Aminoglycoside acetyltransferase isn’t particularly complex, it’s a simple 201 amino acid long protein that is a member of a large family of proteins that transfer acetate from Acetyl Coenzyme A to … well, just about anything. For example, many bacteria use these things for adding acetate to biogenic amines such as serotonin (yes, bacteria have serotonin). In this particular case, a mutation to an aminoglycoside acetyltransferase that normally breaks down the antibiotics kanamycin and neomycin (and other structurally similar antibiotics) results in an enzyme that can still breakdown aminoglycoside antibiotics, but can now break down structurally unrelated fluoroquinone antibiotics (eg. ciprofloxacin) . Figure 3 from Maurice F, Broutin I, Podglajen I, Benas P, Collatz E, Dardel F. Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance. EMBO Rep. 2008 Feb 22; A shows the structure of one of the standard amionglycoside antibiotics, the counter-ion HEPES and ciprofloxacin, B shows how HEPES fits into the standard aminoglycoside acetyltransferase Ib, with important binding sites identified, C shows how the mutant binding sites now fit ciprofloxacin into the enzyme. This is particularly significant, as the wholly synthetic fluoroquinones have never been present in the environment before humans produced them. The first report of metabolic resistance to fluoroquinones was in 2006, so this is a recently evolved mutation. A single mutation is enough to produce an enzyme that can break down fluoroquinones (Robicsek et al, 2006). This shows just how mutable proteins are, and how very simple changes can produce significant novel metabolic pathways. Remember, the enzyme can now act of a wholly synthetic chemical, never present in the environment before, which doesn’t look like the natural substrate for this enzyme. In this particular case, we can easily recreate the mutations that lead to the development of fluoroquinone metabolizing enzymes. Contra Wells, we can explain the origin of this enzyme without hypotheticals. What about penicillin resistance? Beta lactamases, a group of enzymes which break down penicillin, have diverse origins, but most trace their lineage to a group of cell wall synthesis enzymes, the D-Alanine D-Alanine peptidases (which in turn are minor modifications of more general peptidase enzymes). We can test the idea that beta-lactamases originated from D-Alanine D-Alanine peptidases by making the same putative mutations in D-Alanine D-Alanine peptidase and see if we can produce a beta lactamase. In fact, a single mutation is all it takes to convert a D-Alanine D-Alanine peptidase to a beta-lactamase (Peimbert M, Segovia L. 2003). The D-Alanine D-Alanine peptidases have generated a number of different antibiotic resistance proteins. It only takes a single mutation in a D-Alanine D-Alanine peptidase to convert it to a vancomycin resistance enzyme (Park et al 1996). Our understanding of the evolution of antibiotic resistance, far from being predicated on “unlikely mutations over unimaginable times”, is based on very likely mutations over a few decades, that we can, and have, tested experimentally. Now, you just have to go to the original Science Daily report to see Wells is wrong, that the researchers have both the ancestor and the evolved enzyme. No hypothetical mutations needed. If you expend a bit more effort you can go to the linked abstract from the actual paper, or do a Wikipedia search of antibiotic resistance, to see that Wells is is very wrong. Who did Wells think he was fooling?First, some bacteria happen to have a very complex enzyme (acetyltransferase), the origin of which Darwinism hasn’t really explained. Come to think of it, most cases of antibiotic resistance (including resistance to penicillin) involve complex enzymes, and the only “explanations” for them put forward by Darwinists are untestable just-so stories about imaginary mutations over unimaginable time scales.
— Wells
While Mendels’s theory of genetics didn’t quite contradict Darwins’s theory of genetics (they were both particulate theories, but Darwin's was a somatic cell based theory), it did contradict the most widely held theories of inheritance at the time (blending inheritance - almost no-one accepted Darwin's theory of inheritance, even people who accepted evolution and natural selection). Importantly, Mendel’s theory did support Darwin’s theory of natural selection, by showing how variants would not be lost over time (as they were with blending inheritance). Darwinists didn’t reject Mendel’s theory. Mendel’s theory was originally ignored partly because published in an obscure journal with limited distribution and partly because it attempted a radical mathematical analysis of biology that the few people who read Mendel’s paper did not understand. It was rediscovered by evolutionary biologists in 1900 seeking to understand heredity. Biologists of all stripes rapidly took the theory up. This can all be found at Wikipedia and other online sources, so it is hard to see what Wells is hoping to accomplish with his farrago of nonsense. Mendel’s work was heavily promoted by evolutionary biologists who thought saltation (mutational jumps) drove evolution. The big problem for natural selection was that although Mendelian inheritance explained how favourable traits could persist and not be diluted out, the traits appeared to be binary, you either had a trait or not (incomplete dominance not withstanding). How could it explain traits that appeared to have continuous variation? This was solved between 1918 by statistician RA FisYet Mendel’s theory of genetics contradicted Darwin’s, and Darwinists rejected Mendelian genetics for half a century.
— Wells
This is the exact opposite of the truth. Mendelian genetics describes the particulate nature of the gene, and how these particulate genes are inherited. Natural selection describes how these particulate genes spread through the population, based on the degree of fitness they provide to the organism. The issue is a bit simpler in bacteria, where there is usually only one copy of a gene. We know that organisms vary, and that mutations will generate new variations, new genes, not previously seen. We know that if there is selection pressure, these genes will spread. We know that if we control the selection pressure (either by using controlled, high doses of antibiotics to ensure all bacteria are wiped out, or by using multiple antibiotics in chronic infections), we can reduce the appearance and spread of resistance genes. We can even predict the emergence of new resistant strains using evolutionary analysis (Delmas et al., 2005; Orencia et al., 2001). All this from understanding evolutionary biologyAnd although an understanding of genetics is important when dealing with antibiotic resistance, Darwin’s theory of the origin of species by natural selection is not.
— Wells
No, they understood that the difference between the fluoroquinone metabolizing enzyme and the parent enzyme was due to mutations, so they sought out the sequence differences, and determined how they affected the structure. As well, based on the structural flexibility they determined, they made predictions of the likely ability of the parent and child enzymes to evolve further, novel actions and antibiotic substrates, based on known selection pressures.Third, Dardel and his colleagues made their discovery using protein crystallography. They were not guided by Darwinian evolutionary theory; in fact, they had no need of that hypothesis.
— Wells
Understanding how novel mechanisms arise via mutation, understanding how selection pressure makes these mutant genes spread, understanding how to modify selection pressure to reduce/prevent the spread of antibiotic resistance genes. Understanding the importance of the structural basis of the target mutations. That’s how. You can intelligently design your antibiotic all you like, make it fit snugly into its target enzyme, make it resistant to degradation by the current crop of degradation enzymes. But if you don’t take account of the evolutionary potential of the bacterial enzymes and the target enzyme, and understand how resistance spreads, then your intelligently designed antibiotic is toast before it even gets through clinical trials (crunchy, tasty and easily broken down). update: Orac has weighed in on this article as well. PZ Myers mentions it as well. References:So how, exactly, is Darwinian evolution essential to understanding and overcoming antibiotic resistance as the Darwinists claim it is?
— Wells
210 Comments
Nigel D · 3 March 2008
rimpal · 3 March 2008
Fisking Wells? Such fun, like shooting fish in a barrel
Ravilyn Sanders · 3 March 2008
Dembski, Wells, Behe and their cohorts probably know that we, the pro science folks, are not dumb. These articles are meant for the consumption of their followers. The televangelists and the vocal
opinion "influencers" take up these articles and dress it up even
more. Since there is not going to be a record or paper trial they
can get to be even more outrageous and misleading in their speeches
and sermons. So the correct question is, How stupid they think their flock are?.
And the answer is quite obvious: very, extremely, totally, 100%, completely, insanely.
And the follow up question is Are they right in making such an assumption?
And, sadly the answer again seems to be, yes.
Bob · 3 March 2008
A first year college biology assignment: "Read the Wells article and write an analysis of it" might yield some interesting results.
Wounded · 3 March 2008
Kim · 3 March 2008
What is the most shocking for me is that Wikipedia is already more accurate than the creationists......
Frederic Dardel · 3 March 2008
As principal investigator of the study under discussion, I'd like to strongly support the view advocated this page. In fact, I was completely amazed to see how our work has been misrepresented by M. Wells.
Actually, we did indeed use darwinian evolution within this work (something unusual in structural biology). In order to obtain an enzyme with increased stability (a critical point for structural studies), we used selective pressure to obtain mutants of the enzyme. We selected for bateria with increased aminiglycoside resistance, by plating them on antibiotic containing medium. It turned out that some bacteria evolved such stabler enzymes variants which made this whole study possible !
Finally, I would not consider myself as a chemist, I got my PhD in molecular microbiology. It seems that M. Wells finds it easier to portray us as non-biologists, and hence implicitly as non-evolutionists
Stephen Wells · 3 March 2008
I'm horrified that this guy shares my surname. Please don't assume that all Wellses are as dumb as this one.
John Marley · 3 March 2008
Wells knows exactly how stupid his audience is. (It isn't us btw)
He knows he can get away with saying this stuff because he knows his target audience won't do any fact checking. And even if some of them do, most of those will take his word over that of those atheist scientists.
I doubt he even cares what we think.
Ian · 3 March 2008
"How stupid do they think we are"
That's a leading question we probably shouldn't proffer with people of the limited integrity of Billy The Kidder and Michael Behemoth around!
Levi · 3 March 2008
wamba · 3 March 2008
wamba · 3 March 2008
raven · 3 March 2008
Dave Cerutti · 3 March 2008
[quote]But Darwin’s theory isn’t really about how existing species change over time.[/quote]
That's up there with Ben Stein's Hovind-esque mischaracterization of evolution as a theory that must explain the origin of stars and planets.
Roy · 3 March 2008
Stanton · 3 March 2008
I'm convinced that Wells did not even open up a textbook when he was off at the university getting his doctorate at Reverend Moon's behest. I'm certain that he hired someone to sit in for him in class, and hired someone to do all of his assignments and labwork for him.
Glen Davidson · 3 March 2008
Don't forget that Dembski tried to explain ID's output by claiming that it helps them for us to think that they're stupid. He didn't exactly explain how or why, true, yet it appears that Wells is busily doing his part to make ID "look stupid" (they don't actually think that we are, just to be clear on that).
Even they're not stupid, in that they're not low IQ. They just have a stupid idea to sell, they do seem to be too enamored of it even to understand biology (good disinformation designers have to understand what they're twisting and maligning), and they thus can't both be pro-ID and sound intelligent.
When it comes down to it, I do think that Dembski's claim was an attempt to make endless faux pas sound as though it was deliberate. I slipped on that banana peal and got all bruised on purpose, you know. I simply thought that he'd better get that excuse out for the tenth time today, to explain why Wells' comedy routine is a straight line of pratfalls.
Glen D
http://tinyurl.com/3yyvfg
Steverino · 3 March 2008
Sam the Centipede · 3 March 2008
How stupid do they think we are? you ask.
You've missed the point completely! It's now how stupid we are, it's how stupid their target audience, the believers, are. That's what matters.
Creationism isn't about reason, it's about power. And the power of lies is sustained by propaganda, not by reason.
David Stanton · 3 March 2008
Frederic,
Thanks for stopping by and setting the record straight. Your statements alone put the lie to the Wells nonsense. By the way, did Wells contact any of you and ask if you considered evolutionary theory important in your work?
This is pretty stupid stuff coming from people, some of whom at least, claim not to have any problem with "microevolution".
Keep up the good work Frederic. And next time, you can perhaps put some language in the introduction about how your research was guided by evolutionary principles. It won't stop the quote mining or misrepresentation, but it will give the cretins something else to explain away. Other than that, don't worry about it. Real scientists can see the value of your work.
Bob · 3 March 2008
Don't you mean Jonathan Wells?
SteveF · 3 March 2008
raven · 3 March 2008
Greg Esres · 3 March 2008
Frank J · 3 March 2008
MachiavelliDiscourse · 3 March 2008
Just a minor point: there's no 'c' in Fisher's name.
David Stanton · 3 March 2008
Bob wrote:
"Don’t you mean Jonathan Wells?"
H.G. Wells and Orson Wells were also good story tellers, but at least there was a grain of truth in their tales. Of course there is reality and then there is "or Wellsian" doublespeak. I wonder what Colbert would say about the turthiness of that.
Ron Hager · 3 March 2008
If I was not interested in the truth and found that the only way I could get people to freely give me large sums of money was by fabricating lies to support their illogical beliefs, then I too might be passionately inclined to publish those lies as often as possible.
David B. Benson · 3 March 2008
Wells, Wells.
:-)
Mike · 3 March 2008
This framing plays into a major strategy of their campaign. By claiming that false claims are easy for anyone to analyze, say a high school student, they can demand "critical analysis" curriculum that gets their crap into the classroom. Of course, their propaganda has been finely honed for decades to not be easy for a nonprofessional to analyze. Even if you can get someone to sit still and analyze one, or two, propaganda constructs, they've still succeeded in producing the impression that there is an alternative interpretation, and there is still a huge amount of propaganda crap left, the very existance of which will give the same impression. No, the average high school student CAN NOT evaluate the propaganda of the anti-evolution movement. None-the-less, the "critical analysis" compromise strategy is attractive to teachers and local officials (and even a few state level officials who should know better) desperate for a way to remove an annoyance. It has been far more successful than alot of people concerned by the anti-evolution movement realize.
John A. Michon · 3 March 2008
Dr. Stanton,
Oops... Orson Welles... W-e-l-l-E-s!
John A. Michon · 3 March 2008
Dr. Stanton,
Oops... Orson Welles... W-e-l-l-E-s!
James F · 3 March 2008
Elf M. Sternberg · 3 March 2008
Hey, Ian, doesn't this qualify as Blogging About Peer-Reviewed Science?
Dale Husband · 3 March 2008
Boy do I love free speech! The more that Intelligent Design promoters talk, the more they discredit themselves! That essay by Johnathan Wells would have gotten an F in a college biology class!
Tyrannosaurus · 3 March 2008
The sad part is that the Disco Institute cronies use ignorance and the repudiation of reason to advance their agenda to the detriment of religion, science and society.
Wade · 3 March 2008
Posted earlier at Pharyngula,
Meanwhile, over at another blogsite... Jeremy Shere at Earth Sky Blogs just reported some of his views concerning the trailer for Ben Stein's "Expelled". He did a very nice job, but already his site is getting comments from pro-IDers. Check it out at http://blogs.earthsky.org/jeremyshere/2008/03/03/ben-steins-intelligent-design-movie/ .
Kevin B · 3 March 2008
David B. Benson · 3 March 2008
A reminder that stupid people often overrate their intelligence...
MrG · 3 March 2008
I find Wells' article interesting in the sense that it shows the
odd tendency of Darwin bashers to spot a new scientific finding
-- almost *any* scientific finding in almost *any* field -- and
immediately write an article claiming it disproves evolutionary
theory.
I've run into the lunatic fringe in my other interests -- Confederate
apologists (did you know the Civil War had nothing to do with
slavery? And that large numbers of black folk fought for the
Confederacy?) and Einstein bashers ... but Darwin bashers are really
in a league of their own.
David Stanton · 3 March 2008
John wrote:
"Oops… Orson Welles… W-e-l-l-E-s!"
You are correct sir, and thanks for calling me Dr. by the way. Oh Wells, alls Wells that ends Wells.
mona · 3 March 2008
Frank J · 3 March 2008
George · 3 March 2008
How can all of you lie like that. He said that Darwinism is not an important concept in bacteria resistance not 'Evolution'.
Go to wiki and look up the difference
George · 3 March 2008
How can all of you lie like that. He said that Darwinism is not an important concept in bacteria resistance not 'Evolution'.
Go to wiki and look up the difference
Will · 3 March 2008
Hi, I'm somewhat new to this whole design debate, and have been in a few verbal debates with a classmate on this issue. He brought up what he felt was a huge problem for evolution that I honestly cannot find an answer to. After reading Ian Musgrave's article on origin's of life probability, I am convinced that he may be the person to go to for an answer, so if you or anyone on here can give me a rebuttal that I can use, I would greatly appreciate it. Your article on talk origins was an article that put the cdesign guy I keep arguing with at rest.
But here's what he keeps bringing up as an argument to say that literally anything that I try to explain by evolution couldn't have evolved at all. It's hard to sum up in a few words but it's got everything to do with genetic information.
First, he starts off by pointing out that the human genome has 3 billion base pairs, and then he insists that there are only 2 possible base pairs that consist of the 4 nucleotides (I don't know if that's quite right, I think there might be more then 2 kinds of base pairs, but I'm no scientist) in DNA.
He then goes on to say that since there are 2 options (base pairs) for 3 billion locations in the genome, that there is therefore 2 to the 3 billionth power number of combinations for the genome. To make the odds more conservative (and easier to work with) he simply reduces the number to 10 to the 6,000,000th power. He says that this not only makes the "odds" he refers to more hopeful then they really are but that it also compensates for the fact that there are trillions and trillions of combinations for humans that could arise.
The last thing he does with this number is bring up a scenario where say you have 100 mutations happen per living organism that are useful, add information to the genome, don't occur in the junk DNA region, etc (he insists he's trying to be "hopeful"). Then he assumes that there are a trillion trillion trials (10 to the 24th)of those mutations occurring that happen every second, of every minute, of every hour, of every day, of every year, for the 3.5 billion years that life has been on earth. The resulting number that he gets (and that I've gotten when doing the same thing) is never any more then 10 to the 45th power (it's just over 10 to the 43rd to be exact).
The final step he takes is subtract that number from the original 10 to the 6 millionth to compensate for an "unrealistically high amount of trials" (thus concluding with 10 to the 5,999,955th) and then says that because of the odds, even under highly unrealistic circumstances you will never get the genetic information required to "code" for a human, or possibly anything.
I sense that there might be something fallacious in his reasoning, I do know for sure that this is AT BEST negative evidence for evolution and NOT PROOF OF GOD.
But I was just wondering if there was any truth to what he was saying.
Will · 3 March 2008
Glen Davidson · 3 March 2008
Your friend is skipping the evolution part, Will. He's merely calculating the odds of the human genome spontaneously arising, which is not what anyone claims happened. Indeed, all of the evidence is that it evolved, and did not arise at once.
Seriously, you didn't notice the lack of any evolution in his "calculations"? That's the whole point of evolution, that the genetic material adapts over time, and thus it avoids the near-impossibility of human DNA suddenly arising in one shot. Empedocles thought that something akin to that might have happened (with the most rudimentary selection process going on), way back in the BCs, but I don't know that anybody ever thought that was scientific.
Nonetheless, physicists are taking seriously the idea that, if there are an infinity of universes, or at least an extremely large number, that it becomes impossible that brains will not arise with "false memories" and all that entails. But that's just a hypothetical situation, nothing that biology relies upon, certainly not at this point (well, there was one paper that brought up the multiverse re abiogenesis, hardly making this a trend in biology).
Glen D
http://tinyurl.com/3yyvfg
raven · 3 March 2008
JesusThe Reverend Sun Myung Moon.slang · 3 March 2008
Stanton · 3 March 2008
Actually, Raven, you're wrong: Mendellian genetics concerns itself only with the inheritance of traits, and the frequency of the appearance of inherited traits, and not with mutations.
Incorygible · 3 March 2008
Will,
Don't be fooled by the big numbers, the lack of anything resembling an actual evolutionary process, or the ridiculous assumptions pulled out of your friend's nether orifice.
Just use his exact argument to "proove" that his parents didn't give birth to him. After all, given the number of possible gametic combinations, it is overwhelmingly improbable that his parents created him, even if they were constantly going at it and he was one of two dozen children/replications ('hopeful' odds, in his laughable jargon). Ergo, he must have *poofed* into existence without any common descent from mom and dad.
George · 3 March 2008
Did the bacteria go thru a major body plan change? Of course evolution happens and bacteria can go thru minor changes but Darwinism is the theory that a fish can turn into a cow. That study just showed that bacteria can change slightly.
Are you really too stupid to see that?
slang · 3 March 2008
Incorygible · 3 March 2008
George,
Following your astute advice, I "went to wiki to look up the difference [between Darwinism and Evolution]". Can you show me the part about the fish and the cow? Apparently, not only am I "too stupid to see it", but so is my browser's search function.
I did find this, however:
"The term Darwinism is often used in the USA by promoters of creationism to describe evolution, notably by leading members of the intelligent design movement."
George · 3 March 2008
You do not think cows came from fish??
If you really can read the wiki article on Darwinism and realize that it is not the same thing as evolution then there is no way for you to understand these things
Incorygible · 3 March 2008
George: "You do not think that cows came from fish??"
Oh, it's worse than that, my friend. I think that cows ARE fish (phyletically speaking, of course). However, I can also say that "a fish" never turned into "a cow". What a paradox, huh? But then again, as a whichamacallit -- oh yeah, an evolutionary biologist -- there's really no way for me to understand these things, eh George? Moo.
George · 3 March 2008
Cows are fish? interesting. and you cannot see how Darwinism is not the same thing as evolution?
What does an 'evolutionary biologist' do? You do not sound very bright.
MememicBottleneck · 3 March 2008
raven · 3 March 2008
Kevin B · 3 March 2008
George · 3 March 2008
So animals went from a 2 chambered heart to a 3 gradually like:
2.1 to 2.2 to 2.3 etc
hahahaha!
you make me laff!
George · 3 March 2008
MememicBottleneck · 3 March 2008
Bill Gascoyne · 3 March 2008
raven · 3 March 2008
Stanton · 3 March 2008
George · 3 March 2008
Antiquated Tory · 3 March 2008
George,
You are an utter ignoramus and you are making a jackass of yourself. For your own sake, please go away, maybe do a little nominal reading on a subject. Or would that take away your rustic superiority with which you reckon to demolish "book learnin" with a sentence or two?
George · 3 March 2008
Bill Gascoyne · 3 March 2008
And BTW George, we're actually "stupid" enough to think that we and our descendants just might be around long enough that someday our great^n grandkids might build on our understanding so much that they might actually understand the way biology really works, and they won't be so scared of that process that they throw up their hands and say "goddidit."
george · 3 March 2008
George · 3 March 2008
Frank J · 3 March 2008
George · 3 March 2008
Bobby · 3 March 2008
Zarquon · 3 March 2008
Oh look, it's the
GishGeorge gallopGeorge · 3 March 2008
Ontogeny Recapitulates Phylogeny
now puhleeeeeezzze
don't tell me you believe that!
(I should not underestimate how unimformed these people are)
Frank J · 3 March 2008
Kevin B · 3 March 2008
David B. Benson · 3 March 2008
Bobby --- George certainly is all of that.
raven · 3 March 2008
A recent thread explains how fish fins turned into our arms and legs.
A more dramatic example than hearts and chambers.
It took around 350 million years. We have the fossil sequences that demonstrate it from Devonian lobe finned fish to humans. Almost anyone can see them and understand it.
Almost anyone leaves the Georges of the world out of it. Georges ignorance is just proof that some people can't learn, some won't learn, and some both can't and won't. AKA as "creos".
MememicBottleneck · 3 March 2008
George · 3 March 2008
George · 3 March 2008
George · 3 March 2008
"It must be an advantage, because they all have have it."
very telling circular reasoning.
hahahahahaha
you dont even see it. dumb!
prof weird · 3 March 2008
Dave Thomas · 3 March 2008
George, George, George.
Just because you are too stupid to do research on this very question, much less understand how multi-chambered hearts might have evolved in a step-by-step fashion (with every step along the way being a fine'n'dandy "intermediate" that thought it was doing fine living from day to day, having kids, and generally enjoying "the Good Life"), doesn't mean that everyone (especially biologists who study such things for a living) is as feeble-minded as you.
Laugh all you want - but realize that the joke is on you!
Glen Davidson · 3 March 2008
I should perhaps respond again, noting some of the specific problems of this dry calculation by your friend.
The first problem is that he thinks that "a human" is what evolution must produce. That isn't at all the case. Evolution has only to produce a successfully reproducing organism. There are, no doubt, a good many of those possible, as we see in the biological realm.
Secondly, he thinks that a human has to be a specific sequence, rather than a reasonably flexible program of development. Most of the possible mutations are in fact fairly neutral, neither deleterious nor beneficial. So his calculations of (relatively, at least) indifferent substitutions make no sense whatsoever.
Put the first two problems together, and you can already see that it's so much junk calculation. Your friend (assuming it's not you actually) is insisting on a single target out of 3 billion nucleotides, when in fact human variation alone brings down your number substantially (latest numbers are that humans vary by 1%, by itself bringing down his fake numbers down exponentially). As with many other species, it is likely that much of our genome is in fact expendable.
But the biggest problem is what I related previously, there is no evolution going on in that scenario. Effectively it's just an abiogenesis calculation, if the first cell were to be a human cell (an absurdity on all levels). Evolution doesn't begin with 3 billion nucleotides, it almost certainly begins with a number far smaller than those found in the smallest bacterium, less than 160,000 base pairs (that's a parasite, which has fewer than free-living forms can have, but there's reason to believe that free-living organisms not competing with today's life (and living with oxygen) could get by with far fewer than those numbers). Indeed, it may be that early RNA "genomes" could have been a few thousand, or even a few hundred, nucleotides long.
It is virtually certain that human genomes got this long both through addition of junk in various ways, and by the vertebrate line doubling its genome several times. Each doubling allowed for substantial evolutionary possibilities, so that instead of a large genome being a problem for evolution, it in fact provided opportunities for evolution as it increased in size.
But back to the lack of evolution in that scenario. Evolution is not a matter of simply trying over and over to get things right, it is the adaptation of already competent organisms to changing environments, or perhaps simply improving on the organism's own ability to compete in a fairly unchanging environment. A few changes are added at one point, a few at another point, and the whole begins after hundreds of thousands to millions of years to add up to substantial difference from what came previously. It isn't a matter of some useless bunch of DNA undergoing endless mutations to finally become something useful, it is the addition of usefulness to usefulness, that drives evolution.
So again, the biggest problem with the scenario given is that it simply has nothing to do with how evolution operates. It is simply trying to hit the lottery again and again in a virtually impossible-to-hit single combination of nucleotide sequences. That isn't evolution, that's spontaneous generation, and a big reason why we accept evolution instead of the scenario given is precisely that that scenario is in essence impossible.
Evolution, on the other hand, is something that we see happening, and which has evidently occurred, since life bears the predictions of evolution (and not of the scenario given above). Evolution simply requires that relatively likely (according to numbers in the populations, and the time allowed) changes will take place, producing organisms adapted to their environments. It does not have a set goal of nucleotide sequences, nor does it have to reach some impossibly difficult goal by undergoing endless mutational tries. Evolution simply accumulates reasonably likely changes to produce competent organisms, and all of the evidence suggests that humans are the result of these cumulative changes (plus some dramatic chromosomal changes, which are also reasonably likely) who ended up adapted, yet never hit any kind of predetermined and unlikely goal.
Your "friend" assumed two completely unscientific ideas in order to "calculate" evolution's impossibility. One was that life has a telos, a specific sequence of nucleotides in a 3 billion nucleotide collection. The other is that mutations will randomly attempt to achieve this goal over billions of years. The whole point of evolution by natural selection (along with other evolutionary processes) is to avoid randomly attempting a single outcome, or even trying to achieve a set of outcomes.
Evolution can be conceived for our purposes here as being an accumulation (and integration) of relatively likely changes over the course of millions and billions of years. It has no goal, no end, and no attempt to achieve a specified sequence of nucleotides. Evolution is about what works, not about achieving a telos that many fundamentalists smuggle into their calculations, sans legitimation from science.
Glen D
http://tinyurl.com/3yyvfg
raven · 3 March 2008
Looks like George blew out his cerebral cortex. It is OK, he wasn't using it anyway. Or is scouring creo web sites for more lies.
We have a good idea of how fish fins became our arms and legs. A fossil sequence spanning 350 million years. It doesn't require much thought to figure it out, two eyeballs is mostly what is needed. Seeing is believing.
So George we know how fins became limbs. Or do you have another explanation? If so, let's hear it. You can even quote from the bible if you want.
Dan · 3 March 2008
What is the sound of one hand clapping?
It's similar to the sound of George congratulating himself on proving 150 years of science wrong through the two word argument "your dumb".
Glen Davidson · 3 March 2008
I thought that I was quoting Will in my last post, but the quote didn't show up. So anyhow, my point in posting now is to say that it's a response to the scenario that Will brought up (George is too much a meaningless troll to interest me).
Glen D
http://tinyurl.com/3yyvfg
Bill Gascoyne · 3 March 2008
Richard Simons · 3 March 2008
Stanton · 3 March 2008
Stanton · 3 March 2008
Wolfhound · 3 March 2008
I'm afraid I have to call Poe on George. He is WAY too much of a cartoon creotard to be for real.
Just sayin'...
Ian Musgrave · 3 March 2008
Could people please stop feeding the troll.
Alan R. · 3 March 2008
Will,
Assume that "all dice being a "Six" = human. Ask your friend to calculate the odds of throwing 3 billion dice and having them all come up "Six". Now assume you can re-throw an dice that was not a "Six" (Random Mutation & Natural Selection) Within a few dozen throws (Evolution), you will be within the acceptable tolerances of "human".
Dale Husband · 3 March 2008
Just because you can't understand how evolution works, or how evolution applies to experimentation, does not justify dismissing it. People like Johnathan Wells and our resident troll "George", make total fools of themselves when they display publicly their own ignorance!
stevaroni · 4 March 2008
stevaroni · 4 March 2008
Um, oopsie...
Should be 36 x 10^30
not 10 x 36^30.
Oddly, considering I deal with numbers all day long, I'm still kind of dyslexic with them whenever I have to type them out.
So there the odds just got that much better.
Nigel D · 4 March 2008
Nigel D · 4 March 2008
Rolf Aalberg · 4 March 2008
Torbjörn Larsson, OM · 4 March 2008
Torbjörn Larsson, OM · 4 March 2008
Frank J · 4 March 2008
Torbjörn Larsson, OM · 4 March 2008
Ian · 4 March 2008
Hey George, now you've proven you can make idiotic and juvenile comments, why not demonstrate that you can make a grown-up, intelligent one?
Evolutionists have assembled ~150 years' worth of positive science supporting the Theory of Evolution. So what positive peer-reviewed science do you have supporting your position? Wait a minute, let me turn the volume down here so the sound of crickets chirping doesn't deafen me....
Nigel D · 4 March 2008
(2) Why does he give equal weight to all locations?
(3) How does he relate his caluclation of odds to what is known to occur in reality? Incidentally, 10^6,000,000 is a truly vast number, significantly larger than a googol (but nowhere near as large as a googolplex). That is very difficult. How do you define "useful"? A mutation that has an impact on the organism's morphology / behaviour / metabolism / whatever can have several consequences. The mutation can allow it to compete more effectively with other members of its species (whether in finding food, deriving energy / nutrients from food, evading predators, finding mates or whatever). It could inhibit its ability to compete with other members of its species. However, when considering complex multicellular organisms, it could also have no immediate consequence, but could instead allow the organism to cope better with a change in the environment (e.g. drought resistance in plants - most of the time there is no difference. Then, in a particularly dry year, organisms with this mutation suddenly have an advantage). Then, the consequence of the mutation could be to have both an adantage and a disadvantage (as is the case with sickle-cell anaemia), in the which case whether the mutation is useful or not depends very strongly on the exact environmental conditions. So it is very difficult to say that a specific mutation is "useful" or not. And, consequently, it is meaningless to speculate about how many "useful" mutations an organism may possess. What is meant here by "information"? As observed by Dawkins, mutation does not generate information. Selection instead generates information - it is the process by which environmental information is fed back into the genome. Well, then he should try to understand what "junk DNA" really is. It has long been suspected (by evolutionary biologists) that non-coding DNA serves a purpose. Recently, it has been discovered that about 5 % of the non-coding DNA does serve a function (although I cannot recall the article that discusses this, it was blogged in PT a few months ago). He has been deluded into thinking that this is relevant. What he fails to account for, and this is a real whopper, is that his calculations assume that a human being will arise spontaneously from some random string of DNA. This is the same fallacy as one of those in the "tornado in a junkyard" argument. The assumption that something has to occur all at once. Rather, what occurs is small changes, that are selected and thus retained. So, deleterious mutations are rapidly selected out, whereas mutations that are neutral or beneficial are retained. Changing environment operates on this inherent variation to select organisms that best fit the new conditions. Additionally, he fails to account for several other factors:
(1) How many possible mutations there are that simply work. E.g., out of all possible proteins, how many millions or billions or trillions will perform a certain function?
(2) These post-hoc probabilistic calculations assume a purely random process. Natural selection is deterministic (in terms of the pertinent environmental factors determining which genotypes are more or less succesful). Remember that all mutations start from something that works. For a mutation to persist it must be either neutral or beneficial - deleterious mutations tend to be eliminated from the population at a rate determined by the intensity of the selection pressure (except for recessive mutations).
(3) The various mechanisms by which genes can change. His premise is that the genome contains 3 billion base pairs, but our most distant ancestors had significantly smaller genomes. Duplication events during DNA replication or chromosomal recombination can have a dramatic impact on the size of the genome. Duplication of a gene leads to the absence of selection pressure on one copy of that gene. Duplication of non-coding DNA will have little discernible impact. Recall that the size of a genome bears little relationship to the complexity of the organism (just look at the onion family to understand this point).
(4) Evolvability. Some sections of DNA are more liable to change than others. Evidence is growing that evolvability is itself a selectable trait. Thus, different genes (or non-coding regions) may evolve at different rates.
(5) He assumes that all 3 billion base pairs are relevant, whereas in fact most of the human genome (perhaps 90 - 95 % of the non-coding regions) could have any sequence and still perform its function. You were right to do so. While this is true, I am not sure how relevant it is. Evolutionary theory, even if it is flawed, is at the very least a close approximation of reality. It has been tested too often and passed with flying colours too often for us to have any reasonable expectation that a significantly better theory exists to explain biological change. Reality is what it is. Evolution is the only explanation for the diversity and similarities we see in the biological world.
george · 4 March 2008
george · 4 March 2008
"It has been tested too often and passed with flying colours too often for us to have any reasonable expectation that a significantly better theory exists to explain biological change."
It has never been tested. show me!
george · 4 March 2008
george · 4 March 2008
As anyone can plainly see here the Darwinists are empty handed.
And when their logic fall apart they resort to insults and calling people trolls.
This is all they got.
Ron Okimoto · 4 March 2008
The purpose of Wellsian creationist propaganda is not to stand up to scrutiny, but to fool the rubes. Anyone could cross check his assertions, but how many rubes that want to believe it will check? This is just another example of stupid arguments of the moment. They aren't supposed to do anything but fool the ignorant. The sad thing is how long these types of arguments get kicked around when a little research would demonstrate them to be bogus.
Stephen Wells · 4 March 2008
Reality says that creatures can, and do, run around with a 3.5-chambered heart, and George says they can't. Does anyone have a billy-goat to deal with out troll problem?
OT but fantastic: watched the last episode of David Attenborough's "Life in Cold Blood" last night. There was a sequence on the mating of sea turtles which blew my mind- they mate underwater, the male clinging to the female's shell, while a gathering horde of rival males bite at his neck and flippers to try to dislodge him! Imagine the most impressively realised sci-fi space battle ever filmed, and now imagine that it's happening for real right in front of you.
David Stanton · 4 March 2008
George wrote:
"It has never been tested. show me!"
Yea, that's right George, the most explanatory and predictive theory ever developed, to which literally millions of technical journal articles have been devoted, the theory that persuaded all reluctant scientists of every religious persuasion, the central concept of all modern biology has never been tested! All of us atheistic evolutionary biologists just believe it so that we can rape and sodomize without fear of consequences. Brilliant reasoning.
I just know I'm going to regret this, but this dolt has already hijacked this thread beyond repair. OK George, here goes.
Where did Cetaceans come from? Did God just poof them into existence? Evolutionary theory predicted that they came from terrestrial ancestors. All of the palentological, developmental and genetic evidence supports this view. When a theory allows one to make predictions, it can be tested. That's how all of science works. In this case, SINE insertions have been discovered that are shared between Cetaceans and Artiodactyls, in particular the hippopotamus. SINES represent retroviral transposition events. These characters are perfect for phylogenetic analysis since they are rare and irreversible and persist through speciation events.
So George, here we have solid evidence not only that the theory of evolution was tested, but that it passed with flying colors. Of course, this is only my favorite example, thousands of others are freely available to anyone who wants to learn. I'm sure that if anyone is not fed up with your nonsense yet that they will post their favorite examples as well. As for the - what good is the half a heart - nonsense you were selling, I guess the question now becomes what good is one third of a brain? It can only be used to ridicule those who have real knowledge without providing any alternative explanations. By the way, what test has your GODDIDIT hypothesis passed? Does it even make any predictions?
For anyone who is interested, the whale story is well documented on the talkorigins web site. The SINE insertions are described in the articles on plagarized errors in the molecular genetics section. I have yet to see any creationist who has a good answer for this evidence.
george · 4 March 2008
george · 4 March 2008
george · 4 March 2008
George wrote:
"It has never been tested. show me!"
Yea, that's right George, the most explanatory and predictive theory ever developed, to which literally millions of technical journal articles have been devoted,
<<< show me just one that proves Darwinism!
the theory that persuaded all reluctant scientists of every religious persuasion, the central concept of all modern biology has never been tested! All of us atheistic evolutionary biologists just believe it so that we can rape and sodomize without fear of consequences. Brilliant reasoning.
<<< could care less if you are an atheist. its your being dumb and unscientific that bothers me
I just know I'm going to regret this, but this dolt has already hijacked this thread beyond repair. OK George, here goes.
Where did Cetaceans come from? Did God just poof them into existence?
******** can you please leave the concept 'God' out of this. it is not scientifically defineable and should not be used in a scientific debate
Evolutionary theory predicted that they came from terrestrial ancestors. All of the palentological, developmental and genetic evidence supports this view.
********** what evidence? again show it to me
When a theory allows one to make predictions, it can be tested.
************* I think actually proof of null hypothesis is actually more effective. go ahead show me.
That's how all of science works. In this case, SINE insertions have been discovered that are shared between Cetaceans and Artiodactyls, in particular the hippopotamus. SINES represent retroviral transposition events. These characters are perfect for phylogenetic analysis since they are rare and irreversible and persist through speciation events.
************ SINEs do not prove common descent
So George, here we have solid evidence not only that the theory of evolution was tested, but that it passed with flying colors. Of course, this is only my favorite example, thousands of others are freely available to anyone who wants to learn. I'm sure that if anyone is not fed up with your nonsense yet that they will post their favorite examples as well. As for the - what good is the half a heart - nonsense you were selling, I guess the question now becomes what good is one third of a brain? It can only be used to ridicule those who have real knowledge without providing any alternative explanations. By the way, what test has your GODDIDIT hypothesis passed? Does it even make any predictions?
********** stop inserting 'God"
For anyone who is interested, the whale story is well documented on the talkorigins web site. The SINE insertions are described in the articles on plagarized errors in the molecular genetics section. I have yet to see any creationist who has a good answer for this evidence.
george · 4 March 2008
George wrote:
"It has never been tested. show me!"
Yea, that's right George, the most explanatory and predictive theory ever developed, to which literally millions of technical journal articles have been devoted,
show me just one that proves Darwinism!
the theory that persuaded all reluctant scientists of every religious persuasion, the central concept of all modern biology has never been tested! All of us atheistic evolutionary biologists just believe it so that we can rape and sodomize without fear of consequences. Brilliant reasoning.
could care less if you are an atheist. its your being dumb and unscientific that bothers me
I just know I'm going to regret this, but this dolt has already hijacked this thread beyond repair. OK George, here goes.
Where did Cetaceans come from? Did God just poof them into existence?
can you please leave the concept 'God' out of this. it is not scientifically defineable and should not be used in a scientific debate
Evolutionary theory predicted that they came from terrestrial ancestors. All of the palentological, developmental and genetic evidence supports this view.
what evidence? again show it to me
When a theory allows one to make predictions, it can be tested.
I think actually proof of null hypothesis is actually more effective. go ahead show me.
That's how all of science works. In this case, SINE insertions have been discovered that are shared between Cetaceans and Artiodactyls, in particular the hippopotamus. SINES represent retroviral transposition events. These characters are perfect for phylogenetic analysis since they are rare and irreversible and persist through speciation events.
SINEs do not prove common descent
So George, here we have solid evidence not only that the theory of evolution was tested, but that it passed with flying colors. Of course, this is only my favorite example, thousands of others are freely available to anyone who wants to learn. I'm sure that if anyone is not fed up with your nonsense yet that they will post their favorite examples as well. As for the - what good is the half a heart - nonsense you were selling, I guess the question now becomes what good is one third of a brain? It can only be used to ridicule those who have real knowledge without providing any alternative explanations. By the way, what test has your GODDIDIT hypothesis passed? Does it even make any predictions?
stop inserting 'God"
For anyone who is interested, the whale story is well documented on the talkorigins web site. The SINE insertions are described in the articles on plagarized errors in the molecular genetics section. I have yet to see any creationist who has a good answer for this evidence.
george · 4 March 2008
George wrote:
"It has never been tested. show me!"
Yea, that's right George, the most explanatory and predictive theory ever developed, to which literally millions of technical journal articles have been devoted,
show me just one that proves Darwinism!
Sickle_Cell · 4 March 2008
George, I'm an biology undergrad currently studying, among other things, SINEs in cetartiodactyla. Knowing the mechanism of SINE insertions makes it *impossible* for SINEs to exist in anything else but related species. For a good summary of the insertion mechanism, see Okada and Shedlock, "SINE insertions: powerful tools for
molecular systematics", BioEssays 22:148–160, 2000) .
Anyone with access to pubmed can see this article. heck, I got it on PDF, I can send it to you via email! No one's hiding any information from you,
The mechanism of SINE insertion is why only humans (and ALL humans, at that) have Alu sequences but not any other primate. I've even seen SINEs being used to prove the non-relatedeness of human populations! (See "Investigation of the Greek ancestry of populations from northern Pakistan" by Mansoor et. al. I have THAT on pdf as well, so I could send it, too)
I find it mind-boggling that you could say that SINEs are not proof of common descent, because that's really the equivalent of saying that you can't use DNA-sequences to prove that you're related to your parents, paternity tests are routinely done using sequence data. Are you saying that you and your parents don't have a common ancestor? (i.e, your grandfather?)
You know, let's leave the science aside for a moment: What would be proof TO YOU of common descent? A mouse turning to an elephant?
Cedric Katesby · 4 March 2008
George, do you believe in God?
You do?
Wow.
(Talk about a lucky guess)
You're a Christian, right?
Then...start acting like one!
george · 4 March 2008
george · 4 March 2008
george · 4 March 2008
Flint · 4 March 2008
Underlying much of the woohoo babulation on this thread is the foundational assumption that evolution necessarily consists of the process of one CURRENT 'kind' morphing into another CURRENT 'kind', this being all there is or ever was. And so we have a "cow" morphing into a whale. The creationist perspective simply cannot conceive of prior organisms, unlike anything alive today, which were common ancestors to two current 'kinds'.
And I think we should understand that if your model specifies that some invisible magical sky-daddy POOFED all life into existence, all at once, just as we know it today, and that's all that can ever exist, you're going to have a very hard time coming to grips with gradual cumulative change. There's simply no place within your model where such a notion can fit, or gain any purchase whatsoever. Within your context, it is meaningless.
Combine this model with straight dichotomous thinking, where everything MUST be absolutely one thing or absolutely another, where "proof" is all that matters, and "support for a proposal", not being proof, is irrelevant. Stir in a little bit of "I can't understand it, therefore it must be absolutely false" - which combines the black-and-white thinking with the wrong conceptual model, and we circle the same black hole endlessly.
So we're all speaking a language foreign to folks who can't even conceive of a foreign language. They "know" it's noise; it's all they can hear.
Nigel D · 4 March 2008
george · 4 March 2008
george · 4 March 2008
Stanton · 4 March 2008
Anyone else noticed how the hypocritical troll continues to evade answering my question asking him to explain why he thinks that 3.5 billion years of accumulated mutations is not enough for bacteria (not fish) to evolve into cows and whales?
george · 4 March 2008
raven · 4 March 2008
People, George is a pure troll.
His schtick consists of insults (your dumb), lies, and more lies.
He isn't here to learn or inform or criticize, only to waste people's time and a few electrons and photons.
You are playing his game when you respond to him.
He isn't reading your replies. Why should he, he isn't here for any real purpose. Don't knock yourself out looking up something for him
Moderators, if you are reading this. The thread was a good one until it derailed and thanks to Ian M. for posting the very interesting article and the Moonie response. It is time to send the malevolent disruptor to Trollhome. Please.
george · 4 March 2008
Stanton · 4 March 2008
Stephen Wells · 4 March 2008
I think we can recognise anyone who comes out with the "show me the one experiment that proves Darwinism!" crap as green, scaly and bridge-dwelling.
Stanton · 4 March 2008
Stacy S. · 4 March 2008
Aaack! How come I can't use the "Quote" thingy anymore?
george · 4 March 2008
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george · 4 March 2008
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george · 4 March 2008
george · 4 March 2008
george · 4 March 2008
Stacy S. · 4 March 2008
Hey there - ever heard of the preview button?
Stanton · 4 March 2008
Ravilyn Sanders · 4 March 2008
(Addressing the lurkers)
Not all 30 second sound bite questions have neat answers that
fit into 30 second sound bite responses.
The effort required to ask a question is much less than the effort needed to understand the answer. The effort depends on the amount
of knowledge you already have in that field to begin with. If
George walks into the Math department of a univ and declares,
"Explain to me how the low condition number of the matrix results
in high numerical errors in solutions using the LU decomposition
method". The first response from the prof will not be anything
to do with Linear Algebra. It will be, "How much do you know? From
what level I have to teach you?". The fact that George is unwilling
or incapable of understanding the answers, does not mean there
is no answer.
On the ides of March, three years ago Ian Musgrave
posted this comment.
It is not the question that stumps "evilutionists". It is the answer that is incomprehensible to the IDiots.
george · 4 March 2008
Now a question for all of YOU: if there were not transitional fossils would you still believe in Darwinism?
(they are scared to death to answer this one!)
emily · 4 March 2008
Who is this 'they' you speak of? Personally, in the absence of any fossils at all I would consider that a genetical analysis of extant species would still lead to the conclusion that these species had evolved via mutation and natural selection.
george · 4 March 2008
Dave Thomas · 4 March 2008
georgefeeble-minded dishonest hypocrite: I did look it up. You are clearly wrong. Stanton made the comment There is no mention of cows. There is no mention of whales. Only of 3.5 billions of years of evolution. It wasgeorgefeeble-minded dishonest hypocrite who twisted this into I know I shouldn't be feeding the troll. But it's hard not to, especially when his own words show him up as the lying sack of smegma that he is. Send us all to the Bathroom Wall, Ian!george · 4 March 2008
Chad · 4 March 2008
george · 4 March 2008
mplavcan · 4 March 2008
George:
I just came on this thread. First off, every single one of your posts is an unappologetic insult -- name calling, laughing, taunting etc. By any objective standard, you're simply being obnoxious. Second, you have not answered a single question, or provided a single datum of evidence -- you merely offer distortions with no grounding in reality. This suggest that you are completely ignorant of biology. Third, before you taunt folks about transitional fossils, why don't you read Bown and Rose's monograph on Eocene primates, or Gingerich's papers on Hyopsodus or Cantius, or pick up any volume of Paleobiology and read practically ANY paper documenting a massicve fossil record of transitional marine invertebrates, and so on and on and on? THEN you can begin to try to debate why these do not represnt transitional sequences. I'm not holding my breath.
Rolf Aalberg · 4 March 2008
David Stanton · 4 March 2008
Look George, I'll make it real simple for you. If you turned in a paper to me that had the same typographical errors, the same spelling errors and the same gramattical errors as another student, you would both fail, period. That would be considered proof positive of plagarism. The standard would even hold up in a court of law.
Now, can you explain the shared SINE insertions between artiodactyls and cetaceans or can't you? It was predicted by evolutionary theory and it was confirmed by experimental evidence. As others have pointed out, it is but one example of such an anlaysis. There are many others.
And yes, even in the absence of any fossil evidence, the genetic evidence alone is very compelling. But of course the fossil evidence confirms exactly what is predicted by the genetic evidence. Just check out the web site I recommended in order to see all of the evidence. Or of course you could read the primary literature. You do do that don't you George? You don't just spout creationist talking points without knowing what you are talking about do you?
george · 4 March 2008
george · 4 March 2008
george · 4 March 2008
TomS · 4 March 2008
Chad · 4 March 2008
m arie · 4 March 2008
Hi everyone I just think it is a hoot how george is making a fool out of himself!
Steverino · 4 March 2008
George said:
"I would not expect a smegma hypocrite like to reach my level of integrity."
Judging by the quote above you have set your intebrity level bar very low.
Cedric Katesby · 4 March 2008
George, you're not a Christian?
Fine.
(The last few hundred or so trolls around here were fundies so I took a risk and made an assumption)
So, as an 'agnostic' would you please stop being a troll?
If you have a case to make or have serious questions to ask, then do the right thing and open your own thread at ABTC.
Please don't make a habit of derailing threads like you've done this one.
george · 4 March 2008
mplavcan · 4 March 2008
George:
Answer the question. You wanted citations. I gave them to you. I have read Gould too. In fact, pretty much everything he wrote. And piles and piles of other stuff too. This may come as a surprise, but there are other papers our there. Really! And not only that, I have not only seen many of those fossils, I've actually collected a bundle too, and published on some! So, read the papers, then let's talk tansitions.
And for the record, in your first post on this thread, you called everyone here a liar. Now you claim you are simply responding to personal insults. When you make these assertions, please try to remember that we have a written record.
george · 4 March 2008
george · 4 March 2008
Marilyn · 4 March 2008
Well, George, if those who believe in the fact of evolution are so much dumber than you, how exactly is it that they have made such tremendous advances in diagnosing, understanding, treating and preventing diseases such as cancer and cardiovascular disease, and you and your ilk have accomplished exactly nothing in the life sciences realm? Put up or shut up. Science works. Mindless arrogance and willful ignorance don't.
Marilyn · 4 March 2008
By the way, George, I don't believe in "Darwinism" and never have and never will, because that is a meaningless term made up by the ill-informed. I do accept the scientific fact of the modern theory of evolution, and I will continue to accept it until you or someone else can provide some actual evidence that falsifies the theory, or come up with an actual scientific theory that explains reality better. Again, put up or shut up.
mplavcan · 4 March 2008
George:
Comment #144872. "How can all of you lie like that."
Answer to your question. YES. Period. Absolutely. By "Darwinism" you must mean natural selection, since that is in fact his contribution to MET. The mechanism of natural selection has been demonstrated thousands of times experimentally and in nature. It has been modeled over and over and over. Even hard-coure Young Earth Creationists like Ken Hamm and Jonathan Safarti, accept it. Even the good folks from the DI accept it. Go to any search engine and type it in. Then spend the next several years reading all the papers.
If on the other hand you mean "the transmutation of species" YES, absolutely. The is an overwhleming body of evidence from comparative anatomy, developmental biology and embryology, developmental genetics, and population biology that oeverwhelmingly points to MET and supports it to the exclusion of other theories. The concept of the transmutation of species had been around long before Darwin, and had received substantial support among naturalists (as biologists were known back then) to the point where many were compelled to accept the evidence in spite of their religious convictions.
Now, answer my question.
george · 4 March 2008
george · 4 March 2008
Glen Davidson · 4 March 2008
I don't want to feed ye olde troll, but I have to say that, given the amount of fossilization among a number of phyla, and the quantity of the fossil record, I would find a complete lack of transitional fossils to be a very disturbing unfulfilled prediction of MET (in context). Of course by "transitional" I do not mean "ancestral species," I mean something closely related to the "ancestral species."
In other words, the fact that many transitionals have been found is a significant prediction of MET that has turned out to be correct. The "would you believe if..." schtick is being used to try to isolate the converging strands of fulfilled predictions of MET, since nothing other than evolutionary theory makes sense of both crown groups and of extinct groups known only from the fossil record.
It's a kind of misdirection, as well, since a lack of transitionals (in context) ought to be accompanied by other problems with cladistics and genomics. That is, a lack of transitionals, when we have good reason to expect them, should mean that the rest of the evolutionary predictions would be skewed or even nonsensical. So it hardly makes sense to ask "what if there were no transitionals" when there is no meaningful explanation for the whole of biology except for MET.
What is more, there were always transitional taxa known. While no transitional species were known when Darwin wrote his first book, the fact that mammals evolved from reptiles, reptiles evolved from amphibians, and amphibians evolved from fish, was fairly obvious from morphological comparisons. Sure, modern representatives, and even fossil representatives, had their own evolutions since, say, fish and birds separated, but that fish gave rise to birds was not in doubt (to intelligent and intellectually honest people).
Evolutionary theory developed with the knowledge of "intermediate taxa," then, so it's kind of like asking if you'd believe in Christianity if Jesus never existed to ask if you'd accept evolution if transitionals had never been found.
It's a trollish, nonsense question, of course, sort of like asking if you'd accept General Relativity if light didn't bend in the presence of gravity, but all of the other predictions of General Relativity worked out. The fact is that light not bending in the presence of gravity would be a severe problem for it, and yet we'd probably provisionally accept the rest of General Relativity until something meaningful replaced it. The trouble is that, unless some good idea were advanced to replace it, the failure of General Relativity with respect to the bending of light, while the rest of General Relativity worked, makes no sense at all.
One would have to ask if humans can make sense out of the world, if MET successfully predicted everything it does except the expected transitional fossils, or if General Relativity successfully predicted everything it does except light bending in the presence of gravity (of course I don't mean when light is moving directly into the gravity well). Both failures would make nasty gashes into their respective theories, yet would not by themselves yield up any better ideas for explaining everything else that they explain. And of course the fact that both make successful predictions throughout the range of their command of their respective phenomena gives us good reason to accept both.
See, even trolls can help to make a good point, which is that transitional fossils are very important pieces in favor of MET.
Glen D
http://tinyurl.com/3yyvfg
Ravilyn Sanders · 4 March 2008
george · 4 March 2008
Bill Gascoyne · 4 March 2008
emily · 4 March 2008
George: If you were interested in an answer you would have responded to mine.
JHM · 4 March 2008
Rrr · 4 March 2008
Wait. I thought a retort was a kind of glass vessel, ya know, like the mad scientist has for mixing teh colorful, smelly potion. What, never evven been to a movie! What kind of troll is ttah?
Please observe teh spell. ;-)
Marilyn · 4 March 2008
Got it George. You're smart enought to know where to find the evidence yourself, right? It's just that you so enjoy acting like an argumentative ignoramus.
[...withdrawing food dish....]
mplavcan · 4 March 2008
Very well, George. Please explain to me how the Hyopsodus and Cantius records do not represent transitional sequences. Please explain to me how the extensive marine fossil record does not represent multiple transitional fossil sequences -- starting with, say, Foote's stuff or perhaps Stanely just to begin? I'm waiting. Details, George, not insults.
You claim that you didn't insult anyone, then you admit that you did, but that really it was because people were insulting Behe. Sigh.
What on earth do you mean by "Darwinism?" Please define it. I gave specific responses to your querry, parsing out the two possible meanings that you seemed to allude to. Now you insult me because I didn't somehow answer some definition to you have decided on in your mind. Define it precisely.
george · 4 March 2008
george · 4 March 2008
Rrr · 4 March 2008
Seems like "George" here has a severe identity problem. Here he is, signing his excretions as "Glen D", who has a far better track record as even my humble self can tell. But he might not be aware that he isn't in fact even "George"... Then again, that will not be his only, or even his biggest problem.
george · 4 March 2008
george · 4 March 2008
Rrr · 4 March 2008
When did you answer, "George"?
There is no name for what you do. Or if there is, I prefer ignorance.
george · 4 March 2008
Bill Gascoyne · 4 March 2008
Rrr · 4 March 2008
Bill Gascoyne · 4 March 2008
george · 4 March 2008
Ravilyn Sanders · 4 March 2008
David Stanton · 4 March 2008
George,
Please go away. You didn't answer any of my questions, even the most basic ones. You say that evolution has never been tested and yet you are completely unable to address the genetic evidence that exists. You asked for evidence and you were given evidence, if you don't understand it, don't cry about it, take the opportunity to learn. You claim that you are not a creationist, well what is your explanation for the diversity of life we see around us? You stoop to personal insults without even knowing who it is that you are talking to. Just for the record, all of you guesses were completely wrong. Shut up and leave already.
For anyone who really cares, the SINE insertions I mentioned are genetic errors that increase the probability of disease and death. That the same genetic mistakes are shared between species is strong evidence of common descent. George has no explanation other than "I don't understand it therefore it can't be true." I suggest we all ignore him and hope that he will go away.
Getting back on topic, at least in George we have an example of the target audience that Wells is playing to.
David B. Benson · 4 March 2008
Shenanigans!
I call shenanigans.
Send the troll to Trollheim.
phantomreader42 · 4 March 2008
David Fickett-Wilbar · 4 March 2008
I understand the frustration with the postings of trolls, and of the urge to stop feeding them. Certainly there is a point beyond which they lose all usefulness.
However, there is an extent to which they are useful. I am a non-scientist, with my main field being fuzzy studies (with concentrations in religion and linguistics), and I have learned a lot from the responses to trolls. My education in biology is spotty, consisting mostly of websites and popularizing books such as those of Gould and Dawkins. As a result, some of the more technical threads go completely over my head, and I find myself hearing wah, wah wah, like the teachers on Peanuts. In all fairness, I suggest that those who are disappointed in that read some linguistics -- I suggest "Hittite and the Indo-European Verb" -- and see how long it is before wah wah wah kicks in.
The point is, when trolls are encountered the arguments quickly come down to a level I can understand. After all, trolls are almost by definition ignorant of much of the evidence for evoloution, so the most important of it must be explained in very simple terms. Just what is suited for me.
So even though I think this troll thread has run its course, please don't automatically stop once trollness has been determined. Those of us who lurk learn from troll-fighting.
george · 4 March 2008
george · 4 March 2008
george · 4 March 2008
george · 4 March 2008
"You also claim you believe in evolution but not “Darwinism”, without explaining the difference."
I assumed that most people with a junior high or greater education would know the difference.
This is a real failure of our education system when someone can say the above. I would have hope this would have been explained in junior high. Not knowing these fundamentals of biology shows how bad our education system is
Ian Musgrave · 4 March 2008
Oh for goodness sake, this has just turned into a troll-fest. I'm going to turn off the comments now.
george · 4 March 2008
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george · 4 March 2008
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george · 4 March 2008
phantomreader42 · 4 March 2008