[2.] Michael Shermer, Why Darwin Matters: The Case Against Intelligent Design, pg. 75 (Times Books 2006). Now what is the actual argument by Shermer?In 2006, Michael Shermer asserted, "Rather than being intelligently designed, the human genome looks more and more like a mosaic of mutations, fragment copies, borrowed sequences, and discarded strings of DNA that were jerry-built over millions of years of evolution." [2]
— Casey Luskin
Why does Luskin fail to inform us of the context of the argument? Well, the answer is really simple: The facts do not support his vacuous claims about neo-Darwinism and "Junk DNA". To argue that people did not know that there are countless regulatory elements 'hidden' in the "Junk DNA" ignores the history. For those interested in the real science behind these findings, please read John Timmer's Genomic study finds enhancer of human hands (or feet) or Did a gene enhancer humanise our thumbs? at Not Rocket Science. The Yale news release may help explain Luskin's "confusion" but he should know that rather than accepting news releases, one should look at the actual papers to arrive at one's conclusions. In the journal science Science, Wray and Babbitt provide their perspectives on the study.DNA is information, and if the Law of Conservation of Information requires the input of an Intelligent Designer in order to increase specified complexity of the genome, we have to wonder why the Intelligent Designer added to our genome junk DNA, repeated copies of useless DNA, orphan genes, tandem repeats, and pseudogenes, none of which are involved directly in the making of a human being.
The study in question was also published in science as Human-Specific Gain of Function in a Developmental Enhancer Science 5 September 2008: Vol. 321. no. 5894, pp. 1346 - 1350Abstract: Nearly half a century has passed since François Jacob and Jacques Monod demonstrated that specific noncoding sequences are required to activate genes that metabolize lactose in the bacterium Escherichia coli (1). In a prescient observation, they noted that mutations in these regulatory sequences might play a role in the evolution of organismal traits. They further argued that gene function is not only based on the biochemical activity of its product but also on how the gene's expression is regulated. This idea was expanded in 1975 in an influential paper by Mary-Claire King and Alan Wilson (2), who proposed that trait differences between humans and chimpanzees are primarily due to regulatory changes in gene expression. Decades elapsed, however, before it was feasible to begin testing these ideas in detail. Two papers in this issue, by Prabhakar et al. on page 1346 (3), and by Hong et al. on page 1314 (4), demonstrate the power of combining bioinformatic approaches with experimental tests to characterize such regulatory regions. A major impediment to studying the evolutionary importance of mutations in regulatory regions is simply knowing where to look. DNA sequences that regulate the transcription of genes occupy no fixed position relative to coding DNA regions and are often diffuse and widely dispersed. Even when the position of a regulatory element is known, there is the added challenge of identifying which mutations have functional consequences. Within coding sequences, the genetic code imposes familiar regularities: Mutations that change protein structure can be identified exhaustively and unambiguously. By contrast, identifying functional mutations within regulatory regions requires experimental tests of putative regulatory elements from different species or individuals--a costly and time-consuming process. Bioinformatic methods offer a way to identify promising functional noncoding regions and to narrow the focus for experimental tests.
As to the scientific vacuity of Intelligent Design, ask yourself the following simple question: How does Intelligent Design explain these findings? Is it anywhere similar to how Dembski 'argued'?Abstract: § Changes in gene regulation are thought to have contributed to the evolution of human development. However, in vivo evidence for uniquely human developmental regulatory function has remained elusive. In transgenic mice, a conserved noncoding sequence (HACNS1) that evolved extremely rapidly in humans acted as an enhancer of gene expression that has gained a strong limb expression domain relative to the orthologous elements from chimpanzee and rhesus macaque. This gain of function was consistent across two developmental stages in the mouse and included the presumptive anterior wrist and proximal thumb. In vivo analyses with synthetic enhancers, in which human-specific substitutions were introduced into the chimpanzee enhancer sequence or reverted in the human enhancer to the ancestral state, indicated that 13 substitutions clustered in an 81-base pair module otherwise highly constrained among terrestrial vertebrates were sufficient to confer the human-specific limb expression domain.
William A. Dembski Organisms using GAs vs. Organisms being built by GAs thread at ISCID 18. September 2002 Michael Eisen describes his views on the Scientists cynical use of "Junk DNA", if only ID proponents could show a similar skepticism. Finding regulatory elements is quite a bit more complex than finding genes, and only recently the computational power has allowed science to more accurately study regulatory elements. In this caseAs for your example, I'm not going to take the bait. You're asking me to play a game: "Provide as much detail in terms of possible causal mechanisms for your ID position as I do for my Darwinian position." ID is not a mechanistic theory, and it's not ID's task to match your pathetic level of detail in telling mechanistic stories. If ID is correct and an intelligence is responsible and indispensable for certain structures, then it makes no sense to try to ape your method of connecting the dots. True, there may be dots to be connected. But there may also be fundamental discontinuities, and with IC systems that is what ID is discovering.
— Dembski
In other words, science found how a sequence had more than the expected number of differences between humans and chimps. Such an observation requires an explanation. This lead to the conclusionThe recent paper focuses on a sequence, called HACNS1, which is about 550 bases long. If it were picking up mutations at random, the human version would be expected to have four; instead, it has 13 differences with the chimp sequence.
— John Timmer
And that is how real science works.HACNS1 lies outside of any known genes, suggesting it is regulatory DNA. The researchers hooked it up to a gene that couldn't otherwise be expressed and injected the DNA into mice. As expected, the regulatory function caused the gene to be expressed in a very specific pattern in the head and limbs. The key result came when the chimp version was hooked up to the same gene and injected into mice--the limb expression was severely reduced or absent. The obvious inference here is that the sequence drives human-specific gene expression, specifically in the areas that form the hands and feet, which are obviously quite distinct in humans. The researchers also made two constructs that had only six of the 13 changes from chip to humans and found that these drove expression was somewhere in between the humans and the chimp sequences, which is exactly what you'd expect from a gradual, evolutionary change. There's still work to be done, as HACNS1 lies about halfway between two different genes, and the researchers don't know which of the two it regulates. Still, it's a pretty exciting result, and worthy of the attention it received.
— John Timmer
46 Comments
David Stanton · 28 September 2008
But, but, but how could 13 SIMULTANEOUS changes all occur? You can't actually expect anyone to believe that this is evidence for evolution.
Well, someone was going to say this eventually. I just thought I would beat them to it.
PvM · 28 September 2008
Stanton · 28 September 2008
Is the Discovery Institute still trying to use the "Junk DNA has purposes that evolutionists can not find" argument?
And how come they haven't attempted to explain why pufferfish of the family Tetraodontidae have almost no Junk DNA or introns?
Oh, wait, they're not in the business of looking at "pathetic levels of detail," or even explaining anything.
Stanton · 28 September 2008
Mike Elzinga · 28 September 2008
Stanton · 28 September 2008
tacitus · 28 September 2008
I've never really understood how IDists can claim that the absence of junk DNA in a designed organism is a prediction of ID.
Who's to say that their putative designer didn't use a design that either used junk DNA in an essential process or perhaps generated junk DNA as a necessary byproduct?
For example, if I were to analyze a memory dump from a computer that's been running for a few hours, there are going to be regions of memory that have nothing but junk/garbage left in them from old programs that are no longer running. That's just the way computers are designed to operate.
They tell us we have no way to infer what the designer would or could have done, yet in the very next breath they try to claim that ID can predict that a designer just "wouldn't have done it that way" when it comes to junk DNA.
When I have made this point to ID sympathizers in the past, they just say that I don't understand ID. When I then quote Dembski's own words about the inability of ID to predict anything about the designer, and ask them to help me understand why that doesn't prevent them from making predictions about specific design decisions made by said designer, they won't or can't give give me a straight answer.
Of course, it's fairly obvious what's happening. Since God is the only designer they would consider possible, and since God is perfect and his designs are perfect, then there is no place for imperfect stuff like so-called junk DNA in his designs. That would be tantamount to heresy.
PvM · 28 September 2008
iml8 · 28 September 2008
Didja see Luskin's gripes about an article discussing
engineering design that took its inspiration from
biostructures? The article said the
inspirational biostructures were the products of eons of
evolution. "Yeah, and your point is?"
"THE MEDIA TRIES TO QUASH INTELLIGENT DESIGN OVERTONES!"
"Well ... actually, I think it was more of a case that
they didn't expend any cycles on it."
I'm not even going to bother to complain about this.
White Rabbit (Greg Goebel) http://www.vectorsite.net/gblog.html
PvM · 28 September 2008
PvM · 28 September 2008
Mike Elzinga · 28 September 2008
iml8 · 28 September 2008
Dan · 28 September 2008
Casey Luskin reminds me of Muhammad Saeed al-Sahhaf
http://en.wikipedia.org/wiki/Muhammed_Saeed_al-Sahaf
better known as Baghdad Bob.
tacitus · 28 September 2008
PvM · 28 September 2008
PvM · 28 September 2008
Mike Elzinga · 28 September 2008
Paul Burnett · 28 September 2008
JPS · 29 September 2008
Does anyone know of a humanities-grad friendly overview article about non-coding DNA? I'd like to read up a bit before opining on Luskin's argument.
Dave Lovell · 29 September 2008
Albatrossity · 29 September 2008
iml8 · 29 September 2008
eric · 29 September 2008
David Stanton · 29 September 2008
JPD,
A good overview of "junk DNA" can be found at the link that PvM provided above. However, you don't have to read about junk DNA to know that Luskin's argument is nonsense. He isn't even talking about "junk DNA", he's just too ignorant to know it and he hopes you are as well.
Glen Davidson · 29 September 2008
william e emba · 29 September 2008
JPS · 29 September 2008
Mike Elzinga · 29 September 2008
iml8 · 29 September 2008
iml8 · 29 September 2008
DaleP · 29 September 2008
Mike Elzinga · 29 September 2008
Mike Elzinga · 29 September 2008
iml8 · 29 September 2008
Paul Burnett · 29 September 2008
Mike Elzinga · 29 September 2008
Mike Elzinga · 29 September 2008
Chris Lawson · 29 September 2008
Paul Burnett · 29 September 2008
iml8 · 29 September 2008
slpage · 30 September 2008
Luskin seems to think that Dembski's contrived "Law of COnservation of Information" has validity and it relevant and applicable.
What an imbecile.
minimalist · 30 September 2008
iml8 · 30 September 2008
I suspect that (on the principle that if all you have is
a hammer all you see is nails) the TMLC approached the Dover
trial as a legal issue, without understanding that the
case was going to be decided on a scientific basis.
The odd thing is that
there are plenty of lawyers with engineering degrees who
work on patent cases and plenty of lawyers with MDs or
the like who work on product liability cases -- and I
would place a very large bet that both those categories of
cases make Establishment Clause cases very small beer in
comparison. I'm a bit surprised that they didn't have
anybody with a technical background on board.
White Rabbit (Greg Goebel) http://www.vectorsite.net/tadarwin.html
minimalist · 30 September 2008
It makes sense if the TMLC is really all about the Jesus, and makes its bread and butter through wingnut welfare. What with Liberty University and its ilk establishing law schools and grad schools that completely insulate the students from reality, we may soon be up to our ears in people with 'professional' degrees whose educations have been thoroughly focused on The Jesus, with no practical concerns like patent law or product liability.
I really should try to find out what people know about the TMLC; are these actual experienced lawyers or recent graduates of the fundie-school Bubble Universe? We'll be seeing more people like them in the future, no doubt, and it will be worthwhile to be forearmed...
Paul Burnett · 30 September 2008