrates cannot be used for insects and the clock ticks at different rates for mitochondrial DNA than for nuclear genes and for different rates for different mitochondrial genes. So yes, things can get very messy.
Still, the mitochondrial COI gene has proven to be extraordinarily useful for many different groups. Thus it is currently the basis of the Barcode of Life project. However, the various taxonomic ranks are still somewhat arbitrary, due to rate heterogeneity in different groups. So even if we can agree on a definition of species, higher groups may still remain an artificial construct, regardless of degree of divergence or even phylogenetic relationships.
DS · 16 December 2010
The vertebrate example was for the hemoglobin gene.
DS · 16 December 2010
Shoot. I forgot to mention that creationists have no explanation for the molecular clock data, or for the nested hierarchy of genetic similarities that it produces. They lose again.
Robin · 16 December 2010
eric · 16 December 2010
Kris · 16 December 2010
Well, if you must know I do various things in science, mostly involving Paleontology, and Lepidoptera.
I really can't avoid most of the problems since most scientists won't listen to anything that might improve the status quo. They get angry and defensive when problems are pointed out and potentially helpful suggestions are made (not just by me). I have been dealing with it for a long time.
Some scientists would like to fix some of the problems but too many are entrenched in old, non-productive ways. In some cases it's the chaos and confusion that keeps them employed.
It's kind of like having a huge work crew but no one is in charge, or at least no one takes charge. The result? Chaos, waste, and confusion. You know, kind of like a typical government.
Have you ever noticed that religion is often called "organized religion"? Have you ever heard anyone call science 'organized science'? I haven't, and for good reason.
Think about this; throughout history many churches/religions have been very well organized. They have a hierarchy of people who hold certain positions of leadership within the church or religion and they answer to each other a lot like managerial employees do in a large company.
I'm sure you've heard of the "Salvation Army", and the words, "Onward Christian soldiers", and "Holy Wars", and other such things that imply organization and a common cause. Yeah, I know, religions and churches are often at war with each other but some of them are still way more organized than science is. Maybe that's part of the reason they're so successful and science is so poorly known and accepted by the masses.
Yep, it's all my fault. Just thought I'd say that before I'm viciously attacked for pointing out some realities.
Something else to think about: if the 'scientific method' is allegedly so standardized and is truly accepted and practiced by scientists, then why do so many scientists fight with each other so often, including over the methods and standards they use?
I won't be a bit surprised if someone comes along (not necessarily here) and challenges the standards and methods used in the study that is the original subject of this thread, and they might even have some legitimate complaints. Time will tell.
Think of the recent Mono Lake arsenic study. Oh sure, it will be "self correcting", someday. What a lame argument.
harold · 16 December 2010
Kris · 16 December 2010
harold · 16 December 2010
Kris -
If you can get everything right the first time, more power to you. You are indeed superior to scientists and to everyone who posts here. It must be frustrating that lesser beings refuse to acknowledge your glory, but hey, that's life.
The rest of us need feedback and corrections to get things right, and that is why science is grounded in peer review and ultimate self-correction.
The Mono Lake bacterial study is a perfect example of the power of the self-correcting nature of science.
A useful discovery was made (arsenic resistant bacterial lineage), mildly excessive scientific claims were made, and the media reported irresponsibly. But in the end, the useful discovery will be what remains.
harold · 16 December 2010
eric · 16 December 2010
stevaroni · 16 December 2010
Science Avenger · 16 December 2010
DS · 16 December 2010
Don't worry, Kris will no doubt provide examples where scientific studies disagree with creationist claims. He will then go on to claim that the studies were done specifically to destroy creationism, so science is really religion after all. That will prove how close minded those awful scientists are. What can you expect from an amateur butterfly collector?
Apparently he still hasn't read the paper and yet he has the audacity to whine about how others ignore the science. Perhaps he has simply failed to notice that this is a stunning example of where independent data sets agree. I wonder what explanation he has for that?
Steve needs to purge this thread again. If Kris were banished to the bathroom wall permanently we could give him the type of feedback he so richly deserves.
jkc · 16 December 2010
Stanton · 16 December 2010
Flint · 16 December 2010
eric · 16 December 2010
harold · 16 December 2010
Although some individual religions offer claims of absolute truth and rules for every aspect of life, taken together, a collection of untestable and contradictory claims of "absolute truth" is the result. In short, even if you think that one "absolute truth" based religion is true, you still have to randomly pick the right one. So the "absoluteness" is illusionary. At best your chances are as absolute as a lottery ticket. (My subjectively belief is that there is absolutely no risk of going to hell after you die no matter what you do, but that's another matter.)
This is much less of a problem for religions that are more ecumenical and more grounded in the idea of universal ethical standards.
Although science deals only with measurement and description of the physical world, and does not claim absolute truth (which is not the same thing as saying that it does not claim that some things are well-established), the result of scientific activity is an ever-expanding understanding of the physical world, and a high degree of consensus about many things.
Flint · 16 December 2010
Henry J · 16 December 2010
harold · 16 December 2010
Flint -
Since we mainly agree on things, I won't belabor the point, but I will make one more comment.
I can't read the minds of religious people, nor of anyone else.
There is kind of a fashion on the internet of insisting that the religious are brainwashed automatons who are convinced of some arbitrary "absolute truth", in a way so hard-wired and unchangeable as to resemble the fly-snapping neural circuitry of a frog.
The appeal of this claim is obvious. It allows a strong sense of superiority, while simultaneously declaring creationists to be innocent of machinations, thus avoiding the awkwardness of confronting potentially ugly underlying motivations.
I personally think this oversimplifies.
I think many religious behaviors are beneficial to those who choose them (although they aren't what I choose) and harmless to others, and are emotional in nature. Singing inspiring songs in church, praying in symbolic empathy with those who face some hardship, and so on. However, these behaviors ultimately rely on the idea of an invisible friend, who may or may not be able to affect things here on earth, but who is infinitely sympathetic and trustworthy. Science denial isn't really necessary. Certainly that's the kind of religion I was raised with. My grandparents went to Baptist church on every possible occasion, and would have gone more often if it had been possible (which, mercifully, it was not). The emphasis was almost entirely on what a wonderful, kind man Jesus was, how people mistreated him but know better now, how much Jesus cares whenever people or warm-blooded animals that aren't raised for food are suffering, and in general, how much better he is than everyone else but how much he likes us anyway, and what a good idea it is to try to be more like him. Which it generally was, as he was presented as being compassionate, honest, forgiving, intelligent, perceptive, tolerant, standing up for the underdog, making bad people decide to be good, etc. This was not a "liberal" church except by decadent post-modern standards that label any criticism of infantile narcissistic self-indulgence as "liberal"; it was deservedly considered very strict and austere by other denominations.
Another type of "religious behavior", which is not mutually exclusive, is to identify with a group or political movement and adopt religious views associated with that group or ideology, partly for group identity and partly as a defense against ethical criticisms ("since Gawd sed to kill teh gayz it must be moral to discriminate against them"). This can be done somewhat sincerely, grossly insincerely (Tom Tancredo, Bobby Jindal, Ann Coulter), or in a manner indicating a profoundly disturbed psyche (Christine O'Donnell). I'm sorry for mentioning politicians, but they make such great examples. Plenty of repulsive politicians have been communist or ostentatiously, hypocritically "liberal", let's not side track any further than the side track we're already on.
Yet another type is to attempt to indulge authoritarian fantasies up by self-identifying as the "one true prophet". Examples of this abound, and are often associated with violent events.
While it's true that people are unlikely to easily give up these reinforcing behaviors easily, many creationists would switch in a flash. Tom Tancredo probably "converted" from Catholicism to creationism because the Pope is only hard core right wing on issues that have something to do with sex, and can be outright "progressive" on issues like war, torture, death penalty, health care, programs for the needy, etc. Meanwhile, you can find a Protestant clergyman who is right wing on every issue (or "progressive" on every issue), so Tancredo presumably found someone whose God coincidentally commands exactly what you need to support to get elected in some designer-forsaken gated community and "converted".
A lot of the other creationists, from the trolls here on up, are just wanna-be authoritarian rulers or the like, and their sincerity is about as deep as I perceive that of some of those I have mentioned here to be.
Flint · 16 December 2010
Kris · 16 December 2010
Kris · 16 December 2010
Kris · 16 December 2010
Kris · 17 December 2010
Kris · 17 December 2010
Kris · 17 December 2010
Kris · 17 December 2010
Kris · 17 December 2010
Kris · 17 December 2010
Kris · 17 December 2010
Here's something else you all may find interesting:
http://www.sciencedaily.com/releases/2010/12/101216142523.htm
Stuart Weinstein · 17 December 2010
Stuart Weinstein · 17 December 2010
Kris · 17 December 2010
Robin · 17 December 2010
Kris · 17 December 2010
SWT · 17 December 2010
Kris, you keep writing that science has "messes" and needs to "clean up its act."
What specific changes do you advocate?
eric · 17 December 2010
ben · 17 December 2010
Stuart Weinstein · 17 December 2010
Robin · 17 December 2010
DS · 17 December 2010
Robin · 17 December 2010
DS · 17 December 2010
Of course every real scientist knows that the scientific method is "standardized" as much as it possible already. Now matter what the study question or the methods, the same important issues are always addressed in any good study:
1) Testable hypothesis
2) Good experimental design
3) Appropriate methods
4) Ability to be reproduced
5) Sufficient sample size
6) Appropriate analysis and statistical significance
7) Peer review
If "someone" has a problem with any particular scientific study. then"someone" can publish a rebuttal paper. Whining and moaning about things you don't understand isn't really going to help now is it?
Now if "someone" has any suggestions for improvement, then "someone" might take that other "someone" seriously. Until then, "someone" can piss off.
Robin · 17 December 2010
harold · 17 December 2010
Robin -
You are not being "defensive".
The term "defensive" implies unreasonable objection to valid criticism.
Kris is defensive.
I can note objectively that every post Kris puts up consists of some combination of the following - worthlessly vague claims that "science" is somehow horribly flawed, worthlessly vague claims that he could tell "scientists" what to do, an uproariously evasive lack of specifics, and an implied worthless post-modern argument that creationism is "just as good" as science because science is so bad.
I will stick to that objective observation.
stevaroni · 17 December 2010
mrg · 17 December 2010
Kris · 17 December 2010
Robin · 17 December 2010
SWT · 17 December 2010
harold · 17 December 2010
DS · 17 December 2010
So the answer is no, Kris is not a real scientist as he claimed. ANd the answer is no, he has no intention of actually reading the paper that is the topic of this thread or actually discussing any of the science in it. Glad he cleared that up once and for all.
Now Kris, if you want to argue about the molecular clock, you really should understand what you are talking about. Here area few references to get you started. If you are a real scientist you will read them. If not, you will be admitting that you cannot. In that case, my original diagnosis about you just having a bad case of science envy will once again be confirmed.
Goodman (1987) Globins: A case study in molecular phylogeny. Cold Spring Harbor Symp Quant Biol 52:875-890.
Ayala et. al. (1998) Origin of the Metazoan phyla: Molecular clocks confirm paleontological estimates. PNAS 95(2):606-611.
Lynch (1993) A method for calibrating molecular clocks and its application to animal mitochondrial DNA. 135:1197-1208.
ben · 17 December 2010
John Vanko · 17 December 2010
John Vanko · 17 December 2010
"Robin said, in response to..."
fnxtr · 17 December 2010
Anybody wanna bet he's either an engineer or a "computer scientist"? Anyone?
mrg · 17 December 2010
Robin · 17 December 2010
Robin · 17 December 2010
stevaroni · 17 December 2010
Henry J · 17 December 2010
harold · 17 December 2010
stevaroni -
In defense of engineers -
1) Many creationist trolls who claim to be or imply that they are engineers or computer scientists are outright lying. They simply hope that biomedical people won't know enough about engineering to know that they are lying. They are usually wrong.
2) Many are technically doing a task with an occupational description of "(something) engineer" but don't have, and would not be able to obtain, an actually engineering degree.
That's not to say that there aren't some creationist engineers, but the numbers are exaggerated by the pretenders.
I have never seen an amoeba blogging, and I rotated through a clinical parasitology lab - although that was in the early days of the internet.
harold · 17 December 2010
That should be "actual engineering degree" of course.
mrg · 17 December 2010
harold · 17 December 2010
mrg -
Yes, it is indeed true that even the self-proclaimed engineers who actually are engineers are not qualified.
However, self-declaration of "engineer" or "computer scientist" status in trolls should be viewed with great skepticism.
John Vanko · 17 December 2010
Robin · 20 December 2010
John Vanko · 20 December 2010