So let me spell it out: DIRECTED EVOLUTION IS NON-DARWINIAN. DARWINIAN EVOLUTION IS NON-DIRECTED. ... Just because the word "evolution" is used doesn't mean that homage is being paid to Darwin. "Directed evolution" properly falls under ID.The sad thing is, this little outburst should really be directed at Matti Leisola and Ossi Turunen, the guys who wrote the paper under consideration, and not at me. Here is what the authors wrote:
At one end is an approach commonly referred to as a rational design, which aims to understand the principles of protein structure and function well enough to apply them in designing new properties or even novel proteins using de novo design. The value of this approach in purely scientific terms is indisputable. However, because the difficulty is likewise indisputable, any approach that might succeed sooner is worth exploring. That realization has motivated work at the other end of the spectrum, where the emphasis is on finding what works rather than predicting what works. Darwinian evolution is the inspiration behind this. In the extreme form, this means avoiding protein design principles altogether and relying instead on huge sequence libraries and carefully designed selection methods.Why didn't Dembski, with all his brilliance, bother telling his ID author heroes that they were really talking about "intelligent design" the whole time? Instead they're under the horrible misapprehension that directed evolution techniques were inspired by Darwinian evolution. And later they go on to say that there's an "Overreliance on the Darwinian methodology", meaning the directed evolutionary methods they spent the previous paragraphs describing. Here's more:
Whoa, what's that? Leisola and Turunen agree that mutation and selection are "Darwinian principles", and that these principles are responsible for the success of directed evolution? Say it ain't so! Tell me something Bill: Did you even read the paper? Putting aside the fact that Dembski is flatly contradicted by the very "pro-ID" paper he originally cited, his claim is utterly illogical. Dembski's original error was to conflate rational design techniques with "intelligent design", which as I pointed out at the time is just plain wrong. Protein engineers do not operate under the premise that natural proteins were designed by some unknown intelligence for unknown reasons using unknown methods at some unknown point in the past. Quite the opposite, even those relying strictly on rational design methods use phylogenetic trees and other facets of evolutionary theory to guide their research. Now Dembski has gone and doubled-down on the absurdity, declaring that the method at the "other end of the spectrum", which is directed evolution, is now also "intelligent design". Goodness, is there anything that doesn't fall under that vague and useless term? As I explained previously, directed evolution methods involve the experimenter using random mutagenesis and a selection screen. This is the Darwinian mechanism. The fact that an experimenter chooses which screen to use doesn't matter, because the experimenter is simply mimicking what the environment does on a constant basis all over the planet. In fact, as far as the organism or protein sequence under selection is concerned, the experimenter is just another piece of the environment. And it definitely has nothing to do with ID, which is -- and let's drop the pretense for a change -- God supernaturally zapping stuff. Given Dembski's reasoning, we should conclude that wind tunnel experiments are an example of ID because the experimenter sets the speed and direction of the wind. Therefore, airplane lift could not happen due to undirected naturalistic forces. If you think this is ridiculous, you are correct.It is often said that random genetic methods to improve enzyme properties "rely on simple but powerful Darwinian principles of mutation and selection" (Johannes and Zhao 2006). We agree.
29 Comments
Vyoma · 11 April 2007
When you get right down to it, I think the only people left who still care what Dembski has to say are the people who hang about on his website. I don't see much evidence that anyone else puts much stock in his ideas or, frankly, even know who he is... including creationists I've met in my neck of the woods (there are very, very few people that I've met here who use the words "intelligent design" as anything other than a more modern-sounding title for "creationism," and they'll say so unabashedly).
Most of them haven't read anything Dembski has ever written anywhere, nor do they appear to know he has a website.
Essentially, Dembski has become irrelevant to anyone outside of a small core of his true-believers (if he ever was relevant in the first place). Even most man-in-the-street type ID proponents couldn't say who the guy is, and in the scientific sphere, nobody is motivated one way or the other by Dembski.
Maybe he's still got some impact on the theological circles he claims to be most comfortable in?
PoxyHowzes · 11 April 2007
Grammar police here: the phrase "the very pro-ID paper" means, I think, "the exact same pro-ID paper," not "the paper that is so pro-ID." (actually, it is grammatical, just potentially ambiguous.)
Steve Reuland · 11 April 2007
Glen Davidson · 11 April 2007
It's "Darwinian evolution" in the same sense that any Petri-dish evolution experiment is. That is, it's evolution under laboratory conditions.
In that sense it is somewhat different from evolutionary theory, which deals with evolution "in nature". But of course it's proof of principle, exactly the sorts of "experiments" that should be done with respect to evolutionary theory, if they can be.
Dembski apparently thinks that doing experiments under controlled conditions somehow voids the scientific method, when it is (part of) the scientific method. Presumably it's why he does none.
Glen D
http://tinyurl.com/35s39o
Dave S. · 11 April 2007
raven · 11 April 2007
Bill Gascoyne · 11 April 2007
raven · 11 April 2007
Henry J · 11 April 2007
Re "What's the difference between direction by natural selection for differential reproduction of the fittest and human direction toward some chosen goal?"
My guess: populations produced by natural selection are probably better able to adapt to changing conditions, and populations produced by artificial (human guided) selection are more apt to require continued human support for their survival.
Henry
David Stanton · 11 April 2007
So, a successful application of a theory is not the theory, because the theory (which was developed to explain what happens in nature) said nothing about any particular applications.
OK, so: a light bulb is not a theory of physics and theories of physics say nothing about light bulbs; an atomic reactor is not atomic theory and atomic theory doesn't have anything to say about an atomic reactor, etc.
Pretty silly argument.
Vyoma · 11 April 2007
raven · 11 April 2007
FWIW, there is nothing particularly new about directed evolution of proteins for binding or activity. This has been done for at least 15 years. Phage display has been used to select higher affinity antibodies directed against a given target and so on.
The same general principles have been used to make RNA chunks (aptamers) that bind to a given target or catalytic RNAs (ribozymes) that perform various catalytic reactions. One of them is an RNA ligase with weak polymerase activity. I will have to check but one aptamer drug, Macugen, binds to vegf and is used to treat macular degeneration and was probably derived by directed RNA evolution.
This is very old molbio news. Whether a creo molecular biologist has his name on a paper in the field or not should be totally irrelevant as to whether it has any relevance to evolution or ID.
Jason F · 11 April 2007
Kevin · 11 April 2007
"Tell me something Bill: Did you even read the paper"
read? what is this "read" of which you type?
Dave Carlson · 12 April 2007
Torbjörn Larsson · 12 April 2007
trrll · 12 April 2007
Embarrassing as this is for Dembski, he really had no choice but to reverse himself. Desperate for examples of ID-based research, he prematurely embraced this paper, then realized that he had painted himself into a very dangerous corner.
For Dembski to acknowledge any kind of directed evolution as a valid simulation of natural selection would be a fatal blow to the entire intellectual facade that he has labored to create. Dembski's fundamental argument, after all, is that it is impossible for Darwinian mechanisms to generate any kind of non-trivial information. As long as Dembski can keep this on a purely theoretical level, he is insulated from challenges. But if any kind of laboratory or computer simulation is valid, then it becomes possible to test Dembski's claims experimentally, and Dembski clearly knows how that would come out. It is not good enough for rational protein design to be superior to natural-selection-simulation based protein design (even if that were true, which at this point it still isn't), because Dembski's thesis requires that natural selection should not work at all.
So Dembski has no choice but to insist that any kind of natural selection based method of design possesses some form of "smuggled intelligence," which is entirely responsible for its success.
secondclass · 12 April 2007
Mike Treat · 12 April 2007
I pop over to Panda's Thumb every once in a while just to confirm how silly those that worship at the alter of materialism can make themselves look. Your ad hominem attacks on Dembski are downright silly. First you question whether he read the paper mentioned in this thread (possible but unfounded). Then you question whether anyone that supports ID *can* read or even know what a web site is. Classy. You claim that Dembski is doing more to undermine ID than you can do yourself. The way I see it, vitriol like that displayed at Panda's Thumb does more to undermine your case than anything else I've seen. Your venom inherently smacks of hysteria to anyone with an open mind regarding which inference -- macro-evolution (sorry, it's just an inference) or intelligent design -- best explains the incredible complexity, diversity, and interdependence displayed within life as we understand it. The open-minded takes one look and concludes they can't trust materialistic fundamentalists such as yourselves. Perhaps they won't (and shouldn't) trust some elements of the ID crowd either. All fundamentalism is wrong-headed: whether pro *or* anti ID. Plus, Darwinian theory says *nothing* empirical about how the first self-replicating life-form came to be in the first place. But I forget. Having an open mind on these issues is unacceptable. To be an accepted member of the church of materialism requires that one chant pro-Darwinian phrases and nothing else. God (or whoever) forbid that we only go as far as the evidence actually leads. We *MUST* choose *NOW* to worship random chance. What's so bad about having an open mind? I'm *sure* all the nice folks at Panda's Thumb will respond to this posting with civil, well-thought out responses rather than name-calling -- thereby refuting my main point that you folks do more harm than good to your cause. The more we learn about life the less likely it is that undirected random chance can accomplish it all. You're looking sillier all the time.
Henry J · 12 April 2007
Mike,
If name-calling refutes one's own argument, then you just clobbered yours.
Henry
TheBogNug · 12 April 2007
You are right Mike. Undirected random chance would not accomplish much at all. Of course, the great part of natural selection is that it isn't undirected random chance. It is wrapped in that word, "selection". I would've guessed with such an open mind you would have read and understood enough of evolutionary theory to have grasped that critical point.
RBH · 12 April 2007
harold · 12 April 2007
Mike Treat -
Your post suggests to me that you, yourself, might benefit from becoming more open-minded.
The large number of insults in your post ("silly", "hysterical", etc) serves no purpose except to make communication more strained.
Your complaint that the theory of evolution does not explain how life began is valid but irrelevant. The theory of evolution explains how cellular and post-cellular life evolves.
I'm not sure what you mean by "macro-evolution", but evolution of cellular and post-cellular life on earth from a common ancestor, by the process of variable replication of nucleic acids, natural selection acting on phenotypes, and a number of other natural processes (mainly random genetic drift) is not "based on conjecture". It is supported by strong evidence from molecular biology, biochemistry, genetics, physiology, anatomy, anthropology, and paleontology.
You make the very common error of confusing "ad hominem" with "insult" or "criticism". An ad hominem is not an insult, it is the illogical act of using an an irrelevant insult to argue against an unrelated position held by the insulted party (imaginary example - "David Duke believes that Paris is the capital of Czech Republic, and David Duke is a racist, so Paris must not be the capital of Czech Republic"). Note that even if the conclusion is coincidentally correct, as here, and even if the insult or personal criticism is valid, as may be the case here, the logical process is still wrong. This is not an independently good reason to conclude that Paris is not the capital of the Czech Republic.
Dembski is sharply criticized here (more than deservedly so, in my opinion), and even insulted. These criticisms are not ad hominems, however. In fact, Dembski's demonstrably wrong opinions give rise to the criticisms, rather than the criticisms leading anyone to conclude that his opinions are wrong.
Your (incorrect) statement that posters here are "fundamentalist materialists", however, comes close to ad hominem, since you use it as a justification for not accepting unrelated arguments. I'm not a "fundamentalist materialist", but if I were, the bacterial flagellum may still have evolved rather than having been pinned on by a magical "designer".
The irony of your declaration that insults invalidate arguments, in combination with your heavy use of insults, has already been commented on.
Insults don't invalidate arguments. "Two plus two is four, you bloated imbecile" accurately expressed that two plus two is four, despite the insult. They do hamper communication at times, however.
Steve Reuland · 12 April 2007
Vyoma · 12 April 2007
secondclass · 12 April 2007
Raging Bee · 13 April 2007
The way I see it, vitriol like that displayed at Panda's Thumb does more to undermine your case than anything else I've seen.
Hey, at least we're not blaming Dembski for the Holocaust, eugenics, and all the other evils his crowd have blamed on "Darwinism." I really don't think you're in a position to lecture us on the subject of "vitriol"
Science Avenger · 13 April 2007
Science Avenger · 13 April 2007