Just as none of the parts of the Foghorn system is used for anything except controlling the fall of the telephone pole, so none of the cascade proteins are used for anything except controlling [he formation of a blood clot. Yet in the absence of any one of the components, blood does not clot, and the system fails. (Behe 1996, pp. 85-86)Actually, the clotting cascade proteins do have functions other than clotting, indeed Casey's so-called "Irreducible Core" proteins have other important functions. I go into greater detail in this post about how these functions may have pre-adapted the clotting proteins for their role in clotting. This exposes a major flaw in the concept of irreducible complexity (read the post for the full argument). Casey also chides Miller for not doing any knock-out experiments on blood clotting systems. This is heavily ironic as no ID proponent, not even Behe, has done any experiments on the blood clotting system. As I point out in my post Behe vs Lampreys+, it's the evolutionary biologists that have been doing all the heavy lifting in regard to understanding the clotting system. In fact I issued a challenge to the ID proponents, the Amphioxus genome had just been published at http://genome.jgi-psf.org/Brafl1/Brafl1.home.html. Amphioxus is a primitive chordate, more primitive than lampreys, that clot their haemolymph. I challenged the ID proponents to predict which coagulation factors are present in Amphioxus, search the Amphioxus genome database and report on whether the genes found match their predictions. Since then, silence. I can tell you one thing for sure. The Amphioxus has no gene for fibrinogen, the final step in the modern clotting cascade, yet it still clots its haemolymph. So the very basis of the "Irreducible Core" that Casey goes on about is absent in these animals, and one of Behe's iconic pathways is exposed as reducible. Notes:
UPDATE: Yeah, yeah: I can't spell when writing at 1 am in the morning. But the most embarrassing bit was I got Ken Miller's name wrong (sorry Ken). Still, the science is right.
* I could have contributed sooner, but I could be playing frisbee on the beach with my kids or surfing the internet. Guess which one I chose.
+This post also has a very nice diagram of the reducibly complex clotting system that Ken Miller discusses (section 4, "An Irreducible Core"). This diagram looks eerily similar to the diagram that Casey uses, as he copied the diagram that I provided for Barbara Forrest and Paul Gross for "Biochemistry by design," Trends in Biochemical Sciences, Vol. 32(7):301-310 (2007). He's made a few minor modifications (hint Casey, the correct citation method is "diagram redrawn from" not "information obtained from"), but if he asked nicely, I could have given him the original diagram.
34 Comments
Pete Dunkelberg · 5 January 2009
Just Bob · 5 January 2009
Hey...uhh...I think that should bepiling on , not "pilling on," which would mean, I guess, throwing aspirins.
Lazy Day · 5 January 2009
Dave S. · 5 January 2009
fibrinogen, prothrombin, Stuart factor, and proaccelerin." Saving IC is as easy as that. Clearly that's what Behe really meant and how dare Miller missrepresent him like he did!!!gabriel · 5 January 2009
Frank J · 5 January 2009
Wow, Zimmer, Miller Matzke and now Musgrave, all shooting the poor (& I mean that in both senses) messenger. That means one thing - the “Darwinists” are panicking.
Just kidding - I couldn’t resist!
Luskin is so wrong in so many ways that I can’t think of any way to give it justice other than with long, detailed rebuttals with plenty of technical references. Unfortunately such rebuttals won’t be read and understood by many people who might be impressed by ID’s sound bites but are not wedded to their childhood fairy tales. Luskin and other DI activists will certainly spin the rebuttals as “Darwinist hysteria,” and mine the rebuttals for more juicy facts to misrepresent. Granted, their spin might not be read and understood by many people either, but if it reaches even a slightly larger audience, the DI wins the round.
So it’s not surprising that Miller ends his rebuttal on a calm, but cautionary note. AIUI, during the next trial there will be a new book (“Explore Evolution”?) peddled for ID’s replacement strategy (“strengths and weaknesses”?), so the description of IC in “Pandas” and any contradictions with “Darwin’s Black Box” might be moot. The DI certainly has more rhetorical tricks up its sleeve – and less clumsy messengers than Luskin if necessary. Maybe Dembski himself might show up at the next trial (yeah, right).
A commenter on another thread was worried that a judge who’s not as science-literate as Judge Jones could easily tip the outcome in the DI’s favor. While common wisdom is that a Scalia-type authoritarian would be most DI-friendly, I would not be surprised if a liberal judge rules in favor of the next scam. After all, the DI is hell-bent on liberalizing the boundaries of science to accommodate ID – and astrology, as Behe admitted at Dover.
Mike Elzinga · 5 January 2009
These excellent reviews of ID/Creationist distortions and misconceptions come at a good time.
I don’t know if anyone else here is experiencing this, but in the last few weeks there has been a sudden upsurge in letters to the editor of our local newspaper pushing the ID/Creationist arguments. There seems to be a “disturbance in the Force.” Apparently local fundamentalist churches are putting on the war paint for another battle.
I just sent a letter to our local newspaper rebutting a really stupid revival of the “entropy argument”. There have also been a number of others pushing the “fairness or academic freedom” argument, one complaining about persecution, and another pushing other creationist misconceptions.
The letter about entropy was from a former local who moved to Texas. He is obviously fired up by events taking place there.
If indeed there is a new war being started, perhaps getting a convenient updated collection of all these takedowns would be helpful to any public school science teachers lurking out there.
Just Bob · 5 January 2009
John Kwok · 5 January 2009
Jedidiah Palosaari · 5 January 2009
wolfwalker · 5 January 2009
Ian Musgrave · 5 January 2009
Steve Fonken · 5 January 2009
mplavcan · 5 January 2009
Dave Luckett · 5 January 2009
We can't know what Jesse Kilgore went through. Who can know what path led to those October woods?
But I think that part of it, at least, was that Jesse Kilgore had nothing to fall back on. His faith was uncompromising - until it became impossible. And then it was nothing.
But is that the fault of the impact of new ideas, or is it the fault of the faith? Can it really be true that mere exposure to the idea of atheism, or science, or whatever the DI wants to blame, is to be held responsible for that poor young man's death? I don't think so. I think the true cause is the rigidity and fragility of the faith Jesse Kilgore was born into. An informed, educated, intellectually adequate Christianity would have countered Dawkins, and accommodated the material evidence of the real world. Jesse Kilgore's biblical fundamentalism could not do that; but that is an indictment against it, not against the person who introduced him to new ideas.
Introducing people to new ideas is what college professors do; it's what college is for. That his faith was shattered by that is proof of its fragility. That he could find no new meaning in it is proof of its inadequacy. I hope he found the peace that it denied him.
As for the DI, it is blind to all decency. It battened upon this poor young man's agony, wrapping a pitch for donations in unctuous condolence. Be damned to them.
KP · 5 January 2009
Jedidiah Palosaari · 5 January 2009
Shoot- I forgot to mention in my responses, the other obvious point- we don't believe that evolution is an unguided process. No one believes that. Whether you're a theistic evolutionist or not, you believe it's guided- by natural selection.
Stanton · 6 January 2009
H.H. · 6 January 2009
One detail that seems to often be omitted by the faithful who repeat this story is that Jesse Kilgore was also a returning Iraq War veteran--a group with an unfortunately high rate of suicide. The only person who knows why Jesse Kilgore really killed himself is Jesse Kilgore. His father is distraught and looking for answers. He found a Dawkins book about atheism under his kid's mattress, and it has become a focal point for all of his misplaced confusion, grief, and anger. His reaction is understandable, if severely misguided. I suspect the DI fully understands this, but are more than happy to use this man's grief for their gain, because they just really are that low.
Christophe Thill · 6 January 2009
By the way, why doesn't Behe speak himself? Isn't it what he would do if he really was a scientist? Would he need a lawyer to speak in his place?
Frank J · 6 January 2009
Ron Okimoto · 6 January 2009
SWT · 6 January 2009
Frank J · 6 January 2009
Brian Regal · 6 January 2009
Reading the story about poor Jesse the suicidal college student made me think of an episode in my own life. Before I became an historian of science I made my living as a scientific illustrator (I did the illustrations for Fastovsky and Weishampel's dinosaur textbook. Illustrations that no one apprently liked). In the Sping of, I think, 1990, I was doing a showing of my artwork at a local county gallery and the newspaper sent a photographer to my house for an interview on my work. The photographer became fixated on my paintings of dinosaurs and cavemen to the point of agitation. Finally he couldn't take it any more and blurted out "How do you reconcile all this with the Bible!" At first taken aback, I calmly explained how I felt, how evolution worked etc. By the time he left he was shaking my hand all smiles and thanking me for clearing up so many questions he had. I hope he didn't do what Jesse did, becasue I think I undermined his faith with just a minute or two of earnest conversation.
stevaroni · 6 January 2009
Karen S. · 6 January 2009
Shame on the DI for prostituting this tragedy for their own gain.
Frank J · 6 January 2009
KP · 6 January 2009
eric · 6 January 2009
KP · 6 January 2009
Jedidiah Palosaari · 6 January 2009
Ron, you bring up something else to mind. The DI is incessantly calling for "equal time". They want both sides taught- both evolution, and ID- they say. Yet here, they are attributing suicide to reading a philosophical perspective that they tie to evolution. Their implication is that you will die if you read these thoughts. It would appear to give lie to their claim to equal time as well. Unless they are actually advocating that everyone have the opportunity to be taught both perspectives, yet one perspective will surely kill you???
Frank J · 7 January 2009
Ron Okimoto · 7 January 2009