"It will be determined to what extent the phylogenetic tree, as derived from molecular data in complete independence from the results of organismal biology, coincides with the phylogenetic tree constructed on the basis of organismal biology. If the two phylogenetic trees are mostly in agreement with respect to the topology of branching, the best available single proof of the reality of macro-evolution would be furnished. Indeed, only the theory of evolution, combined with the realization that events at any supramolecular level are consistent with molecular events, could reasonably account for such a congruence between lines of evidence obtained independently, namely amino acid sequences of homologous polypeptide chains on the one hand, and the finds of organismal taxonomy and paleontology on the other hand. Besides offering an intellectual satisfaction to some, the advertising of such evidence would of course amount to beating a dead horse. Some beating of dead horses may be ethical, when here and there they display unexpected twitches that look like life." Emile Zuckerkandl and Linus Pauling, discussing the possibility of the twin nested hierarchy before the first molecular phylogenies had been made. (1965) "Evolutionary Divergence and Convergence in Proteins." in Evolving Genes and Proteins, p. 101. (source)
Common ancestry passes another test. News at 11.
Many readers will be familiar with longtime TalkOrigins regular Doug Theobald -- he is the author of "29+ Evidences for Macroevolution: The Scientific Case for Common Descent," pretty much the most impressive FAQ of all time. Oh, and he's a professor too, and has published some other stuff.
Today he has published a pretty impressive paper in Nature. It is entitled "A formal test of the theory of universal common ancestry." Basically, it applies the likelihood-based and Bayesian phylogenetic techniques that have been developed over the last decade or two, adds in some standard model-selection theory, and uses these to assess "universal common ancestry" (UCA). A lot of arguments "for common ancestry", e.g. biogeography, are really arguments for the common ancestry of groups of modern-day organisms -- like mammals -- rather than arguments that every living thing we know about shares common ancestry. There have been some powerful arguments for UCA over the years -- e.g. the extremely conserved (if not quite identical) genetic code (and as everyone except Paul Nelson knows, "almost identical" and "identical" are virtually the same thing statistically, so his decade of yammering about the non-universality of the genetic code has had no impact on this evidence). However, although the arguments remain powerful and convincing, they weren't usually quantitative and statistical, and it takes some serious work to construct a statistical assessment of something as deep and universal as common ancestry. This is what Doug has done.
He's getting a lot of press. Just in Nature there is a News & Views from Mike Steel and David Penny, and a Nature podcast.
I can't wait to read creationist/ID reaction to this paper. They will likely do what they always do, which is make up something ad hoc on the spot, like, "Oh, God would have done it [i.e. produced the observed sequence patterns] that way when he miraculously created species." Until they produce a quantifiable model to compare to the common ancestry one via a likelihood ratio test (LRT) or Akaike Information Criterion (AIC), such verbiage is pretty much pointless. Either that, or there will just be confused bickering based on misunderstandings of likelihood, probability, statistics, etc. It should be great sport.
So that you can follow the chaos, here's a quickie for those who didn't learn this stuff in kindergarten or in frequentist-dominated intro stats classes:
1. likelihood = the probability of the data, given a model = P(data|model)
2. Two (or more) models* can be compared by taking a single dataset** and calculating the likelihood under each model. The highest likelihood model confers the highest probability on the data, and is considered to be the model that best explains the data. If the difference in likelihoods is big enough, one can say (using various tests) that one model is statistically significantly better than another model.
* Models like, say, different phylogenetic trees and/or different sets of transition probabilities between DNA or amino acid sequences.
** A single dataset like, for example, an alignment of a bunch of gene or protein sequences.
3. posterior probability = probability of the model, given the data = P(model|data)
4. Bayes' Theorem allows you to take a prior probability of a model (P(model), e.g. your model could be "this coin has a 50% chance of landing heads on a toss" -- these are your initial beliefs), add some data (say, coin tosses), calculate the likelihood of that data given the model, and then calculate a posterior probability (your updated beliefs).
5. So probability, likelihood, and posterior probability are related, but they are not the same thing.
6. For much more, including a primer on the differences between frequentist, likelihoodist, and Bayesian schools of thought in statistics (I get these categories from Sober 2008, Evolution and Evidence, so please argue with me about something other than this), please see these lecture notes for a introductory lecture I recently gave on Bayesian phylogenetics: http://ib.berkeley.edu/courses/ib200a/IB200A_SyllabusHandouts.shtml, Tuesday, March 9 (PDF).
Congrats to Doug! A lot of work went into this paper, and I think it will be a classic. Apart from debunking creationists, it also takes down a few other misconceptions that are pretty silly but have for some become widespread even with scientists, i.e. (1) the idea that lateral gene transfer contradicts UCA; and relatedly, (2) the idea that UCA means that all life descends from one literal single individual organism, rather than from an ancestral population. The latter idea is particularly strange: did anyone ever think that the "common ancestor" of e.g. humans and chimps was a single individual? I think not; it was always an ancestral population. So why should the common ancestor of all life have been a single individual organism, especially since we have known of bacterial conjugation for 50+ years. I suspect that many people have been mislead by the fact that "ancestor" is a singular, rather than plural, and then mistakenly extrapolated this to mean single individual organism.
So, enjoy, and please post links/comments on creationist reactions. Here's the first, from Todd Wood: Testing universal common ancestry?.
Full disclosure: I am not entirely neutral, as both I and fellow PTer John Wilkins got to see the paper during its development, and give comments etc.)
PS: Oh yeah. I almost forgot. This quote is for those who think the results are trivial:
163 Comments
BWE · 12 May 2010
Most excellent.Thanks for the write-up Nick.
John Harshman · 12 May 2010
The paper itself (like the commentary) is paywalled, so all I have to go on here is Todd Charles Wood's commentary. And I think he makes a couple of valid points. Here's my version, which may not be Wood's:
1. Theobald is really, apparently, testing whether the sequences are significantly similar, i.e. more so than can be explained by chance resemblance. If they are, the single-tree model explains the data best. If they aren't, a multiple-tree model is at least as good. But he began by choosing proteins that were similar enough for homology to be clear. Is that a bias? Well, I'm pretty sure that level of similarity can't be explained by chance even if we correct for the sequences having been chosen from a universe of many more sequences. But it's something to think about. The creation model assumed here -- randomized sequences -- is falsified if we find any proteins at all with detectable homology.
2. It's not explicitly claimed to be a test of separate creation, but everyone is going to take it that way. Given that, what's the proper model for separate creation? We don't know. It could be that a rational creator would have originally made "kinds" using conserved (in the creation model, that equals "under strong purifying selection") proteins that were initially identical. Why not? (Then again, why? That's a problem with creation models.) And that's the same as having a common ancestor on a star tree. This is actually a test of significant similarity, and a creator could have made proteins with any degree of similarity from complete to none. The only creation model falsified here is one in which each "conserved" protein in each kind is randomly chosen from among all possible sequences that would perform the same function. And even then we would have to know how many such sequences there are, and know their range of similarity; this model seems to assume that sequences are effectively unconstrained.
Reed A. Cartwright · 12 May 2010
Dr. Theobald is rather busy at the moment with the end of the semester and media inquiries. He has promised me that he will write something up about this research for us later this week.
Diogenes · 12 May 2010
So THIS explains the Tea Party!
Nick (Matzke) · 12 May 2010
John Harshman · 12 May 2010
I see a problem here. A randomized protein, even with preserved amino acid frequencies, is a major assumption. If we suppose that god wanted the protein to function, and to have the same function (more or less) in the different organisms, that's not a good model. Presumably a small proportion of the randomized sequences would have the appropriate function. What constraints are imposed by functional necessity? We don't know, and would have to take that into account in any model of separate creation. I strongly suspect that constraints aren't enough to account for the observed data, but the present study doesn't show that.
It seems to me there are two more or less reasonable (scare quotes may be appropriate there) creation models: one in which god chooses random sequences from the set of all possible functional sequences, and one in which he chooses identical sequences. The first case emphasizes his infinite creativity, while the second emphasizes his (I guess) efficiency. Either seems equally likely considering his claimed attributes. Again, I haven't see the paper, but as described by Wood neither model is tested. A randomized model would inflate the likelihood difference compared to that first, functionally constrained model. And the second model would produce (after some considerable evolution, though potentially within separate kinds, as in a lawn) a correlation structure just like real common descent: instead of an ancestor there's a single identical part common to a variety of models. Like I said, that would be a star tree, so if Theobald also tests and rejects a star tree, he has dealt with that model. Does he?
Mike Haubrich · 12 May 2010
Pete Dunkelberg · 12 May 2010
Mike Haubrich, don't get hung up on the 'definition' red herring. Whole civilizations preceded the definition concept. This has nothing to do with what Nick said; it is immaterial whether some would say "X is life" or "X is not quite life" at some early stage. Don't think of the first life as a cell as we know them either.
I'm glad Nick made this 'starter' post on the paper. This will help everyone next week when Doug gets deeper into it. Stay tuned!
John Kwok · 12 May 2010
Scott · 12 May 2010
Nick (Matzke) · 12 May 2010
I don't think Mike was disagreeing with me, just applying the same logic further back. And he's right, it's probably populations all the way back to chemicals. Especially if you take the direction of recent OOL work which suggests self-replicating RNA-like molecules might be more likely to emerge from a collection of short sequences than from a single sequence...
Nick (Matzke) · 12 May 2010
Scott -- interesting points. The molecular Adam/Eve stuff was based specifically on mitochondria DNA (passed only through the mother) and Y-chromosome (passed only through the father, most of it doesn't recombine with the X). Each non-recombining marker does indeed trace back to a single individual -- this is called "coalescence". But the single individuals lived tens of thousands of years apart from each other, and each was living in a population at the time. And the thousands of recombining regions in the rest of the genome (the autosomes) each have their own histories, with few/none of them the same as the mtDNA or Y-DNA.
Nick (Matzke) · 12 May 2010
Joe Felsenstein · 13 May 2010
TomS · 13 May 2010
Creationists have, for quite a while, been saying that similarity between living things is an indication of a common designer. As if the pattern of similarities and differences reflected in taxonomy could be reduced to "all living things are similar".
As a practical matter, I think that if one could convince creationists of common ancestry just within the order Primates over a few tens of millions of years, that would be the end of creationism. There would be a few holdouts for separate creation/design of larger taxa, or about supernatural intervention hundreds of millions or billions of years ago, but there would be no general public interest in that.
John Harshman · 13 May 2010
eric · 13 May 2010
I have a question on the Zuckerandl and Pauling quote, and I'm not sure whether it bears on the paper or not (I don't have a subscription to Nature, so I'm going on what's written here). I was under the impression that modern 'organismal biology' phylogenetic trees incorporated genetic data - i.e. are sometimes corrected based on the genetic data - so the two tree types are no longer independent but rather dependent factors. This would greatly increase the probability of the two matching regardless of whether the model is correct. Is this a relevant issue? If so, how was it addressed?
John Kwok · 13 May 2010
stevaroni · 13 May 2010
DS · 13 May 2010
TomS wrote:
"Creationists have, for quite a while, been saying that similarity between living things is an indication of a common designer. As if the pattern of similarities and differences reflected in taxonomy could be reduced to “all living things are similar”."
Exactly. That is why it is so important to point out that not only are thing "similar" but they are similar in a very specific way. That is that they are similar in exactly the way predicted by descent with modification. Many of these similarities do not make any sense whatsoever from a design perspective. The precise types of similarities and the precise pattern of similarities are what is important, not some nebulous "god could have done it that way so common design" similarity.
Jim Thomerson · 13 May 2010
I've been convinced for some time of a single common ancestor for all living things. This raises some interesting speculation. If the conditions were right for the origin of the common ancestor, perhaps the conditions were right for origin or other potential common ancestors. Was it a matter that they were out competed by the common ancestor? Or were conditions for the origin of the common ancestor so rare and unusual that no competitors originated? This has some connection to speculation about origin of life elsewhere in the universe. If it is difficult and unusual, there may not be much life off earth, If it is common and easy, there may be living things all around.
Nick (Matzke) · 13 May 2010
Nick (Matzke) · 13 May 2010
"I’ve been convinced for some time of a single common ancestor for all living things. This raises some interesting speculation. If the conditions were right for the origin of the common ancestor, perhaps the conditions were right for origin or other potential common ancestors. Was it a matter that they were out competed by the common ancestor? Or were conditions for the origin of the common ancestor so rare and unusual that no competitors originated?"
Like I said, it could be populations all the way down. It is important to realize that even without competition/selection, in any replicating population, one replicator will eventually take over the entire population. Google "coalescence". Throw in selection and you get even more of this. This kind of selective sweep probably happened umpteen times in the gradual origin of replicating sequences and then cells and then the LUCA. The only significance of the LUCA is that it represents just the *last* time this happened on a global scale. (but different genes, etc., might have done it differently, producing different trees, but nevertheless there is good evidence that a bunch of genes did this, as Theobald shows)
eric · 13 May 2010
Douglas Theobald · 13 May 2010
Mike Elzinga · 13 May 2010
AnswersInGenitals · 13 May 2010
John Kwok · 13 May 2010
Robert Byers · 14 May 2010
I think I talked with this man on the Dawkins forums.
two points.
First biogeography is a friend to YEC. The migrations from the ark filling the earth all work fine.
In fact otherwise it seems to be a chaos of migration.
Its creationist doctrine that all life comes from a common blueprint.
Even kinds are just a twist on the blueprint. Everything has eyes, ears, legs, head.
It seems clear that there is a thinking being behind such organization and it seems that if evolution was true diversity and great happanchance would make creatures so wildly different looking.
The sameness of creatures inside and out and like sameness with all biology suggests simple plans that lead to logical diversity.
The sameness and fewness of creatures shows a poverty of evolution but fits limited kinds coming from simple, relative, basic plans from a general blueprint.
Perhaps models on what the biology should look like from billions of years and millions etc of selections should be made. The world today and in fossil seems rather bare and simple from what otherwise evolution would predict.
Dave Luckett · 14 May 2010
Leave it. You couldn't ask for better.
peter · 14 May 2010
"Leave it. You couldn’t ask for better."
Yes, Byers at his ignorant best.
Sylvilagus · 14 May 2010
Frank J · 14 May 2010
TomS · 14 May 2010
Frank J · 14 May 2010
Steve P. · 14 May 2010
Gary Hurd · 14 May 2010
In a comment to the AtBC thread, "Uncommonly Dense Thread 3," REC pointed out that creationist dipstick Cornelius Hunter had blagged on Doug's article.
Having screwed himself, Cornhole retraced his blog after Doug tried to gently point out the many errors- but ol' Corney still calls Doug a liar.
Stanton · 14 May 2010
One problem with your approach, Steve P., is that creationists and Intelligent Design proponents refuse to explain how to divine the goals of the "Intelligent Designer" in the first place. Another problems is that creationists and Intelligent Design proponents refuse to explain how the "Intelligent Designer" tinkers with life in the first place.
And then there is the tremendous problem of how creationists and Intelligent Design proponents refuse to explain how saying
GODDESIGNERDIDIT is relevant to science to begin with (many at the Discovery Institute have even confessed the opposite).So, Steve P., before you continue whining about current scientific theories and procedures, it would be best if you explained to us exactly how and why saying
GODDESIGNERDIDIT will benefit researchers.(cue Steve P. making a moronic and childish taunt as a reply)
Stanton · 14 May 2010
DS · 14 May 2010
Everyone knows that I would never stoop so low as to respond to Byers. However, interestingly enough, I already addressed exactly these points in my post above, so fortunately I don't have to. Except to point out, as so many others already have also, that his migration routine is also completely bogus as well. I guess this guy never heard of continental drift.
Funny how he somehow addressed completely new research without ever reading it, or explaining it, or even referring to it. Just the same old lies and distortions. Doesn't this guy ever come up with anything new? Oh well, at least he admitted that the supposed "blueprint" was actually "simple" and "basic". Doesn't seem to be much of a barrier to evolution then I guess. And of course if you are completely ignorant of all evolutionary theory it is easy to claim that it doesn't fit the data. More is the pity.
Just Bob · 14 May 2010
DS · 14 May 2010
Steve P; has indeed spouted all of this nonsense long ago. The thing is that he refuses to even read the literature that proves him wrong. You can't argue with that kind of closed mindedness, so I won't even try. I will simply point out once again that Steve is deliberately ignoring almost all of the research in modern genetics and it is all completely consistent with the modern theory of evolution. The supposed gap is found only between his ears.
DS · 14 May 2010
6.66
Includes points for two word sentence without capitalization and has religious implications.
stevaroni · 14 May 2010
fnxtr · 14 May 2010
John Kwok · 14 May 2010
hoary puccoon · 14 May 2010
DS--
Minor point that drives me crazy. "Continental drift" was rejected by geologists because it makes no sense. Granite plowing through basalt? Never happened. Plate tectonics, on the other hand, not only explains the pattern of fossil distribution perfectly, but also has all kinds of evidence, like sea floor spreading, to back it up. Writing continental drift when you mean plate tectonics may sound less like techno-jargon, but they really aren't the same thing.
Plus, you're setting up a situation where creationists can correctly "disprove" continental drift-- without mentioning the fact that geologists have already done so. Of course, the geologists who replaced continental drift with plate techtonics actually strengthened the evidence for ancient dispersions and subsequent evolutionary radiations. But the creationists won't mention that, will they?
Frank J · 14 May 2010
Mike Elzinga · 14 May 2010
DS · 14 May 2010
Lynn Wilhelm · 14 May 2010
I'm enjoying this conversation immensely. I can't even hope to get this much from reading the paper--stats, ugh! So thanks to all of you who can put it into easier concepts.
I have a comment on the semantics of the term common ancestor. I suppose that as a layperson I have always thought of this meaning a single organism--until I really think about it anyway. When Dawkins talks about going back to that ancestor and making the turn through the lineage of another organism, I don't recall him saying "ancestors".
The answer to this confusion would not be to use the plural*, but perhaps some term like ancestor species would work better. Perhaps it's a bit cumbersome, but I'm going to try to start using the term.
Just like using the terms continental drift or global warming opens a conversation up for debate (among laymen), so can common ancestor.
What do you think? Is there a better term.
*the plural would not work because it implies the entire lineage, which is likely why we don't use it now.
Sylvilagus · 14 May 2010
John Harshman · 14 May 2010
OK, now I've actually read the paper, thanks to Doug Theobald. I have quite a few questions, but I guess I'll wait until he's free.
Jim Thomerson · 14 May 2010
I think most of us think of common ancestor as being a species. The process for forming lineages from a common ancestor is speciation. Cladistic speciation is the splitting up of an ancestral species. So, perhaps, we have not really thought much about the nature of the common ancestor. A bacteriologist might see speciation differently, perhaps.
Grant · 14 May 2010
I wrote a blog article about this yesterday if anyone wants another non-paywall coverage of this:
http://sciblogs.co.nz/code-for-life/2010/05/14/testing-common-ancestry-to-all-modern-day-life/
Steve P. · 14 May 2010
Sylvilagus · 14 May 2010
Stanton · 14 May 2010
Dale Husband · 14 May 2010
RBH · 14 May 2010
RBH · 14 May 2010
Steve P. · 15 May 2010
Steve P. · 15 May 2010
Mike Elzinga · 15 May 2010
Dave Luckett · 15 May 2010
A tiny crack of light opens into SteveP's ideas. He has been very averse about specifying them so far. Steve appears to be conceding an ancient Earth, ancient life, and common ancestry of all life (and hence, slow change in allele over generational time).
It's the mechanism he balks at. Mutation, natural selection and genetic drift, he thinks, are insufficient to explain the origin of species, notwithstanding ample evidence that they operate to change allele over generational time, and that it has been demonstrated that they are sufficient in all known cases of change in allele.
Although he has produced no evidence for it, Steve thinks an invisible hand is guiding change in allele in a given direction. He hasn't the faintest idea whose this hand might be, nor how it operates, nor what it does, nor can he give any specific instance of its operations, nor can he cast any light on the direction of its intervention, which can only be seen in retrospect.
That is, his conjecture has no structure, no specific proposal, no testable implication, and no evidence whatsoever. His entire argument consists only of the repeated assertion that there must be such a cause, and that the observed natural causes are insufficient to explain the origin of species and the variety of life.
This is nothing more than the arguments from incredulity and ignorance in fancier dress than usual. Steve is saying no more than "I don't know how it happens, but I can't believe it happens this way, so it doesn't happen this way."
The most hilarious aspect of this is that the violence Steve has done to his own rationality is irrelevant. He has gouged out his own reasoning faculties for nothing. Denying the operant end of the theory of evolution means nothing to the dominionists and reconstructionists and the marching morons who support them. If they ever achieved their goals, they would as cheerfully immolate Steve as anyone else here.
Hence, his extreme reluctance to specify his own ideas. He knows, I think, that he has no allies at all. Hardly anyone occupies his contorted position: accepting common ancestry, but denying that speciation is explained by natural causes.
It's odd that a person as alive to his strategic position could be so obtuse in the matter he argues.
Robert Byers · 15 May 2010
Robert Byers · 15 May 2010
Dave Luckett · 15 May 2010
Maybe a 6. Only marginally incoherent. A point extra for the supreme vapidity of "Its more math theory then chaos theory". Perhaps half one more for the way he destroys his own thesis in the last sentence.
DS · 15 May 2010
Funny how Steve conveniently mentions only "replication error" and forgets all about selection. Oh well, what can you expect from a guy who doesn't even believe in competition?
As for Byers, yea, no one ever bothered to think about how a blind process would look different from one guided by an intelligence before. how novel.
It seems that the only argument that creationists have is to project their own ignorance onto everyone else. That should fool everybody.
Sylvilagus · 15 May 2010
Frank J · 15 May 2010
Frank J · 15 May 2010
John Kwok · 15 May 2010
I endorse completely your latest comments in rebuttal to Steve P. You didn't need to clarify yourself in your second comment, but I concur with your assessment.
Behe loves to play word games so much that I think he should have earned his Ph. D. in that. However, that's a mere aside.
More importantly, of course, is asking oneself whether an Intelligent Designer would be so "inefficient" to allow, over the course of the Phanerozoic Eon (approximately the last 540 million years of Earth's history, from the Cambrian Period to the present) at least seven, maybe eight, mass extinctions which completely "reshuffled the deck" with respect to biological diversity. Why go through the trouble of exterminating Burgess Shale type faunas, conodonts, graptolites, trilobites, nautiloid and ammonoid cephalopods, early mammal-like reptiles, all dinosaurs except for the sole avian lineage, and countless others, if all these meant "unsuccessful Designs" for an Intelligent Designer - I must presume Klingon scientists - to weed out. Doesn't strike me as a rational course of action for any Intelligent Designer to take.
TomS · 15 May 2010
Stanton · 15 May 2010
Dale Husband · 15 May 2010
Dale Husband · 15 May 2010
hoary puccoon · 15 May 2010
Did nobody else react to Byers's statement, "....evolution must say there is something right about so many unrelated creatures coming ending [sic] up with two eyes...."
Unrelated creatures? The entire basis of evolution is that all these two-eyed critters are related creatures. It's under the doctrine of separate creation that our boring binocularity makes no sense. (Haven't we all wished at times for eyes in the back of our heads?)
Frank J · 15 May 2010
stevaroni · 15 May 2010
RWard · 15 May 2010
SteveP,
You've used the term 'replication error' many times in this thread. I assume by that term you mean 'mutation', if so why not just use the term commonly used in discussions of evolution?
I only ask because I suspect you have a possibly amusing reason for using the non-standard term.
Frank J · 15 May 2010
Stanton · 15 May 2010
Henry J · 15 May 2010
Oh, lack of reply on here doesn't equate to lack of reaction - there may be other reactions than simply posting a response on this blog. Of course, we're talking about somebody who doesn't seem to realize that "common conclusion from a common blueprint" is what evolution says.
0112358 · 15 May 2010
I find the idea of common descent to be a bit paradoxical depending on how it is defined. It is usually defined as the idea that all life has descended from a single self-replicating entity that somehow came into existence in the distant past. But if one self-replicating entity came into existence, why not two? And if two, why not 3? It seems to me that the idea of common descent is a basic admittance to the staggeringly low likelihood of the appearance of life. Could it be that the formation of life was a very likely event in the primeval world? If so, the lifeforms we know today might not all trace back to one single common ancestor.
Henry J · 16 May 2010
Dave Luckett · 16 May 2010
Yes, it could be that the formation of life was a very unlikely event. I know this goes against intuition, but "very unlikely" is nothing like the same as "impossible". What we are considering is every successive chemical environment on the planet, over a period of a billion and a half years. When dealing with such enormous numbers, anything that can happen, did happen. And life, manifestly, can happen.
It simply does not follow that because life is unlikely, it must have arisen several or many times. In fact the converse is true. Life, once it occurred, changed its environment by being part of it, and this may explain the fact that other types of life, were they possible at all, did not arise.
fnxtr · 16 May 2010
Oh, good. Mr. Fibonacci. Here we go again.
Steve P. · 16 May 2010
Sylvilagus · 16 May 2010
stvs · 16 May 2010
Sylvilagus · 16 May 2010
Frank J · 16 May 2010
Just Bob · 16 May 2010
Just Bob · 16 May 2010
TomS · 16 May 2010
Just Bob · 16 May 2010
0112358 · 17 May 2010
Henry J · 17 May 2010
Robert Byers · 17 May 2010
Dave Luckett · 18 May 2010
Disappointing. 3. Apart from the confession of near-idiotic ignorance, is actually coherent. Must Do Better, Byers.
Robert Byers · 18 May 2010
Jesse · 18 May 2010
Robert Byers · 18 May 2010
Robin · 18 May 2010
Lynn Wilhelm · 18 May 2010
fnxtr · 18 May 2010
http://en.wikipedia.org/wiki/Four-eyed_fish
Sylvilagus · 18 May 2010
Stanton · 18 May 2010
Just Bob · 18 May 2010
stevaroni · 18 May 2010
Just Bob · 18 May 2010
MrG · 18 May 2010
Just Bob · 18 May 2010
Jesse · 18 May 2010
stevaroni · 18 May 2010
DS · 18 May 2010
2.666
Just the same crap over and over again. As has already been pointed out, most species do not have two eyes so Byers has not even got his facts straight. big surprise.
As for the ark nonsense, yea a single origin of all living things four thousand years ago is certainly the best explanation for the current distribution of organisms on the surface of the earth. That's what all of the experts have concluded. That;'s what it says in all the textbooks. Right?
0112358 · 18 May 2010
John Kwok · 19 May 2010
David Fickett-Wilbar · 19 May 2010
Dave Luckett · 19 May 2010
It depends on whether you regard "platypus" as a Greek word, or an English word. I take it to be an English word, made up from Greek roots by a classicist, no doubt, but an English word nonetheless. If it is an English word, it should be pluralised by English conventions. Therefore the plural is "platypusses".
"Octopus", on the other hand, is a genuine Greek word. It would then depend on whether you think it has become an English word. I think it has, so the plural is "octopusses". If you differ, it's "octopodes".
Jesse · 19 May 2010
English is a whore of a language that mixes and matches. Platypi sounds better and it's in the tradition of mixing things that don't match.
MrG · 19 May 2010
Along the lines of the old weak gag about the fellow trying to order ... mongooses? ... mongeese? ... mongi?
"Dear Sir: Please send me a mongoose. And while you're at it, please send me another one."
Dale Husband · 19 May 2010
0112358 · 19 May 2010
phantomreader42 · 19 May 2010
Stanton · 19 May 2010
Malcolm · 20 May 2010
Robert Byers · 20 May 2010
Robert Byers · 20 May 2010
Dave Luckett · 20 May 2010
Alas, only a 2. While the ideation is risible, the actual expression is actually coherent. "Not to see same shaped creatures as the same creatures" is worth a couple of points, I suppose, for sheer, overwhelming stupidity and the pride of ignorance, but this is not the Byers word-salad we've come to know.
Dave Luckett · 20 May 2010
Say, Byers, here's an idea. Why don't you submit your ground-breaking research on the commonality of marsupials and other animals shaped like them to “The Proceedings of the Natural History Society of South Burlington (Vermont)"? The editor tells us that he would welcome such, and you would both no doubt amuse each other endlessly.
Dale Husband · 20 May 2010
Lynn Wilhelm · 20 May 2010
John Kwok · 20 May 2010
Which such bizarre "logic" as yours, I am reasonably certain that the Canadian Navy would never leave its home ports of Halifax and Victoria afloat. Moreover, as a Canadian civil servant, aren't you ashamed to be writing such drivel as this? Based on prior scores, I would assign a grade of one for your latest instance of breathtakingly inane lunacy:
"Lets keep thinking here. To say that all creatures with two eyes come from a single original creature and so evolution never on its way to great diversity saw a chance or need for more eyes is a great saying. You have evolution doing everything else about changing this into that but the eyes stay put. Truly a living fossil. Saying evolution only had so much to work with and yet claiming evolution as the origin for biological diversity is defeating itself as a saying."
As for the rest of your absurdity, it's mere verbal diarrhea emanating from you.
W. H. Heydt · 21 May 2010
0112358 · 21 May 2010
Jesse · 21 May 2010
Stanton · 22 May 2010
Ichthyic · 22 May 2010
Theobald acknowledges that if you shuffle the columns in a given clad so that the correlations between that clad and the rest of the tree are eliminated then the multiple ancestry models fit better.
this assumption best fits the independent data we do have, so...
sure you could randomly reassemble the tree, but would it make sense?
nope.
In short his research shows that a single tree structure is the best way to model correlations among a subset of proteins that are shared by the 3 domains of life.
frankly, that's still quite a strong statement, and the only one so far that statistically is based on the data we actually can use to model with.
Ichthyic · 22 May 2010
Creationists should really come up with a commonly accepted definition of “kind” so that they can compare it against physical evidence.
I believe their current attempts to do so revolve around the "field" (if one could actually call it that without laughing) of "baraminology":
http://baraminology.blogspot.com/
so far, what I see is that slowly but surely, as they better define their terms and then try to actually apply them to the data at hand, they themselves are coming to the same conclusion post-hoc as evolutionary biologists did ages ago.
they won't admit this, of course, but it sure looks that way to anyone who cares to look at the state of their current "research".
Henry J · 22 May 2010
The definition that seems to come closest to the usage of "kind" is simply "clade" - the basic meaning of both is that descendants of members are still part of that grouping.
Henry
John Kwok · 22 May 2010
John Harshman · 23 May 2010
Henry J · 23 May 2010
Oh. Then a "kind" can contain several clades, since evolution within a "kind" is kind of allowed (depending on who you're talking to at the moment).
(How come "clade" isn't in the spell checker?)
Stanton · 23 May 2010
Robert Byers · 24 May 2010
Dave Luckett · 24 May 2010
Better. 6.5. The first para is up to the old standard, about equal parts ignorance, idiocy and incoherence, the three I's of a classic Byers. (Three, Byers, not two. Here's one place where a vertebrate has three I's. Always assuming that you're a vertebrate.)
Henry J · 24 May 2010
John Harshman · 25 May 2010
If this thread isn't dead yet (though it was coughin' up blood last night) I would like to return to the topic with a few questions.
It's pretty clear how a scrambled sequence order can produce a data set that prefers separate trees to a single one, since that would eliminate an effectively infinitely long branch. But I don't understand how the unscrambled data set prefers a single tree to separate ones. How can a part of the tree, and two trees are just a single tree minus one branch, have a lower likelihood than the whole tree? I can see how a model selection critierion like AIC might prefer the single tree, given the extra free parameters in the separate trees, but I don't see how the raw likelihood scores can come out better for the single tree.
Second quetion: I don't understand how a single sequence (H, for example) can have a likelihood score.
Is anyone still reading?
John Harshman · 25 May 2010
Apparently not.
0112358 · 25 May 2010
John Harshman · 25 May 2010
0112358 · 27 May 2010
John Harshman · 27 May 2010
You are merely repeating your previous statement. And I don't see how that affects the likelihood calculation for a tree. The likelihood is the product of a great many probabilities of state transformations between nodes. Separate trees have all the same nodes as a single tree, minus two. The probabilities for the shared internodes should be the same in both cases. A combined tree would divide two internodes and add another. Adding an internode should reduce the likelihood, since its transition probablities are additional multipliers.
Can you explain this?
John Harshman · 27 May 2010
One potential explanation is that the two broken internodes (that is, the two branches by which the separate trees are attached) have significantly higher transition probabilities when broken than when unbroken. Is that it, perhaps?
0112358 · 27 May 2010
Howard A. Landman · 29 May 2010
I think what Cornelius Hunter fails to understand is that, for the cases where Doug Theobald is evaluating sets of models which are disjoint and complete, his numbers are not just relative likeliness but absolute likeliness. The argument that they are only relative requires the existence of unaccounted-for alternatives.
For example, when testing "humans share ancestry with the rest of life" versus "humans have separate ancestry from the rest of life", there is no other possibility. The absolute likelihoods of the two models must sum to 1. Now, it is certainly possible that some other model could be better - for example, it could theoretically have been the case that the model "humans and other primates have separate ancestry from the rest of the tree of life" was more likely than either of the above - but in that case the complementary model would be "humans and other primates share ancestry with the rest of life".
The key thing here is that adding constraints to a model can only lower its likelihood. So, once you have established that "humans have separate ancestry from the rest of life" has likelihood no greater than 10^-3000 with no additional constraints, you have also shown that ALL models which include that as one constraint (and have other constraints as well) have likelihoods which are no greater. Thus, NO creationist model which includes the idea that humans were created separately can be any better than that.
John Harshman · 30 May 2010
Howard A. Landman · 3 June 2010
John, I'd like to hear Doug's view on that. It seems to me that Bayes' Rule is sufficient to transform what was said in the paper into something very close to what I said.
Specifically, consider two complementary hypotheses like (A) "Humans had no common ancestor with any of the 11 other species considered in the paper" and (B) "Humans had a common ancestor with at least one of the 11 other species considered in the paper", and let D stand for the data. We obviously must have P(A) + P(B) = 1 and P(A|D) + P(B|D) = 1, and also by Bayes Rule P(A|D) = P(D|A)P(A)/P(D) and P(B|D) = P(D|B)P(B)/P(D).
What Doug gives us is essentially P(D|A) and P(D|B). And yes, those don't add up to 1, nor did I ever say they did. But if you make the maximum entropy assumption that the a priori probabilities of A and B (ignoring the data) are equal, then we have P(A) = P(B) = 0.5. Given that, then P(A|D)/P(B|D) = P(D|A)/P(D|B), and hence P(A|D) = P(D|A)/(P(D|A) + P(D|B)) and P(B|D) = P(D|B)/(P(D|A) + P(D|B)) by simple normalization.
That was my claim: that you can calculate the absolute probabilities of the hypotheses corresponding to the models from what's given in the paper with only a few, reasonable, assumptions. You still see something wrong there?
John Harshman · 3 June 2010
Howard A. Landman · 5 June 2010
I agree that the paleontological and other data should give common ancestry a very much better than 50% a priori likelihood. I was trying to be (perhaps unfairly) fair to the creationists. When you have a 3000 orders of magnitude advantage, you can afford to be generous.
It is true that the a priori probabilities P(A) and P(B) directly affect the final probabilities. But it doesn't seem to matter much whether we start believing that common ancestry is 99.99999999% likely or 0.00000001% likely; the end result after applying 10^3000 from the protein evidence is that we either think UCA is 10^3010 times more likely, or that it's 10^2990 times more likely. Either one is completely overwhelming odds.
I see your point about a single tree not covering all possibilities. However, the two trees Doug compares are (usually) identical except for a single disconnection in one. Thus it seems to me that the relative likelihoods mostly give information about that particular connection or disconnection, and not much about the rest of the tree (which should apply roughly equally to both models, and hence cancel out). I would expect, for example, that if you rearranged a few other branches of the tree the same way in both models, without anything jumping from one subtree to the other, then the relative likelihood would be nearly unchanged. This is easily testable, and if true would mean that the "sum over all trees that fit your requirements" would just give roughly the same answer we already got from the first tree, regardless of what relative weighting we gave those trees in the sum.
The presence or absence of a single edge on the graph corresponds pretty directly to the kind of complementary hypotheses I proposed. So, while I acknowledge that there are some gaps in my chain of reasoning that are not (yet) completely rigorous, it still seems unlikely to me that any of these would throw off the conclusion by very much.
John Harshman · 5 June 2010
I think you are straying quite far from your original claim here. Would you agree? In fact you have gone from "absolute probability" to "relative probability", though you think the relative probabilities could be used to estimate absolute probabilities. That may be true, but each new assumption (and you have at least two rounds of them so far in response to my objections) adds another layer of uncertainty. You also fail to consider other alternative trees that divide the taxa into two or more groups.
Also, where are you getting this figure of 10^2990? According to the supplementary information, the log likelihood of ABE is -126,299 while the log likelihood of ABE(-H) + H is -140,339, which would mean that the difference in log likelihoods is nearly 14,000, or a factor of 10^6000. I will note that the log likelihood of ABE(-H) is -121,200, while H is -19,139. So just about the whole difference here lies with H. How does anyone come up with a likelihood for H? That's one thing I can't figure out.