Back in the middle of last month, I had a few things to say about Casey Luskin (DI flak) and his understanding of so-called junk DNA. It's now the middle of the month again, and Casey is again talking a lot - and understanding very little - about "junk" DNA. Larry Moran has a post up where he tries to educate Casey about the fact that a hell of a lot of DNA is still, at least as far as we know, junk. I'm going to take a look at something a little bit different - one of the methods scientists use to identify areas of "junk" DNA that have important functions. It's a pretty cool way of doing things, but it's not one that Casey likes to talk about - because it's really one of the finest examples of how our understanding of Darwinian evolution has lead to new discoveries about living things.
Read more (at The Questionable Authority):
80 Comments
Bruce Thompson GQ · 16 July 2007
The reference to monthly cycles suggests a hormonal component to this discussion of "junk DNA". Is it that everyone is a little tired of the "blondeness" of Casey's arguments or is there something new here? Perhaps everyone is just a little cranky this Monday?
Since comparative genomics is no easy task I suspect everyone is a little cranky.
Delta Pi Gamma (Scientia et Fermentum)
Basement Activist · 16 July 2007
Casey's arguments are bogus.
Therefore there is no God.
Isn't that what this is all about?
J. Biggs · 16 July 2007
Basement Activist or Blair or whoever you are. Why don't you troll somewhere else. You have not said anything close to intelligent and most of us are aware that you are posting under multiple names. At the very least, choose a name and stick with it, out of common courtesy or just out of the fear that you may be banned from posting.
fnxtr · 16 July 2007
There may be a God.
There may not.
Either way, Casey's arguments ARE bogus. They're not even arguments, they're what we laymen call "bull$#!+".
Tim Fuller · 16 July 2007
Fighting over the philisophical problems invovled in analyzing DNA is fun to watch from the sidelines. I am not a biology major (nor did I stay at a Holiday Inn Express last night) but I'm LUCID enough to know the ID crowd are lunatic Christians (some of you who are fighting the good fight against these loonies might want to check their Christian Reconstructionist credentials).
On the other hand, and this is obviously a lay opinion...I think the 'junk' is just stuff scientists haven't worked out a purpose for. Of course it's also possible that nature worked out a way for extraneous DNA to be acquired and really have no knowable greater purpose.
In the end, whatever is discovered will be the work of true biology and not the Scooby Doo Dinosaur Team (IDiots).
Enjoy.
Bond, James Bond · 16 July 2007
How is this for a ID prediction.
When scientists "begin" to decipher the remaining 99% of the human genome, not deciphered by ENCODE so far, they will find an increasing amount of interwoven complexity that astounds them. The interwoven complexity will be so thorough that it will clearly demonstrate that the genome is clearly a integrated whole thus ruling out evolution.
Mike Dunford · 16 July 2007
Given that:
(a) "interwoven complexity" is an entirely undefined term and unmeasurable quantity;
(b) "interwoven complexity" is apparently something that has both an "amount" and can be "so thorough";
(c) it's unclear exactly why the genome isn't already considered to be "a [sic] integrated whole," and;
(d) no explanation is given for why discovering that the "so thorough" "amount" of "interwoven complexity" that finally reveals the genome to be "a [sic] integrated whole" would "rul[e] out evolution,"
that sounds exactly like an Intelligent Design prediction. Well done.
Henry J · 16 July 2007
Re "not the Scooby Doo Dinosaur Team"
But but... Scooby Doo is smart for one of his kind. ;)
Henry
Henry J · 16 July 2007
Re "that sounds exactly like an Intelligent Design prediction. Well done."
Also a prediction of a theory has to logically follow from the premise of that theory.
Add that a bioengineer could either (1) exclude all unused stuff or (2) include some for whatever reason, the basic premise doesn't imply anything either way regarding the question of unused DNA segments. So that so-called prediction follows (if it does) from secondary, unstated premise(s).
Henry
Torbjörn Larsson, OM · 17 July 2007
Torbjörn Larsson, OM · 17 July 2007
hoary puccoon · 17 July 2007
Bond, James Bond--
Don't listen to them, sweetie. You did make an ID prediction, and that's a good thing. Bravo.
The only thing is, in science, predictions not only have to be made, they have to be tested. So far, your prediction is untested, so all it merits is a shrug.
If your theory is tested and shot down, are you going to acknowledge you were wrong? Or are you going to pretend you meant something else and flip on to another untested theory, which IF it were proven true would shoot down evolution.... And so on.
I seriously doubt that theism is what really bothers most of us about ID. The thing that's so irritating is your endless refusal to test a hypothesis--any hypothesis-- and reject it if it doesn't fit the data. In other words, your refusal to do science.
Bond, James Bond · 17 July 2007
Thanks for your civility hoary puccoon. This is strange for you to accuse ID of failing to make concrete predictions. Like for instance, Behe always predicted IC (irreducible complexity) and IC has not been refuted with anything more than preposterous "just so" stories from naturalists, thus scientifically the IC prediction stands.
What's even more problematic for naturalists is that naturalists will say that most of the DNA is now junk. Yet when it is found in the future that most all of the DNA does indeed have function and is indeed an integrated whole the naturalists will severely modify their theory so as to reflect this. So the truth is that naturalists fail to make concrete predictions.
Iam confident I will not be found wrong in the complexity prediction because of the prediction track record so far,
1. Materialism did not predict the big bang. Yet Theism always said the universe was created.
2. Materialism did not predict a sub-atomic (quantum) world that blatantly defies our concepts of time and space. Yet Theism always said the universe is the craftsmanship of God who is not limited by time or space.
3. Materialism did not predict the fact that time, as we understand it, comes to a complete stop at the speed of light, as revealed by Einstein's special theory of relativity. Yet Theism always said that God exists in a timeless eternity.
4. Materialism did not predict the stunning precision for the underlying universal constants for the universe, found in the Anthropic Principle. Yet Theism always said God laid the foundation of the universe, so the stunning unchanging clockwork precision found for the various universal constants is not at all unexpected for Theism.
5 Materialism predicted that complex life in this universe should be fairly common, Yet statistical analysis of the many required parameters that enable complex life to be possible on earth reveals that the earth is extremely unique in its ability to support life in this universe. Theism would have expected the earth to be extremely unique in this universe.
6. Materialism did not predict the fact that the DNA code is, according to Bill Gates, far, far more advanced than any computer code ever written by man. Yet Theism would have naturally expected this level of complexity in the DNA code.
7. Materialism presumed a extremely beneficial and flexible mutation rate for DNA, which is not the case at all. Yet Theism would have naturally presumed such a high if not, what most likely is, complete negative mutation rate to an organism's DNA.
8. Materialism presumed a very simple first life form. Yet the simplest life ever found on Earth is, according to Geneticist Michael Denton PhD., far more complex than any machine man has made through concerted effort. Yet Theism would have naturally expected this complexity.
9. Materialism predicted that it took a very long time for life to develop on earth, Yet we find evidence for photo-synthetic life in the oldest sedimentary rocks ever found on earth (Sarah Simpson, Scientific American, 2003). Theism would have expected this sudden appearance of life on earth.
10. Materialism predicted the gradual unfolding of life to be self-evident in the fossil record. The Cambrian Explosion, by itself, destroys this myth. Yet Theism would have expected such sudden appearance of the many different and completely unique fossils in the Cambrian explosion.
11. Materialism predicted that there should be numerous transitional fossils found in the fossil record. Yet fossils are characterized by sudden appearance in the fossil record and stability as long as they are found in the fossil record. There is not one example of transition between major species out of millions of collected fossils. Theism would have expected fossils to suddenly appear in the fossil record with no evidence of transition to dramatically new forms.
Pam Singer · 17 July 2007
I am somewhat confused on part of the evolution process. Please, claify this for me.
As I understand it, random mutations account for part of our evolution. Did these randomly mutated creatures have to find other similarly randomly mutated creatures to mate with in order to carry on the mutated beneficial gene; or were these mutations of the kind that does not require a like-mutation to procreate?
Let me add that mutations that need another like-mutation to procreate have never been proven by any type of inbreeding, have they? Inbreeding has always proven to be very unbeneficial to the survival of the species.
Which leads to my last question . .
I have been reading for the last few years now, that there is a consensus among the majority, that humans have been genetically traced to a two human ancestory: A genetic "Adam and Eve".
If this is true, how is it possible that these two humans, and their immediate offspring (who had to mate with their parent or siblings at first) came to evolve at all since what inbreeding shows us, the small gene pool would have produced inbreds that may as well have been lead fed, as far as beneficial mutations of any type go.
I welcome your comments, because I don't understand, and I really want to.
Thank you.
Mike Haubrich, FCD · 17 July 2007
Bond, James Bond, "Predict"
Inigo Montoya: You keep using that word. I do not think it means what you think it means.
Popper's Ghost · 17 July 2007
Popper's Ghost · 17 July 2007
Mike Dunford · 17 July 2007
Pam:
Those are a reasonable set of questions, based around some very common misconceptions about the way evolution works. I'm running out the door to catch a flight right now, and won't be back home until late this evening, but I'll try to answer them then. When I do, it won't be in this thread. The response is going to be long enough that I'll put it up as a new post on the front page. I'll send you an email when I do.
fusilier · 17 July 2007
harold · 17 July 2007
Popper's Ghost · 17 July 2007
Popper's Ghost · 17 July 2007
Flint · 17 July 2007
harold · 17 July 2007
dhogaza · 17 July 2007
raven · 17 July 2007
raven · 17 July 2007
The problem with the junk DNA debates is typical of science. There isn't enough data to answer the question right now except in a provisional and simple minded sense.
When scientists argue endlessly about piecemeal and conflicting data, it means there is not enough data. The solution is to do more experiments and get more data! Been through this many times before and getting more of the required data works very well.
This isn't done by sitting in a chair either. Someone has to design the experiments, do them, collect the data, analyze it and repeat ad infinitum. Given the complexity and size of the mammalian genome(s), this could take decades.
One way to approach this, would be to do insertion and deletion analysis on mouse populations. The mouse genome seems to be rather plastic with chromosome numbers that even vary between populations by a lot. In addition there are a number of closely related species that are even interfertile. If sequence stretches are lost/gained in wild breeding populations, you can infer that they didn't have much effect on fitness and weren't important.
The above is why the DI will always be a fringe group of nonentities. They don't do science but rather sit on the sidelines and take potshots on real science from a pseudoscientific and ideologically motivated perspective. That isn't how science is done. All they are is a speedbump and minor nuisance on the road of increasing human knowledge.
Tim Fuller · 17 July 2007
For the record, I believe that ID is total bunk, but I also believe any attempt at finding design at the biological level is foolish. Any attempt at finding design should begin at the level of particle physics.
I wonder if this argument over design (based on DNA or observed lifeforms) is just searching for deeper meanings in shallow water?
There will always be the philisophical question of who designed the designer, but if we let go of that (for the sake of argument) and all agree that there is a designer, then wouldn't the obvious place to look for design be at a level much lower than a biological one? I can't help but wonder if the ID crowd focuses on the biology part because it's easier to make false inferences as people have built-in biological prejudices (what, me a monkey??).
It's also easier to confuse the layperson with biological homilies than mathematical certanties.
Is there a branch of ID that focuses on trying to confuse the physics as much as they do the biology?
Enjoy.
Flint · 17 July 2007
Raging Bee · 17 July 2007
Bond: your last comment was nothing but a re-paste of points you made before. They were conclusively refuted then; and the fact that you re-pasted them anyway (and had them refuted all over again) prove you're not interested in any form of actual debate or dialogue.
Raging Bee · 17 July 2007
...Yet Theism would have naturally presumed such a high if not, what most likely is, complete negative mutation rate to an organism's DNA.
Really? Show us the part of the Bible -- or any other "theistic" text -- where "Theism" says any such thing. Do you have any clue what any of those books REALLY say?
harold · 17 July 2007
Glen Davidson · 17 July 2007
Glen Davidson · 17 July 2007
Glen Davidson · 17 July 2007
Bruce Thompson GQ · 17 July 2007
I'm finding all these Luskin inspired blonde specious arguments difficult to read. The light blonde text color tends to blend into the background of the screen. Can't help but make you cranky.
Delta Pi Gamma (Scientia et Fermentum)
Glen Davidson · 17 July 2007
Glen Davidson · 17 July 2007
PvM · 17 July 2007
ofro · 17 July 2007
harold · 17 July 2007
Glen Davidson · 17 July 2007
Tyrannosaurus · 17 July 2007
If we apply Casey's arguments to the existence of God, I am afraid God case is in grave danger of been talked out of existence (if you are a believer). Good job Casey!!!!
Glen Davidson · 17 July 2007
Glen Davidson · 17 July 2007
Popper's Ghost · 17 July 2007
Lenny's Pizza Guy · 17 July 2007
Popper's Ghost · 17 July 2007
Tim Fuller · 17 July 2007
But "a few thousand interbreeding individuals" is the closest we are believed to have come to dedicated inbreeding during our recent evolution.
-------
So I'm told, yet I've never actually visited Alabama.
Enjoy.
harold · 17 July 2007
Popper's Ghost · 17 July 2007
harold · 17 July 2007
paul fcd · 17 July 2007
lenny was way better than harold and popper's ghost.
what was this post about? Politics!
It was about junk dna...
Glen Davidson · 17 July 2007
harold · 18 July 2007
paul fcd · 18 July 2007
Well, Glen, I've been a bystander here for only 4 years, and actually respect your views, I like your posts, especially as they have become shorter. Lenny was one of my favourites in years gone by for his clarity of view, if not for his repetitiveness. I just finished reading his book, and found it worth the read, and very informative about the politics of ID.
Harold, however has this odd "I'm going to jump on this troll" attitude, that is quite frankly, bizarre. Read 188648 and see his sly insinuations, and assumptions about my (and others) politics. He is both wrong and insulting and it irks me. Hence my opinion, and another reason why Lenny was the superior commentator.
So "Sorry buddy" but I am acutely aware of ID and its politics, it's your unwarranted assumptions of other posters politics that make me unlurk and vent in the first place.
sincerely, paul
Paul Flocken · 19 July 2007
Harold, Glen, and Popper,
You may have more success addressing Bond's arguments where they originally appeared, or not, considering the forum. Dignifying him with an answer here, when his crowd will not allow it there, is just beating your head against the bricks. Or perhaps Bond is really
unReasonable Kansan, who is banned anyway.Glen Davidson · 19 July 2007
CJO · 19 July 2007
It's GilDogen from Dr. Dr. Dr. Dembski's basemen-- er, blog.
Glen Davidson · 19 July 2007
harold · 19 July 2007
Paul Flocken -
You'll note that I proactively suggested that he might be plagiarizing, right at the beginning of the thread.
Doh! · 19 July 2007
I apologize if this is not the place to ask this question but this is my first post and although I've been following the ID/Evo debate here for quite awhile, I'm not sure of the proper etiquette. Anyway...
I understand on the position of those on the side of Evolution that ID is not a "theory" because it is not falsifiable but I have yet to find what it would take (that is, short of "Made by God" stamped on every lifeform)to falsify the "theory" of Evolution.
So that's my question. Can someone tell me how the TOE could be proven false? I know that there needs to be an answer; otherwise, this would be a case of the pot calling the kettle black! Thanks.
Doh! · 19 July 2007
Sorry. The start of the second paragraph should read: I understand the position of those on the...
David Stanton · 19 July 2007
Dohl,
There are lots of things that could falsify the theory of evolution. That is why it is science. In fact, many of these things could not possibly have been envisioned by Darwin.
For example, based on morphol;ogical and developmental characters, we are fairly confident that the vertebrates represent a good monophyletic group. Therefore, if some vertebrates were more closely related genetically to butterflies and somewere more closely related to jellyfish, evolution would effectively be falsified. However, that has not been found to be the case.
The order of appearance in the fossil record of major groups could also potentially falsify evolution. If for example, vertebrates appeared before bacteria, that would be difficult to explain if evolution were true. Or, (the classic example), if fossil rabbits were discovered in precambrian strata, that would effectively falsify evolution. Needless to say, nothing like this has ever been observed either.
Of course, since the theory has been tested so many times in so many different ways and has not been falsified in 150 years and since the theory has such tremendous predictive and explanatory power, it will take more that just one anomalous data point to falsify the theory now. But contrast that with the ID approach where anything is possible and no designer is identified.
Glen Davidson · 19 July 2007
Glen Davidson · 19 July 2007
I'd like to add another four theoretic falsification possibilities for evolution, because they are among the best for anyone who isn't steeped in biological knowledge.
1. Evolution would be falsified if there were no vestigial organs. This isn't a favorite "argument" in general any more, partly because some incautious evolutionists "found" lots of vestigial organs, plus we've mostly moved beyond those matters in evolutionary research.
But even though vestigials might naively be expected to disappear rather quickly once they really were vestigial, evolution under the constraints of shared developmental processes across organs and traits would continue to predict that at least some vestigial organs would exist. And they do. Juvenile platypus teeth, the coccyx in humans, and the teeth of young baleen whales are some of these. The fact that there might be some function among these does not change the fact that they are essentially useless in the functions that related organisms have for them.
We're lucky that we have platypus teeth, however, because they are important to show the relationships between platypus ancestors and the modern species. Just another thoughtful aspect of this world from the "designer";):)
2. Evolutionary relationships would be revealed in the developmental programs of organisms, or evolution (under known constraints) would be falsified. Haeckel's claims have long been exploded, of course, but we still get claws on the wings of some birds while they're still in their eggs (and in juvenile hoatzins), humans have many similarities with our ancestors at a certain stage of development, including the tail that turns into our vestigial coccyx, and the testes in most mammals have to descend (before birth in humans, after in some mammals) into the scrotum from the ancestral position in the abdomen.
3. And evolution would be falsified if no transitional fossils could be found. This is a prediction involving the collectivity of data, and the lack of a transitional for, say, gibbons would not be devastating, both because gibbons fossilize poorly (wet forest environments) and because we don't bother looking much for gibbon fossils.
But among reasonably easy-to-fossilize organisms, transitional fossils would be predicted to have been found by now, and they have been found for all of the "class transitions" of vertebrates. So, for example we have transitional forms for the evolution of birds, amphibians, and mammals. Likewise for hominins, rhinoceruses, whales, horses, and many plant classes.
Again, this brings up one reason why I have issues with falsification as "the standard", though I often resort to it as shorthand as well in calling for ID to follow normal science standards (I also don't like it because it takes the emphasis away from induction and positive evidence). It isn't that a particular observation, or lack thereof, would falsify evolution, but that in the present context we'd expect to have found many transitionals, and we have. It's a probabilistic version of "falsifiability", not the direct "deterministic" sort of falsification is all that many know of.
4. The following falsification standard relates to previously-mentioned vestigials, evolutionary constraints, and the marks of design, but I'd also mention that if everything was more or less "optimally" designed, evolution would be immediately falsified. Or even if we didn't hold the organic world to standards of perfection, at least we could say that if everything was built as well as, say, the latest and best computer chips are, that would falsify evolution.
Instead we have a variety of problems in the biological realm, including the fact that no large leaps to better materials (like synthetic composites) are possible, the eye has its blood vessels on the wrong side of the retina (despite IDist claims to the contrary, it is not fully compensated, or optimal---otherwise birds wouldn't evolutionarily minimize this defect) due to inherited developmental constraints, and vestigials exist.
5 (okay, I just thought of this one, so it's not "four" any more). Additionally, transitional forms are quite obviously not as well adapted as "later models" are, so that clearly archaeopteryx labored under difficulties that later birds do not have. Yes, once again the prediction of evolution, in this case that later forms of an inherited trait will generally be better than the earliest-found forms, is borne out by the evidence.
You could falsify evolution, then, by showing (in a line which has many fossil representatives through time) that the first representatives of a complex integrated ability like flying are as good at it as the versions found tens of millions of years later. Where we have clear examples, like flying, or walking in the amphibians, the earlier versions indeed are poorer at it than later organisms are, such as the swift and the cheetah.
Glen D
http://geocities.com/interelectromagnetic
Steviepinhead · 19 July 2007
Well, that latest comment was more like the "old" Glen for length, but was intersting and well-said nonetheless.
As pointed as Stanton's more succinct reply, just with more point and sub-points.
(If my old eyes yet serve me, however, Stanton meant to reply to "Doh!" and not to "Dohl." Which leads me to speculate that Stanton may have old eyes as well.)
David Stanton · 19 July 2007
Steviepinhead,
You are correct sir. However an equally plausible hypothesis might be that my right hand knoweth not what my left hand doeth.
Steviepinhead · 19 July 2007
I ruled out the fumbled-finegered-typist hypothesis based on the impeccability of the great bulk of your prose as posted here.
I am, of course, always willing to revise my hypotheses when presented with additional, conflicting data.
Steviepinhead · 19 July 2007
Of course, just to make others feel better, I always include at least one *deliberate* typo in any post that touches, even glancingly, on typing ability.
In the above case, this inclusion was "finegered" for "fingered."
Note, however, the rule "at least one."
If you note others, you may be sure that they, too, were *deliberate.*
harold · 19 July 2007
Doh! -
When the theory of evolution first became prominent, almost nothing was known about biochemistry. Genetics was not yet understood at all. The role of DNA was not even understood. It was not completely accepted that microbes could cause infectious disease! Many other very basic things were unknown.
We have been learning more and more about life for 150 years. Each new thing we learned potentially could have caused problems for the theory of evolution, but each new thing we learned - biochemistry, cellular biology, electron microscopy, molecular biology, etc, etc, etc - continued to support the theory of evolution.
ID offers nothing. If life shows signs of common descent it's "common design". If common descent is ruled out, it's "individual design".
Here's a helpful link...but before you click it, please answer a question for me.
Do you care? Or were you just mouthing what you hoped would be a creationist "gotcha"? Do you give a damn what the evidence actually shows, or are you dedicated to creationism, the hell with the honest evidence?
http://www.talkorigins.org/faqs/comdesc/section1.html
David Stanton · 19 July 2007
I like Glen's list. And he's right, if no transitional fossils had ever been found, that would be a huge problem for the theory of evolution and would probably be enough to falsify it. Of course that one has kind of gone by the wayside. We can't really undiscover the fossils at this point, so ignoring them will have to do for some.
However, we have yet to sequence even a single gene from most known organisms. (That is in fact the goal of the Barcode of Like Database project). Since there is so much work to be done, and since there are so many possible opportunites to disprove evolution, you would think that the ID crowd and creationists in general would be pumping huge sums of money into automated sequencing efforts. I wonder why they don't seem to be doing that?
As for junk DNA research, why bother when no matter what anyone else discovers you can always claim that you predicted it?
hoary puccoon · 20 July 2007
Doh!-- I hope you reply back, because people have put a lot of effort into answering you.
Taking the theory of evolution from an historical perspective, keep in mind;
1. The Genesis story was already in trouble as a scientific theory before Darwin wrote word one of The Origin of Species. The real doubts mostly came from geologists, not biologists, but scientists were flailing around, trying to make sense of layer upon layer of stone that looked like it had been laid down over a long time, not thrown together in 6 days, and then churned up in a flood. If this hadn't been true, Charles Darwin would be long forgotten.
2. The theory of evolution hasn't been disproven-- but not for want of trying. After OoS came out, practically everybody took a shot at knocking down evolution. The ToE came through each challenge stronger than ever. The "disproofs" of the current creationists are often steals from respected 19th-century scientists. Can you blame modern scientists for ignoring issues that were settled over a century ago?
3. The fact of evolution has become more and more apparent over the years-- but Darwin's actual theory has been proven wrong in many, many particulars. If scientists were interested in replacing God with Darwin, why would they be perfectly happy to throw large chunks of his conclusions out the window? In fact, most evolutionary biologists and geologists working today don't care one way or the other about what Darwin said. They base their research proposals on the work of their immediate predecessors, who based their work on their immediate predecessors.... And so on. If, at any iteration, solid evidence had come out against evolution, hordes of researchers would have jumped in with glee. It never happened.
So, sure, in principle evolution could be disproven. But in practice no legitimate scientist sees any way to do this. They don't reject ID or 'scientific' creationism because they don't like its conclusions-- they reject it because it's not science. It may look like science to a naive outsider, but to real scientists trying to run research programs, there's simply nothing in creationism but misstatements and faulty logic-- nothing at all a researcher can use.
Popper' Ghost · 22 July 2007
Popper' Ghost · 22 July 2007
Popper' Ghost · 22 July 2007
Popper' Ghost · 22 July 2007
Popper' Ghost · 22 July 2007
Popper' Ghost · 22 July 2007
Here is some more grist for the recollection mill. Reading it over, I have the same view of your dishonesty at the time as I did then.
make solar panels · 3 March 2010
She's pretty average...definitely better than Beyonce though. I noticed one of her songs sounds almost exactly the same as another song a male pop band does....buuuuut i cant remember what the song is atm!!...but does anyone know what I'm talking about? lol